Santa Cruz hotels from HK$290

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
15 Dec - 16 Dec
Tomorrow
16 Dec - 17 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Cruz hotels

Outdoor pool
Sun Hotel

Sun Hotel

Sun Hotel
3.5 star property
Santa Cruz
8.4 out of 10, Very good, (330)
"Staff spoke English. Airport pickup beat any US hotel. Rooms nice. Restaurant was ok"
United States
Peter
The price is HK$698
HK$698 total
19 Dec - 20 Dec
Sun Hotel
Outdoor pool, pool umbrellas, pool loungers
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (211)
"Great hotel, food and location albeit a little expensive "
United States
Reinaldo
The price is HK$866
HK$866 total
20 Dec - 21 Dec
Marriott Santa Cruz de la Sierra Hotel
Seasonal outdoor pool
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (347)
"Wonderful staff with beautiful pool area and amenities. Great restaurant too."
Canada
Jay
The price is HK$1,020
HK$1,020 total
9 Jan - 10 Jan 2026
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Exterior
Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
5.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (104)
"Luxurious hotel,very chic and beautiful."
United States
Cristhian
The price is HK$778
HK$778 total
1 Jan - 2 Jan 2026
Novotel Santa Cruz De La Sierra
Lounge
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (256)
"Nice hotel "
United States
Narciso Lorenzo
The price is HK$498
HK$498 total
13 Jan - 14 Jan 2026
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Indoor pool, outdoor pool, pool umbrellas
Camino Real Hotel

Camino Real Hotel

Camino Real Hotel
4.5 star property
Santa Cruz
8.8 out of 10, Excellent, (407)
"The parrots. Unique"
United States
Juan P
The price is HK$1,401
HK$1,401 total
25 Dec - 26 Dec
Camino Real Hotel
Restaurant
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra
3.0 star property
Santa Cruz
9.6 out of 10, Exceptional, (74)
"Great Spot"
United States
Jose
The price is HK$296
HK$296 total
22 Dec - 23 Dec
Ibis Santa Cruz DE LA Sierra
Minibar, in-room safe, individually decorated, individually furnished
Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (122)
"Great place: great staff"
United States
Linda
Cosmopolitano Hotel Boutique
Reception
Hotel Cortez

Hotel Cortez

Hotel Cortez
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (123)
"The staff and property are second to none! "
United States
Cynthia
The price is HK$965
HK$965 total
9 Jan - 10 Jan 2026
Hotel Cortez
City view from property
HOTEL OSHO

HOTEL OSHO

HOTEL OSHO
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (34)
"Hot tub worked well and room was very comfortable! 24 hr market across the street came in handy. The best hotel I've stayed at in Bolivia!"
United States
Robert
HOTEL OSHO
Living area
Posada Express Fast Check

Posada Express Fast Check

Posada Express Fast Check
3.0 star property
Santa Cruz
10.0 out of 10, Exceptional, (2)
The price is HK$311
HK$343 total
17 Dec - 18 Dec
Posada Express Fast Check
Outdoor pool, open 9:00 AM to 8:00 PM, pool loungers
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (81)
"Good price, great hotel!"
United States
James
The price is HK$304
HK$304 total
13 Jan - 14 Jan 2026
Premium Suites Deluxe Aparthotel Equipetrol
Private kitchen
Hotel G

Hotel G

Hotel G
3.5 star property
Santa Cruz
7.8 out of 10, Good, (105)
"Good price"
United States
Salem
Hotel G
Front of property
Chairú Eco Hotel

Chairú Eco Hotel

Chairú Eco Hotel
3.5 star property
Santa Cruz
9.6 out of 10, Exceptional, (48)
"Nice property. Would definitely stay there again and again. Only negative was on our last night there was a really noisy party next door that lasted until 2am. "
United States
Andrew
Chairú Eco Hotel
Reception
Lido Hotel

Lido Hotel

Lido Hotel
3.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (30)
"Very helpful and nice staff. Quiet location. near the central plaza. Great value "
United Kingdom
David
The price is HK$357
HK$357 total
23 Dec - 24 Dec
Lido Hotel
Outdoor pool
Urban Suites

Urban Suites

Urban Suites
3.0 star property
Santa Cruz
The price is HK$417
HK$417 total
17 Dec - 18 Dec
Urban Suites
Outdoor pool, open 9:00 AM to 10:00 PM, free pool cabanas
TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (145)
"Nice stay with good service "
United States
Jianyuan
The price is HK$770
HK$770 total
13 Jan - 14 Jan 2026
TRYP by Wyndham Santa Cruz
Hypo-allergenic bedding, down duvets, desk, laptop workspace
Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel
2.5 star property
Santa Cruz
8.4 out of 10, Very good, (7)
"Perfect hotel"
Turkey
Yener
The price is HK$290
HK$290 total
16 Jan - 17 Jan 2026
Equipetrol Suites Apart Hotel
2 outdoor pools
Prince Hotel

Prince Hotel

Prince Hotel
3.0 star property
Santa Cruz
The price is HK$420
HK$436 total
17 Dec - 18 Dec
Prince Hotel
BBQ/picnic Area
Casa Por Temporadas

Casa Por Temporadas

Casa Por Temporadas
2.0 star property
Santa Cruz
10.0 out of 10, Exceptional, (1)
"The front desk staff was amazing! We checked in during a rain storm and the hotel had been hit by lightning and their computers and they computers were out. The staff maintained their professionalism and got us in a room quickly. Thank you for your help "
United States
Cynthia
The price is HK$666
HK$666 total
17 Dec - 18 Dec
Casa Por Temporadas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Holiday Rentals in Santa Cruz

Aparthotel
Outdoor pool, open 9:00 AM to 8:00 PM, pool loungers
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (81)
"Good price, great hotel!"
Premium Suites Deluxe Aparthotel Equipetrol
See all holiday rentals
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most. Learn more about Santa Cruz
Learn more about Santa Cruz

Hamacas

When in Hamacas, you can plan a visit to Santa Cruz Zoo and Las Brisas Shopping Center, some noteworthy sights in the nearby area.

