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Jacksonville Mayo Clinic Florida Hotels

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Check prices for these dates

Tonight
26 Oct - 27 Oct
Tomorrow
27 Oct - 28 Oct
This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.
A modern kitchen with a bar area, seating, and a view of the outdoors.
A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
1.1 km from Mayo Clinic Florida
United States
LISA
HK$1,072
HK$1,217 total
includes taxes & fees
26 Nov - 27 Nov
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
An outdoor patio with a pool, wooden pergola, and seating area.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

2. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Lana
HK$965
HK$1,095 total
includes taxes & fees
22 Nov - 23 Nov
TownePlace Suites by Marriott Jacksonville East
A modern restaurant with a bar area, wooden ceiling, and large windows.
A modern lobby with a curved sofa, round coffee tables, and a large pillar.
A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

3. Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
0.8 km from Mayo Clinic Florida
United States
Brandy
HK$1,240
HK$1,407 total
includes taxes & fees
22 Nov - 23 Nov
Hilton Jacksonville at Mayo Clinic near Beaches
A lobby with a reception desk, seating area, and a staircase.
A modern kitchen with a refrigerator, coffee machine, and a bakery display.
Lobby sitting area
A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

4. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.6 km from Mayo Clinic Florida
United States
Gregory
HK$855
HK$970 total
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A hotel lobby with a bar area, seating arrangements, and a reception desk.
A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.
A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.
An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

5. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
United States
Kerry
HK$931
HK$1,056 total
includes taxes & fees
1 Nov - 2 Nov
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
0.4 km from Mayo Clinic Florida
United States
Patricia
HK$1,192
HK$1,353 total
includes taxes & fees
31 Oct - 1 Nov
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A bedroom with a bed, a bedside table with a lamp, a sofa, a coffee table with a book, and a painting on the wall.
A round marble table with a magazine, a pair of glasses, and a coffee cup.
A living room with a sofa, a coffee table, a hanging light fixture, a framed picture, and a floor lamp.
Room

7. Hotel Palms

Hotel Palms
7.8 km from Mayo Clinic Florida
United States
Vinny
HK$1,534
HK$1,741 total
includes taxes & fees
1 Nov - 2 Nov
Hotel Palms
A hotel entrance with a covered walkway, palm trees, and a parking area.
A modern dining area with wooden tables and red chairs, a coffee press, and a counter with a menu.
A hotel reception area with a modern design, a check-in counter, and a seating area with tables and chairs.
An outdoor seating area with tables and chairs, a stone wall, and a view of the water.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Southside, 7.7 km from Mayo Clinic Florida
United States
Aneudi
HK$753
HK$855 total
includes taxes & fees
23 Nov - 24 Nov
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
An outdoor patio area with seating, a fire pit, and a barbecue grill.
A modern hotel with a sign reading "Towneplace Suites by Marriott" and a parking lot in front.
A modern living room with sofas, a coffee table, and a dining area.
A reception area with a modern design, featuring a reception desk, a refrigerator with snacks, and a wooden slatted wall.

9. TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
10.8 km from Mayo Clinic Florida
United States
irina
HK$933
HK$1,059 total
includes taxes & fees
15 Nov - 16 Nov
TownePlace Suites by Marriott® Jacksonville Mayport
A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.
A modern building entrance with a sign reading "element by Westin".
A modern hotel lobby with a long reception desk, seating area, and large windows.
A modern conference room with a long table, several chairs, and pendant lighting.

10. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
5.4 km from Mayo Clinic Florida
United States
ariel
HK$1,129
HK$1,282 total
includes taxes & fees
8 Nov - 9 Nov
Element by Marriott Jacksonville Beach
Terrace/patio
A hotel room with two beds, a desk, a chair, a small table, a TV, and a kitchen area.
Breakfast area
Lobby

11. Hyatt Studios Jacksonville/St Johns Town Center

Hyatt Studios Jacksonville/St Johns Town Center
Deerwood, 7.8 km from Mayo Clinic Florida
United States
Mandy
HK$972
HK$1,104 total
includes taxes & fees
12 Nov - 13 Nov
Hyatt Studios Jacksonville/St Johns Town Center
A pool with a waterfall feature, surrounded by large rock formations.
A bar with a tiled roof, outdoor seating, and a view of the ocean.
A hotel with a view of the ocean at sunset, featuring a parking lot and palm trees.
A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

12. Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
6.3 km from Mayo Clinic Florida
United States
Maya
HK$1,260
HK$1,430 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn Jacksonville Beach/Oceanfront
A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.
A modern hotel with a pool, palm trees, and a clear blue sky.
A modern bar area with seating, a bar counter, and a view of the city through large windows.
A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".

13. AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
Southside, 8.1 km from Mayo Clinic Florida
United States
Emily
HK$1,169
HK$1,326 total
includes taxes & fees
22 Nov - 23 Nov
AC Hotel Jacksonville St Johns Town Center
An outdoor seating area with a fire feature, chairs, and a table.
A modern bar area with a counter, bar stools, and a television screen.
A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.
A hotel with a central tower, a parking area, and a body of water in the background.

14. Hotel Indigo Jacksonville-Deerwood Park by IHG

Hotel Indigo Jacksonville-Deerwood Park by IHG
Southside, 10.8 km from Mayo Clinic Florida
United States
Cheryl A
HK$863
HK$979 total
includes taxes & fees
22 Nov - 23 Nov
Hotel Indigo Jacksonville-Deerwood Park by IHG
A spacious lobby with a reception desk, seating area, and large windows.
A bar area with wooden chairs, a round table, and a brick wall.
A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.
An indoor dining area with tables and chairs, a ceiling fan, and a view of the outdoors.

15. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
8.5 km from Mayo Clinic Florida
United States
Timothy
HK$894
HK$997 total
includes taxes & fees
16 Nov - 17 Nov
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
An outdoor patio with seating, a fire pit, and string lights.
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a fence.
A modern bar area with a counter, bar stools, and a television screen. There are round tables with chairs in the dining area.
A multi-story hotel with a modern design, featuring a large number of windows and a flat roof.

16. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
Southside, 8.6 km from Mayo Clinic Florida
United States
Becky
HK$998
HK$1,132 total
includes taxes & fees
29 Oct - 30 Oct
Hyatt Place Jacksonville / St. Johns Town Center
A beach with a sandy shore, waves, and buildings in the background.
A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.
A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.
A Best Western hotel with a modern design, located near a beach with a pier.

17. Best Western Oceanfront

Best Western Oceanfront
5.7 km from Mayo Clinic Florida
United States
Williams
HK$955
HK$1,084 total
includes taxes & fees
27 Oct - 28 Oct
Best Western Oceanfront
A buffet with multiple self-service stations, including omelets and other prepared foods.
A modern lobby with seating areas, a flat-screen TV, and a coffee bar.
A pier extending into the ocean at sunset with birds flying above.
A golf course with a water hazard and a bridge.

18. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
4.6 km from Mayo Clinic Florida
United States
Bobby
HK$894
HK$1,015 total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express Jacksonville Beach by IHG
An outdoor patio area with a stone fire pit, wicker furniture, and a grill.
A gym with treadmills, elliptical machines, and weight benches.
A modern living room with a fireplace, leather armchairs, a sofa, and ottomans.
A modern kitchen with dark wooden cabinets, a stainless steel refrigerator, a microwave, and a dishwasher.

19. Residence Inn by Marriott Jacksonville South/Bartram Park

Residence Inn by Marriott Jacksonville South/Bartram Park
17.1 km from Mayo Clinic Florida
United States
Nicholas
HK$981
HK$1,114 total
includes taxes & fees
30 Oct - 31 Oct
Residence Inn by Marriott Jacksonville South/Bartram Park
A self-service beverage station with a refrigerated display and a coffee machine.
A snack display in a store with various chips and snacks.
A modern hotel reception area with a curved wooden reception desk, a digital display, and a view of the lobby.
A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

20. Tru By Hilton Jacksonville St Johns Town Center

Tru By Hilton Jacksonville St Johns Town Center
Southside, 8.7 km from Mayo Clinic Florida
United States
Janice
HK$859
HK$975 total
includes taxes & fees
1 Nov - 2 Nov
Tru By Hilton Jacksonville St Johns Town Center
View all properties

Compare popular hotels close to Mayo Clinic Florida

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
9.4
Exceptional
613 reviews
View
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
TownePlace Suites by Marriott Jacksonville East
9.2
Wonderful
667 reviews
View
A modern restaurant with a bar area, wooden ceiling, and large windows.
Hilton Jacksonville at Mayo Clinic near Beaches
9.2
Wonderful
386 reviews
View
A lobby with a reception desk, seating area, and a staircase.
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
9.0
Wonderful
1,021 reviews
View
A hotel lobby with a bar area, seating arrangements, and a reception desk.
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
9.0
Wonderful
1,005 reviews
View

Hotels recommended for families near Mayo Clinic Florida

A modern restaurant with a bar area, wooden ceiling, and large windows.
A modern lobby with a curved sofa, round coffee tables, and a large pillar.
A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.
A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

