South Main hotels in Houston
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Our top choices for South Main hotels
1. Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.8 out of 10, Excellent, (1,000 reviews)
"Very good all around. Very close to the stadium."
marty
The price is HK$663
HK$776 total
includes taxes & fees
8 Aug - 9 Aug
2. Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,352 reviews)
"Location"
Gurgen
The price is HK$720
HK$842 total
includes taxes & fees
2 Aug - 3 Aug
3. Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Good parking"
joseph
The price is HK$660
HK$772 total
includes taxes & fees
19 Jul - 20 Jul
4. Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (886 reviews)
"This place had"
Marvin
The price is HK$476
HK$556 total
includes taxes & fees
2 Aug - 3 Aug
5. Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,006 reviews)
"convenient to medical center"
Mike
The price is HK$460
HK$538 total
includes taxes & fees
17 Aug - 18 Aug
6. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,592 reviews)
"Clean room, great breakfast and friendly staff."
Sonya
The price is HK$990
HK$1,165 total
includes taxes & fees
1 Aug - 2 Aug
7. Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,830 reviews)
"Great Stay!"
Cairo
The price is HK$1,157
HK$1,353 total
includes taxes & fees
1 Aug - 2 Aug
8. Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,259 reviews)
"Always very friendly and accommodating. Superior transportation support to and from hotel. Excellent breakfast"
Theresa
The price is HK$990
HK$1,165 total
includes taxes & fees
2 Aug - 3 Aug
9. The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,155 reviews)
"The customer service is amazing from the valet to the front desk"
Tanasia
The price is HK$1,334
HK$1,660 total
includes taxes & fees
1 Aug - 2 Aug
10. Hotel Ylem
Hotel Ylem2.3 km from South Main
8.4 out of 10, Very good, (1,532 reviews)
"Nice stay and great staff"
Alelia
The price is HK$587
HK$727 total
includes taxes & fees
8 Aug - 9 Aug
11. Home2 Suites by Hilton Houston Medical Center, TX
Home2 Suites by Hilton Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
9.4 out of 10, Exceptional, (696 reviews)
"Friendly staff, clean rooms, and great buffet breakfast."
Sebastian
The price is HK$1,022
HK$1,196 total
includes taxes & fees
26 Jul - 27 Jul
12. Hilton Garden Inn Houston Medical Center, TX
Hilton Garden Inn Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
9.2 out of 10, Wonderful, (1,002 reviews)
"The staff was very accommodating and the place was very clean."
Donald
The price is HK$894
HK$1,046 total
includes taxes & fees
6 Aug - 7 Aug
13. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (2,037 reviews)
"Great place to stay at super clean and nice area and everything was nearby"
Marvin
The price is HK$855
HK$1,009 total
includes taxes & fees
16 Aug - 17 Aug
14. DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway Plaza6.6 km from South Main
8.4 out of 10, Very good, (1,730 reviews)
"Excellent place to stay with family"
Fahad
The price is HK$717
HK$838 total
includes taxes & fees
1 Aug - 2 Aug
15. Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (353 reviews)
"Clean quiet rooms nice breakfast great staff"
Keitha
The price is HK$670
HK$784 total
includes taxes & fees
23 Jul - 24 Jul
16. Holiday Inn Express Houston - Galleria Area by IHG
Holiday Inn Express Houston - Galleria Area by IHGThe Galleria, 8.6 km from South Main
9.4 out of 10, Exceptional, (1,004 reviews)
"Everything about our stay was excellent. We were there for a business conference and would definitely return for business or a leisure get away."
Marilu
The price is HK$980
HK$1,147 total
includes taxes & fees
30 Jul - 31 Jul
17. Drury Inn & Suites Houston Near the Galleria
Drury Inn & Suites Houston Near the GalleriaThe Galleria, 9.4 km from South Main
9.4 out of 10, Exceptional, (1,480 reviews)
"It was a great hotel clean good food and lively staff"
Kesley
The price is HK$737
HK$862 total
includes taxes & fees
3 Aug - 4 Aug
18. Hyatt Place Houston/Galleria
Hyatt Place Houston/Galleria8.7 km from South Main
8.8 out of 10, Excellent, (1,539 reviews)
"Excellent stay!!!"
Loukisha
The price is HK$792
HK$932 total
includes taxes & fees
24 Jul - 25 Jul
19. Hyatt Regency Houston/Galleria
Hyatt Regency Houston/Galleria8.7 km from South Main
9.2 out of 10, Wonderful, (1,406 reviews)
"Great location, very friendly staff and comfortable bed!"
Iden
The price is HK$1,168
HK$1,376 total
includes taxes & fees
25 Jul - 26 Jul
20. The Royal Sonesta Houston Galleria
The Royal Sonesta Houston GalleriaThe Galleria, 8.8 km from South Main
8.6 out of 10, Excellent, (2,124 reviews)
"The property is really nice and the staff is really friendly"
Fransheska
The price is HK$1,129
HK$1,321 total
includes taxes & fees
19 Jul - 20 Jul
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.8 Excellent 1,000 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 886 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,006 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,001 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,352 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
