Photo by Piccolo Lorenzo

Santa Lucia hotels in Syracuse

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Check prices for these dates

Tonight
30 Dec - 31 Dec
Tomorrow
31 Dec - 1 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

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Our top choices for Santa Lucia hotels

Terrace/patio
Caportigia Boutique Hotel

Caportigia Boutique Hotel

Caportigia Boutique Hotel
5.0 star property
Santa Lucia
9.4 out of 10, Exceptional, (257)
"Fine quality hotel with exceptional service. "
United States
Peter
The price is HK$834
HK$1,009 total
includes taxes & fees
11 Jan - 12 Jan 2026
Caportigia Boutique Hotel
Water view
Re Dionisio Luxury Suites

Re Dionisio Luxury Suites

Re Dionisio Luxury Suites
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (57)
"Spacious room, dated but comfortable."
United States
Kenneth
The price is HK$2,088
HK$2,389 total
includes taxes & fees
6 Jan - 7 Jan 2026
Re Dionisio Luxury Suites
View from room
Calafatari B&B

Calafatari B&B

Calafatari B&B
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (11)
"We had a lovely stay. Anna was very welcoming. We had a lovely large clean room and a nice modern bathroom. She went all out for breakfast. "
United States
Carl and Lina
Calafatari B&B
Memory-foam beds, in-room safe, individually furnished, desk
Fortaleza Charme House

Fortaleza Charme House

Fortaleza Charme House
Santa Lucia
10.0 out of 10, Exceptional, (27)
"Great central location."
United States
Craig
The price is HK$1,314
HK$1,497 total
includes taxes & fees
5 Jan - 6 Jan 2026
Fortaleza Charme House
Property entrance
Giuggiulena Villa

Giuggiulena Villa

Giuggiulena Villa
3.0 star property
Santa Lucia
10.0 out of 10, Exceptional, (126)
"Fantastic stay. Made to feel very welcome and what a lovely relaxing place to stay. Evening meal was exceptional. "
United States
Paul
The price is HK$1,817
HK$2,072 total
includes taxes & fees
4 Jan - 5 Jan 2026
Giuggiulena Villa
Exterior
AmaCasa Siracusa

AmaCasa Siracusa

AmaCasa Siracusa
Santa Lucia
10.0 out of 10, Exceptional, (1)
"Siamo stati molto bene, la struttura internamente è abbastanza ammodernata e l'accesso è stato"
Italy
Alessandro
The price is HK$699
HK$797 total
includes taxes & fees
2 Jan - 3 Jan 2026
AmaCasa Siracusa
Aerial view
Grande Albergo Alfeo

Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (652)
"The room was nice the location convenient. No view to speak of but centrally located"
Canada
Eric
Grande Albergo Alfeo
Desk, laptop workspace, free WiFi
Agorà

Agorà

Agorà
Santa Lucia
10.0 out of 10, Exceptional, (2)
"Trevligt, rent, bra service. Hade turen att få balkong. "
Sweden
Olof
The price is HK$715
HK$815 total
includes taxes & fees
12 Jan - 13 Jan 2026
Agorà
Terrace/patio
Casa Miranda Boutique

Casa Miranda Boutique

Casa Miranda Boutique
Santa Lucia
6.0 out of 10, (1)
The price is HK$1,436
HK$1,638 total
includes taxes & fees
29 Jan - 30 Jan 2026
Casa Miranda Boutique
Egyptian cotton sheets, premium bedding, down duvets, memory-foam beds
Regina Margherita

Regina Margherita

Regina Margherita
Santa Lucia
8.0 out of 10, Very good, (14)
"The area is so close to the Ortigia Island where the beautiful cathedral and Doumo are. Lovely walk around the entire island and areas to go in the water If you like. Many dining options and shopping too. Wonderful area!"
United States
Laura
Regina Margherita
Coffee/tea maker, electric kettle
Nostos rooms & Apartments

Nostos rooms & Apartments

Nostos rooms & Apartments
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (273)
"On a main thoroughfare close to Isola di Ortigia. Friendly management and helpful to me."
United States
John
The price is HK$474
HK$541 total
includes taxes & fees
7 Jan - 8 Jan 2026
Nostos rooms & Apartments
View from room
Hotel Mediterraneo

