Rome Santo Spirito Hospital Hotels

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30 Dec - 31 Dec
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31 Dec - 1 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

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Our top choices for Santo Spirito Hospital hotels

Minibar, in-room safe, individually decorated, individually furnished
Passpartout Boutique Palace

Passpartout Boutique Palace

Passpartout Boutique Palace
0.4 km from Santo Spirito Hospital
9.8 out of 10, Exceptional, (246)
"Excellent location, great dining options nearby, modern boutique hotel."
Canada
Matthew
The price is HK$971
HK$1,196 total
includes taxes & fees
13 Jan - 14 Jan 2026
Passpartout Boutique Palace
Free daily buffet breakfast
Domus Giulia

Domus Giulia

Domus Giulia
0.2 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (140)
"Very nice place next to some great attractions, thank you!"
Canada
Benjamin
Domus Giulia
Premium bedding, free minibar, in-room safe, desk
Corso Vittorio 308

Corso Vittorio 308

Corso Vittorio 308
0.3 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (63)
"The staff and property made for a 5 star stay."
United States
Brady
Corso Vittorio 308
In-room safe, desk, soundproofing, iron/ironing board
Charme 308

Charme 308

Charme 308
0.3 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (95)
"Great location! The room was spotless. We loved everything about this place."
United States
Heather
The price is HK$1,105
HK$1,344 total
includes taxes & fees
8 Jan - 9 Jan 2026
Charme 308
Lobby
Navona Street Hotel

Navona Street Hotel

Navona Street Hotel
3.0 star property
0.4 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (269)
"Staff was very friendly and helpful. "
United States
Eli M
Navona Street Hotel
Free daily continental breakfast
B&B Roma Borgo 91

B&B Roma Borgo 91

B&B Roma Borgo 91
0.5 km from Santo Spirito Hospital
9.8 out of 10, Exceptional, (63)
"Was very clean and wonderful. very much enjoyed our time there."
United States
Joseph
The price is HK$1,722
HK$2,003 total
includes taxes & fees
10 Jan - 11 Jan 2026
B&B Roma Borgo 91
Hypo-allergenic bedding, minibar, in-room safe, desk
Hotel Sant' Anna

Hotel Sant' Anna

Hotel Sant' Anna
3.0 star property
0.4 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (324)
"Wonderful location, very helpful service and staff!"
United States
Stephen
Hotel Sant' Anna
Desk, laptop workspace, soundproofing, free WiFi
Porta Castello Suites

Porta Castello Suites

Porta Castello Suites
0.5 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (182)
"Staff were extremely helpful and the room was amazing"
Australia
Daniel James
The price is HK$547
HK$730 total
includes taxes & fees
8 Jan - 9 Jan 2026
Porta Castello Suites
View from property
Palazzo Medusa

Palazzo Medusa

Palazzo Medusa
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (287)
"Great location, friendly and helpful staff, spotless room - I highly recommend!!!"
United Kingdom
James
The price is HK$752
HK$919 total
includes taxes & fees
11 Jan - 12 Jan 2026
Palazzo Medusa
View from room
B&B Rome River Inn

B&B Rome River Inn

B&B Rome River Inn
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (507)
"Staff very helpful Good location Enjoyed stay"
Australia
Richard
The price is HK$1,154
HK$1,379 total
includes taxes & fees
16 Jan - 17 Jan 2026
B&B Rome River Inn
Select Comfort beds, in-room safe, desk, blackout curtains
B&B At Your Place

B&B At Your Place

B&B At Your Place
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (421)
"The location was superb. It was very near the Vatican and other tourist places. Luca arranged for our pick up and drop off at the airport. We had fresh towels everyday and croissants, coffee and tea was available everyday."
Canada
Kristina
B&B At Your Place
1 bedroom, premium bedding, in-room safe, desk
Capricci Romani

Capricci Romani

Capricci Romani
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (361)
"Really enjoyed the location and staff. Breakfast was amazing. "
United States
Raquel
Capricci Romani
Garden
Villa Agrippina Gran Meliá - The Leading Hotels of the World

Villa Agrippina Gran Meliá - The Leading Hotels of the World

Villa Agrippina Gran Meliá - The Leading Hotels of the World
5.0 star property
Trastevere, 0.2 km from Santo Spirito Hospital
9.2 out of 10, Wonderful, (935)
"Beautiful hotel, very clean, staff so friendly and helpful Would definitely stay again!"
United Kingdom
debra jane
The price is HK$3,676
HK$4,227 total
includes taxes & fees
23 Jan - 24 Jan 2026
Villa Agrippina Gran Meliá - The Leading Hotels of the World
View from room
Maison Ottavia

