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Check prices for these dates

Tonight
11 Dec - 12 Dec
Tomorrow
12 Dec - 13 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for San Diego Santa Fe Depot hotels

Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 1.1 km from San Diego Santa Fe Depot
9.4 out of 10, Exceptional, (1000)
"Great location "
United States
Mohammad
The price is HK$604
HK$926 total
includes taxes & fees
28 Dec - 29 Dec
Staypineapple, Hotel Z, Gaslamp San Diego
Meeting facility
Residence Inn by Marriott San Diego Downtown/Bayfront

Residence Inn by Marriott San Diego Downtown/Bayfront

Residence Inn by Marriott San Diego Downtown/Bayfront
3.0 star property
0.2 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (637)
"Really enjoyed the breakfast! Location was great and overall great stay! Hope to be back sometime in the next year coming up! "
United States
Omar
The price is HK$1,619
HK$1,880 total
includes taxes & fees
4 Jan - 5 Jan 2026
Residence Inn by Marriott San Diego Downtown/Bayfront
Exterior
InterContinental San Diego by IHG

InterContinental San Diego by IHG

InterContinental San Diego by IHG
4.0 star property
0.2 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (1114)
"Room was great, the amenities great, overall very nice. "
United States
Crystal
The price is HK$1,937
HK$2,697 total
includes taxes & fees
16 Dec - 17 Dec
InterContinental San Diego by IHG
Terrace/patio
The Guild Hotel, San Diego Downtown, a Tribute Portfolio Hotel

The Guild Hotel, San Diego Downtown, a Tribute Portfolio Hotel

The Guild Hotel, San Diego Downtown, a Tribute Portfolio Hotel
4.0 star property
0.1 km from San Diego Santa Fe Depot
9.0 out of 10, Wonderful, (1062)
"Great location, kind staff and tasty breakfast. Rooms were of decent size with all renovated with new style."
United States
Rahul
The price is HK$1,020
HK$1,183 total
includes taxes & fees
21 Dec - 22 Dec
The Guild Hotel, San Diego Downtown, a Tribute Portfolio Hotel
Lobby
Hotel Republic San Diego, Autograph Collection

Hotel Republic San Diego, Autograph Collection

Hotel Republic San Diego, Autograph Collection
4.0 star property
0.3 km from San Diego Santa Fe Depot
9.0 out of 10, Wonderful, (1182)
"Amazing stay "
United States
Aaron
The price is HK$993
HK$1,513 total
includes taxes & fees
28 Dec - 29 Dec
Hotel Republic San Diego, Autograph Collection
Lobby
Best Western Plus Bayside Inn

Best Western Plus Bayside Inn

Best Western Plus Bayside Inn
3.0 star property
0.4 km from San Diego Santa Fe Depot
9.0 out of 10, Wonderful, (1000)
"Great staff and location."
United States
Lisa
The price is HK$951
HK$1,100 total
includes taxes & fees
18 Dec - 19 Dec
Best Western Plus Bayside Inn
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Marina District, 0.9 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (1943)
"Great hotel"
United States
Farzana
The price is HK$1,237
HK$1,843 total
includes taxes & fees
19 Dec - 20 Dec
Marriott Marquis San Diego Marina
Memory-foam beds, blackout curtains, iron/ironing board, free WiFi
Stay Classy Hostel

Stay Classy Hostel

Stay Classy Hostel
2.0 star property
East Village, 1.8 km from San Diego Santa Fe Depot
9.6 out of 10, Exceptional, (784)
"Good place to stay "
United States
sai
Stay Classy Hostel
Exterior
Granger Hotel Gaslamp Quarter, A Member Of Design Hotels

Granger Hotel Gaslamp Quarter, A Member Of Design Hotels

Granger Hotel Gaslamp Quarter, A Member Of Design Hotels
4.0 star property
Gaslamp Quarter, 0.8 km from San Diego Santa Fe Depot
9.2 out of 10, Wonderful, (617)
"Welcome drink and breakfast were a nice treat."
United States
Mona
The price is HK$1,082
HK$1,254 total
includes taxes & fees
18 Dec - 19 Dec
Granger Hotel Gaslamp Quarter, A Member Of Design Hotels
Hypo-allergenic bedding, in-room safe, desk, iron/ironing board
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Marina District, 0.7 km from San Diego Santa Fe Depot
9.0 out of 10, Wonderful, (2871)
"Great Location....tons of walking from the hotel Front desk were very nice and polite will be coming back for sure "
United States
Carlos
The price is HK$1,369
HK$2,011 total
includes taxes & fees
19 Dec - 20 Dec
Manchester Grand Hyatt San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top San Diego Santa Fe Depot Hotel Reviews

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

10/10 Excellent
"Room was clean,buffet bkfast was good,staff were friendly & helpful!"
Barry 2-night trip
Posted 2 days ago
Hampton Inn San Diego/Mission Valley

Find out more about San Diego Santa Fe Depot

San Diego Santa Fe Depot hotels information

Number of reviews
12,207
Accommodation
3,914 hotels
Lowest Price
HK$926
Highest Price
HK$2,697

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Frequently asked questions

What's the area like around San Diego Santa Fe Depot?

San Diego Santa Fe Depot is located in a scenic area of San Diego known for its array of dining options and popular zoo. If you're looking for a convenient place to stay, take a look at the 829 hotels and other accommodation options located within a mile of the station.

Where is the best place to stay close to San Diego Santa Fe Depot?

Hard Rock Hotel San Diego is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and an outdoor pool. It's located just a short 0.8 mi (1.3 km) from San Diego Santa Fe Depot. Other good options close by include Manchester Grand Hyatt San Diego and The DEXTRO Little Italy, BW Premier Collection.

How many hotels can I expect to find close to San Diego Santa Fe Depot?

Expedia has 829 hotels and other accommodation options within a mile from the station.

What can I see and do near San Diego Santa Fe Depot?

Study the collections at USS Midway Museum, Maritime Museum of San Diego or San Diego Air and Space Museum. Hotel del Coronado, Star of India and Whaley House Museum are monuments to see when you're exploring the area around San Diego Santa Fe Depot. You can watch performances at San Diego Civic Theatre, The Rady Shell at Jacobs Park and Old Globe Theater if you're interested in local theatre.