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21C Museum Hotel St Louis

4.5 star property
Contemporary art meets comfort at this downtown St. Louis hotel where travelers can unwind after exploring nearby Busch Stadium and other iconic attractions

Choose dates to view prices

21C Museum Hotel St Louis stands in the heart of the city, offering travelers a refined experience with its indoor pool and fitness center. Guests can book a massage at the spa, play billiards at the bar, or start their day with a cooked-to-order breakfast at the coffee shop.

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet-friendly
  • Free Wi-Fi
  • Air-conditioning
The current price is HK$990
HK$1,197 total
includes taxes & fees
5 Apr - 6 Apr

Room options

Available filters for rooms
Showing 10 of 10 rooms

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Room, 1 King Bed

9.0 out of 10
Wonderful
(88 reviews)

Highlights

Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout curtains
Separate bedroom
Bathrobes
Hairdryer
  • 309 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

In-room safe, desk, laptop workspace, blackout curtains

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(27 reviews)

Highlights

Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout curtains
Separate bedroom
Bathrobes
Private bathroom
  • 423 sq ft
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

In-room safe, desk, laptop workspace, blackout curtains

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)

Highlights

Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout curtains
Bathrobes
Hairdryer
Private bathroom
  • 237 sq ft
  • Sleeps 2
  • 1 Single Bunk Bed

View all photos for Loft, 2 Queen Beds

In-room safe, desk, laptop workspace, blackout curtains

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)

Highlights

Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout curtains
Bathrobes
Hairdryer
Private bathroom
  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Room, Accessible (Accessible)

Highlights

Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout curtains
Bathrobes
Hairdryer
Private bathroom
  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

In-room safe, desk, laptop workspace, blackout curtains

Suite, 1 King Bed (21C)

Highlights

Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout curtains
Separate bath and shower
Deep-soaking bath
Hairdryer
  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

In-room safe, desk, laptop workspace, blackout curtains

Suite, 1 King Bed (Library)

Highlights

Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout curtains
Bathrobes
Hairdryer
Private bathroom
  • City view
  • 732 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

In-room safe, desk, laptop workspace, blackout curtains

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(1 review)

Highlights

Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout curtains
Separate bath and shower
Deep-soaking bath
Hairdryer
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Room, 1 Double Bed, Accessible

Highlights

Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout curtains
Bathrobes
Hairdryer
Private bathroom
  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Suite, 1 Double Bed, Accessible

Highlights

Soundproofed
Air conditioning
Heating
Flat-screen TV
Blackout curtains
Bathrobes
Hairdryer
Private bathroom
  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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About the area

Located in St. Louis, 21C Museum Hotel St Louis is in the city centre. St. Louis Union Station and Gateway Arch are notable landmarks, and the area's natural beauty can be seen at Mississippi River and Forest Park. Check out an event or a game at Busch Stadium, and consider making time for St. Louis Zoo, a top attraction not to be missed. Visit our St. Louis travel guide
Map
1528 Locust street, St. Louis, MO, 63103

What's nearby

  • Washington Avenue Historic District
    Washington Avenue Historic District
    2 min walk - 0.2 km
  • City Museum as well as a small group of people
    City Museum
    5 min walk - 0.4 km
  • Union Station, St. Louis, MO
    St. Louis Union Station
    8 min walk - 0.7 km
  • Aerial view of vibrant downtown St. Louis with Enterprise Center and St. Louis Wheel, St. Louis, Missouri, United States.
    Enterprise Center
    8 min walk - 0.7 km
  • St. Louis Aquarium at Union Station
    11 min walk - 1.0 km

Getting around

  • 8th and Pine Station
    13 min walk
  • St. Louis Gateway Station
    14 min walk
  • Lambert-St. Louis International Airport (STL)
    24 min drive

