A colonial-style building with a bell tower, palm trees, and a paved walkway.

Santa Cruz hotels from HK$197

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Tonight
31 Aug - 1 Sept
Tomorrow
1 Sept - 2 Sept
This weekend
4 Sept - 6 Sept
Next weekend
11 Sept - 13 Sept

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Our top choices for Santa Cruz hotels

1. Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra
Santa Cruz
United States
Hui Hua
HK$279
HK$279 total
14 Sept - 15 Sept
Ibis Santa Cruz DE LA Sierra

2. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Santa Cruz
Canada
Andrew
HK$1,060
HK$1,060 total
14 Sept - 15 Sept
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3. Hotel Cortez

Hotel Cortez
Santa Cruz
United States
Leonora
HK$960
HK$960 total
4 Sept - 5 Sept
Hotel Cortez

4. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Santa Cruz
United States
imilse de
HK$577
HK$577 total
1 Oct - 2 Oct
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

5. Hotel Las Américas

Hotel Las Américas
Santa Cruz
Canada
Stanley
HK$205
HK$205 total
1 Sept - 2 Sept
Hotel Las Américas

6. Sun Hotel

Sun Hotel
Santa Cruz
United States
Daniela
HK$847
HK$847 total
2 Sept - 3 Sept
Sun Hotel

7. Camino Real Hotel

Camino Real Hotel
Santa Cruz
United States
Austin
HK$1,137
HK$1,137 total
14 Sept - 15 Sept
Camino Real Hotel

8. Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
Santa Cruz
United States
Ruben
HK$212
HK$212 total
1 Sept - 2 Sept
Apart Hotel Premium Suites Santa Cruz

9. Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
Santa Cruz
United States
Luisa
HK$361
HK$361 total
7 Sept - 8 Sept
Premium Suites Deluxe Aparthotel Equipetrol

10. Delfines Collection Hotel By Mercure

Delfines Collection Hotel By Mercure
Santa Cruz
United Kingdom
Mathetes
HK$395
HK$395 total
4 Sept - 5 Sept
Delfines Collection Hotel By Mercure

11. Hotel Pascana centro

Hotel Pascana centro
Santa Cruz
HK$394
HK$394 total
1 Sept - 2 Sept
Hotel Pascana centro

12. Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
Santa Cruz
United States
Deivis
HK$932
HK$932 total
12 Sept - 13 Sept
Marriott Santa Cruz de la Sierra Hotel

13. HOTEL OSHO

HOTEL OSHO
Santa Cruz
Canada
David
HK$428
HK$428 total
2 Sept - 3 Sept
HOTEL OSHO

14. Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
Santa Cruz
United States
ERNESTO
HK$969
HK$969 total
1 Oct - 2 Oct
Novotel Santa Cruz De La Sierra

15. Chairú Eco Hotel

Chairú Eco Hotel
Santa Cruz
Canada
Shabbir
HK$441
HK$441 total
1 Sept - 2 Sept
Chairú Eco Hotel

16. Alfonsina Hotel Boutique by Inboccaluppo

Alfonsina Hotel Boutique by Inboccaluppo
Santa Cruz
United States
Elizabeth
HK$845
HK$845 total
4 Sept - 5 Sept
Alfonsina Hotel Boutique by Inboccaluppo

17. Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro
Santa Cruz
HK$319
HK$359 total
17 Sept - 18 Sept
Hotel LP Santa Cruz Centro

18. Hotel G

Hotel G
Santa Cruz
Mexico
JACOB
HK$193
HK$193 total
29 Sept - 30 Sept
Hotel G

19. Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
Santa Cruz
United States
GONZALO
HK$1,286
HK$1,286 total
14 Sept - 15 Sept
Swissôtel Santa Cruz De La Sierra

20. TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
Santa Cruz
United States
Pluetina
HK$855
HK$855 total
1 Sept - 2 Sept
TRYP by Wyndham Santa Cruz
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Holiday Rentals in Santa Cruz

Aparthotel

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
Santa Cruz
"great place to stay!"
Premium Suites Deluxe Aparthotel Equipetrol
Apartment

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
Santa Cruz
"Great location."
Apart Hotel Premium Suites Santa Cruz
Aparthotel

Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel
Santa Cruz
"Perfect hotel"
Equipetrol Suites Apart Hotel
Aparthotel

Terranova Suites

Terranova Suites
Santa Cruz
"Easy to access"
Terranova Suites
Apartment

AMERICA APARTMENTS

AMERICA APARTMENTS
Santa Cruz
"Clean room, great staff "
AMERICA APARTMENTS
Holiday Home

Casa Vida

Casa Vida
Santa Cruz
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"
Casa Vida
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Where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most.Learn more about Santa Cruz
Learn more about Santa Cruz

Hamacas

When in Hamacas, you can plan a visit to Santa Cruz Zoo and Las Brisas Shopping Center, some noteworthy sights in the nearby area.

