Photo by Abbie Moon

Vacation Homes in Scott County

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
12 Dec - 14 Dec
In two weeks
19 Dec - 21 Dec
In one month
2 Jan - 4 Jan
In two months
30 Jan - 1 Feb

Top Cities in Scott County

Vacation HomesVacation Homes

Sikeston

Sikeston

Featured Vacation Homes in Scott County

Exterior
Quaint, Beautiful Home next to SEMO and Hospital

Quaint, Beautiful Home next to SEMO and Hospital

Cape Girardeau
9.8 out of 10, Exceptional, (42)
"Location was perfect. The house was clean and met all our needs. Would definitely stay here again in the future."
United States
Beau L.
Quaint, Beautiful Home next to SEMO and Hospital
Exterior
Magical Victorian near hiking / wine trail

Magical Victorian near hiking / wine trail

Anna
10.0 out of 10, Exceptional, (4)
"The house was beautiful! We were in awe of the decor and layout. This is a must-stay if you are in southern Illinois!"
United States
Lori C.
The price is HK$1,618
HK$2,954 total
includes taxes & fees
6 Jan - 7 Jan 2026
Magical Victorian near hiking / wine trail
Fridge, microwave, oven, stovetop
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

Cape Girardeau
10.0 out of 10, Exceptional, (28)
"Great property and a super host! He was super helpful and always willing to help with any questions we had. Would definitely rent here again!"
United States
Mark M.
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau
Exterior
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Cape Girardeau
8.8 out of 10, Excellent, (34)
"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "
United States
Emily D.
The price is HK$1,051
HK$1,687 total
includes taxes & fees
7 Dec - 8 Dec
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Interior
Little Blue Cottage on Spanish

Little Blue Cottage on Spanish

Cape Girardeau
8.6 out of 10, Excellent, (48)
"Some issues with check-in. Very nice area. Lot of history."
United States
Jeffrey M.
The price is HK$630
HK$786 total
includes taxes & fees
15 Dec - 16 Dec
Little Blue Cottage on Spanish
Property grounds
Need a cozy winter getaway or base camp for duck and deer hunters? We got you!

Need a cozy winter getaway or base camp for duck and deer hunters? We got you!

2.0 star property
Tamms
10.0 out of 10, Exceptional, (23)
"Great place to stay, nice people"
United States
Jack W.
Need a cozy winter getaway or base camp for duck and deer hunters? We got you!
Microwave, oven, stovetop, dishwasher
3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (3)
"Cute place, clean and spacious. Convenient location. Very nice stay! Would stay again. "
United States
Rebecca E.
3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau
Fridge, microwave, oven, stovetop
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Cape Girardeau
10.0 out of 10, Exceptional, (148)
"Such a great place and location"
United States
Tracy H.
The price is HK$1,167
HK$1,906 total
includes taxes & fees
6 Jan - 7 Jan 2026
Serenity South -- Gardens, River-Views, and Refreshing Space
Exterior
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Cape Girardeau
9.6 out of 10, Exceptional, (7)
"Nice place, great times"
United States
Jace W.
The price is HK$2,095
HK$3,406 total
includes taxes & fees
7 Dec - 8 Dec
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Fridge, microwave, oven, stovetop
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi

Cape Girardeau
10.0 out of 10, Exceptional, (10)
"A large and comfortable house with cool historical details and just about everything you need to have a great, easy, smooth-running vacation. Great location for downtown exploring."
United States
Virginia C.
Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi
Dining
Next Door to Mercy Hospital - Pet Friendly - Fast Wifi

Next Door to Mercy Hospital - Pet Friendly - Fast Wifi

Cape Girardeau
8.0 out of 10, Very good, (5)
"Great place for our family to have a quick get together in short notice."
United States
Red Bear Den
Next Door to Mercy Hospital - Pet Friendly - Fast Wifi
Interior
Charming 3-bedroom house near downtown

Charming 3-bedroom house near downtown

2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (2)
"My husband and I along with one other couple stayed here while in Cape for a wedding. The location was nice and was a short distance for driving or Ubering around town. The price was great!! Highly recommend."
United States
Danielle U.
Charming 3-bedroom house near downtown
Smart TV, fireplace, stereo
Dexter Homestead. Very Cozy & NEW Remodel !

