A gazebo with columns, a large tree with hanging roots, and a building in the background.

Santa Ana hotels in Panama City

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Check prices for these dates

This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

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Our top choices for Santa Ana hotels

A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.

1. Casco View Life Residences

Casco View Life Residences
4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (112 reviews)
"It is a new place, an apartment was in pristine condition. The building is 2 blocks away from the old town."
United States
Arshak Andrew
The price is HK$657
HK$958 total
includes taxes & fees
21 Oct - 22 Oct
Casco View Life Residences
A bedroom with a bed, a bedside table with a lamp, a chair, a TV mounted on the wall, and a window with curtains.

2. Hotel Caracas - Casco Viejo

Hotel Caracas - Casco Viejo
3.0 star property
Santa Ana
8.0 out of 10, Very good, (21 reviews)
"great staff"
United States
Keith
The price is HK$403
HK$443 total
includes taxes & fees
26 Oct - 27 Oct
Hotel Caracas - Casco Viejo
A hotel room with a large bed, a window with curtains, a city view, and a lamp.

3. Hotel República

Hotel República
2.0 star property
Santa Ana
6.8 out of 10, (197 reviews)
"Good location. Walking distance to shops and public transport."
Canada
Danilo
The price is HK$230
HK$723 total
includes taxes & fees
3 Nov - 4 Nov
Hotel República
An indoor dining area with tables and chairs, a mural on the wall, and hanging plants.

4. Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (76 reviews)
"Excellent staff, close to metro and embassies. A good location, good room for a great price. I would stay again. "
United Kingdom
Mark
The price is HK$230
HK$253 total
includes taxes & fees
21 Oct - 22 Oct
Hostal La Cigarra
A bar area with a curved counter, multiple seating options, and a variety of bottles and glasses on display.

5. Hotel Riazor

Hotel Riazor
3.0 star property
Santa Ana
3.8 out of 10, (11 reviews)
"Rough neighborhood "
Canada
Del
The price is HK$212
HK$233 total
includes taxes & fees
21 Oct - 22 Oct
Hotel Riazor
A conference room with a wooden table and black office chairs, large windows with a view, and a poster on the wall.

6. Casco View Apartments & Rooftop Pool

Casco View Apartments & Rooftop Pool
3.5 star property
Santa Ana
The price is HK$667
HK$734 total
includes taxes & fees
26 Oct - 27 Oct
Casco View Apartments & Rooftop Pool
A modern hotel room with a large bed, a sofa, a TV, and a view of the city.

7. La Manzana Barrio Vivo by Wynwood

La Manzana Barrio Vivo by Wynwood
3.0 star property
Santa Ana
7.6 out of 10, Good, (19 reviews)
"Very clean and safe property"
United States
Javier Alberto Lindauer
The price is HK$659
HK$941 total
includes taxes & fees
27 Oct - 28 Oct
La Manzana Barrio Vivo by Wynwood
A hotel entrance with a green facade and a metal fence.

8. ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (15 reviews)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
The price is HK$289
HK$318 total
includes taxes & fees
21 Oct - 22 Oct
ART CASCO The Hotel
A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.

9. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (6,102 reviews)
"Very nice hotel"
United States
Margo
The price is HK$939
HK$1,033 total
includes taxes & fees
27 Oct - 28 Oct
Hotel Riu Plaza Panama
A modern lobby with a chandelier, seating area, reception desk, and a staircase.

10. The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,292 reviews)
"Good location, great breakfast. Clean rooms and helpful staff"
United States
Frank
The price is HK$626
HK$689 total
includes taxes & fees
15 Nov - 16 Nov
The Executive Hotel
A restaurant with multiple dining tables, chairs, and a central water feature.

11. Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
5.0 star property
San Felipe, 0.9 km from Santa Ana
9.8 out of 10, Exceptional, (364 reviews)
"Execelente hotel."
United States
Carlos A
The price is HK$2,195
HK$2,414 total
includes taxes & fees
25 Oct - 26 Oct
Hotel La Compañía Casco Antiguo
A covered outdoor seating area with a view of a city skyline and water.

12. Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2,248 reviews)
"I love the breakfast with it's increible view of the bay"
United States
Milton
The price is HK$1,030
HK$1,133 total
includes taxes & fees
1 Nov - 2 Nov
Plaza Paitilla Inn Hotel
A multi-story building with balconies, arched windows, and decorative railings.

13. Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
San Felipe, 0.9 km from Santa Ana
9.2 out of 10, Wonderful, (1,018 reviews)
"The breakfast was excellent. We enjoyed the pool and the gym. All of the staff were very friendly"
United States
Yvonne
The price is HK$1,287
HK$1,415 total
includes taxes & fees
3 Nov - 4 Nov
Central Hotel Panama Casco Viejo
A multi-story hotel with a Marriott sign, surrounded by high-rise buildings and a busy street with cars.

14. Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall
4.0 star property
San Francisco, 4.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,000 reviews)
"I enjoyed my stay at this hotel, great location , breakfast was fresh every morning, room was clean and the staff was friendly. I definitely would be staying here again.."
United States
SHARROW
The price is HK$994
HK$1,094 total
includes taxes & fees
7 Nov - 8 Nov
Courtyard by Marriott Panama Multiplaza Mall
A spacious outdoor patio with wicker furniture, potted plants, and umbrellas providing shade.

