Otay Mesa hotels in San Diego
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Our top choices for Otay Mesa hotels
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.0 out of 10, Very good, (1,591 reviews)
"Great place to stay. Really clean and helpful staff "
Zulma
The price is HK$928
HK$1,055 total
includes taxes & fees
25 Jan - 26 Jan
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay MesaOtay Mesa
7.2 out of 10, Good, (1,003 reviews)
"Clean, convenient location "
Mary
The price is HK$773
HK$879 total
includes taxes & fees
25 Jan - 26 Jan
Wyndham San Diego Bayside
Wyndham San Diego Bayside25.7 km from Otay Mesa
8.4 out of 10, Very good, (5,987 reviews)
"The room was clean, staff friendly "
Samuel Clyde
The price is HK$1,054
HK$1,493 total
includes taxes & fees
18 Jan - 19 Jan
Paradise Point Resort & Spa
Paradise Point Resort & SpaMission Bay, 34.5 km from Otay Mesa
8.6 out of 10, Excellent, (2,369 reviews)
"Great facility and amenities. We look forward to taking our family back again. "
Andy
The price is HK$802
HK$1,335 total
includes taxes & fees
19 Jan - 20 Jan
The Bristol Hotel San Diego
The Bristol Hotel San Diego24.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,478 reviews)
"I loved my stay here"
José
The price is HK$1,178
HK$1,366 total
includes taxes & fees
27 Jan - 28 Jan
Sycuan Casino Resort
Sycuan Casino Resort28.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1,672 reviews)
"Very clean resort. "
Petrina
The Sofia Hotel
The Sofia Hotel24.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,695 reviews)
"Great location and history to the hotel "
Stephanie
San Diego Mission Bay Resort
San Diego Mission Bay ResortMission Bay, 33.1 km from Otay Mesa
8.4 out of 10, Very good, (1,335 reviews)
"Loved the bay front room with the large grass area right out the door!"
Todd and Danielle
The price is HK$1,186
HK$1,775 total
includes taxes & fees
2 Feb - 3 Feb
The Dana on Mission Bay
The Dana on Mission BayMission Bay, 33.8 km from Otay Mesa
9.0 out of 10, Wonderful, (3,989 reviews)
"We had a wonderful stay!"
Megan
The price is HK$1,162
HK$1,515 total
includes taxes & fees
14 Jan - 15 Jan
Staypineapple, Hotel Z, Gaslamp San Diego
Staypineapple, Hotel Z, Gaslamp San DiegoGaslamp Quarter, 24.2 km from Otay Mesa
9.4 out of 10, Exceptional, (1,000 reviews)
"An excellent stay in an excellent area! Super clean and staff is very nice."
Emily
The price is HK$554
HK$868 total
includes taxes & fees
26 Jan - 27 Jan
Hyatt Regency Mission Bay Spa and Marina
Hyatt Regency Mission Bay Spa and MarinaMission Bay, 33.9 km from Otay Mesa
8.4 out of 10, Very good, (1,602 reviews)
"Beautiful grounds with lots of activities for all ages."
Brandon
The price is HK$1,240
HK$1,837 total
includes taxes & fees
22 Jan - 23 Jan
Best Western Plus Island Palms Hotel & Marina
Best Western Plus Island Palms Hotel & Marina29.3 km from Otay Mesa
8.8 out of 10, Excellent, (1,584 reviews)
"Great place.very clean great for family would definitely stay there again."
Joseph
The price is HK$1,035
HK$1,190 total
includes taxes & fees
28 Jan - 29 Jan
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld31.3 km from Otay Mesa
7.4 out of 10, Good, (4,135 reviews)
"Get location to the airport, safe, great staff, & overall wonderful stay"
Tyler
The price is HK$659
HK$758 total
includes taxes & fees
28 Jan - 29 Jan
Courtyard by Marriott San Diego Mission Valley/Hotel Circle
Courtyard by Marriott San Diego Mission Valley/Hotel Circle28.8 km from Otay Mesa
8.4 out of 10, Very good, (1,454 reviews)
"Nice location, confortable hotel"
Anna Maria
The price is HK$805
HK$925 total
includes taxes & fees
25 Jan - 26 Jan
The DEXTRO Little Italy, BW Premier Collection
The DEXTRO Little Italy, BW Premier Collection25.4 km from Otay Mesa
9.0 out of 10, Wonderful, (900 reviews)
"Great stay. Would definitely stay again."
Zoraima
The price is HK$861
HK$998 total
includes taxes & fees
22 Jan - 23 Jan
Handlery Hotel
Handlery Hotel29.1 km from Otay Mesa
8.2 out of 10, Very good, (2,285 reviews)
"Room and staff were excellent"
Bryant
Palihotel San Diego Gaslamp Quarter
Palihotel San Diego Gaslamp QuarterGaslamp Quarter, 24.5 km from Otay Mesa
8.6 out of 10, Excellent, (2,178 reviews)
"Excellent location, wonderful staff."
phuc
The price is HK$1,006
HK$1,166 total
includes taxes & fees
14 Jan - 15 Jan
Best Western Yacht Harbor Hotel
Best Western Yacht Harbor Hotel29.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,676 reviews)
"Spotless room, nice staff, great breakfast"
DAVID
The price is HK$742
HK$852 total
includes taxes & fees
18 Jan - 19 Jan
Loews Coronado Bay Resort
Loews Coronado Bay Resort17.2 km from Otay Mesa
8.8 out of 10, Excellent, (1,062 reviews)
"The staff and amenities were spectacular. "
Andrew
The price is HK$1,552
HK$2,103 total
includes taxes & fees
8 Feb - 9 Feb
Courtyard by Marriott San Diego Downtown Little Italy
Courtyard by Marriott San Diego Downtown Little ItalyLittle Italy, 25.5 km from Otay Mesa
8.8 out of 10, Excellent, (233 reviews)
"Great place to stay "
Jacorey
The price is HK$1,162
HK$1,347 total
includes taxes & fees
19 Jan - 20 Jan
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Gaslamp Quarter
San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.
Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Ocean Beach
Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Ocean Beach Farmers Market.
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