A paved courtyard with a brick pathway, trees, and a distant view of a road and buildings.

Search Vacation Homes in Southeast Iowa

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
17 Jul - 19 Jul
In two months
28 Aug - 30 Aug
In three months
25 Sept - 27 Sept
In four months
23 Oct - 25 Oct

Our top choices for Southeast Iowa holiday homes

Exterior

Charming One Bedroom home in Keosauqua near shops

Charming One Bedroom home in Keosauqua near shops
Keosauqua
9.0 out of 10, Wonderful, (12 reviews)
"Quiet, clean and comfortable. Nicely appointed. We saw a deer and a turkey when we stepped out of the house Sunday morning. Good communications. "
United States
Melinda L.
The price is HK$649
HK$1,254 total
includes taxes & fees
6 Jul - 7 Jul
Charming One Bedroom home in Keosauqua near shops
Outdoor dining

Private Woodsy Cabin close to River and Keosauqua

Private Woodsy Cabin close to River and Keosauqua
Keosauqua
9.8 out of 10, Exceptional, (19 reviews)
"Perfect location !! Lovely place and I can't say enough about how much we loved their turkey!"
United States
Julie
The price is HK$953
HK$1,621 total
includes taxes & fees
7 Jul - 8 Jul
Private Woodsy Cabin close to River and Keosauqua
Interior

PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets

PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets
Nauvoo
9.0 out of 10, Wonderful, (4 reviews)
"Can’t say enough about the stunning view of the Mississippi River from every part of the home! The home was extremely comfortable for the two of us. We really enjoyed our stay!"
United States
Debbie L.
The price is HK$1,129
HK$2,602 total
includes taxes & fees
6 Jul - 7 Jul
PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets
Interior

Grand Victorian on the Mississippi

Grand Victorian on the Mississippi
Fort Madison
9.8 out of 10, Exceptional, (27 reviews)
"The home was beautifully decorated! We enjoyed our stay."
United States
Theresa G.
Grand Victorian on the Mississippi
Property grounds

Riverside Waterfront on the Mississippi River

Riverside Waterfront on the Mississippi River
Pontoosuc
9.8 out of 10, Exceptional, (21 reviews)
"Great place good location "
United States
willmer m.
The price is HK$1,726
HK$3,026 total
includes taxes & fees
2 Aug - 3 Aug
Riverside Waterfront on the Mississippi River
Interior

Nauvoo Windmill Farmhouse 10-12 people

Nauvoo Windmill Farmhouse 10-12 people
Niota
10.0 out of 10, Exceptional, (14 reviews)
"Great stay very peaceful "
United States
larry r.
The price is HK$2,083
HK$3,097 total
includes taxes & fees
13 Jul - 14 Jul
Nauvoo Windmill Farmhouse 10-12 people
WiFi, bed sheets

Woodland Retreat High Above the Mississippi River

Woodland Retreat High Above the Mississippi River
Hamilton
The price is HK$1,165
HK$2,223 total
includes taxes & fees
9 Jul - 10 Jul
Woodland Retreat High Above the Mississippi River
Exterior

Historic 1840s Lamoreaux House / Modern Addition

Historic 1840s Lamoreaux House / Modern Addition
Nauvoo
9.6 out of 10, Exceptional, (21 reviews)
The price is HK$1,941
HK$2,831 total
includes taxes & fees
20 Jul - 21 Jul
Historic 1840s Lamoreaux House / Modern Addition
Living area

Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.

Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.
Blandinsville
9.4 out of 10, Exceptional, (17 reviews)
"We loved how clean the house was. It was good for staying at for commencement at WIU. Mattresses were comfortable. Shower was nice. Very nice place to stay."
United States
Annie
The price is HK$949
HK$1,380 total
includes taxes & fees
20 Jul - 21 Jul
Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.
Terrace/patio

Cozy House

Cozy House
Biggsville
10.0 out of 10, Exceptional, (7 reviews)
"Great place for our needs!"
United States
jdl j.
The price is HK$671
HK$1,376 total
includes taxes & fees
5 Jul - 6 Jul
Cozy House
Outdoor dining

