Jacksonville Mayo Clinic Florida Hotels: 2026 Limited-Time Hotel Deals @Expedia

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Our top choices for Mayo Clinic Florida hotels

A spacious living area with a high ceiling, a fireplace, and a bar area in the background.

A multi-story hotel with a central entrance, surrounded by well-maintained lawns and palm trees.

A modern kitchen with a bar area, seating, and a view of the outdoors.

An outdoor patio area with seating and a central fire feature, surrounded by buildings and palm trees.

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

1.1 km from Mayo Clinic Florida

Michaelanne

HK$1,189

HK$1,350 total

includes taxes & fees

3 Oct - 4 Oct

A modern restaurant with a bar area, wooden ceiling, and large windows.

A covered outdoor seating area with chairs and sofas, a fountain, and a view of a lake and trees.

A modern lobby with a central seating area, wooden shelving with decorative items, and a large pillar.

A modern lobby with a curved sofa, round coffee tables, and a large pillar.

2. Hilton Jacksonville at Mayo Clinic near Beaches

0.8 km from Mayo Clinic Florida

Kristen

HK$1,338

HK$1,518 total

includes taxes & fees

17 Oct - 18 Oct

An outdoor seating area with a fire pit, wicker furniture, and a covered patio.

A multi-story hotel with a modern design, featuring a covered outdoor area with seating and a fire pit.

A modern kitchen with wooden cabinets, a built-in oven, and a coffee machine.

A hotel room with a bed, a sofa, a nightstand, and a wall-mounted lamp.

3. TownePlace Suites by Marriott Jacksonville East

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

gregory

HK$933

HK$1,059 total

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a bar area, seating arrangements, and a reception desk.

An outdoor patio with a brick wall, a round table with striped chairs, and two large umbrellas.

A hotel room with a bed, a desk, a sofa, and a small table. There is a mirror, a lamp, and a picture on the wall.

A hotel pool area with a long, narrow pool, multiple lounge chairs, and a covered seating area.

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida

Patsy

HK$859

HK$975 total

includes taxes & fees

18 Oct - 19 Oct

A lobby with a reception desk, seating area, and a staircase.

An indoor swimming pool with clear views of trees outside, a tiled floor, and a covered seating area.

A modern kitchen with a refrigerator, coffee machine, and a bakery display.

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.6 km from Mayo Clinic Florida

frances

HK$792

HK$899 total

includes taxes & fees

11 Oct - 12 Oct

An outdoor seating area with stone fire pit, wicker furniture, and potted plants.

A bar area with a long counter, multiple stools, and shelves stocked with bottles.

A hotel pool area with lounge chairs and umbrellas, surrounded by multi-story buildings with balconies.

A modern living room with two armchairs, a sofa, a coffee table, and a flat-screen TV mounted on the wall.

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

0.4 km from Mayo Clinic Florida

Patricia

HK$1,192

HK$1,353 total

includes taxes & fees

17 Oct - 18 Oct

A backyard with a swimming pool, wooden deck, and outdoor furniture.

A hotel room with two beds, a floral wallpaper, a ceiling light, and a wall-mounted air conditioner.

A wooden fence with a blue and white striped umbrella, two green lounge chairs, and a white chair.

A compact kitchen with a refrigerator, microwave, and a dining area with a table and chairs.

7. Hotel Palms

7.8 km from Mayo Clinic Florida

Vinny

HK$1,115

HK$1,265 total

includes taxes & fees

24 Sept - 25 Sept

A multi-story hotel with a modern design, featuring a covered entrance and a parking area with handicapped accessibility.

A coastal cityscape with a long beach, a large hotel with a curved facade, and a clear sky.

A Holiday Inn Express & Suites lobby with a reception desk, seating area, and a view of the outside.

A hotel room with two beds, a desk, a chair, and a large window with a view.

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Southside, 7.7 km from Mayo Clinic Florida

Ian

HK$1,028

HK$1,166 total

includes taxes & fees

1 Oct - 2 Oct

A modern outdoor seating area with white wicker chairs, a glass fire pit with burning wood, and a view of palm trees and a building in the background.

A modern building entrance with a sign reading "element by Westin".

A modern conference room with a long table, several chairs, and pendant lighting.

A modern hotel lobby with a long reception desk, seating area, and large windows.

9. Element by Marriott Jacksonville Beach

5.4 km from Mayo Clinic Florida

Nick

HK$1,193

HK$1,353 total

includes taxes & fees

1 Oct - 2 Oct

An outdoor patio area with seating, a fire pit, and a barbecue grill.

