Tower of the Americas San Antonio: 180 Degree Aerial Panorama

Medical Center District hotels in San Antonio

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Medical Center District hotels

Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1,347 reviews)
"Price is affordable for us, is very clean and we love bed and pillows, breakfast is good."
United States
Estela
The price is HK$705
HK$834 total
includes taxes & fees
6 Jul - 7 Jul
Drury Inn & Suites San Antonio Northwest Medical Center

Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1,003 reviews)
"The room was spacious and clean, the staff was friendly and helpful, and our stay was well spent."
United States
Dale
The price is HK$726
HK$858 total
includes taxes & fees
28 Jun - 29 Jun
Courtyard by Marriott Medical Center San Antonio

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very good, (3,447 reviews)
"plenty of paking, great staff awesome jacuzzi great stay"
United States
Luz
The price is HK$696
HK$823 total
includes taxes & fees
23 Jun - 24 Jun
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.4 out of 10, Good, (239 reviews)
"It was quiet and clean and the staff was very friendly"
United States
Ronnie
The price is HK$439
HK$556 total
includes taxes & fees
10 Jul - 11 Jul
OYO Inn & Suites Medical Center San Antonio

Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.2 out of 10, (543 reviews)
The price is HK$317
HK$375 total
includes taxes & fees
23 Jun - 24 Jun
Flex Studios

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3.0 star property
Medical Center District
7.0 out of 10, Good, (1,005 reviews)
"It was a comfortable stay"
United States
Eric
The price is HK$487
HK$568 total
includes taxes & fees
29 Jun - 30 Jun
Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Park Inn by Radisson

Park Inn by Radisson
2.0 star property
Medical Center District
7.2 out of 10, Good, (1,002 reviews)
"This was our 2nd time staying and it was even better than the last. The room was very clean, nicely updated, and super comfy. The morning coffee was a hit as well. We come to SA often so this is going to be our first choice for stays. We had been on a road trip for 6 days and this was our final stop. Literally the best place we stayed."
United States
Elizabeth
The price is HK$526
HK$614 total
includes taxes & fees
5 Jul - 6 Jul
Park Inn by Radisson

San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1,085 reviews)
"The Marriot from check in to check out was top notch. Ricky checked me in and was by far the most pleasant, helpful, and accommodating of any concierge I’ve ever encountered. Great stay!"
United States
Paul
The price is HK$859
HK$1,021 total
includes taxes & fees
4 Jul - 5 Jul
San Antonio Marriott Northwest Medical Center

Studio 6 Extended Stay - San Antonio, TX - Medical Center

Studio 6 Extended Stay - San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.8 out of 10, (919 reviews)
"It was an amazing stay "
United States
Cordale
The price is HK$392
HK$479 total
includes taxes & fees
23 Jun - 24 Jun
Studio 6 Extended Stay - San Antonio, TX - Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.4 out of 10, Good, (306 reviews)
"We liked that the property was quiet and staff was courteous and helpful. We would have liked more towels in the bathroom."
United States
Alma
The price is HK$368
HK$429 total
includes taxes & fees
1 Jul - 2 Jul
Studio 6 San Antonio, Tx - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (1,002 reviews)
"The staff and the fast check in and out."
United States
José
The price is HK$320
HK$398 total
includes taxes & fees
23 Jun - 24 Jun
Motel 6 San Antonio, TX - Northwest Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
Medical Center District
9.0 out of 10, Wonderful, (1,007 reviews)
"Was a great stay. "
United States
Sunanda
The price is HK$678
HK$791 total
includes taxes & fees
5 Jul - 6 Jul
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.4 out of 10, Good, (297 reviews)
"The stay wasn’t HORRIBLE but it definitely wasn’t great. When we got to our room there were old clothes from previous guest in the drawers…on top of that we needed clean towels and they had nothing available. The worst part to say though is that there were some very suspicious people walking around and peeping through my truck window-I’m not sure if they were even guests. I thought the neighborhood was good but it’s actually kinda bad, so don’t expect a relaxing night. Everything else was mid...
United States
Alyssa
The price is HK$494
HK$576 total
includes taxes & fees
29 Jun - 30 Jun
Atria Inn & Suites

