Jacksonville Mayo Clinic Florida Hotels: 2026 Limited-Time Hotel Deals @Expedia

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

A modern kitchen with a bar area, seating, and a view of the outdoors.

A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Michaelanne

HK$1,073

HK$1,218 total

includes taxes & fees

30 Oct - 31 Oct

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.

A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

2. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

gregory

HK$965

HK$1,096 total

includes taxes & fees

18 Oct - 19 Oct

A modern restaurant with a bar area, wooden ceiling, and large windows.

A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

3. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Patricia

HK$1,327

HK$1,507 total

includes taxes & fees

17 Oct - 18 Oct

A lobby with a reception desk, seating area, and a staircase.

A modern kitchen with a refrigerator, coffee machine, and a bakery display.

A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

frances

HK$753

HK$855 total

includes taxes & fees

25 Oct - 26 Oct

A hotel lobby with a bar area, seating arrangements, and a reception desk.

A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.

A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Patsy

HK$859

HK$975 total

includes taxes & fees

11 Oct - 12 Oct

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Patricia

HK$1,193

HK$1,354 total

includes taxes & fees

17 Oct - 18 Oct

A door with the number 312, a window with blinds, a green door mat, a chair with a geometric pattern, and small plants.

A backyard with a swimming pool, wooden deck, and outdoor furniture.

A swimming pool with a wooden deck, lounge chairs, and umbrellas.

7. Hotel Palms

7.8 km from Mayo Clinic Florida

Vinny

HK$1,247

HK$1,415 total

includes taxes & fees

11 Oct - 12 Oct

A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.

A hotel room with two beds, a desk, a chair, and a large window with a view.

A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.

A gym with treadmills, elliptical machines, and free weights.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.7 km from Mayo Clinic Florida

Ian

HK$902

HK$1,024 total

includes taxes & fees

11 Oct - 12 Oct

A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

A pathway leading to a sunset over a beach with sand and grass.

A modern conference room with a long table, several chairs, and pendant lighting.

A modern hotel lobby with a long reception desk, seating area, and large windows.

9. Element by Marriott Jacksonville Beach

5.4 km from Mayo Clinic Florida

Nick

HK$1,193

HK$1,354 total

includes taxes & fees

25 Oct - 26 Oct

A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

A modern hotel building with a flat roof, large windows, and a sign reading 'HYATT studios'.

10. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 7.8 km from Mayo Clinic Florida

Camoya

HK$902

HK$1,024 total

includes taxes & fees

30 Oct - 31 Oct

A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.

An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.

A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".

A modern hotel with a pool, palm trees, and a clear blue sky.

11. AC Hotel Jacksonville St Johns Town Center

Southside, 8.1 km from Mayo Clinic Florida

Emily

HK$1,405

HK$1,594 total

includes taxes & fees

10 Oct - 11 Oct

An outdoor seating area with a fire feature, chairs, and a table.

A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.

A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

12. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

Carol

HK$997

HK$1,131 total

includes taxes & fees

11 Oct - 12 Oct

A pool with a waterfall feature, surrounded by large rock formations.

A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

A beachfront hotel with multiple floors, a sandy beach with umbrellas, and a view of the ocean.

13. Hampton Inn Jacksonville Beach/Oceanfront

6.3 km from Mayo Clinic Florida

Hope

HK$1,261

HK$1,431 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor patio with seating, a fire pit, and string lights.

A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.

A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.

A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.

14. Hyatt Place Jacksonville / St. Johns Town Center

Southside, 8.6 km from Mayo Clinic Florida

Becky

HK$998

HK$1,133 total

includes taxes & fees

11 Oct - 12 Oct

A self-service beverage station with a refrigerated display and a coffee machine.

A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

A modern lounge area with seating, tables, and hanging lights.

A snack display in a store with various chips and snacks.

15. Tru By Hilton Jacksonville St Johns Town Center

Southside, 8.7 km from Mayo Clinic Florida

Mary

HK$859

HK$975 total

includes taxes & fees

11 Oct - 12 Oct

A modern bar area with wooden accents, a variety of beverages, and seating arrangements.

A modern hotel lobby with a sofa set, armchairs, a coffee table, and a patterned carpet.

