Photo by Mark Rentz

Isla Santa María Holiday Rentals

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Check prices for these dates

In two weeks
16 Jan - 18 Jan
In two months
27 Feb - 1 Mar
In three months
27 Mar - 29 Mar
In four months
24 Apr - 26 Apr

Our top choices for Isla Santa María holiday rentals

Terrace/patio
Torre Mar Galapagos Boutique Suites

Aparthotel in Puerto Ayora

Torre Mar Galapagos Boutique Suites
3.0 star property
9.0 out of 10, Wonderful, (16)
"Great room and a very walkable location. John was a fantastic host, has given me his whatsapp on day one and stayed in communication the whole time."
United States
Samuel
Torre Mar Galapagos Boutique Suites
Balcony
Galapagos Coliving Ecuador Casa Tuna

Apartment in Puerto Ayora

Galapagos Coliving Ecuador Casa Tuna
3.0 star property
Galapagos Coliving Ecuador Casa Tuna
TV, books
Torre Mar Galapagos Villa

Villa in Puerto Ayora, Santa Cruz Island

Torre Mar Galapagos Villa
2.0 star property
10.0 out of 10, Exceptional, (1)
"We had a very nice time staying at Torre Mar. It was very conveniently located. We were 5 families...me (the mom) and my 4 kids, their spouses and 6 grandkids. Everyone had their own "suite". The advertising is a little confusing. I thought we were renting a "home", and then realized it was an apartment/hotel....but as I said, it was very nice for each family to have private space. The owner John was very friendly, although we did have some miscommunication issues, which is interesting...
United States
Betty A.
Torre Mar Galapagos Villa
Terrace/patio
¡Bienvenido a tu hogar isleño en Galápagos!

Apartment in Puerto Ayora

¡Bienvenido a tu hogar isleño en Galápagos!
The price is HK$637
HK$793 total
20 Jan - 21 Jan 2026
¡Bienvenido a tu hogar isleño en Galápagos!
Terrace/patio
Casa Vacacional en Puerto Ayora, Santa Cruz, Galápagos

Holiday Home in Puerto Ayora

Casa Vacacional en Puerto Ayora, Santa Cruz, Galápagos
10.0 out of 10, Exceptional, (1)
"Nice and beautiful house to stay very impressed "
United States
John
The price is HK$700
HK$855 total
4 Jan - 5 Jan 2026
Casa Vacacional en Puerto Ayora, Santa Cruz, Galápagos
Interior
Charming studio in Puerto Ayora with all the services for a comfortable stay

Apartment in Puerto Ayora

Charming studio in Puerto Ayora with all the services for a comfortable stay
Charming studio in Puerto Ayora with all the services for a comfortable stay
Microwave, oven
Jardin de Galápagos.

Holiday Home in Galápagos Islands

Jardin de Galápagos.
The price is HK$525
HK$938 total
5 Jan - 6 Jan 2026
Jardin de Galápagos.
Property grounds
Two Bedroom house - The Galapagos Pearl Hotel

Holiday Home in Puerto Ayora

Two Bedroom house - The Galapagos Pearl Hotel
10.0 out of 10, Exceptional, (1)
"We stayed 3 nights in the "casa grande" associated with the Galapagos Pearl Hotel and could not have been more pleased. The casa has 2 bedrooms, a small kitchen, one bathroom, and is conveniently located right next to the pool and the outdoor dining area where Yolanda serves breakfast. Your room is cleaned every day. The garden surrounding the pool and casa is lush and full of geckos, cats, and beautiful plantings. Yolanda is from the Galapagos, she is a wonderful host and her daughter helped us...
United States
Laura E.
Two Bedroom house - The Galapagos Pearl Hotel
1 bedroom, iron/ironing board, WiFi, bed sheets
GALAPAGOS DIVER ESTUDIO.

Apartment in Puerto Ayora

GALAPAGOS DIVER ESTUDIO.
10.0 out of 10, Exceptional, (1)
"Perfect start to finish. Very clean! Drinking water provided. The host helped us with a small hiccup regarding our transfer so we were able to catch the ferry to San Cristóbal with no problem. Highly recommend!"
United States
Shannyn Z.
The price is HK$428
HK$700 total
24 Jan - 25 Jan 2026
GALAPAGOS DIVER ESTUDIO.
2 bedrooms, desk, free WiFi, bed sheets
This two-bedroom is a perfect island getaway.

Apartment in Puerto Ayora, Santa Cruz Island

This two-bedroom is a perfect island getaway.
8.8 out of 10, Excellent, (5)
"Donna communicated with us before our trip to provide information about arrival and to offer transportation assistance from the airport. Once we were there she offered to arrange tours, suggest dining places and made reservations for us. She did everything she could to make our stay easy and enjoyable. On one of the tours she was our guide. That was so helpful."
United States
Cynthia H.
The price is HK$1,205
HK$1,557 total
19 Jan - 20 Jan 2026
This two-bedroom is a perfect island getaway.
Terrace/patio
Cozy 2-bedroom apartment in charming Puerto Ayora with AC, WiFi

Apartment in Puerto Ayora

Cozy 2-bedroom apartment in charming Puerto Ayora with AC, WiFi
The price is HK$637
HK$793 total
2 Jan - 3 Jan 2026
Cozy 2-bedroom apartment in charming Puerto Ayora with AC, WiFi
Marina
2 Suites Equipadas Para que tu Estancia sea Confortable,ven Galápagos Up Suites

Apartment in Puerto Ayora

2 Suites Equipadas Para que tu Estancia sea Confortable,ven Galápagos Up Suites
2 Suites Equipadas Para que tu Estancia sea Confortable,ven Galápagos Up Suites
1 bedroom, free WiFi, bed sheets
Ocean view Penthouse

