St. Charles Vacation Homes

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Our top choices for St. Charles holiday homes

A hallway with a wooden wall, a door leading to a bedroom, and a staircase.

1. St. Charles 1860's Gem - Sleeps 6!

St. Charles Historic District

Joe R.

HK$2,104 total

includes taxes & fees

4 Oct - 5 Oct

A modern kitchen with dark green cabinets, a stainless steel refrigerator, and a dining area with a dark wooden table and black chairs.

2. 3BR Close to Historic Main Street-Low Cleaning Fee

Saint Charles

HK$2,112 total

includes taxes & fees

18 Oct - 19 Oct

A modern kitchen with white cabinets, a black refrigerator, and a central island.

3. Cottage on Main st- Low Cleaning Fee

St. Charles Historic District

Debbie A.

HK$2,316 total

includes taxes & fees

5 Oct - 6 Oct

Two white washing machines in a room with a concrete floor, a metal vent, and a wooden shelf above.

4. 3BR Retreat Near Historic Main Street-Low Cleaning-Sleeps 6

Saint Charles

Elizabeth S.

HK$1,968 total

includes taxes & fees

19 Oct - 20 Oct

A living room with a gray sectional sofa, a wooden coffee table, and a patterned rug.

5. 5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

St. Charles Historic District

Amy S.

HK$1,984 total

includes taxes & fees

8 Oct - 9 Oct

A living room with a flat-screen TV, a sofa with patterned cushions, a coffee table, and a rug.

6. Cottage on Historic Main Street- Low Cleaning fee

St. Charles Historic District

Daneen H.

HK$2,404 total

includes taxes & fees

4 Oct - 5 Oct

A modern living room with a grey sectional sofa, a wooden coffee table, and a staircase with wooden steps.

7. Near Streets of St Charles | 2 King Beds

Saint Charles

Chloe

HK$2,365 total

includes taxes & fees

5 Oct - 6 Oct

A living room with a sofa, armchairs, a coffee table, a lamp, a ceiling fan, and a rug.

8. Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

St. Charles Historic District

Jeffrey E.

HK$1,978 total

includes taxes & fees

25 Oct - 26 Oct

A two-story house with a front porch, a mailbox, and a number 815 sign.

9. HotTub-2br2b-near Historic Main Street

St. Charles Historic District

Jessie W.

HK$2,324 total

includes taxes & fees

12 Oct - 13 Oct

A modern kitchen with white cabinetry, stainless steel appliances, and a dining area with a wooden table and chairs.

10. Historic 1805 Main Street 2BR

St. Charles Historic District

McRay H.

HK$2,750 total

includes taxes & fees

6 Oct - 7 Oct

A modern kitchen with white cabinetry, a stainless steel refrigerator, and a granite countertop.

11. Historic 1908 Frenchtown Home

St. Charles Historic District

Kim V.

HK$2,607 total

includes taxes & fees

5 Oct - 6 Oct

A bedroom with a bed, a wall-mounted hanging ornament, and a vase with flowers.

12. The Below Deck Suite

Saint Charles

Amy B.

A staircase with white steps and black handrails, leading to a landing with a black railing.

13. Dog-Friendly 2BR | Near Streets of St Charles

Saint Charles

Rebecca O.

HK$2,416 total

includes taxes & fees

6 Oct - 7 Oct

A modern kitchen with white cabinets, a stainless steel refrigerator, and a central island with bar stools.

14. Stunning 1890's Home - Sleeps 8!

St. Charles Historic District

Jason T.

HK$3,368 total

includes taxes & fees

6 Oct - 7 Oct

A modern kitchen with white cabinetry, a stainless steel range, and a built-in oven.

15. The Chalet | St Charles 2BR Private Retreat on 1.2 Acres | By Mercer Stays

Saint Charles

Leslie R.

HK$5,193 total

includes taxes & fees

5 Oct - 6 Oct

A spacious living room with hardwood floors, a white armchair, a dark sofa, and a television on a stand.

16. Casa de Saint Charles

Saint Charles

Xavier H.

HK$2,667 total

includes taxes & fees

5 Oct - 6 Oct

A wooden-paneled room with a sofa, a small bedside table with a lamp, and a marble-patterned rug.

17. The Knotty Pine House

Saint Charles

HK$2,503 total

includes taxes & fees

4 Oct - 5 Oct

A modern living room with a fireplace, two armchairs, a small table, and decorative plants.

18. The Reunion House | St Charles 4BR Sleeps 14 Game Room Hot Tub | Mercer Stays

Saint Charles

Amanda P.

HK$8,417 total

includes taxes & fees

5 Oct - 6 Oct

A modern kitchen with white cabinetry, stainless steel appliances, a large island with stools, pendant lighting, and a view of the outdoors.

19. The Stadium by Mercer Stays | Private 2.2Acre Sports Estate for Teams & Families

Saint Charles

Adriane B.

HK$10,572 total

includes taxes & fees

5 Oct - 6 Oct

A living room with a beige sofa, a wooden coffee table, and a ceiling fan.

20. Music House · Music House on Main Street at The Wine Garden

Saint Charles

Zack P.

HK$4,966 total

includes taxes & fees

4 Oct - 5 Oct

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Top St. Charles Hotel Reviews

Pear Tree Inn St. Louis Airport

8/10 Good

"I picked Pear Tree because it was so close to the airport for a quick overnight stay and that they had a shuttle. As a solo woman traveler i wanted to be sure i could be picked up by the hotel. On arrival i was greeted by the super nice desk clerk. When going to my room there was some cleaning product that had leaked onto the floor and the desk clerk quickly remedied the issue and gave me another room. The room was clean, the sheets were awesome, bed was very comfortable and the room was spacious. Being so close to the airport you do hear plane noise so i did pack some earplugs. The bathroom and all the amenities in the room were clean and in working condition. The hot breakfast was good. The coffee could have been better but it was ok. All in all it was a very good and economical option for an airport hotel. Would recommend for sure."

Drury Plaza Hotel St. Louis Union Station

8/10 Good

"The hotel was in a good location and right across from Union Station and its entertainment amenities. Staff was very friendly and gave me recommendations to visit around the city. At night, it is a bit isolated and would only recommend one drive to other areas instead of walking."

Sonesta ES Suites St. Louis - Chesterfield

8/10 Good

"Very clean and worked well for us. Polite staff. Breakfast was good with several hot choices. We were there two nights and there was no housekeeping so ask for extra towels if needed. After our stay I got several phone calls from Sonesta asking for a review. I would rather get an e-mail. Otherwise, a good price and there was no cancellation fee."

Country Inn & Suites by Radisson, St. Charles Historic District

8/10 Good

"nice size free parking spots in the garage. Breakfast was slim. one morning just had sausage and eggs and waffles. next morning had biscuits and gravy and waffles. hotel was clean staffing was friendly. location was good. The cookies were delicious."

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