A modern kitchen with wooden cabinets, a central island with jars, and a countertop with toasters.

A modern living room with sofas, a coffee table, and a dining area.

A modern hotel with a sign reading "Towneplace Suites by Marriott" and a parking lot in front.

10. TownePlace Suites by Marriott® Jacksonville Mayport

10.8 km from Mayo Clinic Florida

irina

HK$926

HK$1,050 total

includes taxes & fees

27 Sept - 28 Sept

A laptop on a wooden desk with a white mug, a spoon, and a smartphone.

A kitchen counter with a coffee maker, a blender, a book titled 'CHECKERS,' and a water bottle.

11. Hyatt Studios Jacksonville/St Johns Town Center

Deerwood, 7.8 km from Mayo Clinic Florida

Phi

HK$878

HK$997 total

includes taxes & fees

1 Oct - 2 Oct

A pool with a waterfall feature, surrounded by large rock formations.

A bar with a tiled roof, outdoor seating, and a view of the ocean.

A hotel with a pool, a parking lot, and a view of the ocean.

A beachfront hotel with multiple balconies, a sandy beach, and ocean views.

12. Hampton Inn Jacksonville Beach/Oceanfront

6.3 km from Mayo Clinic Florida

Hope

HK$1,327

HK$1,506 total

includes taxes & fees

20 Oct - 21 Oct

A spacious lobby with a reception desk, seating area, and large windows.

A modern coffee shop interior with a central counter, shelves stocked with snacks, and a refrigerated section labeled 'FROZEN' and 'CHILLED'.

A multi-story hotel with a central entrance, large windows, and a well-lit facade.

A bar area with wooden chairs, a round table, and a brick wall.

13. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

8.5 km from Mayo Clinic Florida

Joyce

HK$924

HK$1,030 total

includes taxes & fees

19 Oct - 20 Oct

A spacious lobby with a glass floor, a reception desk, and a view of the ocean.

A modern building with multiple balconies overlooking a beach.

A bar area with a view of the beach, wooden bar stools, and a counter with a menu display.

A multi-story hotel with a beach view, parking lot, and a nearby restaurant.

14. Margaritaville Jacksonville Beach

5.9 km from Mayo Clinic Florida

Keisha

HK$1,171

HK$1,329 total

includes taxes & fees

28 Sept - 29 Sept

A modern bar area with a central island, multiple seating options, and a variety of bottles displayed on shelves.

An outdoor seating area with white furniture and a well-maintained lawn, surrounded by large windows and a modern building facade.

A modern bar area with seating, a bar counter, and a view of the city through large windows.

A modern hotel with a pool, palm trees, and a clear blue sky.

15. AC Hotel Jacksonville St Johns Town Center

Southside, 8.1 km from Mayo Clinic Florida

Alysha

HK$1,443

HK$1,638 total

includes taxes & fees

25 Sept - 26 Sept

A beach with a sandy shore, waves, and buildings in the background.

A Best Western hotel with a modern design, located near a beach with a pier.

A modern cafe with a central counter, seating area, and a wooden accent wall with 'BW' letters.

A balcony with two green chairs and a small table, overlooking a beach and a boardwalk.

16. Best Western Oceanfront

5.7 km from Mayo Clinic Florida

Sonya

HK$990

HK$1,123 total

includes taxes & fees

24 Sept - 25 Sept

An outdoor seating area with a fire feature, chairs, and a table.

A modern bar area with a curved counter, multiple bar stools, and a variety of liquor bottles.

A modern hotel room with two beds, a flat-screen TV, a desk, and a large window with a view of a building.

A modern bar area with a counter, bar stools, and a television screen.

17. Hotel Indigo Jacksonville-Deerwood Park by IHG

Southside, 10.8 km from Mayo Clinic Florida

Carol

HK$996

HK$1,131 total

includes taxes & fees

27 Sept - 28 Sept

A hotel room with two beds, a desk with a computer, a chair, and a colorful carpet.

A pier extending into the ocean at sunset with birds flying above.

A golf course with a water hazard and a bridge.

A hotel room with a microwave, coffee maker, and refrigerator on the counter. There is a door with a sign and a towel rack visible.

18. Holiday Inn Express Jacksonville Beach by IHG

4.6 km from Mayo Clinic Florida

Jose

HK$926

HK$1,050 total

includes taxes & fees

28 Sept - 29 Sept

A self-service beverage station with a refrigerated display and a coffee machine.

A modern lounge area with seating, tables, and hanging lights.

