A colonial-style building with a bell tower, palm trees, and a paved walkway.

Santa Cruz hotels from HK$159

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Check prices for these dates

Tonight
7 Aug - 8 Aug
Tomorrow
8 Aug - 9 Aug
This weekend
7 Aug - 9 Aug
Next weekend
14 Aug - 16 Aug

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Our top choices for Santa Cruz hotels

1. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Santa Cruz
United States
imilse de
HK$577
HK$577 total
9 Aug - 10 Aug
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

2. Hotel Cortez

Hotel Cortez
Santa Cruz
United States
Sarinela
HK$932
HK$932 total
8 Aug - 9 Aug
Hotel Cortez

3. Sun Hotel

Sun Hotel
Santa Cruz
United States
JACK
HK$847
HK$847 total
8 Aug - 9 Aug
Sun Hotel

4. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Santa Cruz
Canada
Andrew
HK$993
HK$993 total
23 Aug - 24 Aug
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

5. Camino Real Hotel

Camino Real Hotel
Santa Cruz
United States
Austin
HK$1,138
HK$1,138 total
1 Sept - 2 Sept
Camino Real Hotel

6. Chairú Eco Hotel

Chairú Eco Hotel
Santa Cruz
United States
marcia
HK$424
HK$424 total
15 Aug - 16 Aug
Chairú Eco Hotel

7. Lido Hotel

Lido Hotel
Santa Cruz
United States
Gabrielle
HK$297
HK$297 total
8 Aug - 9 Aug
Lido Hotel

8. Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra
Santa Cruz
United States
Sarinela
HK$267
HK$267 total
23 Aug - 24 Aug
Ibis Santa Cruz DE LA Sierra

9. Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
Santa Cruz
United States
Luisa
HK$276
HK$312 total
21 Aug - 22 Aug
Premium Suites Deluxe Aparthotel Equipetrol

10. Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
Santa Cruz
United States
Deivis
HK$830
HK$830 total
14 Aug - 15 Aug
Marriott Santa Cruz de la Sierra Hotel

11. Delfines Collection Hotel By Mercure

Delfines Collection Hotel By Mercure
Santa Cruz
United States
ALEJANDRO
HK$374
HK$374 total
22 Aug - 23 Aug
Delfines Collection Hotel By Mercure

12. HOTEL OSHO

HOTEL OSHO
Santa Cruz
Canada
David
HK$337
HK$455 total
11 Aug - 12 Aug
HOTEL OSHO

13. TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
Santa Cruz
United States
Pluetina
HK$769
HK$769 total
15 Aug - 16 Aug
TRYP by Wyndham Santa Cruz

14. Hotel LP Equipetrol

Hotel LP Equipetrol
Santa Cruz
United States
Ricardo
HK$310
HK$349 total
30 Aug - 31 Aug
Hotel LP Equipetrol

15. Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
Santa Cruz
United States
ERNESTO
HK$969
HK$969 total
1 Sept - 2 Sept
Novotel Santa Cruz De La Sierra

16. Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
Santa Cruz
United States
Ruben
HK$212
HK$212 total
9 Aug - 10 Aug
Apart Hotel Premium Suites Santa Cruz

17. Hotel Las Américas

Hotel Las Américas
Santa Cruz
Canada
Stanley
HK$271
HK$271 total
8 Aug - 9 Aug
Hotel Las Américas

18. Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
Santa Cruz
United States
GONZALO
HK$1,161
HK$1,161 total
23 Aug - 24 Aug
Swissôtel Santa Cruz De La Sierra

19. Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique
Santa Cruz
United States
Heidi
HK$465
HK$465 total
22 Aug - 23 Aug
Cosmopolitano Hotel Boutique

20. Hotel G

Hotel G
Santa Cruz
Mexico
JACOB
HK$164
HK$164 total
5 Sept - 6 Sept
Hotel G
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Holiday Rentals in Santa Cruz

Aparthotel

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
Santa Cruz
"great place to stay!"
Premium Suites Deluxe Aparthotel Equipetrol
Apartment

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
Santa Cruz
"Great location."
Apart Hotel Premium Suites Santa Cruz
Aparthotel

Terranova Suites

Terranova Suites
Santa Cruz
"Easy to access"
Terranova Suites
Aparthotel

Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel
Santa Cruz
"Perfect hotel"
Equipetrol Suites Apart Hotel
Apartment

AMERICA APARTMENTS

AMERICA APARTMENTS
Santa Cruz
"Clean room, great staff "
AMERICA APARTMENTS
Aparthotel

Apart Hotel Toborochi

Apart Hotel Toborochi
Santa Cruz
"Very comfortable and quiet place and very good location. "
Apart Hotel Toborochi
Holiday Home

Casa Vida

Casa Vida
Santa Cruz
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"
Casa Vida
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Where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most.Learn more about Santa Cruz
Learn more about Santa Cruz

Hamacas

When in Hamacas, you can plan a visit to Santa Cruz Zoo and Las Brisas Shopping Center, some noteworthy sights in the nearby area.

