Medical Center District

San Antonio

A cityscape with a prominent tower, a large body of water, and a sunset.
A canal with colorful umbrellas and trees along the banks.
A riverside café with colorful umbrellas and tables.
A tranquil waterway flanked by lush greenery and stone pathways.
A canal with a boat, surrounded by lush greenery and a stone bridge.

Stay near popular Medical Center District attractions

USAA Corporate Office Headquarters

7.8/10 (7 reviews)
USAA Corporate Office Headquarters is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Stroll along the riverfront or attend a sporting event in this family-friendly area.
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Things to do

San Antonio Zoo Any Day Ticket including ZooLights

San Antonio: Zoo Entry & Zoorassic Park Dinosaur Experience

HK$232
per adult
96% of travellers recommend
San Antonio: Zoo Entry & Zoorassic Park Dinosaur Experience
SEA LIFE San Antonio

SEA LIFE San Antonio

HK$204
per adult
76% of travellers recommend
SEA LIFE San Antonio
San Antonio: Fredericksburg Wineries Day Trip with Tastings

San Antonio: Fredericksburg Wineries Day Trip with Tastings

HK$1,404
per adult
100% of travellers recommend
San Antonio: Fredericksburg Wineries Day Trip with Tastings
San Antonio: Discovery Tour at Natural Bridge Caverns

San Antonio: Discovery Tour at Natural Bridge Caverns

HK$298
per adult
98% of travellers recommend
San Antonio: Discovery Tour at Natural Bridge Caverns
Entrance to the Hard Rock Cafe in San Antonio

Dining at Hard Rock Cafe San Antonio

HK$314
per traveller
76% of travellers recommend
Dining at Hard Rock Cafe San Antonio
San Antonio: Botanical Garden Admission Ticket

San Antonio: Botanical Garden Admission Ticket

HK$141
per adult
100% of travellers recommend
San Antonio: Botanical Garden Admission Ticket
See all activities in San Antonio

Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is HK$696 per night from 21 Jul to 22 Jul
HK$696
HK$823 total
21 Jul - 22 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very good! (3,503 reviews)
"Breakfast was amazing and hot fresh food clean room and the ladies at the front desk they were amazing greeted my husband and I really appreciate both of them. They went over and about their duties. It was a pleasure meeting the staff at the front desk with a smile 😃 on their face. When ever we ..."

Reviewed on 20 Jul 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
The price is HK$698 per night from 7 Aug to 8 Aug
HK$698
HK$825 total
7 Aug - 8 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,011 reviews)
"Clean room"

Reviewed on 20 Jul 2026

Courtyard by Marriott Medical Center San Antonio
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
The price is HK$706 per night from 27 Jul to 28 Jul
HK$706
HK$834 total
27 Jul - 28 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,397 reviews)
"The room was clean and comfortable. The staff was friendly and helpful. The noise from the freeway did reach our room on 7th floor facing the freeway. It sounded like white noise. Breakfast and kickback happy hour had good variety and fun."

Reviewed on 19 Jul 2026

Drury Inn & Suites San Antonio Northwest Medical Center
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is HK$860 per night from 1 Aug to 2 Aug
HK$860
HK$1,022 total
1 Aug - 2 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy room service, a 24-hour fitness centre and Wi-Fi (surcharge). Our guests praise the helpful staff ...
8.6/10 Excellent! (1,124 reviews)
"Hotel was very convenient for our trip. Parking @ almost $11.00 per day was quite steep….."

Reviewed on 18 Jul 2026

San Antonio Marriott Northwest Medical Center
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
The price is HK$1,003 per night from 3 Aug to 4 Aug
HK$1,003
HK$1,186 total
3 Aug - 4 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and 2 hot tubs. Our guests praise the breakfast and the pool in their reviews. ...
Drury Plaza Hotel San Antonio Riverwalk
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
The price is HK$922 per night from 5 Aug to 6 Aug
HK$922
HK$1,314 total
5 Aug - 6 Aug
includes taxes & fees
Stay at this luxury hotel in San Antonio. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean rooms in ...
9.4/10 Exceptional! (2,917 reviews)
"Very beautiful and historic hotel. Walking distance to many restaurants and stores. Mini fridge in the room. Would stay here again."

Reviewed on 20 Jul 2026

Hotel Valencia Riverwalk
See all 4,859 properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most. Learn more about Medical Center District
Learn more about Medical Center District
A boat tour on a canal with a bridge in the background.

Downtown San Antonio

A scenic riverfront great entertainment and top sights from Alamo to Alamodome – discover Downtown San Antonio, a destination also famous for its historic sites.

A large, modern building with a blue and white color scheme, featuring a prominent circular window and a 'Welcome' sign.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

A large, abstract sculpture with a flowing design, set against a dramatic sky.
Photo by Sarah C.
Open Photo by Sarah C.

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing.

A nighttime amusement park with roller coasters, a bridge, and a full moon.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

Medical Center District

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