Stay near popular Santa Cruz attractions

Plaza 24 de Septiembre showing heritage elements and heritage architecture as well as a large group of people

Plaza 24 de Septiembre

4.4/5 (70 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
See properties
San Lorenzo Cathedral which includes heritage elements, a church or cathedral and heritage architecture

San Lorenzo Cathedral

4.5/5 (36 reviews)
This grand neoclassical cathedral dominates Santa Cruz's skyline with its towering spires and ornate façade. Climb the bell tower at sunset for breathtaking panoramic views of the city.
See properties

Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

See all hotels in Santa Cruz
San Lorenzo Cathedral which includes a park

Top Santa Cruz Hotel Reviews

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

10/10 Excellent
"Great spacious property with nice pool!"
Douglas 1-night trip
Posted 11 hours ago
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

More cheap stays in Santa Cruz

Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel

Equipetrol Santa Cruz Departamento de Santa Cruz
The price is HK$290 per night from 16 Jan to 17 Jan
HK$290
HK$290 total
16 Jan - 17 Jan 2026
8.6/10 Excellent! (8 reviews)

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is a favourite with Expedia customers. This hotel offers a restaurant and free parking. Reviews from our site also recommend Chairú Eco Hotel and TRYP by Wyndham Santa Cruz as top options for your trip. See all available top hotels, or vacation rentals in Santa Cruz.
What are some of the best holiday rentals that Santa Cruz has to offer?
Casa Vida: This highly rated holiday home rental in Santa Cruz is located in a rural location, and has an outdoor pool, a patio and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a full-sized fridge, a stovetop and a microwave, so that you can cook with friends or family. Kick off your shoes and enjoy yourself with a private garden and a selection of games. Some other homes for rent in Santa Cruz include Cozy and independent. Downtown house JH. and Seasonal House. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
What's the best budget-friendly accommodation in Santa Cruz?
Based on our traveller reviews, residencial francia - Hostel is a top choice for a less expensive stay. Other choices for your budget-friendly stay include Residencial Ikandire II and Nomad Hostel. View all budget hotels in Santa Cruz.
What's the best family accommodation in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a hotel with an outdoor pool and a restaurant, and it's a top choice on Expedia for families. Other choices for your child-friendly holiday include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia. Also, attractions such as Santa Cruz Zoo and Play Land Amusement Park are fun for children of all ages. Find more child-friendly accommodations in Santa Cruz.
What's the best LGBTQ-friendly accommodation in Santa Cruz?
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your holiday. See all available hotels listed as LGBTQ-friendly in Santa Cruz.
What's the best dog-friendly accommodation option in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is a top hotel for people travelling with their pets, and offers a restaurant and free WiFi for its human guests. Two other good options for you and your pet's trip include HOTEL OSHO and Hotel LP Equipetrol. See more pet-friendly hotel accommodations in Santa Cruz.
What's the best luxury accommodation option in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia and Novotel Santa Cruz De La Sierra are other upscale choices for your holiday. Find more luxury hotels in Santa Cruz.
What are some accommodation options with pools in Santa Cruz?
Sun Hotel is a top hotel with a children's pool, an outdoor pool and free buffet breakfast. A couple of other options that feature an on-site pool include Yotau All Suites Hotel and Buganvillas Hotel Suites & Spa. View all hotels with pools in Santa Cruz.
What is the best spa hotel in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a top luxury spa hotel featuring a rooftop terrace, a fitness centre, tennis courts and a bar. Spend an afternoon at Hotel Spa where you'll find massage treatments. Other popular spa hotels in Santa Cruz include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Hotel Cortez. See all spa hotels in Santa Cruz.
What's it like to stay in Santa Cruz?
Visitors to Santa Cruz will definitely enjoy the shopping. Tourists can also enjoy the city's cafés, zoo and cathedral. In Santa Cruz, there are 285 hotels and other accommodation options to choose from. Find out more about Santa Cruz.
What is there to see in Santa Cruz?
Cultural venues include Cine Center, Ethno-folkloric Museum and Sacred Art Museum. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre and Blacutt Square might be worth a visit. Natural beauty is on display at Guembe Biocenter, Arenal Park and Municipal Botanical Garden of Santa Cruz. Take a look at what more there is to see and do in Expedia's Santa Cruz guide.
How should I get around Santa Cruz?
If you want to venture outside the area, hop on a train at Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.
What's the weather like in Santa Cruz?
The hottest months are usually October and November, with an average temperature of 26°C, while the coldest months are June and July, with an average of 21°C. Average annual precipitation for Santa Cruz is 1208 mm.

Explore a world of travel with Expedia