A coastal landscape with clear turquoise waters, rocky hills, and a distant mountain range.

Samos Prefecture 5 Stars Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check availability on Samos Prefecture 5 Star Hotels

Tonight
23 Oct - 24 Oct
Tomorrow
24 Oct - 25 Oct
This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

Our top choices for Samos Prefecture 5-star hotels

1. Casa Cook Samos

Casa Cook Samos
Samos
United States
ercan
HK$1,997
HK$2,319 total
includes taxes & fees
27 Oct - 28 Oct
Casa Cook Samos

2. Proteas Blu Resort - Adults Only

Proteas Blu Resort - Adults Only
Samos
Germany
Artsem
Proteas Blu Resort - Adults Only

3. Doryssa Seaside Resort

Doryssa Seaside Resort
Samos
United States
Athanasios
Doryssa Seaside Resort

4. Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)

Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
Samos
HK$1,228
HK$1,477 total
includes taxes & fees
29 Oct - 30 Oct
Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Samos Prefecture.
Hydrele Beach Hotel

Hydrele Beach Hotel

Potokaki beach, Pythagorion Samos Samos island
Get ratesHydrele Beach Hotel
Samian Mare Hotel Suites & Spa

Samian Mare Hotel Suites & Spa

Kanari 123 Samos Samos Island
HK$679
HK$832 total
27 Oct - 28 Oct
includes taxes & fees
9.2/10 Wonderful! (37 reviews)
Samian Mare Hotel Suites & Spa
Doryssa Theorem Hotel

Doryssa Theorem Hotel

Pythagoreio Samos Samos Island
Get ratesDoryssa Theorem Hotel
Still don't see what you're looking for?
See all properties in Samos Prefecture.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Samos Prefecture

Explore attractions like Balos Beach and Lemonakia Beach as you discover things to see and do in Samos Prefecture.

See all hotels in Samos Prefecture
A beach with blue chairs and a hammock overlooking the sea.
Photo by Erdem Yücel

Top Samos Prefecture Hotel Reviews

Explore a world of travel with Expedia