Restaurants

  • Imo's Pizza Headquarters & Retail Store
    7 min walk
  • Budweiser Kiel Club
    6 min walk
  • Rosalita's Cantina
    6 min walk
  • White Knight Diner
    4 min walk
  • Blood & Sand
    2 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel near Enterprise Center
Located close to St. Louis Union Station and Busch Stadium, 21C Museum Hotel St Louis provides a coffee shop/cafe, dry cleaning/laundry services and a bar. Treat yourself to a massage or other spa services. In addition to a gym and a business centre, guests can connect to free in-room WiFi.
You'll also enjoy the following perks during your stay:
  • An indoor pool
  • Cooked-to-order breakfast (surcharge), valet parking (surcharge) and a lift
  • A vending machine, concierge services and a banquet hall
  • ATM/banking services, a 24-hour front desk and meeting rooms
  • Guest reviews say great things about the dining options, pool and helpful staff
Room features
All 104 rooms include comforts such as laptop-friendly workspaces and air conditioning, as well as perks such as free WiFi and desk chairs. Guest reviews highly rate the cleanliness rooms at the property.
More amenities include:
  • Free toiletries and hairdryers
  • Flat-screen TVs with premium channels
  • Wardrobes/cupboards, heating and daily housekeeping

Awards and affiliations

Eco-certified property
This property participates in Green Key Global – a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Valet parking on site (USD 50 per day; includes in/out privileges)
  • Limited on-site valet parking

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business centre
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Grab bar in shower (89 centimetre high)
  • Handrails in stairways (91 centimetre high)
  • Lever door handles
  • Lift (107 centimetre wide door)
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible registration desk (91 centimetre high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoke-free property

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Dressing gowns
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age - 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets are allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available.
Cots (infant beds) are not available

Payment types at the property

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Does 21C Museum Hotel St Louis have a pool?

Yes, this property has an indoor pool.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of 6 Mar 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on 5 Apr 2026 start from HK$990, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is 21C Museum Hotel St Louis pet-friendly?

Yes, dogs are allowed at this property. There's a fee of USD 100 per accommodation, per stay. Service animals are exempt from fees.

How much is parking at 21C Museum Hotel St Louis ?

Valet parking is available for USD 50 per day.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; check-in end time: 11:00 AM. Late check-in is available during limited hours.

What time is check-out at 21C Museum Hotel St Louis ?

Checkout is at 11:00 AM.

Where is 21C Museum Hotel St Louis located?

Located in Downtown West, this luxury hotel is within a 10-minute walk of Campbell House Museum, St. Louis Union Station, and City Museum. Enterprise Center and America's Center Convention Complex are also within 15 minutes. 8th and Pine Station is 13 minutes by foot and Convention Center Station is 15 minutes.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on selected room rates because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

21C Museum Hotel St Louis Reviews

9.0

Wonderful

9.2

Cleanliness

9.2

Amenities

9.0

Staff & service

9.4

Property conditions & facilities
Rating 10 - Excellent. 1170 out of 1638 reviews
Rating 8 - Good. 249 out of 1638 reviews
Rating 6 - Okay. 111 out of 1638 reviews
Rating 4 - Poor. 49 out of 1638 reviews
Rating 2 - Terrible. 59 out of 1638 reviews

Reviews

10/10 Excellent

Dimitre

Liked: Cleanliness, amenities, property conditions & facilities
Great hotel! Art, food and drinks were fantastic
Stayed 1 night in Jan 2026

10/10 Excellent

Juanita

Liked: Cleanliness, amenities, property conditions & facilities
The rooms were nice and clean. Staff was friendly.
Stayed 1 night in Jan 2026

8/10 Good

Mikel

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great Location, great atmosphere. Drinks and food on the floor level, beautiful artwork is on display.
Stayed 1 night in Jan 2026

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Cool hotel to stay at near enterprise center. Had fun with the penguins and liked the activities in the hotel (museum, pool table, shuffleboard)
Stayed 1 night in Jan 2026

10/10 Excellent

Meredith

Liked: Cleanliness, amenities, property conditions & facilities
Hotel was very quiet and staff helpful and courteous. The coffee shop was great for coffee and breakfast and the rooms were clean with hot water and great water pressure. The only thing I would change was the mattress - bed was very firm, kind of felt like lying on a table. Gallery was a fun feature and next time I'm in STL I will be back!
Stayed 1 night in Jan 2026

10/10 Excellent

Sharon

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Hotel was comfortable, clean and unique. All staff was wonderful
Stayed 3 nights in Dec 2025

10/10 Excellent

London

Liked: Cleanliness, amenities, property conditions & facilities
Room was perfect and parking was a breeze. We really enjoyed the art was wonderful.
Stayed 1 night in Nov 2025

