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Jacksonville Mayo Clinic Florida Hotels

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Check prices for these dates

Tonight
21 Oct - 22 Oct
Tomorrow
22 Oct - 23 Oct
This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.
A modern kitchen with a bar area, seating, and a view of the outdoors.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
1.1 km from Mayo Clinic Florida
United States
LISA
HK$1,073
HK$1,218 total
includes taxes & fees
20 Nov - 21 Nov
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
A modern restaurant with a bar area, wooden ceiling, and large windows.
A modern lobby with a curved sofa, round coffee tables, and a large pillar.
A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.
A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.

2. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
0.8 km from Mayo Clinic Florida
United States
Brandy
HK$1,274
HK$1,446 total
includes taxes & fees
21 Nov - 22 Nov
Hilton Jacksonville at Mayo Clinic near Beaches
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.
A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

3. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
gregory
HK$1,036
HK$1,176 total
includes taxes & fees
30 Oct - 31 Oct
TownePlace Suites by Marriott Jacksonville East
A hotel lobby with a bar area, seating arrangements, and a reception desk.
A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.
A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.
A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Kerry
HK$931
HK$1,057 total
includes taxes & fees
27 Oct - 28 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
A lobby with a reception desk, seating area, and a staircase.
A modern kitchen with a refrigerator, coffee machine, and a bakery display.
An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.
Lobby sitting area

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.6 km from Mayo Clinic Florida
United States
frances
HK$824
HK$935 total
includes taxes & fees
14 Nov - 15 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
0.4 km from Mayo Clinic Florida
United States
Patricia
HK$1,193
HK$1,354 total
includes taxes & fees
7 Nov - 8 Nov
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A round marble table with a magazine, a pair of glasses, and a coffee cup.
A cafe with a front desk, a coffee machine, and two chairs outside.
A backyard with a swimming pool, wooden deck, and outdoor furniture.
A hotel room with two beds, a nightstand with a lamp, and a pair of slippers on the floor.

7. Hotel Palms

Hotel Palms
7.8 km from Mayo Clinic Florida
United States
Vinny
HK$1,496
HK$1,698 total
includes taxes & fees
1 Nov - 2 Nov
Hotel Palms
A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.
A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.
A kitchen counter with a flat-screen TV displaying a breakfast menu, a coffee machine, and a sign for fresh pancakes.
A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Southside, 7.7 km from Mayo Clinic Florida
United States
Aneudi
HK$746
HK$846 total
includes taxes & fees
19 Nov - 20 Nov
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.
Lobby
A modern kitchen with a built-in refrigerator, microwave, and a wooden cabinet with a hanging rack.
Lobby

9. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
Deerwood, 7.8 km from Mayo Clinic Florida
United States
Mandy
HK$863
HK$980 total
includes taxes & fees
28 Oct - 29 Oct
Hyatt Studios Jacksonville/St Johns Town Center
An outdoor seating area with a fire feature, chairs, and a table.
A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.
A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.
A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.

10. Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
Southside, 10.8 km from Mayo Clinic Florida
United States
Carol
HK$989
HK$1,122 total
includes taxes & fees
20 Nov - 21 Nov
Hotel Indigo Jacksonville-Deerwood Park by IHG
A pool with a waterfall feature, surrounded by large rock formations.
An outdoor seating area with round tables and blue chairs, shaded by blue umbrellas with a logo, in front of a building with balconies and palm trees.
A beachside bar with a long counter, multiple chairs, and a view of the ocean.
A hotel room with two beds, a desk with a flat-screen TV, a chair, and a large window with a view of palm trees.

11. Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
6.3 km from Mayo Clinic Florida
United States
Maya
HK$1,261
HK$1,431 total
includes taxes & fees
1 Nov - 2 Nov
Hampton Inn Jacksonville Beach/Oceanfront
An outdoor patio with seating, a fire pit, and string lights.
A modern living room with a dining area, a flat-screen TV, and a bookshelf.
A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.

12. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
Southside, 8.6 km from Mayo Clinic Florida
United States
Becky
HK$998
HK$1,133 total
includes taxes & fees
25 Oct - 26 Oct
Hyatt Place Jacksonville / St. Johns Town Center
An outdoor patio area with a stone fire pit, wicker furniture, and a grill.
A modern living room with a fireplace, leather armchairs, a sofa, and ottomans.
A gym with treadmills, elliptical machines, and weight benches.
A modern kitchen with dark wooden cabinets, a stainless steel refrigerator, a microwave, and a dishwasher.

