Jacksonville Mayo Clinic Florida Hotels

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9 Dec - 10 Dec
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10 Dec - 11 Dec
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12 Dec - 14 Dec
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19 Dec - 21 Dec

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Our top choices for Mayo Clinic Florida hotels

Reception
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3.0 star property
1.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (445)
"Great facility to stay."
United States
Gary
The price is HK$1,159
HK$1,316 total
includes taxes & fees
19 Dec - 20 Dec
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Terrace/patio
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

2.5 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1002)
"Staff was super friendly and professional...rooms super clean and comfy"
United States
Brian
The price is HK$803
HK$911 total
includes taxes & fees
15 Dec - 16 Dec
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.5 star property
2.7 km from Mayo Clinic Florida
8.6 out of 10, Excellent, (1004)
"Good location for a family vacation "
United States
Angel
The price is HK$817
HK$927 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Terrace/patio
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

3.0 star property
0.3 km from Mayo Clinic Florida
8.4 out of 10, Very good, (751)
"Nice hotel, close to shops and mayo clinic."
United States
Judy
The price is HK$1,253
HK$1,422 total
includes taxes & fees
20 Dec - 21 Dec
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Lobby
Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

4.5 star property
0.8 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (50)
"Beautiful hotel. Close to Mayo Clinic."
United States
Patty
The price is HK$951
HK$1,079 total
includes taxes & fees
20 Dec - 21 Dec
Hilton Jacksonville At Mayo Clinic
Lobby
Element Jacksonville Beach

Element Jacksonville Beach

3.0 star property
5.4 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (520)
"The hotel was spotless as usual.The staff was fantastic incredible cleanliness"
United States
Robert
The price is HK$918
HK$1,042 total
includes taxes & fees
4 Jan - 5 Jan 2026
Element Jacksonville Beach
Exterior
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

2.5 star property
Southside, 7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (1006)
"Nice refurbished rooms.. "
United States
David
The price is HK$1,035
HK$1,174 total
includes taxes & fees
24 Dec - 25 Dec
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Reception
Ponte Vedra Inn & Club

Ponte Vedra Inn & Club

5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (812)
"Wonderful place to visit to relax. Very clean, very friendly and courteous staff. Great view from the balcony."
United States
Greg
The price is HK$3,104
HK$3,687 total
includes taxes & fees
4 Jan - 5 Jan 2026
Ponte Vedra Inn & Club
Beach/ocean view
The Lodge and Club at Ponte Vedra Beach

The Lodge and Club at Ponte Vedra Beach

5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (686)
"Clean room, excellent service and only steps from the ocean. The facility could use some TLC but, all in all, a wonderful place to stay. We’ll be back for sure. "
United States
Robert
The price is HK$3,104
HK$3,687 total
includes taxes & fees
3 Jan - 4 Jan 2026
The Lodge and Club at Ponte Vedra Beach
Lounge
AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center

2.5 star property
Southside, 8.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (162)
"Staff was excellent...highly recommend this Hotel"
Canada
Robert
The price is HK$1,276
HK$1,448 total
includes taxes & fees
19 Dec - 20 Dec
AC Hotel Jacksonville St Johns Town Center
2 outdoor pools, open 7:00 AM to 9:00 PM, pool umbrellas, pool loungers
Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront

3.0 star property
6.3 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (2586)
"We thoroughly enjoyed our stay! "
United States
Diane
The price is HK$909
HK$1,031 total
includes taxes & fees
22 Dec - 23 Dec
Hampton Inn Jacksonville Beach/Oceanfront
Sports facility
Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center

3.0 star property
Southside, 8.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1006)
"Good location, friendly staff, clean "
United States
john
The price is HK$927
HK$1,053 total
includes taxes & fees
12 Dec - 13 Dec
Hyatt Place Jacksonville / St. Johns Town Center
Property amenity
Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel

4.0 star property
Deerwood, 9.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1001)
"Good hotel!"
United States
Charlie
The price is HK$694
HK$788 total
includes taxes & fees
21 Dec - 22 Dec
Sheraton Jacksonville Hotel
On the beach, white sand, surfing, kayaking
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 star property
5.9 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (3431)
"Excellent location & property "
United States
Doris
The price is HK$1,113
HK$1,264 total
includes taxes & fees
11 Dec - 12 Dec
Margaritaville Jacksonville Beach
On the beach
Best Western Oceanfront

Best Western Oceanfront

3.0 star property
5.7 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1002)
"The room was clean and the bed was very comfortable! The view was beautiful! I will definitely stay here again in the future "
United States
Tinya
The price is HK$958
HK$1,088 total
includes taxes & fees
22 Dec - 23 Dec
Best Western Oceanfront
Exterior
Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront

3.0 star property
5.6 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1002)
"Easy to walk to the beach and local restaurant"
United States
Allen D
The price is HK$1,385
HK$1,572 total
includes taxes & fees
4 Jan - 5 Jan 2026
Four Points by Sheraton Jacksonville Beachfront
Free daily buffet breakfast
Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG

3.0 star property
4.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1000)
"The check in was simple and a room was ready for us before check out time. We were able to rest and sleep well during our stay in Jacksonville Beach."
United States
David
The price is HK$895
HK$1,016 total
includes taxes & fees
18 Dec - 19 Dec
Holiday Inn Express Jacksonville Beach by IHG
On the beach, windsurfing
Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront

4.0 star property
5.8 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (619)
"Loved staying here. Great hotel. Very clean. The check-in process was smooth and Jay was awesome. I would recommend!"
United States
Kedric
The price is HK$1,183
HK$1,342 total
includes taxes & fees
21 Dec - 22 Dec
Springhill Suites By Marriott Jacksonville Beach Oceanfront
Exterior
Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG

3.5 star property
Southside, 10.8 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1008)
"Very nice stay "
United States
Timmothy
The price is HK$887
HK$1,007 total
includes taxes & fees
21 Dec - 22 Dec
Hotel Indigo Jacksonville-Deerwood Park by IHG
Outdoor pool, open 8:00 AM to 8:00 PM, pool umbrellas, pool loungers
Seahorse Oceanfront Inn

Seahorse Oceanfront Inn

2.5 star property
8 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (598)
"Quintessential beachfront hotel with timeless setting. Close to great restaurants. We’ll be back."
United States
Keith
Seahorse Oceanfront Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"Room overlooked the water and was an amazing sunrise "
John 1-night trip
Posted 20 hours ago
Margaritaville Jacksonville Beach

Hotels near other Mayo Clinic Florida attractions

Adventure Landing

4.1/5 (157 reviews)
This amusement park east of Jacksonville is a fun daytrip for the whole family with thrilling rides, exciting attractions for kids and a shipwreck-themed waterpark.
See properties

Windsor Parke Golf Club

Enjoy a round of golf in Jacksonville at Windsor Parke Golf Club. Amble around the area's beautiful beaches or attend a sporting event.
See properties

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 41 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville At Mayo Clinic and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 41 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can enjoy live performances at Players by the Sea and Wilson Center For the Arts. Spend some time exploring the the natural beauty of Oceanfront Park, Cradle Creek Preserve and Huguenot Park. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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