Santa Isabel Holiday Rentals
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Our top choices for Santa Isabel holiday rentals

Holiday Home in Santa Isabel
Private Oceanfront Caribbean Escape – Infinity Pool + Tranquil Garden Sanctuary10.0 out of 10, Exceptional, (2)
The price is HK$2,516
HK$5,601 total
includes taxes & fees
23 Dec - 24 Dec

Holiday Home in Santa Isabel
Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL10.0 out of 10, Exceptional, (1)
The price is HK$2,276
HK$4,587 total
includes taxes & fees
22 Dec - 23 Dec

Holiday Home in Santa Isabel
Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep8.8 out of 10, Excellent, (44)
The price is HK$1,556
HK$2,824 total
includes taxes & fees
22 Dec - 23 Dec

Holiday Home in Santa Isabel
Modern Cozy Home in Puerto Rican Paradise9.2 out of 10, Wonderful, (16)
The price is HK$904
HK$1,176 total
includes taxes & fees
8 Jan - 9 Jan 2026
The price is HK$904
HK$1,176 total
includes taxes & fees
8 Jan - 9 Jan 2026
The price is HK$977
HK$1,254 total
includes taxes & fees
9 Jan - 10 Jan 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Santa Isabel Hotel Reviews

Meliá Century Hotel Ponce
10/10 Excellent
Find out more about Santa Isabel
Search for holiday rentals in Santa Isabel on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Isabel using one of the methods below:
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