10/10 Excellent

Hannah

Liked: Staff & service, amenities
Disliked: Cleanliness
Great room, good staff and amenities.
Stayed 1 night in Nov 2025

10/10 Excellent

Theresa

Liked: Cleanliness, staff & service, amenities
Clean, quiet and the staff was great!
Stayed 2 nights in Nov 2025

10/10 Excellent

Jemma

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
The food was great, the room was clean and the staff were so nice and accommodating
Stayed 1 night in Oct 2025

10/10 Excellent

Barbara

Liked: Cleanliness, amenities, property conditions & facilities
The room was spotless and the details were beautiful. The hotel was a really fun experience!
Stayed 1 night in Oct 2025

10/10 Excellent

Cory

Liked: Cleanliness, amenities, property conditions & facilities
Very clean nice place. Staff was very nice and helpful
Stayed 2 nights in Dec 2025

10/10 Excellent

Aisha

Liked: Cleanliness, amenities, property conditions & facilities
I really enjoyed my stay. My room was clean and the amenities were amazing. The gym was modern and up to date. The pool and hot tub were perfect and I even took a moment to get in the sauna. I haven't been that relaxed in a long time.
Stayed 2 nights in Dec 2025

10/10 Excellent

Chris

Liked: Cleanliness, amenities, property conditions & facilities
Great staff and clean room
Stayed 2 nights in Nov 2025

10/10 Excellent

Douglas

Liked: Cleanliness, amenities, property conditions & facilities
The entire hotel was fantastic. Beautifully decorated, so much to see. The art gallery was fantastic, the servers at the bar were friendly and phenomenal and just made for a great evening. The food was fantastic. Every inch of the building was well styled and the room was fantastic. Can’t wait to go back! Highly recommend.
Stayed 1 night in Dec 2025

10/10 Excellent

Jenifer

Liked: Cleanliness, amenities, property conditions & facilities
Staff is wonderful. We checked in late after a long journey and they could not have been nicer to us at check in also in the restaurant and bar. We loved the vibe and the location. I’d return again if ever in the area.
Stayed 1 night in Nov 2025

10/10 Excellent

Frank

Liked: Cleanliness, amenities, property conditions & facilities
Awesome hotel. One of the best I've stayed in. However, they need a good chef in both the bar/restaurant and the cafe. Other than the food, it was great.
Stayed 3 nights in Nov 2025

10/10 Excellent

Christopher

Liked: Cleanliness, staff & service, amenities
Beautiful venue; comfortable room; clean; good location.
Stayed 2 nights in Nov 2025

10/10 Excellent

Sheyanne

Liked: Cleanliness, property conditions & facilities
Staff was amazing
Stayed 1 night in Oct 2025

10/10 Excellent

Kristin

Liked: Cleanliness, amenities, property conditions & facilities
Clean rooms, amazing art and unique everything!
Stayed 1 night in Nov 2025

10/10 Excellent

Benjamin

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Amazing pool, great food and drink options, terrific staff.
Stayed 1 night in Aug 2025

10/10 Excellent

Laura

Liked: Cleanliness, staff & service, amenities
Clean room. Yummy dinner. Beautiful artwork.
Stayed 1 night in Nov 2025

8/10 Good

Julie

Liked: Cleanliness, amenities, property conditions & facilities
This hotel is so unique and everyone was so nice! Loved my room (Room 709) however on 2 dates (January 6 and 10), my room was not serviced at all. My towels were still in a pile on the floor when I came back at night. I still had extras so it was okay, but just surprised me. I loved all of the amenities and the bed was very comfortable. Idol Wolf was incredible! Food was so delicious!! Loved going to Good Press in the morning too! The Black Walnut Latte was so good!
Stayed 7 nights in Jan 2026

10/10 Excellent

Megan

Liked: Cleanliness, property conditions & facilities, room comfort
Incredible lofted ceilings - detailed and thoughtful way to engage with a relaxing and business experience.
Stayed 3 nights in Nov 2025

10/10 Excellent

JeTaun

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
My stay was nice and comfortable. The staff was very courteous
Stayed 3 nights in Sep 2025