Default HTG hotel image

Santa Cruz Holiday Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
28 Aug - 30 Aug
In two months
9 Oct - 11 Oct
In three months
6 Nov - 8 Nov
In four months
4 Dec - 6 Dec

Our top choices for Santa Cruz holiday rentals

1 bedroom, premium bedding, down duvets, in-room safe

1. Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.2 out of 10, Wonderful, (291 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
The price is HK$542
HK$542 total
14 Aug - 15 Aug
Portal del Rodeo ApartaHotel - Arkadia Mall
Lobby

2. Haven, A Design Hotel

Haven, A Design Hotel
4.0 star property
El Poblado
8.8 out of 10, Excellent, (720 reviews)
"Excellent food in the restaurant, with a beautiful view from the rooftop. Great staff!!"
United States
Miguel
The price is HK$711
HK$711 total
17 Aug - 18 Aug
Haven, A Design Hotel
Reception

3. Sites Hotel

Sites Hotel
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (1,155 reviews)
"Excelente hotel."
United States
Fernanda
The price is HK$677
HK$677 total
12 Sept - 13 Sept
Sites Hotel
Front of property

4. Seissta Medellin

Seissta Medellin
4.0 star property
El Poblado
9.4 out of 10, Exceptional, (272 reviews)
"Very Clean and Friendly Staff."
United States
Paul
The price is HK$819
HK$819 total
25 Aug - 26 Aug
Seissta Medellin
Free daily full breakfast

5. Laureles Guest House - LGH Hotel

Laureles Guest House - LGH Hotel
3.5 star property
Laureles
9.2 out of 10, Wonderful, (102 reviews)
"Excellent breakfast, good location "
United States
dickie
The price is HK$364
HK$364 total
17 Aug - 18 Aug
Laureles Guest House - LGH Hotel
Restaurant

6. Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (69 reviews)
"Awesome breakfast, great location. Great host"
United States
James
The price is HK$331
HK$331 total
13 Sept - 14 Sept
Edificio Helena
In-room safe, blackout curtains, iron/ironing board (on request)

7. Origen Local Suites

Origen Local Suites
3.0 star property
Laureles
9.4 out of 10, Exceptional, (212 reviews)
"Great place.!"
United States
jeremy
The price is HK$536
HK$536 total
24 Aug - 25 Aug
Origen Local Suites
View from room

8. San Peter Suites

San Peter Suites
3.0 star property
Laureles
8.0 out of 10, Very good, (54 reviews)
"This ia a great place, super relaxed and friendly staff "
United States
Duncan
The price is HK$494
HK$494 total
14 Aug - 15 Aug
San Peter Suites
Living area

9. Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.4 out of 10, Exceptional, (43 reviews)
"Exelente servicio"
United States
Ernesto
The price is HK$470
HK$589 total
17 Aug - 18 Aug
Skyline Ecoliving
Free WiFi

10. hotel civitas medellin

hotel civitas medellin
2.5 star property
La Candelaria
8.8 out of 10, Excellent, (3 reviews)
"Hotel in a good location, comfortable and has a great staff."
United States
Valencia
The price is HK$243
HK$243 total
14 Aug - 15 Aug
hotel civitas medellin
View from room

11. Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.4 out of 10, Very good, (484 reviews)
"Good"
United States
Christian
The price is HK$750
HK$750 total
15 Aug - 16 Aug
Travelers Rio Verde Living Suites
Living area

12. Alcázar de Oviedo By EE Hotels

Alcázar de Oviedo By EE Hotels
3.0 star property
El Poblado
9.4 out of 10, Exceptional, (178 reviews)
"Great"
United States
Jin
The price is HK$901
HK$901 total
15 Aug - 16 Aug
Alcázar de Oviedo By EE Hotels
1 bedroom, minibar, desk, iron/ironing board (on request)

13. Soy Local Provenza

Soy Local Provenza
3.0 star property
El Poblado
8.2 out of 10, Very good, (150 reviews)
"Great location, great service."
United States
MELANY
The price is HK$423
HK$423 total
17 Aug - 18 Aug
Soy Local Provenza
Living area