Apartment in Puerto Ayora, Santa Cruz Island

Ocean view Penthouse
2.0 star property
10.0 out of 10, Exceptional, (1)
"We enjoyed our stay. The air conditioning was a welcome retreat after a day spent exploring. The views are amazing. "
United States
Greta S.
The price is HK$1,244
HK$1,586 total
28 Jan - 29 Jan 2026
Ocean view Penthouse
TV, books
Spacious two-bedroom suite with a balcony

Apartment in Puerto Ayora, Santa Cruz Island

Spacious two-bedroom suite with a balcony
2.0 star property
10.0 out of 10, Exceptional, (22)
"Great place to stay with great hosts who were very accommodating. Very walkable to all the places or a short taxi anywhere for 1.50. Would highly recommend."
United States
Jon g.
The price is HK$1,477
HK$1,854 total
28 Jan - 29 Jan 2026
Spacious two-bedroom suite with a balcony
TV, books
The Oceanview two-bedroom with balcony

Apartment in Puerto Ayora, Santa Cruz Island

The Oceanview two-bedroom with balcony
10.0 out of 10, Exceptional, (25)
"Excellent place to stay. Walking distance to everything. A small panderia (bakery) a block away has the best croissants for breakfast. Donna and team are phenomenal."
United States
Richard L.
The price is HK$1,478
HK$1,910 total
9 Jan - 10 Jan 2026
The Oceanview two-bedroom with balcony
Terrace/patio
2-bedroom apartment with AC, WiFi in fabulous Puerto Ayora

Apartment in Puerto Ayora

2-bedroom apartment with AC, WiFi in fabulous Puerto Ayora
2-bedroom apartment with AC, WiFi in fabulous Puerto Ayora
Private kitchen
FAMILY SUITE in Puerto Ayora

Apartment in Puerto Ayora

FAMILY SUITE in Puerto Ayora
2.0 star property
10.0 out of 10, Exceptional, (1)
"Great lodging with effective space for multiple groups of travelers. Location is perfect, off the tourist path, and easy to access by any taxis in Puerto Arroyo (just say you want to go to Parque Cascada). Groceries are available anywhere near the house, better produce quality found in the shops on Baltra Ave. Property manager is easy to communicate with and responds instantly."
United States
Nathan M.
The price is HK$1,555
HK$1,765 total
1 Jan - 2 Jan 2026
FAMILY SUITE in Puerto Ayora
Property grounds
Endemic Suite - Apartamento con Azotea Vista 360

Apartment in Puerto Ayora

Endemic Suite - Apartamento con Azotea Vista 360
The price is HK$505
HK$661 total
6 Jan - 7 Jan 2026
Endemic Suite - Apartamento con Azotea Vista 360
Outdoor dining
Island Life Two-Bedroom Galapagos Casita

Holiday Home in Puerto Ayora

Island Life Two-Bedroom Galapagos Casita
10.0 out of 10, Exceptional, (3)
"We had a great time and are grateful to John and Donna for hosting us. The casita was very comfortable and quiet. Great wifi and air conditioning for when we needed to relax. Thank you again!"
Canada
Victoria K.
The price is HK$1,205
HK$1,557 total
4 Jan - 5 Jan 2026
Island Life Two-Bedroom Galapagos Casita
Dishwasher, cookware/dishes/utensils, dining tables
Galarous island apartments

Aparthotel in Puerto Ayora

Galarous island apartments
The price is HK$855
HK$1,011 total
3 Jan - 4 Jan 2026
Galarous island apartments
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Isla Santa María Hotel Reviews

Fernandina Hotel & Spa Galápagos

Fernandina Hotel & Spa Galápagos

10/10 Excellent
"We loved our stay there, near many attractions that you can easily walk to or take the taxi for ~$2 dollars to the Darwin Research Station/Pier or more if further away, staff were friendly & accommodating. Breakfasts was delicious & our rooms were newly renovated (you can ask if are available). We love that they have a pool, hot tub, ping pong table, spa, water dispensers, outdoor tables for gathering/reading/dining & ice available upon requests. Unforgettable journeys & escape home in Galapagos!! We definitely recommend & would love to return if extra blessings permits. "
Victoria 3-night trip
Posted 4 days ago
Fernandina Hotel & Spa Galápagos

Find out more about Isla Santa María

Search for holiday rentals in Isla Santa María on Expedia! You can easily find your home rentals, villas, holiday apartments in Isla Santa María using one of the methods below:

  • View our selection of featured holiday rentals in Isla Santa María
  • Use the map to find apartments and other holiday homes in the Isla Santa María neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Isla Santa María while they last

Look no further and take a look at our great range of rental properties in Isla Santa María!

Frequently asked questions

Can I find holiday rentals in Isla Santa María?

Yes, there are holiday rentals in Isla Santa María close to Galápagos National Park, or you can select a more secluded option if you're looking for a relaxing stay.

What are some of the best holiday rentals that Isla Santa María has to offer?

Villa Galapagos: This holiday home rental outside of Isla Santa María is located near the beach, and offers a private garden, air conditioning and daily housekeeping to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop and a microwave.

What’s there to see and do in Isla Santa María?

Family-friendly attractions include Galápagos National Park, whereas Post Office Bay is a spot to enjoy the outdoors. Other places in town to visit include Punta Suarez.

What’s a holiday rental in Isla Santa María like?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in Isla Santa María. Holiday rentals offer amenities such as laundry facilities and kitchens so you'll feel just like you're staying in your own home. If you're concerned about cleanliness, holiday rentals can offer a sense of seclusion away from public hotel lifts and busy concierge desks while still allowing you the experience of travel. You'll also have more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a great option for a family trip.