15. Hotel San Felipe

Hotel San Felipe
4.0 star property
San Felipe, 0.7 km from Santa Ana
9.4 out of 10, Exceptional, (466 reviews)
"The staff was very friendly and accommodating. We also went to the restaurant above the hotel and enjoyed a great meal and views. The room was a very comfortable size. And the location was nearby plenty of shopping and restaurants. Will definitely be staying here again!"
United States
Jordan
The price is HK$1,230
HK$1,352 total
includes taxes & fees
27 Oct - 28 Oct
Hotel San Felipe
A spacious indoor area with high ceilings, large windows, and multiple dining tables.

16. American Trade Hotel

American Trade Hotel
4.5 star property
San Felipe, 0.7 km from Santa Ana
9.4 out of 10, Exceptional, (820 reviews)
"Beautiful hotel"
United States
Ashleigh-Ann
The price is HK$1,928
HK$2,121 total
includes taxes & fees
1 Nov - 2 Nov
American Trade Hotel
A rooftop pool area with lounge chairs and a small table, surrounded by high-rise buildings.

17. TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro
3.5 star property
El Cangrejo, 3.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,004 reviews)
"Room clean staff very welcoming and breakfast was fantastic also Dinner"
United States
Donna
The price is HK$680
HK$748 total
includes taxes & fees
10 Nov - 11 Nov
TRYP by Wyndham Panamá Centro
A rooftop pool with sun loungers and a city skyline in the background.

18. Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino
4.0 star property
El Cangrejo, 3.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,206 reviews)
"Breakfast, Cafe, was just perfect location"
United States
Bruno
The price is HK$742
HK$1,247 total
includes taxes & fees
24 Oct - 25 Oct
Waymore Hotel Spa & Casino
A hotel room with a four-poster bed, a desk with a lamp, a chair, a small table with a plant, and a view of the outside balcony.

19. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
San Felipe, 1.1 km from Santa Ana
9.8 out of 10, Exceptional, (762 reviews)
"Amazing service and beautiful hotel"
United States
Jose
The price is HK$2,790
HK$3,069 total
includes taxes & fees
4 Nov - 5 Nov
Sofitel Legend Casco Viejo, Panama City
A modern lobby with seating areas, large windows, and a visible exit sign.

20. Holiday Inn Panama Distrito Financiero by IHG

Holiday Inn Panama Distrito Financiero by IHG
4.0 star property
Campo Alegre, 3.7 km from Santa Ana
8.8 out of 10, Excellent, (1,000 reviews)
"Good and very comfortable place to stay and close to everything"
United States
Douglas R Ng
The price is HK$667
HK$777 total
includes taxes & fees
17 Nov - 18 Nov
Holiday Inn Panama Distrito Financiero by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.
Casco View Life Residences
4.0 star property
9.0
Wonderful
112 reviews
View
A bedroom with a bed, a bedside table with a lamp, a chair, a TV mounted on the wall, and a window with curtains.
Hotel Caracas - Casco Viejo
3.0 star property
8.0
Very good
21 reviews
View
An indoor dining area with tables and chairs, a mural on the wall, and hanging plants.
Hostal La Cigarra
2.0 star property
7.6
Good
76 reviews
View
A modern hotel room with a large bed, a sofa, a TV, and a view of the city.
La Manzana Barrio Vivo by Wynwood
3.0 star property
7.6
Good
19 reviews
View
A hotel room with a large bed, a window with curtains, a city view, and a lamp.
Hotel República
2.0 star property
6.8
197 reviews
View

Hotels recommended for families in Santa Ana

A bedroom with a bed, a bedside table with a lamp, a chair, a TV mounted on the wall, and a window with curtains.

Hotel Caracas - Casco Viejo

Hotel Caracas - Casco Viejo
3.0 star property
Santa Ana
8.0 out of 10, Very good, (21)
The price is HK$403
HK$443 total
includes taxes & fees
26 Oct - 27 Oct
Hotel Caracas - Casco Viejo

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.
A coastal cityscape with a prominent church tower, a river, and distant mountains.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A modern, spiraling skyscraper with a unique design, surrounded by other buildings in an urban setting.
Photo by Fabiola Tile
Open Photo by Fabiola Tile

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

Top Santa Ana Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

8/10 Good
"It was a excellence stay i enjoyed it however the internet in my room was very poor that the only bad thing about the hole"
Dillon 2-night trip
Posted 3 hours ago
Hotel Riu Plaza Panama

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Avenida Balboa and El Machetazo Santa Ana while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on our traveller data, Hotel Caracas - Casco Viejo is one of the top choices for your stay in Santa Ana. This hotel is a short 7-minute walk from Avenida Balboa, and it offers a restaurant and a bar. Another good choice for your stay in the area is Casco View Life Residences.
How many hotels can I expect to find in Santa Ana?
Expedia has 135 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider El Machetazo Santa Ana or Avenida Balboa, and pick out the perfect souvenir. When you're sightseeing in Panama City, Albrook Shopping Mall and Avenida Central are also worth a stop.