Drury Plaza Hotel San Antonio Airport

Drury Plaza Hotel San Antonio Airport
3.0 star property
9 km from Medical Center District
9.4 out of 10, Exceptional, (2,120 reviews)
"Beautiful hotel and good breakfast"
United States
Michelle
The price is HK$721
HK$852 total
includes taxes & fees
19 Jul - 20 Jul
Drury Plaza Hotel San Antonio Airport

Wyndham Garden San Antonio Airport

Wyndham Garden San Antonio Airport
3.0 star property
Uptown, 9.2 km from Medical Center District
8.8 out of 10, Excellent, (1,629 reviews)
"Near the highway and many places to eat."
United States
Denise Marie
The price is HK$699
HK$827 total
includes taxes & fees
23 Jun - 24 Jun
Wyndham Garden San Antonio Airport

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
2.5 star property
Uptown, 9.3 km from Medical Center District
9.2 out of 10, Wonderful, (1,847 reviews)
"Good place to stay"
United States
Marie
The price is HK$620
HK$732 total
includes taxes & fees
23 Jun - 24 Jun
Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

La Quinta Inn & Suites by Wyndham San Antonio Airport

La Quinta Inn & Suites by Wyndham San Antonio Airport
3.0 star property
9.3 km from Medical Center District
7.8 out of 10, Good, (2,747 reviews)
"Would stay again"
United States
Abagail
The price is HK$621
HK$734 total
includes taxes & fees
28 Jun - 29 Jun
La Quinta Inn & Suites by Wyndham San Antonio Airport

Drury Plaza Hotel San Antonio North Stone Oak

Drury Plaza Hotel San Antonio North Stone Oak
3.0 star property
Stone Oak, 14.8 km from Medical Center District
9.6 out of 10, Exceptional, (1,420 reviews)
"Wonderful hotel clean , nice staff and location excellent"
United States
Maria
The price is HK$831
HK$982 total
includes taxes & fees
5 Jul - 6 Jul
Drury Plaza Hotel San Antonio North Stone Oak

Hyatt Place San Antonio–North/Stone Oak

Hyatt Place San Antonio–North/Stone Oak
3.0 star property
Stone Oak, 16 km from Medical Center District
9.0 out of 10, Wonderful, (1,005 reviews)
"Great stay! Very clean rooms, friendly staff, and great free breakfast!"
United States
Stephen
The price is HK$799
HK$945 total
includes taxes & fees
12 Jul - 13 Jul
Hyatt Place San Antonio–North/Stone Oak

Extended Stay America Premier Suites - San Antonio - Schertz

Extended Stay America Premier Suites - San Antonio - Schertz
2.5 star property
29.4 km from Medical Center District
9.2 out of 10, Wonderful, (321 reviews)
"The place was awesome and will definitely stay again"
United States
Joshua
The price is HK$776
HK$892 total
includes taxes & fees
23 Jun - 24 Jun
Extended Stay America Premier Suites - San Antonio - Schertz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Medical Center District

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Lobby
Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
9.2
Wonderful
1,347 reviews
View
Lobby lounge
Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
9.0
Wonderful
1,007 reviews
View
Bar (on property)
Courtyard by Marriott Medical Center San Antonio
3.0 star property
8.8
Excellent
1,003 reviews
View
Lobby
San Antonio Marriott Northwest Medical Center
3.5 star property
8.6
Excellent
1,085 reviews
View
Free daily buffet breakfast
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
8.4
Very good
3,447 reviews
View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and San Antonio River are top sights worth seeing.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Stone Creek Village and Stone Ridge Market while you're in town.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

Top Medical Center District Hotel Reviews

Frequently asked questions

What is Medical Center District like?
Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and Cinemark San Antonio 16 while you're in the neighbourhood.
What's a favourite hotel to stay in Medical Center District?
Based on our traveller data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include San Antonio Marriott Northwest Medical Center and Drury Inn & Suites San Antonio Northwest Medical Center.
How many hotels will I be able to find in Medical Center District?
Expedia has 134 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.
What can I see and do in this San Antonio neighbourhood?
USAA Corporate Office Headquarters, Cinemark San Antonio 16 and The San Antonio Art Institute are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.

Explore a world of travel with Expedia