Dexter Homestead. Very Cozy & NEW Remodel !

Dexter
8.0 out of 10, Very good, (26)
"A weekin Dexter at this old, charming house. "
United States
Susan R.
The price is HK$771
HK$1,605 total
includes taxes & fees
22 Dec - 23 Dec
Dexter Homestead. Very Cozy & NEW Remodel !
Fridge, microwave, oven, stovetop
Charming 2-bedroom house in delightful Jackson with AC, WiFi

Charming 2-bedroom house in delightful Jackson with AC, WiFi

Jackson
10.0 out of 10, Exceptional, (5)
"Nice clean property second stay."
United States
Jeffrey S.
Charming 2-bedroom house in delightful Jackson with AC, WiFi
Fridge, microwave, oven, stovetop
Urban 2-bedroom Escape in Downtown Cape Girardeau

Urban 2-bedroom Escape in Downtown Cape Girardeau

Cape Girardeau
10.0 out of 10, Exceptional, (9)
"Great house in a great location. Well-stocked kitchen with some thoughtful extras. You can tell that the owner cares which means a lot to someone originally from Cape. 10/10 would stay again."
United States
Elizabeth C.
Urban 2-bedroom Escape in Downtown Cape Girardeau
Fridge, microwave, oven, stovetop
A Storybook Christmas Stay in an 1847 Historic Riverfront Home

A Storybook Christmas Stay in an 1847 Historic Riverfront Home

Cape Girardeau
9.6 out of 10, Exceptional, (15)
"Wonderful older house with great updates! Beds were comfortable and the yard lovely. "
United States
Sylvia H.
A Storybook Christmas Stay in an 1847 Historic Riverfront Home
Fridge, microwave, oven, stovetop
Large Home next to Southeast Hospital - 2 King Beds - Fast Wifi

Large Home next to Southeast Hospital - 2 King Beds - Fast Wifi

Cape Girardeau
10.0 out of 10, Exceptional, (4)
"The property was nice, spacious, and easy access to everything! We enjoyed our stay!"
United States
Abby T.
Large Home next to Southeast Hospital - 2 King Beds - Fast Wifi
Fridge, microwave, oven, stovetop
Steps to Southeast Hospital - Fast Wifi - King Bed

Steps to Southeast Hospital - Fast Wifi - King Bed

Cape Girardeau
10.0 out of 10, Exceptional, (6)
"Great place and in a great location close to everything"
United States
Tina C.
Steps to Southeast Hospital - Fast Wifi - King Bed
Interior
Country Setting & Views - Garage Parking - Fast Wifi

Country Setting & Views - Garage Parking - Fast Wifi

Jackson
8.0 out of 10, Very good, (1)
"Very nice property in a very nice location. Overall a nice place to stay. Pros: 1) House by itself on a large piece of land 2) Very quiet and peaceful 3)House is large with plenty of room 4) Nicely remodeled with very nice furnishings 5) The one bed we slept on was very comfortable 6) Amazing view of the sun coming up over the hill in the mornings Cons: 1) Although newly remodeled, it's still a very old house and the old house smell is crazy strong. I mean VERY strong 2) The smart thermostat...
United States
Alex M.
Country Setting & Views - Garage Parking - Fast Wifi
Interior
Charming 2-bedroom with AC, WiFi in lovely Jonesboro

Charming 2-bedroom with AC, WiFi in lovely Jonesboro

Jonesboro
10.0 out of 10, Exceptional, (3)
"great place. wonderful host."
United States
Carla m.
The price is HK$859
HK$1,983 total
includes taxes & fees
7 Dec - 8 Dec
Charming 2-bedroom with AC, WiFi in lovely Jonesboro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Scott County Hotel Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
Brian 1-night trip
Posted 4 days ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Find out more about Scott County

Scott County Vacation Homes information

Number of reviews
397
Accommodation
36 Vacation Homes
Lowest Price
HK$786
Highest Price
HK$3,406