Jacksonville Mayo Clinic Florida Hotels: 2026 Limited-Time Hotel Deals @Expedia

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

A modern kitchen with a bar area, seating, and a view of the outdoors.

A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Michaelanne

HK$1,131

HK$1,283 total

includes taxes & fees

18 Oct - 19 Oct

A modern restaurant with a bar area, wooden ceiling, and large windows.

A modern lobby with a curved sofa, round coffee tables, and a large pillar.

A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

2. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Kristen

HK$1,280

HK$1,453 total

includes taxes & fees

2 Oct - 3 Oct

A lobby with a reception desk, seating area, and a staircase.

An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

3. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

frances

HK$729

HK$828 total

includes taxes & fees

25 Oct - 26 Oct

A hotel lobby with a bar area, seating arrangements, and a reception desk.

An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.

A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Patsy

HK$859

HK$975 total

includes taxes & fees

4 Oct - 5 Oct

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

An outdoor patio with a pool, wooden pergola, and seating area.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.

5. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

gregory

HK$933

HK$1,059 total

includes taxes & fees

4 Oct - 5 Oct

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.

A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Patricia

HK$1,192

HK$1,353 total

includes taxes & fees

3 Oct - 4 Oct

A hotel room with two beds, a floral wallpaper, a ceiling light, and a wall-mounted air conditioner.

A door with the number 312, a window with blinds, a green door mat, a chair with a geometric pattern, and small plants.

A compact kitchen with a refrigerator, microwave, and a dining area with a table and chairs.

A backyard with a swimming pool, wooden deck, and outdoor furniture.

7. Hotel Palms

7.8 km from Mayo Clinic Florida

Vinny

HK$1,114

HK$1,265 total

includes taxes & fees

27 Sept - 28 Sept

A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.

A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.

A breakfast bar with a digital menu display, various food dispensers, and a yogurt machine.

A hotel room with two beds, a desk, a chair, and a large window with a view.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.7 km from Mayo Clinic Florida

Ian

HK$996

HK$1,130 total

includes taxes & fees

26 Oct - 27 Oct

A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

A kitchen counter with a coffee maker, a blender, a book titled 'CHECKERS,' and a water bottle.

9. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 7.8 km from Mayo Clinic Florida

Phi

HK$902

HK$1,024 total

includes taxes & fees

3 Oct - 4 Oct

An outdoor patio area with seating, a fire pit, and a barbecue grill.

A modern kitchen with wooden cabinets, a central island with jars, and a countertop with toasters.

A reception area with a modern design, featuring a reception desk, a refrigerator with snacks, and a wooden slatted wall.

A modern living room with sofas, a coffee table, and a dining area.

10. TownePlace Suites by Marriott® Jacksonville Mayport

10.8 km from Mayo Clinic Florida

irina

HK$925

HK$1,050 total

includes taxes & fees

30 Sept - 1 Oct

A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

A modern building entrance with a sign reading "element by Westin".

A modern conference room with a long table, several chairs, and pendant lighting.

A pathway leading to a sunset over a beach with sand and grass.

11. Element by Marriott Jacksonville Beach

5.4 km from Mayo Clinic Florida

Nick

HK$1,192

HK$1,353 total

includes taxes & fees

1 Oct - 2 Oct

A covered entrance with a dark tiled floor, white columns, and a green bench.

A gym with treadmills, elliptical machines, and dumbbells.

A large, multi-story hotel with a prominent entrance, a covered area with lights, and a star-shaped design on the facade.

A snack area with shelves stocked with various snacks and a sign reading "Welcome to Jacksonville Beach."

12. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

4.2 km from Mayo Clinic Florida

Robert

HK$927

HK$1,052 total

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

A bar area with a view of the beach, wooden bar stools, and a counter with a menu display.

A multi-story hotel with a beach view, parking lot, and a nearby restaurant.

A cafe with a tropical mural, a coffee menu, and a variety of seating options.

13. Margaritaville Jacksonville Beach

5.9 km from Mayo Clinic Florida

Keisha

HK$1,171

HK$1,329 total

includes taxes & fees

28 Sept - 29 Sept

A self-service beverage station with a refrigerated display and a coffee machine.

A snack display in a store with various chips and snacks.

A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

A modern hotel reception area with a curved wooden reception desk, a digital display, and a view of the lobby.