Hotel Mediterraneo

Hotel Mediterraneo
3.0 star property
Santa Lucia
7.8 out of 10, Good, (122)
"Very friendly and helpful staff."
United States
David
Hotel Mediterraneo
Minibar, in-room safe, desk, soundproofing
Lakkios

Lakkios

Lakkios
3.0 star property
Santa Lucia
9.0 out of 10, Wonderful, (63)
"Nice, central, clean, easy to park, quiet during the night, staff was welcoming, nice breakfast with view - excellent choice!"
Norway
Jon-Kåre
Lakkios
In-room safe, soundproofing, iron/ironing board, free WiFi
Isonzo Suites

Isonzo Suites

Isonzo Suites
Santa Lucia
8.4 out of 10, Very good, (5)
"."
Italy
Gianluca
The price is HK$505
HK$847 total
includes taxes & fees
12 Jan - 13 Jan 2026
Isonzo Suites
Premium bedding, minibar, desk, soundproofing
B&B Nike

B&B Nike

B&B Nike
Santa Lucia
8.8 out of 10, Excellent, (75)
"Clean, good location. "
United States
Salvatore
B&B Nike
Exterior
Hotel dei Coloniali

Hotel dei Coloniali

Hotel dei Coloniali
3.0 star property
Santa Lucia
7.4 out of 10, Good, (166)
"Convenient location for Syracuse town, but in a scruffy area and the whole property is looking tired. Breakfast was adequate. The owner was charming and happy to help."
United Kingdom
Rod
Hotel dei Coloniali
Egyptian cotton sheets, premium bedding, down duvets, blackout curtains
Fortuna Guest House

Fortuna Guest House

Fortuna Guest House
1.0 star property
Santa Lucia
9.2 out of 10, Wonderful, (16)
"The owner was really nice and helpful! Really enjoyed our stay here."
Finland
Kirsi
The price is HK$748
HK$853 total
includes taxes & fees
7 Jan - 8 Jan 2026
Fortuna Guest House
Exterior
Hotel Le Muse

Hotel Le Muse

Hotel Le Muse
3.0 star property
Santa Lucia
7.4 out of 10, Good, (71)
"The room was great and the staff was exceptionally helpful"
United States
Henry
The price is HK$716
HK$817 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hotel Le Muse
Premium bedding, desk, cots/infant beds, rollaway beds
B&B Siracusa

B&B Siracusa

B&B Siracusa
Santa Lucia
9.0 out of 10, Wonderful, (59)
"Good location, very modern clean accommodation."
Canada
Malcolm
The price is HK$681
HK$777 total
includes taxes & fees
2 Jan - 3 Jan 2026
B&B Siracusa
Full-sized fridge, oven, stovetop, cookware/dishes/utensils
Gymnasium

Gymnasium

Gymnasium
3.0 star property
Santa Lucia
8.8 out of 10, Excellent, (40)
"Nice kitchen area, centrally located."
United States
Richard
Gymnasium
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Lucia

Find the best Santa Lucia areas for the activities you enjoy most.

Ortigia

Ortigia is popular for its seaside views, and if you're looking for more to see and do, you might think about a trip to Cathedral of Syracuse or Piazza del Duomo.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider stopping by Ionian Sea while you're exploring the neighbourhood.

Grottasanta

Grottasanta is noteworthy for its historical sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

Top Santa Lucia Hotel Reviews

Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

10/10 Excellent
"Every aspect of our stay was superb. The staff were friendly and helpfull. Our room was spotless, and the decor of the entire hotel was harmonious. "
Thomas 2-night trip
Posted 5 days ago
Grand Hotel Ortigia Siracusa

Frequently asked questions

What is Santa Lucia like?
Santa Lucia is a neighbourhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Make sure that you visit Porto Piccolo and Ionian Sea while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Lucia?
Based on Expedia customer reviews, Fortaleza Charme House is the highest ranked property in Santa Lucia. This inn offers a beach bar and free WiFi. Other top choices in the neighbourhood include Giuggiulena Villa and Lakkios.
How many hotels will I find in Santa Lucia?
Expedia has 292 hotels and other accommodation options in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.
If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review the best options available in Santa Lucia.
What are the top things to see and do in Santa Lucia?
Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops worth a visit in the neighbourhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.

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