A modern hotel reception area with a curved wooden reception desk, a digital display, and a view of the lobby.

A snack display in a store with various chips and snacks.

19. Tru By Hilton Jacksonville St Johns Town Center

Southside, 8.7 km from Mayo Clinic Florida

Mary

HK$859

HK$975 total

includes taxes & fees

27 Sept - 28 Sept

A hotel room with a bed, a TV, a wooden dresser, a mirror, and a view of the sea.

A hotel room with a large bed, a desk, a chair, a TV, and a view of the ocean.

A coastal hotel with a long promenade, beach access, and a pier in the distance.

20. Four Points by Sheraton Jacksonville Beachfront

5.6 km from Mayo Clinic Florida

Susan

HK$1,393

HK$1,582 total

includes taxes & fees

18 Oct - 19 Oct

View all properties

Compare popular hotels close to Mayo Clinic Florida

Property	Property class	Guest rating
Residence Inn By Marriott Jacksonville - Mayo Clinic Area	9.4 Exceptional 602 reviews	View
Hilton Jacksonville at Mayo Clinic near Beaches	9.4 Exceptional 359 reviews	View
TownePlace Suites by Marriott Jacksonville East	9.2 Wonderful 659 reviews	View
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic	9.0 Wonderful 1,003 reviews	View
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG	9.0 Wonderful 1,006 reviews	View

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent

"The property was clean, the staff was exceptional, they even had little candy bars for snack on Friday night."

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent

"Room was clean, staff were very pleasant and helpful. Will definitely stay here again when I come back to Jacksonville."

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

8/10 Good

"Wish coffee was more available and didn't have to wait for it"

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

10/10 Excellent

"Everything was nice and clean! Very well kept! The hosts are very responsive and friendly! Location was perfect and quiet! Definitely would stay here again!"

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

10/10 Excellent

"The staff was very helpful and the parking easy and, in parts, quite shady. It was within easy walking distance of the Mayo Clinic!"

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

8/10 Good

"The location was perfect for us, as I had appointments at Mayo Clinic. Leo was a great host and addressed our concerns promptly."

Heated Pool Family Fun Minutes to Mayo & Jax Beach

10/10 Excellent

"We had a fantastic time at this property! It was perfect for our trip."

Comfy Mayo Retreat: Pool & Close to Beach

10/10 Excellent

"Great location with a really nice park close by to walk the dogs. The pool was perfect!"

Beach Retreat in Jacksonville: Pet/Family-Friendly

10/10 Excellent

"Our stay was great there was plenty of room for our group of 12. The house was clean and the pool was a huge hit."

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 46 hotels and other accommodation options you'll find within a mile.

Where is the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville at Mayo Clinic near Beaches and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.

How many hotels are there near Mayo Clinic Florida?

Expedia has 46 hotels and other accommodation options within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.

What can I see and do near Mayo Clinic Florida?

You can catch a show at SeaWalk Pavillion, Wilson Center For the Arts and Blue Jay Listening Room. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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Jacksonville Mayo Clinic Florida Hotels

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Treat yourself

Be picky

Check prices for these dates

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Star rating

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Our top choices for Mayo Clinic Florida hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. Hilton Jacksonville at Mayo Clinic near Beaches

3. TownePlace Suites by Marriott Jacksonville East

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

5. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

6. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

7. Hotel Palms

8. Holiday Inn Express & Suites Jacksonville - Town Center by IHG

9. Element by Marriott Jacksonville Beach

10. TownePlace Suites by Marriott® Jacksonville Mayport

11. Hyatt Studios Jacksonville/St Johns Town Center

12. Hampton Inn Jacksonville Beach/Oceanfront

13. Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

14. Margaritaville Jacksonville Beach

15. AC Hotel Jacksonville St Johns Town Center

16. Best Western Oceanfront

17. Hotel Indigo Jacksonville-Deerwood Park by IHG

18. Holiday Inn Express Jacksonville Beach by IHG

19. Tru By Hilton Jacksonville St Johns Town Center

20. Four Points by Sheraton Jacksonville Beachfront

Compare popular hotels close to Mayo Clinic Florida

Top Mayo Clinic Florida Hotel Reviews

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Light Grey Getaway under 2 miles to mayo, 4 miles to the beach

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Stylish Retreat Near Beaches & Attractions - Private, Clean, Comfortable

Heated Pool Family Fun Minutes to Mayo & Jax Beach

Comfy Mayo Retreat: Pool & Close to Beach

Beach Retreat in Jacksonville: Pet/Family-Friendly

Frequently asked questions

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