South Main hotels in Houston
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Our top choices for South Main hotels
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (837 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
Myra
The price is HK$679
HK$794 total
includes taxes & fees
2 Apr - 3 Apr
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,003 reviews)
"Clean room, helpful staff and good location to hospital."
George
The price is HK$845
HK$989 total
includes taxes & fees
31 Mar - 1 Apr
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,002 reviews)
"Courteous staff, clean room, quite property"
Javier
The price is HK$541
HK$633 total
includes taxes & fees
3 Apr - 4 Apr
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Easy access to stadium "
Richard
The price is HK$546
HK$639 total
includes taxes & fees
23 Mar - 24 Mar
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,231 reviews)
"Front desk staff was very professional and kind."
MARINA
The price is HK$780
HK$913 total
includes taxes & fees
23 Mar - 24 Mar
Spark by Hilton Pearland
Spark by Hilton Pearland13.4 km from South Main
8.8 out of 10, Excellent, (1,002 reviews)
"Clean room very friendly and helpful staff. "
Lisa
The price is HK$771
HK$872 total
includes taxes & fees
2 Apr - 3 Apr
Fairfield Inn & Suites Houston Intercontinental Airport
Fairfield Inn & Suites Houston Intercontinental Airport30.6 km from South Main
8.6 out of 10, Excellent, (1,004 reviews)
"Great place, nice room"
Lester
The price is HK$657
HK$782 total
includes taxes & fees
27 Mar - 28 Mar
Holiday Inn Express & Suites Houston North - IAH Area by IHG
Holiday Inn Express & Suites Houston North - IAH Area by IHG28.9 km from South Main
8.4 out of 10, Very good, (947 reviews)
"Yes room is clean and staff is friendly."
Jia Ning
The price is HK$656
HK$806 total
includes taxes & fees
26 Mar - 27 Mar
Four Points by Sheraton Houston Intercontinental Airport
Four Points by Sheraton Houston Intercontinental Airport29.9 km from South Main
8.4 out of 10, Very good, (1,015 reviews)
"The staff was friendly and the hotel was clean"
Lisa
The price is HK$690
HK$807 total
includes taxes & fees
27 Mar - 28 Mar
Sonesta Simply Suites Houston – NASA Clear Lake
Sonesta Simply Suites Houston – NASA Clear Lake31.8 km from South Main
8.0 out of 10, Very good, (1,010 reviews)
"Clean room and very courteous staff."
Fazlur
The price is HK$429
HK$502 total
includes taxes & fees
5 Mar - 6 Mar
Staybridge Suites Houston IAH - Beltway 8 by IHG
Staybridge Suites Houston IAH - Beltway 8 by IHG29.9 km from South Main
8.0 out of 10, Very good, (917 reviews)
"Great stay, very accommodating and friendly. "
Nia
The price is HK$695
HK$813 total
includes taxes & fees
2 Apr - 3 Apr
Comfort Suites Houston West at Clay Road
Comfort Suites Houston West at Clay Road22.8 km from South Main
8.4 out of 10, Very good, (1,003 reviews)
"Friendly staff, breakfast excellent perfect location! Will definitely stay here again"
wanda
The price is HK$617
HK$722 total
includes taxes & fees
1 Apr - 2 Apr
Hilton Garden Inn Houston/Bush Intercontinental Airport
Hilton Garden Inn Houston/Bush Intercontinental Airport31.1 km from South Main
8.4 out of 10, Very good, (1,005 reviews)
"Place was amazing and the staff were great!!!"
Marlene
The price is HK$826
HK$971 total
includes taxes & fees
22 Mar - 23 Mar
GreenTree Inn Houston IAH Airport
GreenTree Inn Houston IAH Airport31.4 km from South Main
6.8 out of 10, (1,020 reviews)
"Staff was very friendly , room was very clean "
Charlette
The price is HK$421
HK$493 total
includes taxes & fees
5 Mar - 6 Mar
Homewood Suites By Hilton Houston IAH Airport Beltway 8
Homewood Suites By Hilton Houston IAH Airport Beltway 829.9 km from South Main
8.4 out of 10, Very good, (954 reviews)
"I really like the hotel
We stayed (5 family members)
The breakfast have a really good taste."
Saul
The price is HK$621
HK$727 total
includes taxes & fees
23 Mar - 24 Mar
Holiday Inn NW Houston Beltway 8 by IHG
Holiday Inn NW Houston Beltway 8 by IHG29.9 km from South Main
8.8 out of 10, Excellent, (486 reviews)
"The staff was gracious, the room was clean and comfortable, and the building was well maintained. I highly recommend staying here."
Laura
The price is HK$630
HK$725 total
includes taxes & fees
8 Mar - 9 Mar
Hilton Houston North
Hilton Houston North30.5 km from South Main
8.2 out of 10, Very good, (1,006 reviews)
"I had a great stay at this hotel. The room was clean and comfortable."
Victor
The price is HK$936
HK$1,095 total
includes taxes & fees
22 Mar - 23 Mar
Holiday Inn Express & Suites Houston SW - Galleria Area by IHG
Holiday Inn Express & Suites Houston SW - Galleria Area by IHG9.6 km from South Main
8.0 out of 10, Very good, (1,003 reviews)
"Clean room, friendly and responsive staff"
Clara
The price is HK$890
HK$1,041 total
includes taxes & fees
29 Mar - 30 Mar
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD28.7 km from South Main
9.0 out of 10, Wonderful, (998 reviews)
"The hotel was very clean the staff was amazing. We enjoyed our stay"
Teanna
The price is HK$674
HK$789 total
includes taxes & fees
29 Mar - 30 Mar
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,007 reviews)
"Excellent stay! The room was very clean and comfortable, and the staff went above and beyond to be friendly and helpful. Check-in was smooth, the amenities were great, and the overall atmosphere made it a relaxing experience. I’d definitely stay here again!"
Wayne
The price is HK$794
HK$938 total
includes taxes & fees
3 Apr - 4 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Top South Main Hotel Reviews
Hilton Houston Plaza/Medical Center
10/10 Excellent
