Raleigh Museum of Life and Science Hotels: 2026 Limited-Time Hotel Deals @Expedia

Our top choices for Museum of Life and Science hotels

Hampton Inn & Suites Durham/North I-85

1.4 km from Museum of Life and Science

Amy

HK$1,050 total

includes taxes & fees

7 Jun - 8 Jun

Holiday Inn Express Durham by IHG

2.2 km from Museum of Life and Science

Kathy

HK$1,014 total

includes taxes & fees

7 Jun - 8 Jun

Premium bedding, desk, blackout curtains, iron/ironing board

Comfort Inn & Suites Durham near Duke University

Croasdaile Farm Master, 3.2 km from Museum of Life and Science

Kathy

HK$862 total

includes taxes & fees

14 Jun - 15 Jun

Red Roof Inn Durham - Duke Univ Medical Center

2.2 km from Museum of Life and Science

Derrick

HK$590 total

includes taxes & fees

7 Jun - 8 Jun

Stylish Durham Retreat - Walkable, Sleeps 6

2.8 km from Museum of Life and Science

HK$5,526 total

includes taxes & fees

7 Jun - 8 Jun

Hilton Garden Inn Durham/University Medical Center

9th Street District, 3.3 km from Museum of Life and Science

Susan

HK$1,324 total

includes taxes & fees

28 Jun - 29 Jun

Hampton Inn & Suites Durham University Medical Center

4.8 km from Museum of Life and Science

joyce

HK$1,023 total

includes taxes & fees

7 Jun - 8 Jun

SpringHill Suites by Marriott Durham City View

4.6 km from Museum of Life and Science

Evelyn

HK$1,142 total

includes taxes & fees

7 Jun - 8 Jun

University Inn Durham next to Duke University Medical Center

4 km from Museum of Life and Science

Thomas

HK$1,049 total

includes taxes & fees

1 Jun - 2 Jun

Residence Inn Durham McPherson/Duke University Medical Cntr

Trinity Park, 3.3 km from Museum of Life and Science

Tiffany

HK$1,401 total

includes taxes & fees

28 Jun - 29 Jun

JB Duke Hotel

5.6 km from Museum of Life and Science

Andrew

HK$1,770 total

includes taxes & fees

1 Jul - 2 Jul

The Durham Hotel

Downtown Durham, 3.6 km from Museum of Life and Science

George

HK$1,654 total

includes taxes & fees

8 Jun - 9 Jun

Aloft by Marriott Durham Downtown

American Tobacco District, 4 km from Museum of Life and Science

Lucas

HK$1,654 total

includes taxes & fees

28 Jun - 29 Jun

Washington Duke Inn & Golf Club

5.9 km from Museum of Life and Science

Susan

HK$1,779 total

includes taxes & fees

1 Jun - 2 Jun

AC Hotel Durham

4.9 km from Museum of Life and Science

krishnan

HK$1,323 total

includes taxes & fees

28 Jun - 29 Jun

Premium bedding, down duvets, in-room safe, desk

Durham Marriott City Center

Downtown Durham, 3.6 km from Museum of Life and Science

Nancy

HK$1,281 total

includes taxes & fees

28 Jun - 29 Jun

Hilton Durham near Duke University

5.2 km from Museum of Life and Science

Mary

HK$1,051 total

includes taxes & fees

14 Jun - 15 Jun

The Lodge at Duke Medical Center

4 km from Museum of Life and Science

Tracy

HK$1,281 total

includes taxes & fees

1 Jun - 2 Jun

Courtyard Durham Near Duke University/Downtown

Croasdaile Farm Master, 3.4 km from Museum of Life and Science

Cammy

HK$862 total

includes taxes & fees

1 Jul - 2 Jul

21c Museum Hotel Durham

Downtown Durham, 3.7 km from Museum of Life and Science

Kara

HK$1,632 total

includes taxes & fees

17 Jun - 18 Jun

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Top Museum of Life and Science Hotel Reviews

Curated Duke Retreat • Minutes to DPAC, downtown • Espresso, Eco+, Fire Pit

10/10 Excellent

"We had a fantastic stay at Kristin’s cozy cottage. She went out of her way to make us feel welcome. I frankly feel I owe her a hand written thank you note because it felt like I was staying at a friend’s home not a vacation rental. If you want a cozy, clean cottage to come home to, a comfy bed and a well equipped kitchen, Kristin’s home is perfect. I would do it all over again and recommend highly to a friend."

