A densely packed urban area with numerous buildings and a prominent tower on a hill.

Puerto Santa Ana hotels in Guayaquil

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Puerto Santa Ana hotels

A modern bar area with a bar counter, seating, and a large window.

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,003 reviews)
"Love staying at this hotel!"
United States
Isabel
The price is HK$861
HK$967 total
29 Nov - 30 Nov
Wyndham Guayaquil Puerto Santa Ana
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.

2. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (67 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is HK$614
HK$701 total
9 Nov - 10 Nov
River View suites Puerto Santa Ana gye
A rooftop pool with a view of the city skyline.

3. Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (112 reviews)
"So clean and very nice people. I really recommend this facility, nice environment. My next trip lm booking in this apartment"
United States
Pedro
The price is HK$670
HK$678 total
18 Nov - 19 Nov
Luxury Suites Riverfront GYE
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.

4. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is HK$2,415
HK$2,689 total
4 Nov - 5 Nov
Hotel Río Guayas by Art Hotels Ecuador
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.

5. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (151 reviews)
"The facility is very unique. Staff are very friendly. We have an early flight so did not get a chance to have breakfast."
United States
Shuyi
The price is HK$418
HK$468 total
7 Nov - 8 Nov
Mansión del Río
A modern bar area with a bar counter, stools, and a seating area with a table and chairs.

6. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,003 reviews)
"Best hotel and great location food amazing"
United States
Giselle
The price is HK$628
HK$702 total
7 Nov - 8 Nov
Wyndham Garden Guayaquil
A breakfast table with various foods and a view of a park through a window.

7. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (1,002 reviews)
"Great for a short stay"
United States
Maria
The price is HK$485
HK$553 total
20 Nov - 21 Nov
Unipark by Oro Verde Hotels
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

8. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very good, (422 reviews)
"Excelente atención, good service, sauna and pull in great condition, food very good"
United States
Pedro
The price is HK$494
HK$502 total
4 Nov - 5 Nov
Hotel Ramada
An indoor pool with a waterfall, surrounded by lush tropical plants.

9. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,002 reviews)
"Great location, great breakfast buffet, adjacent to Iguana park, not far from airport."
Canada
Victor
The price is HK$590
HK$661 total
28 Nov - 29 Nov
Grand Hotel Guayaquil, Centro Histórico.
A reception desk with a marble top and a modern light fixture above it.

10. TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,007 reviews)
"Convenient near airport."
United States
MIGUEL A.
The price is HK$706
HK$796 total
15 Nov - 16 Nov
TRYP by Wyndham Guayaquil Airport
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

11. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,004 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is HK$635
HK$711 total
14 Nov - 15 Nov
Courtyard by Marriott Guayaquil
A high-rise hotel interior with multiple floors, large windows, and modern lighting fixtures.

12. Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 3.2 km from Puerto Santa Ana
8.8 out of 10, Excellent, (1,004 reviews)
"Really easy to make the reservacion and chek in. Good service"
United States
SILVIA
The price is HK$787
HK$885 total
29 Nov - 30 Nov
Hilton Colon Guayaquil
An outdoor cafe with tables and chairs, surrounded by trees and buildings.

13. Fortune Hotel

Fortune Hotel
3.0 star property
River City, 1 km from Puerto Santa Ana
8.0 out of 10, Very good, (11 reviews)
"Is a great place the only problem is the disco bars outside the hotel "
United States
MARIA
The price is HK$388
HK$396 total
4 Nov - 5 Nov
Fortune Hotel
A spacious indoor area with a central open space surrounded by seating arrangements and a pool.

14. Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (758 reviews)
"Very helpful and accommodating airport shuttle service."
United States
Jerry
The price is HK$667
HK$753 total
7 Nov - 8 Nov
Radisson Hotel Guayaquil
A modern interior with a seating area, a kitchen, and a dining space.

15. Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
3.7 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,003 reviews)
"As close to the airport as you would want to be. No noise, and the pool and hot tube is great after a long travel time."
United States
Frederick
The price is HK$824
HK$926 total
8 Nov - 9 Nov
Holiday Inn Guayaquil Airport by IHG
A buffet setup with pastries and various food items in jars.

16. Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel
5.0 star property
Simón Bolívar, 2.9 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (694 reviews)
"Clean room, nice hotel"
United States
John
The price is HK$759
HK$855 total
13 Nov - 14 Nov
Sheraton Guayaquil Hotel
A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

17. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,004 reviews)
"Very friendly staff, excellent breakfast, maintained and modern rooms. Was a great stay."
United States
ricardo
The price is HK$714
HK$805 total
8 Nov - 9 Nov
Oro Verde Guayaquil
An outdoor seating area with tables and chairs, potted plants, and a view of trees through large windows.

18. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (357 reviews)
"Nice restaurant. Great location. Room was a good place to rest."
United States
Hector
The price is HK$471
HK$530 total
4 Dec - 5 Dec
Ibis Styles El Malecon Guayaquil
A cocktail on a marble table with a pool in the background.

19. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very good, (169 reviews)
"Was ok"
United States
Juan
The price is HK$317
HK$325 total
4 Nov - 5 Nov
Hotel Patrimonial by Greenfield
A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

20. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (966 reviews)
"We have stayed at this hotel several times and it is consistently a good experience. Comfortable bed, good air conditioning, restaurant on site, farmacia nearby. The breakfast buffet is especially good."
United States
Bethany
The price is HK$452
HK$509 total
14 Nov - 15 Nov
Hotel Palace Guayaquil
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Puerto Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern bar area with a bar counter, seating, and a large window.
Wyndham Guayaquil Puerto Santa Ana
4.5 star property
9.4
Exceptional
1,003 reviews
View
A rooftop pool with a view of the city skyline.
Luxury Suites Riverfront GYE
3.5 star property
9.4
Exceptional
112 reviews
View
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.
River View suites Puerto Santa Ana gye
3.0 star property
9.0
Wonderful
67 reviews
View
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.
Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
10.0
Exceptional
5 reviews
View
A lush indoor garden with various plants, including banana trees and hanging ferns.
Hostal Macaw
3.0 star property
10.0
Exceptional
11 reviews
View

Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Ecuador might not have many top sights, but C.C. Riocentro Sur and Mall del Sur are two attractions nearby that you can check out.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travellers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A lizard on a metal fence.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

When in Simón Bolívar, you can plan a visit to Mall del Sol Shopping Center and San Marino Mall, some noteworthy sights in the nearby area.

Top Puerto Santa Ana Hotel Reviews

Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

10/10 Excellent
"Clean room, professional staff, delicious breakfast."
Iris 1-night trip
Posted less than an hour ago
Holiday Inn Guayaquil Airport by IHG

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighbourhood that travellers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveller data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels should I expect to find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 88 Puerto Santa Ana hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes, most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to view the best deals in Puerto Santa Ana.
What is there to do around this Guayaquil neighbourhood?
Emporium by The Point, Santa Ana Garden and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.