Maison Ottavia

Maison Ottavia
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (23)
"Great location, clean and all we need during our trip."
Canada
Mauricio
Maison Ottavia
Front of property – evening/night
Relais Giulia

Relais Giulia

Relais Giulia
0.3 km from Santo Spirito Hospital
9.2 out of 10, Wonderful, (490)
"Clean, convenient, comfortable, charming"
United States
Ray Don
The price is HK$774
HK$962 total
includes taxes & fees
15 Jan - 16 Jan 2026
Relais Giulia
Premium bedding, down duvets, memory-foam beds, minibar
The Bridge Suites

The Bridge Suites

The Bridge Suites
0.3 km from Santo Spirito Hospital
9.2 out of 10, Wonderful, (230)
"Staff was great!"
United States
Philipp
The Bridge Suites
Staircase
All’Orologio

All’Orologio

All’Orologio
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (169)
"Very happy with my choice… staff were excellent communicators before and during my stay, loved the location. "
Canada
Andrew
All’Orologio
View from room
La Maison dell'Orologio

La Maison dell'Orologio

La Maison dell'Orologio
0.4 km from Santo Spirito Hospital
9.4 out of 10, Exceptional, (255)
"Room was cleaned well"
United States
Augusta
La Maison dell'Orologio
Balcony
Passepartout

Passepartout

Passepartout
Parione, 0.6 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (290)
"Kind and helpful and in a great place. It was in the best spot to see every thing I wanted. Perfect for walking to grocery and shopping and restaurants "
United States
Catriona
Passepartout
Exterior
Velantia Vaticano - Guesthouse

Velantia Vaticano - Guesthouse

Velantia Vaticano - Guesthouse
3.0 star property
Prati, 0.6 km from Santo Spirito Hospital
9.6 out of 10, Exceptional, (8)
"Great place to stay for a few days in Rome. Good location, great restaurant next door. Bed was super complicated. Would recommend for a couple or single person. "
Australia
Claudette
Velantia Vaticano - Guesthouse
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santo Spirito Hospital Hotel Reviews

Grand Hotel Olympic

Grand Hotel Olympic

10/10 Excellent
"Clean room. Good housekeeping service . Thank you for my daily sheets clean and fresh towels daily. A plus having breakfast. Overall nice staff "
Joaquin Manuel 5-night trip
Posted 3 days ago
Grand Hotel Olympic

Hotels near other Santo Spirito Hospital attractions

Vittorio Emanuele II Bridge

Spectacular works of art adorn the balustrades and columns of this iconic bridge, which lies beside the ruins of its predecessor.
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Accademia di Storia dell‘Arte Sanitaria

You can study the exhibits at Accademia di Storia dell‘Arte Sanitaria, a museum with a story of its own, during your trip to Rome. Amble around this vibrant area's riverfront or experience its fascinating museums.
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Frequently asked questions

What's the area like around Santo Spirito Hospital?
Santo Spirito Hospital is located in a historic area of Rome known for its stunning cathedral and notable monuments. If you're looking for a convenient place to stay, take a look at the 2026 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay close to Santo Spirito Hospital?
Hotel Dei Mellini is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and a fitness centre. It's located just a short 0.7 mi (1.1 km) from Santo Spirito Hospital. Other good options close by include Grand Hotel Olympic and Hotel Nazionale.
How many hotels can I expect to find close to Santo Spirito Hospital?
Expedia has 2026 hotels and other accommodation options within a mile from Santo Spirito Hospital.
If I need to cancel the hotel reservation for my stay near Santo Spirito Hospital, will I receive a refund?
Yes, you'll find most room reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Add your dates and click on "Search", then you can use the "fully refundable" filter to view the top deals on offer near Santo Spirito Hospital.
What can I see and do near Santo Spirito Hospital?
You might want to spend some time browsing the exhibits at Vatican Museums, Castel Sant'Angelo or Cloister of Bramante. Piazza Navona, Trevi Fountain and Colosseum are well-known local landmarks worth a visit. You can check out the local talent at Auditorium Conciliazione, Paul VI Audience Hall and Sistina Theater.
How can I get to Santo Spirito Hospital?
With so many transport options, seeing the area around Santo Spirito Hospital is a breeze. Take advantage of metro transport at Venezia Tram Stop, Arenula-Cairoli Tram Station and Barberini Station. If you want to journey outside of the area, hop aboard a train from Rome Piazzale Flaminio Station, Rome Termini Station or Rome (XRJ-Termini Rail Station).