Riverview Orchard 2: Master Suite Studio Style

Riverview Orchard 2: Master Suite Studio Style
Hamilton
9.4 out of 10, Exceptional, (6 reviews)
"Very clean, great view, great place! Highly recommend!"
United States
Addison M.
The price is HK$941
HK$1,579 total
includes taxes & fees
8 Jul - 9 Jul
Riverview Orchard 2: Master Suite Studio Style
Interior

Nauvoo Family Home 15 Minutes From Temple

Nauvoo Family Home 15 Minutes From Temple
Hamilton
9.8 out of 10, Exceptional, (26 reviews)
"Everything for our stay was excellent. I would definitely stay here again if in the area. I honestly can’t think of any negatives."
United States
Bj
Nauvoo Family Home 15 Minutes From Temple
Interior

If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill

If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill
Media
The price is HK$706
HK$1,164 total
includes taxes & fees
5 Jul - 6 Jul
If you want quiet, peaceful, & a beautiful sunset, you’ll love House on the Hill
Outdoor dining

The Little Red House

The Little Red House
Fairfield
9.6 out of 10, Exceptional, (9 reviews)
"Beautiful house and very clean!!!"
United States
Kelli J.
The price is HK$769
HK$1,642 total
includes taxes & fees
13 Jul - 14 Jul
The Little Red House
Interior

Home Away From Home

Home Away From Home
Biggsville
10.0 out of 10, Exceptional, (2 reviews)
"Our experience all around was good. Communication with host was easy and they worked with us great. House was clean, in a quite neighborhood and definitely better than a hotel."
United States
Thomas A.
The price is HK$800
HK$1,571 total
includes taxes & fees
10 Jul - 11 Jul
Home Away From Home
Living area

Family friendly 3 bedroom home in Kahoka MO

Family friendly 3 bedroom home in Kahoka MO
Kahoka
9.2 out of 10, Wonderful, (12 reviews)
"Absolutely friendly and welcoming hosts. "
United States
Jay M.
The price is HK$1,129
HK$1,723 total
includes taxes & fees
14 Jul - 15 Jul
Family friendly 3 bedroom home in Kahoka MO
TV

Idyllic Biggsville Vacation Rental: 10 Mi to River

Idyllic Biggsville Vacation Rental: 10 Mi to River
Biggsville
10.0 out of 10, Exceptional, (2 reviews)
"We enjoyed our peaceful stay in this clean, beautiful vacation rental. Perfect for a weekend getaway. "
United States
Lisa S.
The price is HK$863
HK$1,775 total
includes taxes & fees
6 Jul - 7 Jul
Idyllic Biggsville Vacation Rental: 10 Mi to River
Smart TV

Family Home in Carthage

Family Home in Carthage
Carthage
10.0 out of 10, Exceptional, (16 reviews)
"Everything about this location was phenomenal! The host was so welcoming. My family loved this stay and we'd love to stay here again. "
United States
Chris A.
The price is HK$1,719
HK$2,653 total
includes taxes & fees
4 Jul - 5 Jul
Family Home in Carthage
Property grounds

Riverview Orchard 1: Mississippi River & Dam View

Riverview Orchard 1: Mississippi River & Dam View
Hamilton
9.6 out of 10, Exceptional, (7 reviews)
"The views were wonderful. Lots of birds to watch. Well stocked kitchen. "
United States
Mary P.
The price is HK$1,255
HK$2,128 total
includes taxes & fees
2 Aug - 3 Aug
Riverview Orchard 1: Mississippi River & Dam View
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Southeast Iowa Hotel Reviews

The Inn at Old Nauvoo

The Inn at Old Nauvoo

10/10 Excellent
"Very good, the breakfast was very good."
Sergio 1-night trip
Posted 7 hours ago
The Inn at Old Nauvoo

Find out more about Southeast Iowa

Southeast Iowa Vacation Homes information

Number of reviews
201
Accommodation
53 Vacation Homes
Lowest Price
HK$1,164
Highest Price
HK$3,097

Explore a world of travel with Expedia