A calm river with boats, lush greenery, and a clear blue sky.

Big Pine Key 5 Stars Hotels

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Check availability on Big Pine Key 5 Star Hotels

Tonight
23 Oct - 24 Oct
Tomorrow
24 Oct - 25 Oct
This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

Our top choices for Big Pine Key 5-star hotels

An aerial view of a resort with a central pool, multiple buildings, and a beach area with sun loungers.
A beach with white chairs and kayaks, palm trees, and a clear view of the ocean.
A bar area with wooden chairs, a bar counter, and a variety of bottles and glasses.
A beach scene with two white chairs, a hammock, and palm trees.

1. Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
Marathon
United States
Clinton
HK$1,615
HK$2,286 total
includes taxes & fees
25 Oct - 26 Oct
Isla Bella Beach Resort & Spa
A resort pool with a view of the sea, surrounded by palm trees and lounge chairs.
A wooden deck with a spiral staircase leading to an upper level.
A modern kitchen with white cabinetry, a marble island, and wooden bar stools.
A modern white building with a garage, surrounded by palm trees and a clear blue sky.

2. Sea Glass Cove

Sea Glass Cove
Marathon
Sea Glass Cove
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Big Pine Key.
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy Marathon FL
HK$1,624
HK$2,330 total
15 Nov - 16 Nov
includes taxes & fees
8.8/10 Excellent! (1,001 reviews)
Tranquility Bay Beachfront Hotel and Resort
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

1996 Overseas Highway Marathon FL
HK$1,150
HK$1,589 total
15 Nov - 16 Nov
includes taxes & fees
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
Grassy Flats Resort & Beach Club

Grassy Flats Resort & Beach Club

58182 Overseas Hwy Marathon FL
HK$1,579
HK$2,152 total
23 Nov - 24 Nov
includes taxes & fees
Grassy Flats Resort & Beach Club
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colourful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key
A coastal town with a beach, clear waters, a pier, and lush greenery.

Top Big Pine Key Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"fantastic place - maybe nicest in Keys!!!"
JOSEPH 5-night trip
Posted 1 day ago
Isla Bella Beach Resort & Spa

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Big Pine Key?
How much you pay for a 5-star hotel in Big Pine Key depends on factors like when you want to go and the length of your escape. An insider tip for bagging an awesome deal? Use our pricing filters to compare the available options for your preferred dates.
  • Search for the lowest price per night from HK$1,589
What makes a hotel 5 stars in Big Pine Key?
From fine dining venues and 24/7 fitness centers to pools and luxury bedding, the 5-star experience in Big Pine Key is all about luxury and relaxation. But it takes more than just top-notch amenities to get a 5-star rating. Accommodation also have to offer extraordinary guest-centric services like in-room beauty treatments, laundry and dry cleaning and a nightly turn-down service.
Are there any 5-star all-inclusive resorts in Big Pine Key?
Use our handy filters to find a luxury escape in Big Pine Key where most of what you need is included in the price. After your initial search, refine your results for accommodation that have a 5-star rating and are categorised as "All inclusive." The first thing on the schedule at these stays? Pure relaxation and indulgence.

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