Southern Indiana 4 Stars Hotels

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana 4 Star Hotels

Tonight
24 Dec - 25 Dec
Tomorrow
25 Dec - 26 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Our top choices for Southern Indiana 4-star hotels

4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (3881)
"Great place to stay! "
United States
Rochelle
The price is HK$1,037
HK$1,220 total
includes taxes & fees
30 Dec - 31 Dec
Galt House Hotel Trademark Collection by Wyndham
3 bars/lounges, cocktail bar, lobby lounge
Omni Louisville Hotel

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1738)
"This is a beautiful hotel in a great location. Very kind staff and helpful with directions."
United States
Bonnie
The price is HK$1,300
HK$1,530 total
includes taxes & fees
4 Jan - 5 Jan 2026
Omni Louisville Hotel
Reception
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1121)
"Staff was courteous, hotel was beautiful and clean, and breakfast was amazing!"
United States
Shunskis
The price is HK$893
HK$1,051 total
includes taxes & fees
30 Dec - 31 Dec
Embassy Suites Louisville Downtown
Lobby
The Brown Hotel

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1157)
"Fantastic place to stay in Louisville."
United States
Nathaniel
The Brown Hotel
Terrace/patio
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1019)
"Great location and accommodations."
United States
Steve
The price is HK$988
HK$1,162 total
includes taxes & fees
30 Dec - 31 Dec
Hotel Genevieve part of JdV by Hyatt
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1000)
"Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!"
United States
Tammy
The price is HK$1,081
HK$1,311 total
includes taxes & fees
7 Jan - 8 Jan 2026
21c Museum Hotel Louisville
Lobby
Hyatt Regency Louisville

Hyatt Regency Louisville

Hyatt Regency Louisville
4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1001)
"Enjoyed our stay "
United States
Jedediah
The price is HK$988
HK$1,162 total
includes taxes & fees
27 Dec - 28 Dec
Hyatt Regency Louisville
Lobby
The Grady

The Grady

The Grady
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1005)
"Such an amazing hotel...restaurant is delicious! "
United States
Craig
The price is HK$1,127
HK$1,326 total
includes taxes & fees
4 Jan - 5 Jan 2026
The Grady
Exterior
Louisville Marriott Downtown

Louisville Marriott Downtown

Louisville Marriott Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1000)
"Very nice hotel. Great stay!"
United States
Brad
The price is HK$1,304
HK$1,535 total
includes taxes & fees
18 Jan - 19 Jan 2026
Louisville Marriott Downtown
Terrace/patio
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville
9.6 out of 10, Exceptional, (428)
"Great location. Great restraunt, great staff. Pleasurable experience!"
United States
Harrison
The price is HK$1,362
HK$1,603 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hotel Distil, Autograph Collection
Lobby
DoubleTree by Hilton Evansville

DoubleTree by Hilton Evansville

DoubleTree by Hilton Evansville
4.0 star property
Downtown Evansville
8.6 out of 10, Excellent, (1001)
"The staff were extremely friendly "
United States
Jill
The price is HK$759
HK$873 total
includes taxes & fees
11 Jan - 12 Jan 2026
DoubleTree by Hilton Evansville
Exterior
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (56)
"Amazing property! Best hotel in Louisville! Will be staying there again!"
United States
Norman
The price is HK$1,309
HK$1,540 total
includes taxes & fees
1 Jan - 2 Jan 2026
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Exterior
Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
4.0 star property
Downtown Louisville
8.6 out of 10, Excellent, (1001)
"Excellent location and a great lobby bar with a top notch bourbon selection. "
United States
vincent
The price is HK$1,073
HK$1,263 total
includes taxes & fees
27 Dec - 28 Dec
Seelbach Hilton Louisville Downtown
Lounge
Stellar Suites

Stellar Suites

Stellar Suites
4.5 star property
Downtown Louisville
9.6 out of 10, Exceptional, (117)
"Clean and great location "
United States
Greg
The price is HK$899
HK$1,450 total
includes taxes & fees
17 Jan - 18 Jan 2026
Stellar Suites
Property entrance
The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B
4.0 star property
New Albany
9.8 out of 10, Exceptional, (649)
"Have stayed here once before. Accommodations are wonderful and the sit down breakfast is lovely. Highly recommend this beautiful property."
United States
Kathy
The price is HK$691
HK$781 total
includes taxes & fees
25 Dec - 26 Dec
The Pepin Mansion Historic B&B
Seasonal outdoor pool
CozySuites at Nulu

