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Jacksonville Mayo Clinic Florida Hotels

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Check prices for these dates

Tonight
10 Oct - 11 Oct
Tomorrow
11 Oct - 12 Oct
Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A modern kitchen with a bar area, seating, and a view of the outdoors.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
1.1 km from Mayo Clinic Florida
United States
Michaelanne
HK$1,073
HK$1,218 total
includes taxes & fees
23 Oct - 24 Oct
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.

2. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
gregory
HK$965
HK$1,096 total
includes taxes & fees
18 Oct - 19 Oct
TownePlace Suites by Marriott Jacksonville East
A modern restaurant with a bar area, wooden ceiling, and large windows.
A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.
A modern lobby with a curved sofa, round coffee tables, and a large pillar.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

3. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
0.8 km from Mayo Clinic Florida
United States
Patricia
HK$1,327
HK$1,507 total
includes taxes & fees
17 Oct - 18 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
A lobby with a reception desk, seating area, and a staircase.
Lobby sitting area
A modern kitchen with a refrigerator, coffee machine, and a bakery display.
A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.6 km from Mayo Clinic Florida
United States
frances
HK$761
HK$864 total
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A hotel lobby with a bar area, seating arrangements, and a reception desk.
A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.
A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.
An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Patsy
HK$859
HK$975 total
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
0.4 km from Mayo Clinic Florida
United States
Patricia
HK$1,193
HK$1,354 total
includes taxes & fees
17 Oct - 18 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A compact living space with a kitchenette, a woven chair, a round table, and a sofa.
A backyard with a swimming pool, wooden deck, and outdoor furniture.
A room with a round marble table, two woven chairs, and wall decorations including seashells and a framed painting.
A bedroom with two beds, a wardrobe, a nightstand, and a lamp.

7. Hotel Palms

Hotel Palms
7.8 km from Mayo Clinic Florida
United States
Vinny
HK$1,496
HK$1,698 total
includes taxes & fees
12 Oct - 13 Oct
Hotel Palms
A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.
A gym with treadmills, elliptical machines, and free weights.
A hotel room with two beds, a desk, a chair, and a large window with a view.
A beverage refrigerator stocked with various drinks, a small refrigerator, and a wall-mounted display with promotional items.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Southside, 7.7 km from Mayo Clinic Florida
United States
Alan
HK$934
HK$1,060 total
includes taxes & fees
29 Oct - 30 Oct
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
An outdoor patio area with seating, a fire pit, and a barbecue grill.
A modern hotel with a sign reading "Towneplace Suites by Marriott" and a parking lot in front.
A reception area with a modern design, featuring a reception desk, a refrigerator with snacks, and a wooden slatted wall.
A modern living room with sofas, a coffee table, and a dining area.

9. TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
10.8 km from Mayo Clinic Florida
United States
irina
HK$997
HK$1,131 total
includes taxes & fees
18 Oct - 19 Oct
TownePlace Suites by Marriott® Jacksonville Mayport
A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.
A pathway leading to a sunset over a beach with sand and grass.
A modern building entrance with a sign reading "element by Westin".
A modern hotel lobby with a long reception desk, seating area, and large windows.

10. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
5.4 km from Mayo Clinic Florida
United States
Lisa
HK$1,130
HK$1,283 total
includes taxes & fees
25 Oct - 26 Oct
Element by Marriott Jacksonville Beach
A laptop on a wooden desk with a white mug, a spoon, and a smartphone.
Lobby
A modern hotel building with a flat roof, large windows, and a sign reading 'HYATT studios'.
Sports facility

11. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
Deerwood, 7.8 km from Mayo Clinic Florida
United States
Camoya
HK$957
HK$1,087 total
includes taxes & fees
29 Oct - 30 Oct
Hyatt Studios Jacksonville/St Johns Town Center
A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.
An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.
A modern hotel with a pool, palm trees, and a clear blue sky.
A modern bar area with seating, a bar counter, and a view of the city through large windows.

12. AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
Southside, 8.1 km from Mayo Clinic Florida
United States
Emily
HK$1,405
HK$1,594 total
includes taxes & fees
15 Oct - 16 Oct
AC Hotel Jacksonville St Johns Town Center
An outdoor seating area with a fire feature, chairs, and a table.
A modern bar area with a counter, bar stools, and a television screen.
A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.
A gym with treadmills, dumbbells, and exercise balls, overlooking a swimming pool.

13. Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
Southside, 10.8 km from Mayo Clinic Florida
United States
Carol
HK$997
HK$1,131 total
includes taxes & fees
29 Oct - 30 Oct
Hotel Indigo Jacksonville-Deerwood Park by IHG
A pool with a waterfall feature, surrounded by large rock formations.
A beachside bar with a long counter, multiple chairs, and a view of the ocean.
A beachfront hotel with multiple balconies, a sandy beach, and ocean views.
An outdoor seating area with round tables and blue chairs, shaded by blue umbrellas with a logo, in front of a building with balconies and palm trees.

14. Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
6.3 km from Mayo Clinic Florida
United States
Hope
HK$1,261
HK$1,431 total
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Jacksonville Beach/Oceanfront
An outdoor patio with seating, a fire pit, and string lights.
A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.
A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.
A modern living room with a dining area, a flat-screen TV, and a bookshelf.

15. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
Southside, 8.6 km from Mayo Clinic Florida
United States
Becky
HK$998
HK$1,133 total
includes taxes & fees
15 Oct - 16 Oct
Hyatt Place Jacksonville / St. Johns Town Center
A modern bar area with wooden accents, a variety of beverages, and seating arrangements.
A modern hotel lobby with a sofa set, armchairs, a coffee table, and a patterned carpet.
A multi-story hotel with a prominent entrance, a parking lot, and well-maintained landscaping.
A patio area with a stone fire pit, outdoor furniture, and a brick floor.

16. Courtyard by Marriott Jacksonville I-295/East Beltway

Courtyard by Marriott Jacksonville I-295/East Beltway
Arlington, 13.2 km from Mayo Clinic Florida
United States
Chloie Marie
HK$759
HK$862 total
includes taxes & fees
18 Oct - 19 Oct
Courtyard by Marriott Jacksonville I-295/East Beltway
A self-service beverage station with a refrigerated display and a coffee machine.
A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.
A snack display in a store with various chips and snacks.
A modern lounge area with seating, tables, and hanging lights.

17. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
Southside, 8.7 km from Mayo Clinic Florida
United States
Josephine
HK$859
HK$975 total
includes taxes & fees
18 Oct - 19 Oct
Tru By Hilton Jacksonville St Johns Town Center
A hotel room with a TV, desk, two beds, a chair, and a window.
A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.
A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.
A pier extending into the ocean at sunset with birds flying above.

18. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
4.6 km from Mayo Clinic Florida
United States
Bobby
HK$863
HK$980 total
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Express Jacksonville Beach by IHG
A spacious lobby with a reception desk, seating area, and large windows.
An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.
A multi-story hotel with a central entrance, large windows, and a well-lit facade.
A bar area with wooden chairs, a round table, and a brick wall.

19. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
8.5 km from Mayo Clinic Florida
United States
William
HK$925
HK$1,031 total
includes taxes & fees
19 Oct - 20 Oct
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
A beach with a sandy shore, waves, and buildings in the background.
A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.
A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.
A Best Western hotel with a modern design, located near a beach with a pier.

