Jacksonville Mayo Clinic Florida Hotels: 2026 Limited-Time Hotel Deals @Expedia

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Our top choices for Mayo Clinic Florida hotels

A modern restaurant with a bar area, wooden ceiling, and large windows.

A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.

A modern bar area with a central hanging light fixture, bar stools, and a well-stocked liquor display.

A modern lobby with a curved sofa, round coffee tables, and a large pillar.

1. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Patricia

HK$1,280

HK$1,453 total

includes taxes & fees

2 Oct - 3 Oct

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

A reception area with a brick wall, large windows with sheer curtains, and a modern desk setup.

An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

2. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Michaelanne

HK$1,131

HK$1,283 total

includes taxes & fees

18 Oct - 19 Oct

A lobby with a reception desk, seating area, and a staircase.

An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

A modern hotel room with a large bed, a blue sofa, a small table, and a wall-mounted lamp.

3. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

frances

HK$729

HK$828 total

includes taxes & fees

25 Oct - 26 Oct

A hotel lobby with a bar area, seating arrangements, and a reception desk.

A gym with treadmills, elliptical machines, a bench press, and a rack of dumbbells.

A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Patsy

HK$859

HK$975 total

includes taxes & fees

4 Oct - 5 Oct

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

An outdoor patio with a pool, wooden pergola, and seating area.

A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

5. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

gregory

HK$933

HK$1,059 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

A modern hotel lobby with a flat-screen TV, a fireplace, comfortable seating, and a coffee bar.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Patricia

HK$1,192

HK$1,353 total

includes taxes & fees

3 Oct - 4 Oct

A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

A modern hotel building with a flat roof, large windows, and a sign reading 'HYATT studios'.

7. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 7.8 km from Mayo Clinic Florida

Phi

HK$902

HK$1,024 total

includes taxes & fees

3 Oct - 4 Oct

A hotel room with two beds, a floral wallpaper, a ceiling light, and a wall-mounted air conditioner.

A wooden fence with a blue and white striped umbrella, two green lounge chairs, and a white chair.

A door with the number 312, a window with blinds, a green door mat, a chair with a geometric pattern, and small plants.

A compact kitchen with a refrigerator, microwave, and a dining area with a table and chairs.

8. Hotel Palms

7.8 km from Mayo Clinic Florida

Vinny

HK$1,114

HK$1,265 total

includes taxes & fees

27 Sept - 28 Sept

A covered entrance with a dark tiled floor, white columns, and a green bench.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

A gym with treadmills, elliptical machines, and dumbbells.

A large, multi-story hotel with a prominent entrance, a covered area with lights, and a star-shaped design on the facade.

9. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

4.2 km from Mayo Clinic Florida

Robert

HK$927

HK$1,052 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

A modern building with multiple balconies overlooking a beach.

A multi-story hotel with a beach view, parking lot, and a nearby restaurant.

A cafe with a tropical mural, a coffee menu, and a variety of seating options.

10. Margaritaville Jacksonville Beach

5.9 km from Mayo Clinic Florida

Keisha

HK$1,171

HK$1,329 total

includes taxes & fees

8 Oct - 9 Oct

A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

A golf course with a water hazard and a bridge.

A coffee station with two espresso machines and a display of coffee products.

A pier extending into the ocean at sunset with birds flying above.

11. Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

Jose

HK$863

HK$979 total

includes taxes & fees

4 Oct - 5 Oct

A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

A pathway leading to a sunset over a beach with sand and grass.

A modern building entrance with a sign reading "element by Westin".

A modern hotel lobby with a long reception desk, seating area, and large windows.

12. Element by Marriott Jacksonville Beach

5.4 km from Mayo Clinic Florida

Nick

HK$1,192

HK$1,353 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor patio area with seating, a fire pit, and a barbecue grill.

A reception area with a modern design, featuring a reception desk, a refrigerator with snacks, and a wooden slatted wall.

A modern kitchen with wooden cabinets, a central island with jars, and a countertop with toasters.

A modern living room with sofas, a coffee table, and a dining area.

13. TownePlace Suites by Marriott® Jacksonville Mayport

10.8 km from Mayo Clinic Florida

irina

HK$925

HK$1,050 total

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with a reception desk, seating area, and large windows.

A multi-story hotel with a central entrance, large windows, and a well-lit facade.

A bar area with wooden chairs, a round table, and a brick wall.

A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.

14. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

8.5 km from Mayo Clinic Florida

Joyce

HK$924

HK$1,030 total

includes taxes & fees

20 Oct - 21 Oct

A self-service beverage station with a refrigerated display and a coffee machine.

A hotel room with two beds, a desk, a chair, a TV, and a large window with a view.

A modern hotel reception area with a curved wooden reception desk, a digital display, and a view of the lobby.

