
South Central Houston hotels in Houston
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for South Central Houston hotels

Downtowner Inns - Houston Downtown
Downtowner Inns - Houston Downtown
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical Center
DoubleTree by Hilton Houston Medical Center Hotel & Suites
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Houston Marriott Medical Center/Museum District
Houston Marriott Medical Center/Museum District
The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum District
InterContinental Houston by IHG
InterContinental Houston by IHG
Americas Best Value Inn Medical Center Downtown
Americas Best Value Inn Medical Center Downtown
Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum District
La Maison in Midtown an urban B&B
La Maison in Midtown an urban B&B
Wanderstay Boutique Hotel
Wanderstay Boutique Hotel
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
Hilton University of Houston
Hilton University of Houston
Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home
Sophisticated Urban Retreat With Skyline Views 3 Bedroom Home
Newly Built Modern 3 Bedroom Houston Home
Newly Built Modern 3 Bedroom Houston Home
Modern Cozy Home with King Bed
Modern Cozy Home with King Bed
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Southmore Boulevard Motel
Southmore Boulevard Motel
Rodeway Inn & Suites Houston near Medical Center
Rodeway Inn & Suites Houston near Medical Center
Wanderstay Houston Hostel
Wanderstay Houston Hostel
The Green Haus Luxxe Cabana Rooftop Retreat
The Green Haus Luxxe Cabana Rooftop RetreatWhere to stay in South Central Houston

Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.

Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Top South Central Houston Hotel Reviews























































