21c Museum Hotel Durham

6/10 Okay

"I booked this hotel based on reviews. I was not impressed. For over $230 a night I expected more. The hotel seemed to be run by 20+ year olds. The lobby and entrance were dingy and were definitely NOT what the pictures showed. I think some serious AI was done to make the hotel look more appealing. The room was clean. The bathroom was the nicest part. Our window view was the HVAc unit directly out our window and it was quite noisy all night. The restaurant was closed. There’s no onsite parking and valet is $35. We will find somewhere else to stay the next time We are in Durham."

Red Roof Inn Durham - Duke Univ Medical Center

8/10 Good

"The stay was better than the last time, the room I had was more up to date. The only issue I had was I had to pay a 50.00 deposit when I arrived to the hotel. I prepaid for the room in advance and he said it was for a smoking deposit. I just stayed there a few weeks ago and didn’t pay a deposit. I don’t smoke but it should’ve been said online when booking the room and not told at the time of check in. I stayed 2 nights and housekeeping did come knock on my door to bring fresh linen if needed. It was a sign in the lobby saying I’d you needed them to come into your room let the front desk know by 10am which was a good thing for those who didn’t want to be disturbed."

Walk to Duke & Dining • Charming Historic 2BR

10/10 Excellent

"Emily was extremely communicative, both in answering all my questions and responding quickly. She even got an air mattress for us as we needed one more something to sleep on. She knew we were having a problem with VRBO messing up our reservation, with short time for us to find a new location, and she went above and beyond to help us find our place. She was fantastic!"

Hotels near other Museum of Life and Science attractions

Brightleaf Square

4.8/5 (8 reviews)

You can do some window-shopping at Brightleaf Square during your visit to Durham. Discover the lively festivals and stunning cathedral in this family-friendly area.

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Frequently asked questions

What's the area like around Museum of Life and Science?

Museum of Life and Science is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, take a look at the 11 hotels and other accommodation options you'll find within a mile.

What's the best hotel to stay near Museum of Life and Science?

Hampton Inn & Suites Durham/North I-85 is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. It's located just a short 0.8 mi (1.4 km) from Museum of Life and Science. Other good options within 5 miles include Holiday Inn Express Durham by IHG and Courtyard Durham Near Duke University/Downtown.

How many hotels can I expect to find close to Museum of Life and Science?

Expedia has 11 hotels and other accommodation options within a mile from Museum of Life and Science.

If I need to cancel the hotel reservation for my stay near Museum of Life and Science, will I receive a refund?

Yes, the majority of hotel room reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best deals near Museum of Life and Science.

What can I see and do near Museum of Life and Science?

You'll want to browse the exhibits at Nasher Museum of Art at Duke University and Bennett Place. Explore landmarks like American Tobacco Campus, Cameron Indoor Stadium and Wallace Wade Stadium. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

Raleigh Museum of Life and Science Hotels

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Our top choices for Museum of Life and Science hotels

Hampton Inn & Suites Durham/North I-85

Holiday Inn Express Durham by IHG

Comfort Inn & Suites Durham near Duke University

Red Roof Inn Durham - Duke Univ Medical Center

Stylish Durham Retreat - Walkable, Sleeps 6

Hilton Garden Inn Durham/University Medical Center

Hampton Inn & Suites Durham University Medical Center

SpringHill Suites by Marriott Durham City View

University Inn Durham next to Duke University Medical Center

Residence Inn Durham McPherson/Duke University Medical Cntr

JB Duke Hotel

The Durham Hotel

Aloft by Marriott Durham Downtown

Washington Duke Inn & Golf Club

AC Hotel Durham

Durham Marriott City Center

Hilton Durham near Duke University

The Lodge at Duke Medical Center

Courtyard Durham Near Duke University/Downtown

21c Museum Hotel Durham

Top Museum of Life and Science Hotel Reviews

Curated Duke Retreat • Minutes to DPAC, downtown • Espresso, Eco+, Fire Pit

Hotels near other Museum of Life and Science attractions

Brightleaf Square

Frequently asked questions