Serra Mesa hotels in San Diego

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22 Dec - 23 Dec
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23 Dec - 24 Dec
This weekend
26 Dec - 28 Dec
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2 Jan - 4 Jan

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Our top choices for Serra Mesa hotels

Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
9.9 km from Serra Mesa
8.6 out of 10, Excellent, (1464)
"I loved my stay here"
United States
José
The Bristol Hotel San Diego
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Marina District, 10.7 km from Serra Mesa
9.2 out of 10, Wonderful, (1955)
"Amazing hotel Superb view Friendly staff Clean and neat rooms "
United States
Chirag
The price is HK$1,316
HK$1,935 total
includes taxes & fees
23 Dec - 24 Dec
Marriott Marquis San Diego Marina
Hypo-allergenic bedding, in-room safe, desk, iron/ironing board
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Marina District, 10.7 km from Serra Mesa
9.0 out of 10, Wonderful, (2881)
"Lovely hotel with friendly staff."
United States
Lynnea
The price is HK$1,175
HK$1,786 total
includes taxes & fees
23 Dec - 24 Dec
Manchester Grand Hyatt San Diego
Lobby
Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown
4.0 star property
Marina District, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1555)
"Very nice, and clean hotel. Friendly staff, and close to amenities. "
United States
Araceli
The price is HK$1,334
HK$1,828 total
includes taxes & fees
4 Jan - 5 Jan 2026
Embassy Suites by Hilton San Diego Bay Downtown
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
10 km from Serra Mesa
8.6 out of 10, Excellent, (1077)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is HK$1,052
HK$1,445 total
includes taxes & fees
29 Dec - 30 Dec
The Westin San Diego Bayview
Outdoor pool, pool loungers
Hilton San Diego Bayfront

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Marina District, 11.1 km from Serra Mesa
8.6 out of 10, Excellent, (1886)
"Enjoyed my stay"
United States
Brandon
The price is HK$922
HK$1,450 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton San Diego Bayfront
Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
9.3 km from Serra Mesa
8.8 out of 10, Excellent, (774)
"would stay again and recommend "
United States
Brendi
The price is HK$853
HK$989 total
includes taxes & fees
23 Dec - 24 Dec
The DEXTRO Little Italy, BW Premier Collection
Property grounds
Paradise Point Resort & Spa

Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
Mission Bay, 9.8 km from Serra Mesa
8.8 out of 10, Excellent, (2356)
"Great stay, top tier service and excellent customer care "
Canada
Meriem
The price is HK$1,006
HK$1,569 total
includes taxes & fees
11 Jan - 12 Jan 2026
Paradise Point Resort & Spa
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 10.4 km from Serra Mesa
9.4 out of 10, Exceptional, (1006)
"Great location "
United States
Mohammad
The price is HK$631
HK$957 total
includes taxes & fees
5 Jan - 6 Jan 2026
Staypineapple, Hotel Z, Gaslamp San Diego
Premium bedding, in-room safe, desk, laptop workspace
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3563)
"Room was clean, staff was friendly and helpful."
United States
Maria
The price is HK$833
HK$918 total
includes taxes & fees
4 Jan - 5 Jan 2026
Best Western Plus Marina Gateway Hotel
Garden
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
5.7 km from Serra Mesa
9.2 out of 10, Wonderful, (2946)
"Friendly, staff was very helpful, great size rooms, and over all was an amazing stay"
United States
Naya
The price is HK$1,184
HK$1,361 total
includes taxes & fees
4 Jan - 5 Jan 2026
Legacy Resort Hotel & Spa
Outdoor pool, a heated pool
The Wayfarer San Diego

The Wayfarer San Diego

The Wayfarer San Diego
4.0 star property
Mission Beach, 10.9 km from Serra Mesa
9.4 out of 10, Exceptional, (1718)
"Great room, clean and updated property, exceptional service, perfect location. Loved our stay and can't wait to return. "
United States
Michelle
The price is HK$1,395
HK$1,603 total
includes taxes & fees
23 Dec - 24 Dec
The Wayfarer San Diego
2 outdoor pools, a heated pool, pool loungers
The Dana on Mission Bay

The Dana on Mission Bay

The Dana on Mission Bay
3.5 star property
Mission Bay, 10.1 km from Serra Mesa
9.0 out of 10, Wonderful, (3936)
" Nice bay view from room, super friendly staff"
United States
Toshiyuki
The price is HK$1,082
HK$1,399 total
includes taxes & fees
23 Dec - 24 Dec
The Dana on Mission Bay
View from room
Catamaran Resort and Spa

Catamaran Resort and Spa

Catamaran Resort and Spa
4.0 star property
Mission Beach, 10.8 km from Serra Mesa
8.6 out of 10, Excellent, (1112)
"Great place to vacation. "
United States
Manuel
The price is HK$1,184
HK$1,776 total
includes taxes & fees
29 Dec - 30 Dec
Catamaran Resort and Spa
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6047)
"Always an amazing stay"
United States
Jana
The price is HK$1,052
HK$1,445 total
includes taxes & fees
24 Dec - 25 Dec
Wyndham San Diego Bayside
Outdoor pool, open 7:00 AM to 10:00 PM, pool cabanas (surcharge)
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 7.1 km from Serra Mesa
8.4 out of 10, Very good, (1312)
"Room was super clean and updated, location up against the bay was perfect. We really enjoyed our stay and want to come back soon!"
United States
Haley
The price is HK$1,146
HK$1,668 total
includes taxes & fees
1 Jan - 2 Jan 2026
San Diego Mission Bay Resort
City view from property
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy
4.0 star property
Little Italy, 9.3 km from Serra Mesa
9.0 out of 10, Wonderful, (129)
"It was a nice place to stay at"
United States
Eric
The price is HK$1,019
HK$1,181 total
includes taxes & fees
30 Dec - 31 Dec
Courtyard by Marriott San Diego Downtown Little Italy
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter
4.0 star property
Gaslamp Quarter, 10.5 km from Serra Mesa
9.0 out of 10, Wonderful, (1170)
"Amenities and location were great. "
United States
Julie
The price is HK$1,184
HK$1,688 total
includes taxes & fees
23 Dec - 24 Dec
Margaritaville Hotel San Diego Gaslamp Quarter
Outdoor pool, pool loungers
Inn By The Sea La Jolla

Inn By The Sea La Jolla

Inn By The Sea La Jolla
3.5 star property
13.7 km from Serra Mesa
9.4 out of 10, Exceptional, (1746)
"Delightful stay. Perfect location. "
United States
Nicole
The price is HK$1,240
HK$1,425 total
includes taxes & fees
23 Dec - 24 Dec
Inn By The Sea La Jolla
Reception
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
12.9 km from Serra Mesa
8.8 out of 10, Excellent, (1559)
"Staff was great, easy check in and great location"
United States
Alysa
The price is HK$865
HK$995 total
includes taxes & fees
5 Jan - 6 Jan 2026
Best Western Plus Island Palms Hotel & Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter showing signage, street scenes and night scenes

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Pacific Beach Park showing a sandy beach

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Belmont Park showing a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Sunset Cliffs Natural Park.

Top Serra Mesa Hotel Reviews

Lafayette Hotel & Club

Lafayette Hotel & Club

10/10 Excellent
"Enjoyable an"
Barry 1-night trip
Posted 20 hours ago
Lafayette Hotel & Club

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 38 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.

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