South Main hotels in Houston
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Our top choices for South Main hotels
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,004 reviews)
"Good parking"
joseph
The price is HK$619
HK$724 total
includes taxes & fees
4 Jun - 5 Jun
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,001 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
Cleota
The price is HK$797
HK$932 total
includes taxes & fees
6 Jun - 7 Jun
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,286 reviews)
"Would stay again!"
Austin
The price is HK$1,560
HK$1,825 total
includes taxes & fees
18 Jun - 19 Jun
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (867 reviews)
"My stay was perfect "
Fredrick
The price is HK$823
HK$963 total
includes taxes & fees
7 Jun - 8 Jun
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is HK$606
HK$709 total
includes taxes & fees
6 Jun - 7 Jun
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,218 reviews)
"Wonderful place to stay!"
Lisa
The price is HK$926
HK$1,083 total
includes taxes & fees
7 Jun - 8 Jun
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (267 reviews)
"Clean room, and very helpful staff actually enjoyed our stay"
Jessica
The price is HK$776
HK$908 total
includes taxes & fees
5 Jun - 6 Jun
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.6 out of 10, Exceptional, (91 reviews)
"The property was very clean and the staff was great. I would stay here again when back in town."
Cruz
The price is HK$486
HK$568 total
includes taxes & fees
7 Jun - 8 Jun
Hotel Royale
Hotel Royale20.9 km from South Main
9.2 out of 10, Wonderful, (40 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is HK$635
HK$743 total
includes taxes & fees
4 Jun - 5 Jun
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.0 out of 10, Wonderful, (70 reviews)
"We loved it, very nice employees and very clean."
Jorge
The price is HK$691
HK$809 total
includes taxes & fees
5 Jun - 6 Jun
Crystal Inn Northeast Houston Downtown I-610
Crystal Inn Northeast Houston Downtown I-610Northside, 18.9 km from South Main
8.4 out of 10, Very good, (208 reviews)
"Great price and nice rooms"
Armando
The price is HK$529
HK$619 total
includes taxes & fees
5 Jun - 6 Jun
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,010 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
Albert
The price is HK$823
HK$963 total
includes taxes & fees
8 Jun - 9 Jun
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,007 reviews)
"This was a great stay. We liked the suite, would have liked a microwave in there."
Sara
The price is HK$924
HK$1,091 total
includes taxes & fees
7 Jun - 8 Jun
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,196 reviews)
"The room was clean, staff was friendly, breakfast was great, and the area and location was nice and quiet."
Dr. Cherie
The price is HK$659
HK$758 total
includes taxes & fees
8 Jun - 9 Jun
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,908 reviews)
"Nice overnight stay. Great for close to airport!!!"
Jaime
The price is HK$843
HK$992 total
includes taxes & fees
10 Jun - 11 Jun
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (175 reviews)
"It was very clean"
Jesus
Downtowner Inns - Houston Downtown
Downtowner Inns - Houston DowntownMidtown, 9.1 km from South Main
9.2 out of 10, Wonderful, (156 reviews)
"Great place. The staff is very friendly and the place is clean."
Fernando
The price is HK$752
HK$880 total
includes taxes & fees
4 Jun - 5 Jun
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,004 reviews)
"Definitely will stay here again. Great location near Great Wolf Lodge."
Deanndra
The price is HK$894
HK$1,046 total
includes taxes & fees
7 Jun - 8 Jun
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,798 reviews)
"Gorgeous, perfect location, super comfy beds"
Caitlin
The price is HK$1,129
HK$1,320 total
includes taxes & fees
8 Jun - 9 Jun
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.0 out of 10, Very good, (2,063 reviews)
"Clean convenient close to airport and food"
Brian
The price is HK$726
HK$850 total
includes taxes & fees
8 Jun - 9 Jun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,001 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 867 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,286 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,004 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,001 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
The Royal Sonesta Houston Galleria
2/10 Terrible
