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Jacksonville Mayo Clinic Florida Hotels

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Check prices for these dates

Tonight
4 Oct - 5 Oct
Tomorrow
5 Oct - 6 Oct
Next weekend
9 Oct - 11 Oct
In two weeks
16 Oct - 18 Oct

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A modern kitchen with a bar area, seating, and a view of the outdoors.
A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
1.1 km from Mayo Clinic Florida
United States
Michaelanne
HK$1,073
HK$1,218 total
includes taxes & fees
25 Oct - 26 Oct
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.
An outdoor patio with a pool, wooden pergola, and seating area.

2. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
gregory
HK$965
HK$1,096 total
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Jacksonville East
A modern restaurant with a bar area, wooden ceiling, and large windows.
A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.
A modern lobby with a curved sofa, round coffee tables, and a large pillar.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

3. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
0.8 km from Mayo Clinic Florida
United States
Patricia
HK$1,327
HK$1,507 total
includes taxes & fees
10 Oct - 11 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
A lobby with a reception desk, seating area, and a staircase.
A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.
Lobby sitting area
A modern kitchen with a refrigerator, coffee machine, and a bakery display.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.6 km from Mayo Clinic Florida
United States
frances
HK$761
HK$864 total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A hotel lobby with a bar area, seating arrangements, and a reception desk.
A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.
A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.
An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Patsy
HK$859
HK$975 total
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A bar area with a long counter, multiple stools, and shelves stocked with bottles.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
0.4 km from Mayo Clinic Florida
United States
Patricia
HK$1,193
HK$1,354 total
includes taxes & fees
10 Oct - 11 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A hotel room with two beds, a floral wallpaper, a ceiling light, and a wall-mounted air conditioner.
A wooden fence with a blue and white striped umbrella, two green lounge chairs, and a white chair.
A door with the number 312, a window with blinds, a green door mat, a chair with a geometric pattern, and small plants.
A backyard with a swimming pool, wooden deck, and outdoor furniture.

7. Hotel Palms

Hotel Palms
7.8 km from Mayo Clinic Florida
United States
Vinny
HK$1,247
HK$1,415 total
includes taxes & fees
5 Oct - 6 Oct
Hotel Palms
A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.
A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.
A gym with treadmills, elliptical machines, and free weights.
A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Southside, 7.7 km from Mayo Clinic Florida
United States
Ian
HK$934
HK$1,060 total
includes taxes & fees
29 Oct - 30 Oct
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
An outdoor patio area with seating, a fire pit, and a barbecue grill.
A modern living room with sofas, a coffee table, and a dining area.
A modern hotel with a sign reading "Towneplace Suites by Marriott" and a parking lot in front.
A reception area with a modern design, featuring a reception desk, a refrigerator with snacks, and a wooden slatted wall.

9. TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
10.8 km from Mayo Clinic Florida
United States
irina
HK$926
HK$1,051 total
includes taxes & fees
8 Oct - 9 Oct
TownePlace Suites by Marriott® Jacksonville Mayport
A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.
A modern conference room with a long table, several chairs, and pendant lighting.
A modern hotel lobby with a long reception desk, seating area, and large windows.
A modern building entrance with a sign reading "element by Westin".

10. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
5.4 km from Mayo Clinic Florida
United States
Nick
HK$1,130
HK$1,283 total
includes taxes & fees
1 Nov - 2 Nov
Element by Marriott Jacksonville Beach
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.
Lobby
A modern hotel building with a flat roof, large windows, and a sign reading 'HYATT studios'.
Sports facility

11. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
Deerwood, 7.8 km from Mayo Clinic Florida
United States
Corey
HK$902
HK$1,024 total
includes taxes & fees
30 Oct - 31 Oct
Hyatt Studios Jacksonville/St Johns Town Center
A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.
A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".
A modern hotel with a pool, palm trees, and a clear blue sky.
An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.

12. AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
Southside, 8.1 km from Mayo Clinic Florida
United States
Emily
HK$1,405
HK$1,594 total
includes taxes & fees
10 Oct - 11 Oct
AC Hotel Jacksonville St Johns Town Center
An outdoor seating area with a fire feature, chairs, and a table.
A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.
A modern bar area with a counter, bar stools, and a television screen.
A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

13. Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
Southside, 10.8 km from Mayo Clinic Florida
United States
Carol
HK$965
HK$1,096 total
includes taxes & fees
1 Nov - 2 Nov
Hotel Indigo Jacksonville-Deerwood Park by IHG
A pool with a waterfall feature, surrounded by large rock formations.
A bar with a tiled roof, outdoor seating, and a view of the ocean.
A balcony with a view of the ocean, a chair, and a railing.
A hotel with a pool, a parking lot, and a view of the ocean.

14. Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
6.3 km from Mayo Clinic Florida
United States
Hope
HK$1,327
HK$1,507 total
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn Jacksonville Beach/Oceanfront
An outdoor patio with seating, a fire pit, and string lights.
A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.
A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.

15. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
Southside, 8.6 km from Mayo Clinic Florida
United States
Becky
HK$998
HK$1,133 total
includes taxes & fees
8 Oct - 9 Oct
Hyatt Place Jacksonville / St. Johns Town Center
A self-service beverage station with a refrigerated display and a coffee machine.
A modern lounge area with seating, tables, and hanging lights.
A modern hotel reception area with a curved wooden reception desk, a digital display, and a view of the lobby.
A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

16. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
Southside, 8.7 km from Mayo Clinic Florida
United States
Mary
HK$859
HK$975 total
includes taxes & fees
18 Oct - 19 Oct
Tru By Hilton Jacksonville St Johns Town Center
A modern bar area with wooden accents, a variety of beverages, and seating arrangements.
A modern hotel lobby with a sofa set, armchairs, a coffee table, and a patterned carpet.
A patio area with a stone fire pit, outdoor furniture, and a brick floor.
A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.

17. Courtyard by Marriott Jacksonville I-295/East Beltway

Courtyard by Marriott Jacksonville I-295/East Beltway
Arlington, 13.2 km from Mayo Clinic Florida
United States
Chloie Marie
HK$759
HK$862 total
includes taxes & fees
8 Oct - 9 Oct
Courtyard by Marriott Jacksonville I-295/East Beltway
A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.
A pier extending into the ocean at sunset with birds flying above.
A golf course with a water hazard and a bridge.
A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.

18. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
4.6 km from Mayo Clinic Florida
United States
Bobby
HK$840
HK$953 total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express Jacksonville Beach by IHG
A spacious lobby with a reception desk, seating area, and large windows.
A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.
A bar area with wooden chairs, a round table, and a brick wall.
An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.

19. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
8.5 km from Mayo Clinic Florida
United States
William
HK$925
HK$1,031 total
includes taxes & fees
20 Oct - 21 Oct
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
A beach with a sandy shore, waves, and buildings in the background.
A Best Western hotel with a modern design, located near a beach with a pier.
A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.
A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.

20. Best Western Oceanfront

Best Western Oceanfront
5.7 km from Mayo Clinic Florida
United States
Stephanie
HK$1,036
HK$1,176 total
includes taxes & fees
14 Oct - 15 Oct
Best Western Oceanfront
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
9.4
Exceptional
603 reviews
View
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
TownePlace Suites by Marriott Jacksonville East
9.2
Wonderful
661 reviews
View
A modern restaurant with a bar area, wooden ceiling, and large windows.
Hilton Jacksonville at Mayo Clinic near Beaches
9.2
Wonderful
365 reviews
View
A lobby with a reception desk, seating area, and a staircase.
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
9.0
Wonderful
1,000 reviews
View
A hotel lobby with a bar area, seating arrangements, and a reception desk.
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
9.0
Wonderful
1,002 reviews
View

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"Very clean hotel with a colorful tropical vibe in decor."
Hifsa 1-night trip
Posted 2 hours ago
Margaritaville Jacksonville Beach
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

10/10 Excellent
"The manager was VERY helpful. We use this hotel when we go to Mayo spots. L. Bush."
Linda 1-night trip
Posted 12 hours ago
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent
".."
frances 1-night trip
Posted 2 days ago
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent
"The property was very clean and spacious. The host was responsive.She was also helpful with area recommendations. She went above and beyond our expectations. The home is well-supplied with just about anything you could need.The beds were very comfortable.The property is located in a safe and convenient neighborhood.We would definitely stay again."
Connie T. 3-night trip
Posted 6 days ago
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

10/10 Excellent
"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"
Patricia 1-night trip
Posted 2 weeks ago
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good
"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."
Barbara G. 24-night trip
Posted 3 weeks ago
Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable
5/2 Pool Cottage, Walk to Beach close to Mayo

5/2 Pool Cottage, Walk to Beach close to Mayo

10/10 Excellent
"Very clean and had everything we needed. Well worth it. Easy access to Mayo Clinic, beach and shopping. Tons of space in a quite neighborhood. The pool and pool house was bonus !"
Shari M. 6-night trip
Posted 1 month ago
5/2 Pool Cottage, Walk to Beach close to Mayo
Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent
"Place was exactly as pictured and perfect for our stay. Spacious, great amenities, and convenient location. Our family loved the putting green and pool table for some friendly competition. Top of our list as a place to stay the next time we're in JAX!"
Erin L. 3-night trip
Posted 1 month ago
Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent
"Wonderful property! My family loved the pool table and darts. So much fun. Thanks for a great weekend."
Maureen C. 2-night trip
Posted 3 months ago
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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