Poplar Bluff Vacation Homes

A sunset over a calm lake with red autumn leaves on the right.

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Our top choices for Poplar Bluff holiday homes

A spacious living area with a dark grey sofa set, a matching ottoman, and a wooden-paneled wall.

1. 40-Acre Poplar Bluff Nature Lovers Paradise!

Poplar Bluff

Elsie C.

HK$2,320 total

includes taxes & fees

7 Oct - 8 Oct

A house with a front porch decorated with hay bales, a scarecrow, and pumpkins.

2. Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

Poplar Bluff

Anonymous traveller

HK$2,220 total

includes taxes & fees

11 Sept - 12 Sept

3. Cozy 2-bedroom house in welcoming Poplar Bluff

Poplar Bluff

Carrie H.

HK$1,570 total

includes taxes & fees

11 Sept - 12 Sept

A modern kitchen with white cabinets, stainless steel appliances, a central island with stools, and a hanging pendant light.

4. Poplar Bluff pet friendly comfort and convenience

Poplar Bluff

HK$4,801 total

includes taxes & fees

4 Oct - 5 Oct

A campfire surrounded by benches in a wooded park area.

5. Brown's Lake House, Family-Friendly 2 Bedroom Retreat Near Lake Wappapello

Wappapello

Shea E.

HK$1,775 total

includes taxes & fees

13 Sept - 14 Sept

A wooden deck with steps leading to a house, surrounded by trees.

6. Get Away Acres 1/2 mile off highway 60 extra sanitized

Ellsinore

Anonymous traveller

HK$1,027 total

includes taxes & fees

15 Sept - 16 Sept

A kitchen with wooden cabinets, a stainless steel refrigerator, a stove, and a window.

7. Hunting / Fishing Cabin at Lake Wappapello

Williamsville

HK$1,941 total

includes taxes & fees

11 Sept - 12 Sept

A two-story house with a front porch, a covered entryway, and a small garden with white flowers.

8. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter

Kathryn T.

HK$1,700 total

includes taxes & fees

20 Sept - 21 Sept

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Top Poplar Bluff Hotel Reviews

Motel 6 Poplar Bluff, MO

10/10 Excellent

"Nice"

Home Sweet Home, Spacious Sunroom & Fun Deck!

10/10 Excellent

"We really enjoyed our stay in this home. The kitchen was so well equipped with everything that you could ever hope for. My granddaughter has stayed in several Vrbo and has never seen a kitchen so well equipped. We really enjoyed the sun room and deck. The property is central located for easy access to the surrounding town. I would definitely rent this home again."

Find out more about Poplar Bluff