13. Residence Inn by Marriott Jacksonville South/Bartram Park

Residence Inn by Marriott Jacksonville South/Bartram Park
17.1 km from Mayo Clinic Florida
United States
Nicholas
HK$982
HK$1,114 total
includes taxes & fees
25 Oct - 26 Oct
Residence Inn by Marriott Jacksonville South/Bartram Park
A modern bar area with wooden accents, a variety of beverages, and seating arrangements.
A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.
A modern hotel lobby with a sofa set, armchairs, a coffee table, and a patterned carpet.
A modern bar area with a wooden counter, multiple seating options including bar stools and round tables, and a menu board.

14. Courtyard by Marriott Jacksonville I-295/East Beltway

Courtyard by Marriott Jacksonville I-295/East Beltway
Arlington, 13.2 km from Mayo Clinic Florida
United States
Chloie Marie
HK$700
HK$795 total
includes taxes & fees
31 Oct - 1 Nov
Courtyard by Marriott Jacksonville I-295/East Beltway
A beach with a sandy shore, waves, and buildings in the background.
A Best Western hotel with a modern design, located near a beach with a pier.
A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.
A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.

15. Best Western Oceanfront

Best Western Oceanfront
5.7 km from Mayo Clinic Florida
United States
Stephanie
HK$967
HK$1,097 total
includes taxes & fees
27 Oct - 28 Oct
Best Western Oceanfront
A spacious lobby with a reception desk, seating area, and large windows.
A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.
A multi-story hotel with a central entrance, large windows, and a well-lit facade.
An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.

16. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
8.5 km from Mayo Clinic Florida
United States
Madison
HK$897
HK$1,000 total
includes taxes & fees
16 Nov - 17 Nov
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Pool
A hotel room with a bed, a TV, a wooden dresser, a mirror, and a view of the sea.
A hotel with a beach view, multiple parking levels, and a prominent 'Four Points' sign.
A hotel room with a large bed, a desk, a chair, a TV, and a view of the ocean.

17. Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
5.6 km from Mayo Clinic Florida
United States
Rachel
HK$1,461
HK$1,658 total
includes taxes & fees
8 Nov - 9 Nov
Four Points by Sheraton Jacksonville Beachfront
An outdoor patio with blue and red chairs, tables, and potted plants.
A hotel room with a bed, a desk with a microwave, a coffee maker, and a mini-fridge.
A conference room with a large table, chairs, a projector screen, and a view of greenery outside.
A room with a window, a sofa, and an air conditioning unit.

18. Holiday Inn Express Jacksonville South Bartram Prk by IHG

Holiday Inn Express Jacksonville South Bartram Prk by IHG
17.1 km from Mayo Clinic Florida
United States
Max
HK$761
HK$864 total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express Jacksonville South Bartram Prk by IHG
A terrace with wooden tables and chairs, overlooking a beach and a pier.
A bar area with wooden beams, wicker hanging lights, and a bar stocked with bottles.
A beach with a wooden boardwalk leading to a pier.
A spacious outdoor dining area with wooden tables and chairs, a bar with stools, and large windows offering a view of the ocean.

19. Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
5.8 km from Mayo Clinic Florida
United States
MELISSA
HK$1,327
HK$1,507 total
includes taxes & fees
1 Nov - 2 Nov
Springhill Suites By Marriott Jacksonville Beach Oceanfront
A hotel room with a dining area, two beds, a TV, and a kitchenette.
Two people near a grill with a plate of food and a bottle.
A hotel room with a dining area featuring a table, chairs, a television, a microwave, and a coffee maker.
A compact kitchen with dark cabinetry, a built-in refrigerator, a dining table with a chair, and a wall-mounted lamp.

20. Candlewood Suites Jacksonville - Mayport by IHG

Candlewood Suites Jacksonville - Mayport by IHG
9.2 km from Mayo Clinic Florida
United States
Nasar
HK$785
HK$891 total
includes taxes & fees
15 Nov - 16 Nov
Candlewood Suites Jacksonville - Mayport by IHG
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
9.4
Exceptional
611 reviews
View
A modern restaurant with a bar area, wooden ceiling, and large windows.
Hilton Jacksonville at Mayo Clinic near Beaches
9.2
Wonderful
381 reviews
View
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
TownePlace Suites by Marriott Jacksonville East
9.2
Wonderful
666 reviews
View
A hotel lobby with a bar area, seating arrangements, and a reception desk.
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
9.0
Wonderful
1,009 reviews
View
A lobby with a reception desk, seating area, and a staircase.
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
9.0
Wonderful
1,010 reviews
View

Hotels recommended for families near Mayo Clinic Florida

A modern restaurant with a bar area, wooden ceiling, and large windows.
A modern lobby with a curved sofa, round coffee tables, and a large pillar.
A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.
A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.

Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
Jacksonville
HK$1,274
HK$1,446 total
includes taxes & fees
21 Nov - 22 Nov
Hilton Jacksonville at Mayo Clinic near Beaches
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.
A modern kitchen with a bar area, seating, and a view of the outdoors.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Isle of Palms
HK$1,073
HK$1,218 total
includes taxes & fees
20 Nov - 21 Nov
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Jacksonville
HK$1,193
HK$1,354 total
includes taxes & fees
7 Nov - 8 Nov
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A lobby with a reception desk, seating area, and a staircase.
A modern kitchen with a refrigerator, coffee machine, and a bakery display.
An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.
Lobby sitting area

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Jacksonville
HK$824
HK$935 total
includes taxes & fees
14 Nov - 15 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A covered entrance with a dark tiled floor, white columns, and a green bench.
A gym with treadmills, elliptical machines, and dumbbells.
A large, multi-story hotel with a prominent entrance, a covered area with lights, and a star-shaped design on the facade.
A snack area with shelves stocked with various snacks and a sign reading "Welcome to Jacksonville Beach."

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Jacksonville Beach
HK$934
HK$1,060 total
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.
A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods
HK$1,036
HK$1,176 total
includes taxes & fees
30 Oct - 31 Oct
TownePlace Suites by Marriott Jacksonville East
A gym with exercise equipment, a wall with a fitness-related mural, and large windows offering a view of the outdoors.
A bar area with a view of the beach, wooden bar stools, and a counter with a menu display.
A spacious lobby with a glass floor, a reception desk, and a view of the ocean.
A multi-story hotel with a beach view, parking lot, and a nearby restaurant.

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
Oceanfront
HK$1,155
HK$1,311 total
includes taxes & fees
2 Nov - 3 Nov
Margaritaville Jacksonville Beach
A beach with a sandy shore, waves, and buildings in the background.
A Best Western hotel with a modern design, located near a beach with a pier.
A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.
A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.

Best Western Oceanfront

Best Western Oceanfront
Oceanfront
HK$967
HK$1,097 total
includes taxes & fees
27 Oct - 28 Oct
Best Western Oceanfront

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"Wonderful hotel! So clean and beautiful decor and rooms. We loved our stay."
Abby 2-night trip
Posted 3 hours ago
Margaritaville Jacksonville Beach
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

8/10 Good
"Water presssure in the bathroom sink was very low."
Irving 1-night trip
Posted 6 hours ago
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches

10/10 Excellent
"A beautiful place will stay there again"
Brandy 1-night trip
Posted 10 hours ago
Hilton Jacksonville at Mayo Clinic near Beaches
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent
"Very nice stay. Quiet and breakfast is appreciated always."
Tonja 1-night trip
Posted 10 hours ago
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

10/10 Excellent
"Good stay"
Gene 1-night trip
Posted 14 hours ago
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

10/10 Excellent
"Had a great experience while here. Rooms were clean and spacious. Will definitely stay here again."
LISA 2-night trip
Posted 1 day ago
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Cozy & Comfy 3 bedroom residential home

Cozy & Comfy 3 bedroom residential home

10/10 Excellent
"Nice clean. The amenities were great! Master bedroom bed was comfortable. Location was perfect short drive to beaches, resteraunts & entertainment"
LaToya L. 3-night trip
Posted 7 days ago
Cozy & Comfy 3 bedroom residential home
Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent
"Clean, cozy house with a quiet neighborhood, close to several restaurants and shopping. The only downfall was there was no tv in the bunk bed room, there was no grill as listed, and the beds were a little too firm. Would def stay here again! Very clean and well kept."
Kimberly P. 3-night trip
Posted 10 days ago
Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent
"Carson was a great host. The communication process was excellent. He responded back to me fast and the property was cleaned and had everything that we needed. Would definitely come back again."
Anonymous traveller 3-night trip
Posted 3 weeks ago
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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