A modern bar area with a wooden counter, multiple seating options including bar stools and round tables, and a menu board.

A patio area with a stone fire pit, outdoor furniture, and a brick floor.

16. Courtyard by Marriott Jacksonville I-295/East Beltway

Arlington, 13.2 km from Mayo Clinic Florida

Chloie Marie

HK$759

HK$862 total

includes taxes & fees

12 Oct - 13 Oct

A spacious lobby with a reception desk, seating area, and large windows.

A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.

A multi-story hotel with a central entrance, large windows, and a well-lit facade.

A bar area with wooden chairs, a round table, and a brick wall.

17. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

8.5 km from Mayo Clinic Florida

William

HK$925

HK$1,031 total

includes taxes & fees

19 Oct - 20 Oct

A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

A coffee station with two espresso machines and a display of coffee products.

A golf course with a water hazard and a bridge.

A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.

18. Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

Bobby

HK$863

HK$980 total

includes taxes & fees

18 Oct - 19 Oct

A beach with a sandy shore, waves, and buildings in the background.

A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.

A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.

A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.

19. Best Western Oceanfront

5.7 km from Mayo Clinic Florida

Stephanie

HK$1,036

HK$1,176 total

includes taxes & fees

14 Oct - 15 Oct

A hotel room with a bed, a TV, a wooden dresser, a mirror, and a view of the sea.

A hotel room with a large bed, a desk, a chair, a TV, and a view of the ocean.

A coastal hotel with a long promenade, beach access, and a pier in the distance.

20. Four Points by Sheraton Jacksonville Beachfront

5.6 km from Mayo Clinic Florida

Rachel

HK$1,461

HK$1,658 total

includes taxes & fees

25 Oct - 26 Oct

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 604 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 662 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	9.2 Wonderful 368 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,004 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,000 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent

"Clean, nice room"

Margaritaville Jacksonville Beach

10/10 Excellent

"Great location and wonderful staff."

TownePlace Suites by Marriott Jacksonville East

10/10 Excellent

"Staff were very nice and helpful."

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent

"Chris at front desk check-in was most pleasant and professional. She offered very good suggestions regarding the area and best routes for getting to and from our business location. She’s a great brand representative."

Hilton Jacksonville at Mayo Clinic near Beaches

10/10 Excellent

"The room was very clean and the staff was great. I truly enjoyed my stay!!"

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent

"The property was very clean and spacious. The host was responsive.She was also helpful with area recommendations. She went above and beyond our expectations. The home is well-supplied with just about anything you could need.The beds were very comfortable.The property is located in a safe and convenient neighborhood.We would definitely stay again."

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

10/10 Excellent

"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good

"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."

5/2 Pool Cottage, Walk to Beach close to Mayo

10/10 Excellent

"Very clean and had everything we needed. Well worth it. Easy access to Mayo Clinic, beach and shopping. Tons of space in a quite neighborhood. The pool and pool house was bonus !"

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.

Where is the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels are there near Mayo Clinic Florida?

Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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Jacksonville Mayo Clinic Florida Hotels

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Treat yourself

Be picky

Check prices for these dates

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Star rating

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Our top choices for Mayo Clinic Florida hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. TownePlace Suites by Marriott Jacksonville East

3. Hilton Jacksonville at Mayo Clinic near Beaches

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. Hotel Palms

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

9. Element by Marriott Jacksonville Beach

10. Hyatt Studios Jacksonville/St Johns Town Center

11. AC Hotel Jacksonville St Johns Town Center

12. Hotel Indigo Jacksonville-Deerwood Park by IHG

13. Hampton Inn Jacksonville Beach/Oceanfront

14. Hyatt Place Jacksonville / St. Johns Town Center

15. Tru By Hilton Jacksonville St Johns Town Center

16. Courtyard by Marriott Jacksonville I-295/East Beltway

17. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

18. Holiday Inn Express Jacksonville Beach by IHG

19. Best Western Oceanfront

20. Four Points by Sheraton Jacksonville Beachfront

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Margaritaville Jacksonville Beach

TownePlace Suites by Marriott Jacksonville East

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hilton Jacksonville at Mayo Clinic near Beaches

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

5/2 Pool Cottage, Walk to Beach close to Mayo

Frequently asked questions

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