Stay near popular Santa Cruz attractions

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)
Plaza 24 de Septiembre buzzes with local culture beneath swaying palms and colonial architecture. Climb the Cathedral's bell tower for spectacular city views while sampling authentic Bolivian coffee from vendors.
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An interior of a church with high arched ceilings, wooden pews, and a central altar.

San Lorenzo Cathedral

9.0/10 (84 reviews)
This grand neoclassical cathedral dominates Santa Cruz's skyline with its towering spires and ornate façade. Climb the bell tower at sunset for breathtaking panoramic views of the city.
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Ventura Mall

9.0/10 (183 reviews)
Ventura Mall, Santa Cruz's premier shopping destination, features international brands and local boutiques. Enjoy the cinema complex, food court, and entertainment options in this contemporary Bolivian retail hub.
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Guembe Biocenter

8.8/10 (60 reviews)
This vibrant ecological sanctuary showcases hundreds of butterfly species in a lush, tropical environment. Explore walking trails, enjoy boat rides, and learn about biodiversity in this serene natural retreat.
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Santa Cruz Zoo

8.4/10 (53 reviews)
The Santa Cruz Municipal Zoo showcases Bolivia's native wildlife in naturalistic habitats, featuring jaguars, tapirs, and free-ranging sloths. Morning visits offer the best chance to see active animals.
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Cine Center

8.0/10 (53 reviews)
This premier entertainment complex offers state-of-the-art cinema experiences with immersive 4D E-Motion formats. Enjoy the latest films, then explore the shopping centre and diverse dining options in the food court.
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Ramon Tahuichi Aguilera Stadium

8.4/10 (18 reviews)
This multi-purpose stadium hosts Bolivia's most passionate football rivalries and tournaments. Experience the electric atmosphere of a local derby while enjoying modernised facilities and vibrant Santa Cruz culture.
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Lomas de Arena Regional Park

8.4/10 (28 reviews)
Explore surreal desert-like sand dunes nestled within Bolivia's tropical landscape at Lomas de Arena. Sandboard down towering peaks or spot sloths and capybaras while hiking through diverse ecosystems.
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Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

See all hotels in Santa Cruz
A colonial-style building with a bell tower, palm trees, and a paved walkway.

Top Santa Cruz Hotel Reviews

Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

10/10 Excellent
"Everything was great. Came for a business trip and would stay here again."
Sergio 3-night trip
Posted 4 hours ago
Marriott Santa Cruz de la Sierra Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

10/10 Excellent
"Great hotel, breakfast was delicious. Would come back again."
Andrew 2-night trip
Posted 4 days ago
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Sun Hotel

Sun Hotel

8/10 Good
"The transfer from the airport is a bit tricky, look for a guy with a black polo and an orange logo… once in the hotel if you arrive late the kitchen might not be working and there are few options to have late dinner. The room was very spacious and clean, I had a great night sleep but it took around 40 minutes for the AC to cool the whole space as the room is extremely big and they don’t run the A/C 24/7… Breakfast was basic and the hot options were cold, but as I was hungry I was able to have some breakfast. Transfer back to the airport is every hour but they run an exception for me and took me at 11:30am. Overall really nice to have a one night stay to transfer from local to international flights in Santa Cruz if you need a lay over"
Ivan 1-night trip
Posted 5 days ago
Sun Hotel
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

10/10 Excellent
"great place to stay!"
Luisa 1-night trip
Posted 6 days ago
Premium Suites Deluxe Aparthotel Equipetrol
Camino Real Hotel

Camino Real Hotel

10/10 Excellent
"Enjoyed our stay. Warm welcome from the staff and great service. Highly recommended"
Austin 5-night trip
Posted 6 days ago
Camino Real Hotel
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

10/10 Excellent
"Great deal"
Sarinela 1-night trip
Posted 6 days ago
Ibis Santa Cruz DE LA Sierra
Hotel Cortez

Hotel Cortez

10/10 Excellent
"Very good."
Sarinela 1-night trip
Posted 3 weeks ago
Hotel Cortez
Hotel LP Equipetrol

Hotel LP Equipetrol

8/10 Good
"El cuarto agradable, pero faltó servicio de ayuda para subir y bajar maletas, también servicio adecuado de taxi para moverse en Santa Cruz"
José Bernardo 1-night trip
Posted 3 weeks ago
Hotel LP Equipetrol
Alfonsina Hotel Boutique by Inboccaluppo

Alfonsina Hotel Boutique by Inboccaluppo

10/10 Excellent
"Good hotel. Very contemporary; buffet breakfast included. We walked to the old part of the city/cathedral - probably about 40 minutes walk but can stop for a coffee along the way! Restaurant and bar in hotel. Hotel also close to many other restaurants/bars"
Sue 2-night trip
Posted 1 month ago
Alfonsina Hotel Boutique by Inboccaluppo

