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Jacksonville Mayo Clinic Florida Hotels

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Check prices for these dates

Tonight
15 Oct - 16 Oct
Tomorrow
16 Oct - 17 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A modern kitchen with a bar area, seating, and a view of the outdoors.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
1.1 km from Mayo Clinic Florida
United States
Michaelanne
HK$1,073
HK$1,218 total
includes taxes & fees
15 Nov - 16 Nov
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.
An outdoor patio with a pool, wooden pergola, and seating area.

2. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
gregory
HK$965
HK$1,096 total
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Jacksonville East
A modern restaurant with a bar area, wooden ceiling, and large windows.
A modern lobby with a curved sofa, round coffee tables, and a large pillar.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.
A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

3. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
0.8 km from Mayo Clinic Florida
United States
Patricia
HK$1,327
HK$1,507 total
includes taxes & fees
30 Oct - 31 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
A hotel lobby with a bar area, seating arrangements, and a reception desk.
A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.
A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.
An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Patsy
HK$895
HK$1,016 total
includes taxes & fees
29 Oct - 30 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
A lobby with a reception desk, seating area, and a staircase.
An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.
A modern kitchen with a refrigerator, coffee machine, and a bakery display.
A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.6 km from Mayo Clinic Florida
United States
frances
HK$793
HK$900 total
includes taxes & fees
31 Oct - 1 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
0.4 km from Mayo Clinic Florida
United States
Patricia
HK$1,193
HK$1,354 total
includes taxes & fees
24 Oct - 25 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A bedroom with a bed, a dresser, a mirror with a floral frame, a green door, and a potted plant.
A cafe with a front desk, a coffee machine, and two chairs outside.
A kitchen with a sink, a coffee maker, a bottle of Mountain Valley Spring Water, and a jar of cream cheese stuffed olives.
A swimming pool with a wooden deck, lounge chairs, and umbrellas.

7. Hotel Palms

Hotel Palms
7.8 km from Mayo Clinic Florida
United States
Vinny
HK$1,496
HK$1,698 total
includes taxes & fees
18 Oct - 19 Oct
Hotel Palms
A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.
A hotel room with two beds, a desk, a chair, and a large window with a view.
A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.
A kitchen counter with a flat-screen TV displaying a breakfast menu, a coffee machine, and a sign for fresh pancakes.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Southside, 7.7 km from Mayo Clinic Florida
United States
Aneudi
HK$934
HK$1,060 total
includes taxes & fees
29 Oct - 30 Oct
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.
A pathway leading to a sunset over a beach with sand and grass.
A modern hotel lobby with a long reception desk, seating area, and large windows.
A modern conference room with a long table, several chairs, and pendant lighting.

9. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
5.4 km from Mayo Clinic Florida
United States
Lisa
HK$1,130
HK$1,283 total
includes taxes & fees
1 Nov - 2 Nov
Element by Marriott Jacksonville Beach
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.
Room
A conference room with multiple tables and chairs, large windows with curtains, and a flat-screen TV mounted on the wall.
Terrace/patio

10. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
Deerwood, 7.8 km from Mayo Clinic Florida
United States
Camoya
HK$950
HK$1,078 total
includes taxes & fees
29 Oct - 30 Oct
Hyatt Studios Jacksonville/St Johns Town Center
A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.
A modern hotel with a pool, palm trees, and a clear blue sky.
An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.
A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".

11. AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
Southside, 8.1 km from Mayo Clinic Florida
United States
Emily
HK$1,405
HK$1,594 total
includes taxes & fees
16 Oct - 17 Oct
AC Hotel Jacksonville St Johns Town Center
An outdoor seating area with a fire feature, chairs, and a table.
A modern bar area with a counter, bar stools, and a television screen.
A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.
A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.

12. Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
Southside, 10.8 km from Mayo Clinic Florida
United States
Carol
HK$926
HK$1,051 total
includes taxes & fees
12 Nov - 13 Nov
Hotel Indigo Jacksonville-Deerwood Park by IHG
A pool with a waterfall feature, surrounded by large rock formations.
A hotel room with two beds, a desk with a flat-screen TV, a chair, and a large window with a view of palm trees.
A beachfront hotel with multiple balconies, a sandy beach, and ocean views.
A beachside bar with a long counter, multiple chairs, and a view of the ocean.

13. Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
6.3 km from Mayo Clinic Florida
United States
Hope
HK$1,261
HK$1,431 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn Jacksonville Beach/Oceanfront
An outdoor patio with seating, a fire pit, and string lights.
A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.
A modern living room with a dining area, a flat-screen TV, and a bookshelf.
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.

14. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
Southside, 8.6 km from Mayo Clinic Florida
United States
Becky
HK$998
HK$1,133 total
includes taxes & fees
29 Oct - 30 Oct
Hyatt Place Jacksonville / St. Johns Town Center
A self-service beverage station with a refrigerated display and a coffee machine.
A snack display in a store with various chips and snacks.
A modern hotel reception area with a curved wooden reception desk, a digital display, and a view of the lobby.
A modern lounge area with seating, tables, and hanging lights.

15. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
Southside, 8.7 km from Mayo Clinic Florida
United States
Josephine
HK$859
HK$975 total
includes taxes & fees
1 Nov - 2 Nov
Tru By Hilton Jacksonville St Johns Town Center
A modern bar area with wooden accents, a variety of beverages, and seating arrangements.
A patio area with a stone fire pit, outdoor furniture, and a brick floor.
A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.
A modern bar area with a wooden counter, multiple seating options including bar stools and round tables, and a menu board.

16. Courtyard by Marriott Jacksonville I-295/East Beltway

Courtyard by Marriott Jacksonville I-295/East Beltway
Arlington, 13.2 km from Mayo Clinic Florida
United States
Chloie Marie
HK$759
HK$862 total
includes taxes & fees
15 Nov - 16 Nov
Courtyard by Marriott Jacksonville I-295/East Beltway
A spacious lobby with a reception desk, seating area, and large windows.
A bar area with wooden chairs, a round table, and a brick wall.
A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.
A multi-story hotel with a central entrance, large windows, and a well-lit facade.

17. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
8.5 km from Mayo Clinic Florida
United States
William
HK$930
HK$1,037 total
includes taxes & fees
11 Nov - 12 Nov
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.
A coffee station with two espresso machines and a display of coffee products.
A pier extending into the ocean at sunset with birds flying above.
A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.

18. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
4.6 km from Mayo Clinic Florida
United States
Bobby
HK$863
HK$980 total
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Express Jacksonville Beach by IHG
A beach with a sandy shore, waves, and buildings in the background.
A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.
A Best Western hotel with a modern design, located near a beach with a pier.
A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.

19. Best Western Oceanfront

Best Western Oceanfront
5.7 km from Mayo Clinic Florida
United States
Stephanie
HK$1,036
HK$1,176 total
includes taxes & fees
25 Oct - 26 Oct
Best Western Oceanfront
Pool
A hotel with a beach view, multiple parking levels, and a prominent 'Four Points' sign.
A coastal hotel with a long promenade, beach access, and a pier in the distance.
A hotel room with a large bed, a desk, a chair, a TV, and a view of the ocean.

20. Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
5.6 km from Mayo Clinic Florida
United States
Rachel
HK$1,394
HK$1,582 total
includes taxes & fees
1 Nov - 2 Nov
Four Points by Sheraton Jacksonville Beachfront
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
9.4
Exceptional
607 reviews
View
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
TownePlace Suites by Marriott Jacksonville East
9.2
Wonderful
663 reviews
View
A modern restaurant with a bar area, wooden ceiling, and large windows.
Hilton Jacksonville at Mayo Clinic near Beaches
9.2
Wonderful
374 reviews
View
A hotel lobby with a bar area, seating arrangements, and a reception desk.
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
9.0
Wonderful
1,001 reviews
View
A lobby with a reception desk, seating area, and a staircase.
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
9.0
Wonderful
1,004 reviews
View