14. Hotel Santa Ana

Hotel Santa Ana
4.0 star property
El Poblado
9.0 out of 10, Wonderful, (39 reviews)
"Great location, superb staff and service and great breakfasts and food options."
United States
Juan Vicente
The price is HK$439
HK$439 total
31 Aug - 1 Sept
Hotel Santa Ana
1 bedroom, premium bedding, pillow-top beds, in-room safe

15. Soul Lifestyle Apartments

Soul Lifestyle Apartments
3.5 star property
El Poblado
9.0 out of 10, Wonderful, (142 reviews)
"Great spot and very friendly staff who go out of their way to help you! Super good experience and very happy!"
United States
Matthew
The price is HK$1,042
HK$1,304 total
19 Aug - 20 Aug
Soul Lifestyle Apartments
Exterior

16. Botánica 106-estándar

Botánica 106-estándar
2.0 star property
El Poblado
Botánica 106-estándar
Egyptian cotton sheets, premium bedding, down duvets

17. Factory Lofts

Factory Lofts
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (139 reviews)
"All the staff were absolutely great with a special thanks to Andres and Santiago! The cleaning was great and the location very convenient to everything and honestly a lot quieter than most of Calle 70.. Would definitely recommend and hope to visit soon"
United States
Firas Ghazi
The price is HK$699
HK$923 total
24 Aug - 25 Aug
Factory Lofts
Front of property

18. Living 10-36 Dieztreintayseis Short & Long Term

Living 10-36 Dieztreintayseis Short & Long Term
3.5 star property
El Poblado
9.2 out of 10, Wonderful, (51 reviews)
"Loved the room I stayed in and the staff was always accommodating. Great Boutique Hotel to stay."
United States
Rob
The price is HK$586
HK$586 total
17 Aug - 18 Aug
Living 10-36 Dieztreintayseis Short & Long Term
Coffee shop

19. B 48 Living by B Rent

B 48 Living by B Rent
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (22 reviews)
"I love the people & I love the area. One of the best place to stay in Medellin. "
United States
Lusene
The price is HK$472
HK$472 total
14 Aug - 15 Aug
B 48 Living by B Rent
Jetted bathtub

20. GRES Apartamentos

GRES Apartamentos
3.0 star property
El Poblado
10.0 out of 10, Exceptional, (59 reviews)
"This will Always be the place I stay at when I’m in Medellin Wonderful service wonderful stay"
United States
Kenny
The price is HK$721
HK$721 total
16 Aug - 17 Aug
GRES Apartamentos
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Cruz Hotel Reviews

Diez Hotel Categoria Colombia

Diez Hotel Categoria Colombia

10/10 Excellent
"El hotel está espectacular su ubicación excelente sus empleados super atentos enverdad no tengo nada negativo que decir . Me quedaría las veses que valla a Colombia"
juan antonio torres 11-night trip
Posted 4 hours ago
Diez Hotel Categoria Colombia

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
  • Use the map to find apartments and other holiday homes in the Santa Cruz neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a holiday rental in Santa Cruz?

Yes, there are holiday rentals close to the most popular sights in Santa Cruz, or you can select a more secluded option if you're looking for a relaxing stay.

What are some of the best holiday rentals that Santa Cruz has to offer?

Luxe Retreat Private Jacuzzi, A House Best view and price of North Medellin: This holiday home rental outside of Santa Cruz offers a balcony, a rooftop terrace and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a fridge, a stovetop and a microwave, so that you can cook with friends or family. You can relax into your holiday with a garden and 1 hot tub.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the wider area, you’ll find University of Antioquia and Arvi Park.

What’s a holiday rental in Santa Cruz like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Santa Cruz. Holiday rentals offer extras like WiFi and washers and dryers so you'll feel right at home. If you're concerned about a clean environment, holiday rentals can offer a sense of safety away from public hotel lifts and lobbies bustling with people while still allowing you the enjoyment of travel. You'll also find more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a popular option for families.