More cheap stays in Santa Cruz

Ibiza Hostel

Ibiza Hostel

445 Santa Cruz Departamento de Santa Cruz
HK$99
HK$209 total
8 Aug - 9 Aug
Ibiza Hostel
Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel

Equipetrol Santa Cruz Departamento de Santa Cruz
HK$390
HK$390 total
12 Aug - 13 Aug
Equipetrol Suites Apart Hotel
Amaca Hostal

Amaca Hostal

249 Independencia Santa Cruz Departamento de Santa Cruz
Get ratesAmaca Hostal
Casa Por Temporadas

Casa Por Temporadas

Barrio Las Pampitas, calle 3 Nro. 99 Santa Cruz Santa Cruz Department
Get rates
10/10 Exceptional! (1 review)
Casa Por Temporadas
HOTEL CASA BLANCA

HOTEL CASA BLANCA

Avenida Marcelo Terceros Zona Equipetrol Santa Cruz Santa Cruz de la Sierra
Get ratesHOTEL CASA BLANCA
Hotel Viru Viru II

Hotel Viru Viru II

Av. Alameda 72 - Zona Valle Sanchez Santa Cruz Santa Cruz de la Sierra
Get rates
4.8/10 (3 reviews)
Hotel Viru Viru II

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is one of the top choices for your stay based on our traveller data. This hotel offers a restaurant and free parking. Other good choices for your stay include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Marriott Santa Cruz de la Sierra Hotel. See all available top hotels, or vacation rentals in Santa Cruz.
What are some of the best holiday rentals that Santa Cruz has to offer?
Casa Vida: This highly rated holiday home rental in Santa Cruz is located in a rural location, and has an outdoor pool, a patio and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a full-sized fridge, a stovetop and a microwave, so that you can cook with friends or family. Kick off your shoes and enjoy yourself with a private garden and a selection of games. Some other homes for rent in Santa Cruz include Cozy 1-bedroom house in beautiful Santa Cruz de la Sierra with WiFi, AC and Seasonal House. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
What's the best budget-friendly accommodation in Santa Cruz?
Based on our traveller reviews, Ibiza Hostel is a top choice for a less expensive stay. Other choices for your budget-friendly stay include residencial francia - Hostel and Residencial Ikandire II. View all budget hotels in Santa Cruz.
What's the best family accommodation in Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a hotel with 2 restaurants and free parking, and it's a top choice on Expedia for families. Other choices for your child-friendly holiday include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. Also, attractions such as Santa Cruz Zoo and Play Land Amusement Park are fun for children of all ages. Find more child-friendly accommodations in Santa Cruz.
What's the best LGBTQ-friendly accommodation in Santa Cruz?
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your holiday. See all available hotels listed as LGBTQ-friendly in Santa Cruz.
What's the best dog-friendly accommodation option in Santa Cruz?
Casa Por Temporadas is a top dog-friendly guest house, and offers an outdoor pool along with in-room kitchens for its human guests. Two other good options for you and your pet's trip include Ibis Santa Cruz DE LA Sierra and Swissôtel Santa Cruz De La Sierra. See more pet-friendly hotel accommodations in Santa Cruz.
What's the best luxury accommodation option in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Camino Real Hotel and Novotel Santa Cruz De La Sierra are other upscale choices for your holiday. Find more luxury hotels in Santa Cruz.
What are some accommodation options with pools in Santa Cruz?
Yotau All Suites Hotel is a top hotel with 2 outdoor swimming pools, a children's pool and 2 restaurants. A couple of other options that feature an on-site pool include Buganvillas Hotel Suites & Spa and Royal Lodge Hotel. View all hotels with pools in Santa Cruz.
What is the best spa hotel in Santa Cruz?
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel is a top spa hotel featuring a fitness centre, a hair salon and a bar. Enjoy a facial, body scrub or hydrotherapy at Los Tajibos Club Spa. Other popular spa hotels in Santa Cruz include Marriott Santa Cruz de la Sierra Hotel and Camino Real Hotel. See all spa hotels in Santa Cruz.
What's it like to stay in Santa Cruz?
Visitors to Santa Cruz will definitely enjoy the shopping. Tourists can also enjoy the city's cafés, zoo and cathedral. In Santa Cruz, there are 298 hotels and other accommodation options to choose from. Find out more about Santa Cruz.
What is there to see in Santa Cruz?
Cultural venues include Cine Center, Ethno-folkloric Museum and Sacred Art Museum. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre and Blacutt Square might be worth a visit. Natural beauty is on display at Guembe Biocenter, Lomas de Arena Regional Park and Arenal Park. Take a look at what more there is to see and do in Expedia's Santa Cruz guide.
How should I get around Santa Cruz?
If you want to venture outside the area, hop on a train at Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.
What's the weather like in Santa Cruz?
The hottest months are usually October and November, with an average temperature of 26°C, while the coldest months are June and July, with an average of 21°C. Average annual precipitation for Santa Cruz is 1208 mm.