20. Best Western Oceanfront

Best Western Oceanfront
5.7 km from Mayo Clinic Florida
United States
Stephanie
HK$1,024
HK$1,162 total
includes taxes & fees
13 Oct - 14 Oct
Best Western Oceanfront
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
9.4
Exceptional
605 reviews
View
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
TownePlace Suites by Marriott Jacksonville East
9.2
Wonderful
662 reviews
View
A modern restaurant with a bar area, wooden ceiling, and large windows.
Hilton Jacksonville at Mayo Clinic near Beaches
9.2
Wonderful
369 reviews
View
A lobby with a reception desk, seating area, and a staircase.
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
9.0
Wonderful
1,001 reviews
View
A hotel lobby with a bar area, seating arrangements, and a reception desk.
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
9.0
Wonderful
1,003 reviews
View

Hotels recommended for families near Mayo Clinic Florida

A modern restaurant with a bar area, wooden ceiling, and large windows.
A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.
A modern lobby with a curved sofa, round coffee tables, and a large pillar.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
Jacksonville
HK$1,327
HK$1,507 total
includes taxes & fees
17 Oct - 18 Oct
Hilton Jacksonville at Mayo Clinic near Beaches
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A modern kitchen with a bar area, seating, and a view of the outdoors.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.
An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Isle of Palms
HK$1,073
HK$1,218 total
includes taxes & fees
23 Oct - 24 Oct
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Jacksonville
HK$1,193
HK$1,354 total
includes taxes & fees
17 Oct - 18 Oct
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A lobby with a reception desk, seating area, and a staircase.
Lobby sitting area
A modern kitchen with a refrigerator, coffee machine, and a bakery display.
A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Jacksonville
HK$761
HK$864 total
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A hotel lobby with a bar area, seating arrangements, and a reception desk.
A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.
A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.
An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods
HK$859
HK$975 total
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods
HK$965
HK$1,096 total
includes taxes & fees
18 Oct - 19 Oct
TownePlace Suites by Marriott Jacksonville East
A spacious lobby with a glass floor, a reception desk, and a view of the ocean.
A bar area with a view of the beach, wooden bar stools, and a counter with a menu display.
A cafe with a tropical mural, a coffee menu, and a variety of seating options.
A modern building with multiple balconies overlooking a beach.

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
Oceanfront
HK$1,157
HK$1,313 total
includes taxes & fees
1 Nov - 2 Nov
Margaritaville Jacksonville Beach
A beach with a sandy shore, waves, and buildings in the background.
A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.
A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.
A Best Western hotel with a modern design, located near a beach with a pier.

Best Western Oceanfront

Best Western Oceanfront
Oceanfront
HK$1,024
HK$1,162 total
includes taxes & fees
13 Oct - 14 Oct
Best Western Oceanfront

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG

10/10 Excellent
"Perfect stay, great location"
Isaac 2-night trip
Posted 3 hours ago
Holiday Inn Express Jacksonville Beach by IHG
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent
"Very helpful staff! Very clean and updated rooms! Will definitely stay there again!"
Mark 3-night trip
Posted 6 hours ago
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent
"Clean room"
Scott 1-night trip
Posted 9 hours ago
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

10/10 Excellent
"Highly recommended"
Alissa 1-night trip
Posted 9 hours ago
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches

8/10 Good
"Cobran las botellas se agua en la habitación, antes eran cortesía."
Felipe 3-night trip
Posted 2 days ago
Hilton Jacksonville at Mayo Clinic near Beaches
TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East

10/10 Excellent
"Staff were very nice and helpful."
Leah 2-night trip
Posted 4 days ago
TownePlace Suites by Marriott Jacksonville East
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent
"The property was very clean and spacious. The host was responsive.She was also helpful with area recommendations. She went above and beyond our expectations. The home is well-supplied with just about anything you could need.The beds were very comfortable.The property is located in a safe and convenient neighborhood.We would definitely stay again."
Connie T. 3-night trip
Posted 13 days ago
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent
"House was very clean and comfortable. We will definitely stay there again."
Sherry D. 4-night trip
Posted 2 weeks ago
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good
"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."
Barbara G. 24-night trip
Posted 1 month ago
Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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