Stay near popular Santa Cruz attractions

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
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An interior of a church with high arched ceilings, wooden pews, and a central altar.

San Lorenzo Cathedral

9.0/10 (84 reviews)
This grand neoclassical cathedral dominates Santa Cruz's skyline with its towering spires and ornate façade. Climb the bell tower at sunset for breathtaking panoramic views of the city.
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Ventura Mall

9.0/10 (183 reviews)
Ventura Mall, Santa Cruz's premier shopping destination, features international brands and local boutiques. Enjoy the cinema complex, food court, and entertainment options in this contemporary Bolivian retail hub.
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Guembe Biocenter

8.8/10 (60 reviews)
This vibrant ecological sanctuary showcases hundreds of butterfly species in a lush, tropical environment. Explore walking trails, enjoy boat rides, and learn about biodiversity in this serene natural retreat.
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Santa Cruz Zoo

8.4/10 (53 reviews)
The Santa Cruz Municipal Zoo showcases Bolivia's native wildlife in naturalistic habitats, featuring jaguars, tapirs, and free-ranging sloths. Morning visits offer the best chance to see active animals.
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Cine Center

8.0/10 (53 reviews)
This premier entertainment complex offers state-of-the-art cinema experiences with immersive 4D E-Motion formats. Enjoy the latest films, then explore the shopping centre and diverse dining options in the food court.
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Ramon Tahuichi Aguilera Stadium

8.4/10 (18 reviews)
This multi-purpose stadium hosts Bolivia's most passionate football rivalries and tournaments. Experience the electric atmosphere of a local derby while enjoying modernised facilities and vibrant Santa Cruz culture.
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Las Brisas Shopping Center

8.4/10 (40 reviews)
This modern complex offers 80+ stores, a nine-screen cinema, and a unique outdoor restaurant promenade. Explore the gastronomic boulevard for dining experiences beyond the standard food court options.
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Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

See all hotels in Santa Cruz
A colonial-style building with a bell tower, palm trees, and a paved walkway.

Top Santa Cruz Hotel Reviews

Sun Hotel

Sun Hotel

8/10 Good
"The room was clean and the AC worked great. I also enjoyed having good hot water. I was very happy that the room had a king bed instead of two double beds we received when we stayed here earlier in the week. The free shuttle wasn't available, so we had to take a taxi from the airport, but the front desk reimbursed us. I have to say that the front desk staff was not cordial, almost to the point of being unfriendly. This is sad. When we checked in I told the staff that the following night we needed to leave the hotel at 9 pm for the airport. The next day I also confirmed this. However, at 9 pm the shuttle was gone, to wait for an arrival. After 15 minutes, I asked again, and they finally ordered the shuttle to return and take us to the airport. This really cut down our available time at the airport. If Sun Hotel is going to be hostile to foreign visitors, then they shouldn't be in business where they are uniquely positioned 5 minutes from an international airport. Shame on you! And it wasn't a case of a difficult foreigner ... I speak fluent Spanish and was very polite in all our dealings."
Stephen 3-night trip
Posted 1 day ago
Sun Hotel
Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

10/10 Excellent
"All around good price and location"
Alejandro 1-night trip
Posted 2 days ago
Novotel Santa Cruz De La Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

10/10 Excellent
"Las piscinas son buenazas, la comida también, súper bien ubicado. Pero hay una zona que no tiene ascensor si te toca cuarto ahí y tienes silla de ruedas avisar"
DANIELA 2-night trip
Posted 3 days ago
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

10/10 Excellent
"Staff was super as well as how clean the room was."
Francis Marie 8-night trip
Posted 7 days ago
Marriott Santa Cruz de la Sierra Hotel
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

10/10 Excellent
"Buen hotel Limpio y comodo"
Fernan 4-night trip
Posted 9 days ago
Ibis Santa Cruz DE LA Sierra
Delfines Collection Hotel By Mercure

Delfines Collection Hotel By Mercure

10/10 Excellent
"Todo muy bien"
lady 2-night trip
Posted 2 weeks ago
Delfines Collection Hotel By Mercure
Hotel LP Equipetrol

Hotel LP Equipetrol

8/10 Good
"El cuarto agradable, pero faltó servicio de ayuda para subir y bajar maletas, también servicio adecuado de taxi para moverse en Santa Cruz"
José Bernardo 1-night trip
Posted 2 months ago
Hotel LP Equipetrol
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

10/10 Excellent
"Great location."
Ruben 2-night trip
Posted 3 months ago
Apart Hotel Premium Suites Santa Cruz