A snack display in a store with various chips and snacks.

15. Tru By Hilton Jacksonville St Johns Town Center

Southside, 8.7 km from Mayo Clinic Florida

Mary

HK$859

HK$975 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a dining area, two beds, a TV, and a kitchenette.

A covered outdoor seating area with stone steps leading up to a table and chairs.

A hotel room with a dining area featuring a table, chairs, a television, a microwave, and a coffee maker.

Two people near a grill with a plate of food and a bottle.

16. Candlewood Suites Jacksonville - Mayport by IHG

9.2 km from Mayo Clinic Florida

Joe

HK$933

HK$1,059 total

includes taxes & fees

27 Sept - 28 Sept

An outdoor seating area with a fire feature, chairs, and a table.

A modern bar area with a counter, bar stools, and a television screen.

A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.

A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

17. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

Carol

HK$988

HK$1,122 total

includes taxes & fees

25 Oct - 26 Oct

A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.

A modern hotel building with a flat facade, large windows, and a sign reading "ACHTEL JACKSONVILLE".

An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.

A modern hotel with a pool, palm trees, and a clear blue sky.

18. AC Hotel Jacksonville St Johns Town Center

Southside, 8.1 km from Mayo Clinic Florida

Robert

HK$1,365

HK$1,549 total

includes taxes & fees

27 Sept - 28 Sept

An outdoor patio with a fire pit, seating, and a water feature.

A hotel lobby with a curved seating area, multiple tables, and chairs.

A hotel lobby with a reception desk, a coffee station, and potted plants.

A hotel room with a glass dining table, two chairs, a sofa, a TV, and a patterned carpet.

19. Hampton Inn & Suites Jacksonville Deerwood Park

Southside, 11.2 km from Mayo Clinic Florida

Michelle

HK$765

HK$869 total

includes taxes & fees

11 Oct - 12 Oct

A modern bar area with wooden accents, a variety of beverages, and seating arrangements.

A modern bar area with a wooden counter, multiple seating options including bar stools and round tables, and a menu board.

A patio area with a stone fire pit, outdoor furniture, and a brick floor.

A modern hotel lobby with a sofa set, armchairs, a coffee table, and a patterned carpet.

20. Courtyard by Marriott Jacksonville I-295/East Beltway

Arlington, 13.2 km from Mayo Clinic Florida

Chloie Marie

HK$860

HK$976 total

includes taxes & fees

5 Oct - 6 Oct

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Hilton Jacksonville at Mayo Clinic near Beaches	9.4 Exceptional 362 reviews	View
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 602 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,010 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,000 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 660 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

10/10 Excellent

"Great lace and neat to the beach"

Hilton Jacksonville at Mayo Clinic near Beaches

10/10 Excellent

"Very nice stay!"

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

8/10 Good

"Love those scones and waffles"

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent

"Clean room, great breakfast, and having a shuttle makes a world of difference"

TownePlace Suites by Marriott Jacksonville East

10/10 Excellent

"Great place to stay at a reasonable price. Manager went out of his way to help us out when they had a shuttle down for longer than normal. Above and beyond in service and quality! Thank you!"

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

8/10 Good

"Wish coffee was more available and didn't have to wait for it"

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent

"Everything was nice and clean! Very well kept! The hosts are very responsive and friendly! Location was perfect and quiet! Definitely would stay here again!"

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

10/10 Excellent

"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good

"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 44 hotels and other accommodation options you'll find within a mile.

Where is the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels are there near Mayo Clinic Florida?

Expedia has 44 hotels and other accommodation options within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Wilson Center For the Arts and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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Jacksonville Mayo Clinic Florida Hotels

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Our top choices for Mayo Clinic Florida hotels

1. Hilton Jacksonville at Mayo Clinic near Beaches

2. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

5. TownePlace Suites by Marriott Jacksonville East

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. Hyatt Studios Jacksonville/St Johns Town Center

8. Hotel Palms

9. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10. Margaritaville Jacksonville Beach

11. Holiday Inn Express Jacksonville Beach by IHG

12. Element by Marriott Jacksonville Beach

13. TownePlace Suites by Marriott® Jacksonville Mayport

14. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

15. Tru By Hilton Jacksonville St Johns Town Center

16. Candlewood Suites Jacksonville - Mayport by IHG

17. Hotel Indigo Jacksonville-Deerwood Park by IHG

18. AC Hotel Jacksonville St Johns Town Center

19. Hampton Inn & Suites Jacksonville Deerwood Park

20. Courtyard by Marriott Jacksonville I-295/East Beltway

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Margaritaville Jacksonville Beach

Hilton Jacksonville at Mayo Clinic near Beaches

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

TownePlace Suites by Marriott Jacksonville East

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

Frequently asked questions

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