14. Tru By Hilton Jacksonville St Johns Town Center

Southside, 8.7 km from Mayo Clinic Florida

Mary

HK$859

HK$975 total

includes taxes & fees

4 Oct - 5 Oct

An outdoor patio area with wicker furniture, a fire feature, and string lights.

A modern hotel lobby with a gray sofa, a round wooden table, and a blue armchair. A large abstract painting and a mirror with a vase are on the wall.

A restaurant with long communal tables and booths, large windows, and pendant lighting.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, large windows offering views of greenery outside.

15. Sheraton Jacksonville Hotel

Deerwood, 9.6 km from Mayo Clinic Florida

Kerrie

HK$970

HK$1,101 total

includes taxes & fees

26 Sept - 27 Sept

A spacious lobby with a reception desk, seating area, and large windows.

A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.

A multi-story hotel with a central entrance, large windows, and a well-lit facade.

A bar area with wooden chairs, a round table, and a brick wall.

16. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

8.5 km from Mayo Clinic Florida

Joyce

HK$924

HK$1,030 total

includes taxes & fees

19 Oct - 20 Oct

An outdoor seating area with a fire feature, chairs, and a table.

A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.

17. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

Carol

HK$988

HK$1,122 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.

A golf course with a water hazard and a bridge.

A coffee station with two espresso machines and a display of coffee products.

18. Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

Jose

HK$925

HK$1,050 total

includes taxes & fees

28 Sept - 29 Sept

A hotel room with a dining area, two beds, a TV, and a kitchenette.

A covered outdoor seating area with stone steps leading up to a table and chairs.

Two people near a grill with a plate of food and a bottle.

A hotel room with a dining area featuring a table, chairs, a television, a microwave, and a coffee maker.

19. Candlewood Suites Jacksonville - Mayport by IHG

9.2 km from Mayo Clinic Florida

Joe

HK$933

HK$1,059 total

includes taxes & fees

26 Sept - 27 Sept

An outdoor patio area with a stone fire pit, wicker furniture, and a grill.

A modern kitchen with dark wooden cabinets, a stainless steel refrigerator, a microwave, and a dishwasher.

A swimming pool with lounge chairs and a building with multiple floors and balconies.

A gym with treadmills, elliptical machines, and weight benches.

20. Residence Inn by Marriott Jacksonville South/Bartram Park

17.1 km from Mayo Clinic Florida

Charlotte

HK$981

HK$1,114 total

includes taxes & fees

1 Oct - 2 Oct

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 602 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	9.4 Exceptional 361 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,010 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,000 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 660 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

10/10 Excellent

"This room felt like we were in a four seasons. Would recommend"

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

8/10 Good

"Love those scones and waffles"

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent

"Clean room, great breakfast, and having a shuttle makes a world of difference"

TownePlace Suites by Marriott Jacksonville East

10/10 Excellent

"Great place to stay at a reasonable price. Manager went out of his way to help us out when they had a shuttle down for longer than normal. Above and beyond in service and quality! Thank you!"

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

8/10 Good

"Wish coffee was more available and didn't have to wait for it"

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent

"Everything was nice and clean! Very well kept! The hosts are very responsive and friendly! Location was perfect and quiet! Definitely would stay here again!"

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

10/10 Excellent

"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good

"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent

"Place was exactly as pictured and perfect for our stay. Spacious, great amenities, and convenient location. Our family loved the putting green and pool table for some friendly competition. Top of our list as a place to stay the next time we're in JAX!"

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.

Where is the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels are there near Mayo Clinic Florida?

Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Wilson Center For the Arts and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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Jacksonville Mayo Clinic Florida Hotels

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Mayo Clinic Florida hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. Hilton Jacksonville at Mayo Clinic near Beaches

3. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

5. TownePlace Suites by Marriott Jacksonville East

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. Hotel Palms

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

9. Hyatt Studios Jacksonville/St Johns Town Center

10. TownePlace Suites by Marriott® Jacksonville Mayport

11. Element by Marriott Jacksonville Beach

12. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

13. Margaritaville Jacksonville Beach

14. Tru By Hilton Jacksonville St Johns Town Center

15. Sheraton Jacksonville Hotel

16. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

17. Hotel Indigo Jacksonville-Deerwood Park by IHG

18. Holiday Inn Express Jacksonville Beach by IHG

19. Candlewood Suites Jacksonville - Mayport by IHG

20. Residence Inn by Marriott Jacksonville South/Bartram Park

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

TownePlace Suites by Marriott Jacksonville East

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Frequently asked questions

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