Hilton Jacksonville at Mayo Clinic near Beaches

Hilton Jacksonville at Mayo Clinic near Beaches
Jacksonville
HK$1,240
HK$1,407 total
includes taxes & fees
22 Nov - 23 Nov
Hilton Jacksonville at Mayo Clinic near Beaches
A spacious living area with a high ceiling, a fireplace, and a bar area in the background.
A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.
A modern kitchen with a bar area, seating, and a view of the outdoors.
A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Isle of Palms
HK$1,072
HK$1,217 total
includes taxes & fees
26 Nov - 27 Nov
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
An outdoor seating area with stone fire pit, wicker furniture, and potted plants.
A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.
A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.
A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Jacksonville
HK$1,192
HK$1,353 total
includes taxes & fees
31 Oct - 1 Nov
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
A lobby with a reception desk, seating area, and a staircase.
A modern kitchen with a refrigerator, coffee machine, and a bakery display.
Lobby sitting area
A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Jacksonville
HK$855
HK$970 total
includes taxes & fees
8 Nov - 9 Nov
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
A hotel lobby with a bar area, seating arrangements, and a reception desk.
A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.
A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.
An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Golden Glades - The Woods
HK$931
HK$1,056 total
includes taxes & fees
1 Nov - 2 Nov
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
A spacious lobby with a glass floor, a reception desk, and a view of the ocean.
A cafe with a tropical mural, a coffee menu, and a variety of seating options.
A modern building with multiple balconies overlooking a beach.
A multi-story hotel with a beach view, parking lot, and a nearby restaurant.

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
Oceanfront
HK$1,124
HK$1,276 total
includes taxes & fees
27 Oct - 28 Oct
Margaritaville Jacksonville Beach
An outdoor seating area with a fire pit, wicker furniture, and a covered patio.
An outdoor patio with a pool, wooden pergola, and seating area.
A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.
A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
Golden Glades - The Woods
HK$965
HK$1,095 total
includes taxes & fees
22 Nov - 23 Nov
TownePlace Suites by Marriott Jacksonville East
A beach with a sandy shore, waves, and buildings in the background.
A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.
A modern lobby with a grey sofa, two round tables, a reception desk, and a wooden wall with shelves displaying trophies and awards.
A Best Western hotel with a modern design, located near a beach with a pier.

Best Western Oceanfront

Best Western Oceanfront
Oceanfront
HK$955
HK$1,084 total
includes taxes & fees
27 Oct - 28 Oct
Best Western Oceanfront

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

10/10 Excellent
"Very clean nice room"
Krystal 1-night trip
Posted 13 hours ago
Margaritaville Jacksonville Beach
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent
"Very impressed"
Brian 2-night trip
Posted 18 hours ago
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

10/10 Excellent
"All was great from beginning to end."
Brian 3-night trip
Posted 2 days ago
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East

10/10 Excellent
"The room was very clean and comfortable. It would be nice to have the breakfast time last longer than 9:00am though."
Lana 2-night trip
Posted 3 days ago
TownePlace Suites by Marriott Jacksonville East
Cozy & Comfy 3 bedroom residential home

Cozy & Comfy 3 bedroom residential home

10/10 Excellent
"Nice clean. The amenities were great! Master bedroom bed was comfortable. Location was perfect short drive to beaches, resteraunts & entertainment"
LaToya L. 3-night trip
Posted 12 days ago
Cozy & Comfy 3 bedroom residential home
Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green

10/10 Excellent
"Clean, cozy house with a quiet neighborhood, close to several restaurants and shopping. The only downfall was there was no tv in the bunk bed room, there was no grill as listed, and the beds were a little too firm. Would def stay here again! Very clean and well kept."
Kimberly P. 3-night trip
Posted 2 weeks ago
Coastal Family Retreat | 4 Mi to Jax Beach | Near Mayo Clinic | Game Room & Putting Green
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard

10/10 Excellent
"Carson was a great host. The communication process was excellent. He responded back to me fast and the property was cleaned and had everything that we needed. Would definitely come back again."
Anonymous traveller 3-night trip
Posted 1 month ago
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent
"The property was very clean and spacious. The host was responsive.She was also helpful with area recommendations. She went above and beyond our expectations. The home is well-supplied with just about anything you could need.The beds were very comfortable.The property is located in a safe and convenient neighborhood.We would definitely stay again."
Connie T. 3-night trip
Posted 1 month ago
Light Grey Getaway under 2 miles to mayo, 4 miles to the beach
Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good
"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."
Barbara G. 24-night trip
Posted 2 months ago
Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can catch a show at SeaWalk Pavillion, Players by the Sea and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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