Hotels recommended for families near Mayo Clinic Florida

A modern restaurant with a bar area, wooden ceiling, and large windows.
A modern lobby with a curved sofa, round coffee tables, and a large pillar.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.
A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
Jacksonville
HK$1,327
HK$1,507 total
includes taxes & fees
30 Oct - 31 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A modern kitchen with a bar area, seating, and a view of the outdoors.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Isle of Palms
HK$1,073
HK$1,218 total
includes taxes & fees
15 Nov - 16 Nov
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Jacksonville
HK$1,193
HK$1,354 total
includes taxes & fees
24 Oct - 25 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A lobby with a reception desk, seating area, and a staircase.
An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.
A modern kitchen with a refrigerator, coffee machine, and a bakery display.
A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Jacksonville
HK$793
HK$900 total
includes taxes & fees
31 Oct - 1 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A hotel lobby with a bar area, seating arrangements, and a reception desk.
A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.
A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.
An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods
HK$895
HK$1,016 total
includes taxes & fees
29 Oct - 30 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.
An outdoor patio with a pool, wooden pergola, and seating area.

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods
HK$965
HK$1,096 total
includes taxes & fees
25 Oct - 26 Oct
TownePlace Suites by Marriott Jacksonville East
A spacious lobby with a glass floor, a reception desk, and a view of the ocean.
A multi-story hotel with a beach view, parking lot, and a nearby restaurant.
A modern building with multiple balconies overlooking a beach.
A bar area with a view of the beach, wooden bar stools, and a counter with a menu display.

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
Oceanfront
HK$1,157
HK$1,313 total
includes taxes & fees
8 Nov - 9 Nov
Margaritaville Jacksonville Beach
A beach with a sandy shore, waves, and buildings in the background.
A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.
A Best Western hotel with a modern design, located near a beach with a pier.
A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.

Best Western Oceanfront

Best Western Oceanfront
Oceanfront
HK$1,036
HK$1,176 total
includes taxes & fees
25 Oct - 26 Oct
Best Western Oceanfront

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent
"Everything was good. Will visit again"
Beth 1-night trip
Posted 1 hour ago
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent
"Great location"
William Garita 2-night trip
Posted 13 hours ago
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"Truly enjoyed the property and stay! Great coffee and good drinks"
Sherri 1-night trip
Posted 17 hours ago
Margaritaville Jacksonville Beach
Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG

10/10 Excellent
"Clean and updated. Excellent staff. Breakfast was very good. Easy access to the highway."
Michael 1-night trip
Posted 1 day ago
Holiday Inn Express Jacksonville Beach by IHG
Cozy & Comfy 3 bedroom residential home

Cozy & Comfy 3 bedroom residential home

10/10 Excellent
"Nice clean. The amenities were great! Master bedroom bed was comfortable. Location was perfect short drive to beaches, resteraunts & entertainment"
LaToya L. 3-night trip
Posted 1 day ago
Cozy & Comfy 3 bedroom residential home
TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East

10/10 Excellent
"Nice"
Adalberto 1-night trip
Posted 2 days ago
TownePlace Suites by Marriott Jacksonville East
Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent
"Clean, cozy house with a quiet neighborhood, close to several restaurants and shopping. The only downfall was there was no tv in the bunk bed room, there was no grill as listed, and the beds were a little too firm. Would def stay here again! Very clean and well kept."
Kimberly P. 3-night trip
Posted 4 days ago
Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent
"Carson was a great host. The communication process was excellent. He responded back to me fast and the property was cleaned and had everything that we needed. Would definitely come back again."
Anonymous traveller 3-night trip
Posted 2 weeks ago
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent
"The property was very clean and spacious. The host was responsive.She was also helpful with area recommendations. She went above and beyond our expectations. The home is well-supplied with just about anything you could need.The beds were very comfortable.The property is located in a safe and convenient neighborhood.We would definitely stay again."
Connie T. 3-night trip
Posted 3 weeks ago
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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