More cheap stays in Santa Cruz

Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel

Equipetrol Santa Cruz Departamento de Santa Cruz
HK$390
HK$390 total
1 Sept - 2 Sept
Equipetrol Suites Apart Hotel
Ibiza Hostel

Ibiza Hostel

445 Santa Cruz Departamento de Santa Cruz
Get ratesIbiza Hostel
Amaca Hostal

Amaca Hostal

249 Independencia Santa Cruz Departamento de Santa Cruz
Get ratesAmaca Hostal
Casa Por Temporadas

Casa Por Temporadas

Barrio Las Pampitas, calle 3 Nro. 99 Santa Cruz Santa Cruz Department
Get rates
10/10 Exceptional! (1 review)
Casa Por Temporadas
HOTEL CASA BLANCA

HOTEL CASA BLANCA

Avenida Marcelo Terceros Zona Equipetrol Santa Cruz Santa Cruz de la Sierra
Get ratesHOTEL CASA BLANCA
Hotel Viru Viru II

Hotel Viru Viru II

Av. Alameda 72 - Zona Valle Sanchez Santa Cruz Santa Cruz de la Sierra
Get rates
4.8/10 (3 reviews)
Hotel Viru Viru II

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is one of the top choices for your stay based on our traveller data. This hotel offers a full-service spa and 2 restaurants. Other good choices for your stay include Ibis Santa Cruz DE LA Sierra and Marriott Santa Cruz de la Sierra Hotel. See all available top hotels, or vacation rentals in Santa Cruz.
What are some of the best holiday rentals that Santa Cruz has to offer?
Casa Vida: This highly rated holiday home rental in Santa Cruz is located in a rural location, and has an outdoor pool, a patio and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a full-sized fridge, a stovetop and a microwave, so that you can cook with friends or family. Kick off your shoes and enjoy yourself with a private garden and a selection of games. Some other homes for rent in Santa Cruz include Cozy 1-bedroom house in beautiful Santa Cruz de la Sierra with WiFi, AC and Seasonal House. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
What's the best budget-friendly accommodation in Santa Cruz?
Based on our traveller reviews, Ibiza Hostel is a top choice for a less expensive stay. Other choices for your budget-friendly stay include residencial francia - Hostel and Residencial Ikandire II. View all budget hotels in Santa Cruz.
What's the best family accommodation in Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a hotel with 2 restaurants and free parking, and it's a top choice on Expedia for families. Other choices for your child-friendly holiday include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. Also, attractions such as Santa Cruz Zoo and Play Land Amusement Park are fun for children of all ages. Find more child-friendly accommodations in Santa Cruz.
What's the best LGBTQ-friendly accommodation in Santa Cruz?
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your holiday. See all available hotels listed as LGBTQ-friendly in Santa Cruz.
What's the best dog-friendly accommodation option in Santa Cruz?
Casa Por Temporadas is a top dog-friendly guest house, and offers an outdoor pool along with in-room kitchens for its human guests. Two other good options for you and your pet's trip include Ibis Santa Cruz DE LA Sierra and Swissôtel Santa Cruz De La Sierra. See more pet-friendly hotel accommodations in Santa Cruz.
What's the best luxury accommodation option in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Camino Real Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia are other upscale choices for your holiday. Find more luxury hotels in Santa Cruz.
What are some accommodation options with pools in Santa Cruz?
Yotau All Suites Hotel is a top hotel with 2 outdoor swimming pools, a children's pool and 2 restaurants. A couple of other options that feature an on-site pool include Buganvillas Hotel Suites & Spa and Loft sobrio, rooftop panorámico y piscina infinita. View all hotels with pools in Santa Cruz.
What is the best spa hotel in Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a top spa hotel featuring a fitness centre, a hair salon and a bar. Enjoy a facial, body scrub or hydrotherapy at Los Tajibos Club Spa. Other popular spa hotels in Santa Cruz include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. See all spa hotels in Santa Cruz.
What's it like to stay in Santa Cruz?
Visitors to Santa Cruz will definitely enjoy the shopping. Tourists can also enjoy the city's cafés, zoo and cathedral. In Santa Cruz, there are 305 hotels and other accommodation options to choose from. Find out more about Santa Cruz.
What is there to see in Santa Cruz?
Cultural venues include Cine Center, Ethno-folkloric Museum and Sacred Art Museum. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre and Blacutt Square might be worth a visit. Natural beauty is on display at Guembe Biocenter, Lomas de Arena Regional Park and Arenal Park. Take a look at what more there is to see and do in Expedia's Santa Cruz guide.
How should I get around Santa Cruz?
If you want to venture outside the area, hop on a train at Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.
What's the weather like in Santa Cruz?
The hottest months are usually October and November, with an average temperature of 26°C, while the coldest months are June and July, with an average of 21°C. Average annual precipitation for Santa Cruz is 1208 mm.