CozySuites at Nulu

CozySuites at Nulu
4.0 star property
Downtown Louisville
8.2 out of 10, Very good, (26)
"The unit was clean, all communications were timely, the property has all the amenities, and NULU is very walkable. A perfect stay! My only regret is that I wasn't able to extend the stay. Highly recommended if you're in the Louisville area "
United States
William
The price is HK$465
HK$1,443 total
includes taxes & fees
22 Jan - 23 Jan 2026
CozySuites at Nulu
Exterior
stayAPT Suites Louisville North-Clarksville

stayAPT Suites Louisville North-Clarksville

stayAPT Suites Louisville North-Clarksville
4.0 star property
Clarksville
9.8 out of 10, Exceptional, (43)
"Excellent stay. One of my favorite hotels in the area. They never disappoint "
United States
Julia
The price is HK$1,147
HK$1,297 total
includes taxes & fees
27 Dec - 28 Dec
stayAPT Suites Louisville North-Clarksville
32-inch Smart TV with cable channels
The Reserve on Main

The Reserve on Main

The Reserve on Main
4.0 star property
Downtown Louisville
10.0 out of 10, Exceptional, (1)
"Incredible stay. This stay was clean and inspiring for anyone wishing to take a break and recharge. We highly recommend this stay to everyone staying in the city. "
Canada
georgios
The price is HK$1,283
HK$1,878 total
includes taxes & fees
28 Dec - 29 Dec
The Reserve on Main
Private kitchen
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
4.0 star property
Sellersburg
9.4 out of 10, Exceptional, (10)
"Very nice house in a nice neighborhood, spacious home environmental, felt more that at home there,"
United States
Tammy
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
Lounge
Holiday Inn Evansville Airport

Holiday Inn Evansville Airport

Holiday Inn Evansville Airport
4.0 star property
Evansville
8.0 out of 10, Very good, (604)
"Nice hotel but it doesn’t have a fridge in the room or microwave."
United States
Anonymous traveller
Holiday Inn Evansville Airport
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Southern Indiana

Find lots to see and do in Southern Indiana—live music, sports teams and sights from Patoka Lake Swimming Beach to Patoka Lake.

See all hotels in Southern Indiana
Belle of Louisville which includes a ferry and a bay or harbour as well as a small group of people

Top Southern Indiana Hotel Reviews

DoubleTree by Hilton Evansville

DoubleTree by Hilton Evansville

10/10 Excellent
"Didnt eat breakfast. "
Steven 1-night trip
Posted 3 days ago
DoubleTree by Hilton Evansville

Frequently asked questions

What are the best 4-star hotels in Southern Indiana?
Based on reviews by our guests, Galt House Hotel Trademark Collection by Wyndham is among the best 4-star hotels in Southern Indiana. Situated in Louisville, it includes massage services and beauty services. Hyatt Regency Louisville is another sought-after option here. Also with a 4-star rating and offering premium bedding and designer toiletries, you're sure to have a comfortable stay.
How much does it cost to stay in a 4-star hotel in Southern Indiana?
To book a 4-star hotel in Southern Indiana that's within your budget, take advantage of Expedia's handy filters. Take a look at what's available during your preferred dates and use our pricing filter to set your limit. You can also sort your results by the most budget-friendly option first.

  • Search for the lowest price from HK$781

What's the difference between 5-star and 4-star hotels in Southern Indiana?
Give yourself the luxury treatment during your Southern Indiana escape by checking in to a 4-star hotel. As well as featuring upmarket surroundings, these properties are typically packed with amenities such as large beds, bathrobes and plenty more. A 5-star hotel will go the extra mile to make your stay an even more indulgent and memorable one. 24-hour concierge assistance, luxurious spas and world-class dining are a few of the exclusive services and conveniences you'll likely be able to enjoy.