South Main hotels in Houston
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Our top choices for South Main hotels
1. Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.8 out of 10, Excellent, (1,000 reviews)
"Great Staff, room and location!"
chris
The price is HK$745
HK$872 total
includes taxes & fees
21 Sept - 22 Sept
2. Wyndham Houston at Reliant Park & Medical Center
Wyndham Houston at Reliant Park & Medical CenterSouth Main
7.2 out of 10, Good, (1,404 reviews)
"Staff friendly rooms nice and clean."
Miguel
The price is HK$738
HK$863 total
includes taxes & fees
24 Sept - 25 Sept
3. Wingate Houston at Reliant Park & Medical Center
Wingate Houston at Reliant Park & Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"My overall stay was good and property was well maintained and cleaned and staff was super helpful"
Terry
The price is HK$721
HK$844 total
includes taxes & fees
27 Sept - 28 Sept
4. Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (896 reviews)
"Great amenities!"
Michelle
The price is HK$612
HK$716 total
includes taxes & fees
21 Sept - 22 Sept
5. Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Regular aceptable ."
Oscar
The price is HK$527
HK$616 total
includes taxes & fees
12 Oct - 13 Oct
6. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG1.4 km from South Main
9.4 out of 10, Exceptional, (1,000 reviews)
"I’ll stay again"
Kevin
The price is HK$925
HK$1,089 total
includes taxes & fees
17 Sept - 18 Sept
7. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,653 reviews)
"Lovely stay!"
Lamarr
The price is HK$996
HK$1,171 total
includes taxes & fees
5 Oct - 6 Oct
8. Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,277 reviews)
"Excellent place to stay, very clean."
Kelly
The price is HK$1,053
HK$1,239 total
includes taxes & fees
28 Sept - 29 Sept
9. Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,855 reviews)
"I loved staying here!"
Kamauri
The price is HK$1,152
HK$1,352 total
includes taxes & fees
11 Oct - 12 Oct
10. Courtyard By Marriott Houston Medical Center Reliant Park
Courtyard By Marriott Houston Medical Center Reliant Park2.7 km from South Main
8.6 out of 10, Excellent, (1,002 reviews)
"Great Hotel!"
Jorge
The price is HK$875
HK$1,035 total
includes taxes & fees
17 Sept - 18 Sept
11. Home2 Suites by Hilton Houston Medical Center, TX
Home2 Suites by Hilton Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
9.2 out of 10, Wonderful, (731 reviews)
"The staff, the suite and breakfast were great. Very nice hotel."
Charles
The price is HK$1,024
HK$1,199 total
includes taxes & fees
26 Sept - 27 Sept
12. The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,190 reviews)
"Great place to stay"
Kevin
The price is HK$1,074
HK$1,337 total
includes taxes & fees
27 Sept - 28 Sept
13. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (2,144 reviews)
"Our stay was great"
Cindy
The price is HK$830
HK$980 total
includes taxes & fees
19 Sept - 20 Sept
14. Hilton Garden Inn Houston Medical Center, TX
Hilton Garden Inn Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
9.2 out of 10, Wonderful, (1,001 reviews)
"nice hotel"
Tameka
The price is HK$894
HK$1,046 total
includes taxes & fees
24 Sept - 25 Sept
15. Hotel Ylem
Hotel Ylem2.3 km from South Main
8.4 out of 10, Very good, (1,563 reviews)
"We found a clean room, all amenities, tv and
a/c
The breakfast is so good and fresh"
GUSTAVO
The price is HK$577
HK$714 total
includes taxes & fees
15 Sept - 16 Sept
16. Homewood Suites by Hilton Houston Memorial
Homewood Suites by Hilton Houston Memorial16.4 km from South Main
9.6 out of 10, Exceptional, (999 reviews)
"Very friendly staff. Great breakfast. Centrally located"
Roland
The price is HK$795
HK$930 total
includes taxes & fees
27 Sept - 28 Sept
17. Hyatt Place Houston/Galleria
Hyatt Place Houston/Galleria8.7 km from South Main
8.8 out of 10, Excellent, (1,608 reviews)
"A good stay overall"
Adaobi
The price is HK$855
HK$1,005 total
includes taxes & fees
20 Sept - 21 Sept
18. DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway PlazaGreenway Plaza-Upper Kirby, 6.6 km from South Main
8.4 out of 10, Very good, (1,870 reviews)
"Great hotel"
mary lou
The price is HK$701
HK$820 total
includes taxes & fees
24 Sept - 25 Sept
19. Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum District6.3 km from South Main
9.2 out of 10, Wonderful, (1,001 reviews)
"Nice hotel"
Deul
The price is HK$1,509
HK$2,075 total
includes taxes & fees
13 Sept - 14 Sept
20. Holiday Inn Express Houston - Galleria Area by IHG
Holiday Inn Express Houston - Galleria Area by IHGThe Galleria, 8.6 km from South Main
9.4 out of 10, Exceptional, (1,002 reviews)
"10/10 would definitely stay here again and highly recommend!"
Kaylyn
The price is HK$996
HK$1,165 total
includes taxes & fees
20 Sept - 21 Sept
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,000 reviews | View | ||||||
 Wyndham Houston at Reliant Park & Medical Center | 7.2 Good 1,404 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 896 reviews | View | ||||||
 Wingate Houston at Reliant Park & Medical Center | 6.6 1,000 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,001 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
The Royal Sonesta Houston Galleria
8/10 Good
