A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Defiance hotels from HK$541

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6 Nov - 8 Nov
In two weeks
13 Nov - 15 Nov

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Our top choices for Defiance hotels

A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.4 out of 10, Very good, (1,001 reviews)
"This was a clean, safe and convenient place to stay while traveling through St. Louis."
United States
Greg
The price is HK$727
HK$857 total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express St. Louis West - O'Fallon by IHG
A hotel entrance with a stone facade, a wooden archway, and a paved walkway.

2. Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG
3.0 star property
O'Fallon
8.4 out of 10, Very good, (488 reviews)
"Everything was great. Rooms were clean, bedding comfortable, breakfast really good."
United States
Cheri
The price is HK$927
HK$1,093 total
includes taxes & fees
1 Nov - 2 Nov
Staybridge Suites O'Fallon Chesterfield by IHG
A hotel room with a bed, a sofa, a coffee table, and wall art.

3. Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,155 reviews)
"Rooms are very clean, the staff is friendly and the location is great. We enjoyed are stay."
United States
Matthew
The price is HK$614
HK$725 total
includes taxes & fees
8 Nov - 9 Nov
Sleep Inn & Suites O'Fallon MO - Technology Drive
An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

4. TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (335 reviews)
"Excellent 1 night stay. Clean and comfortable"
United States
Thomas
The price is HK$957
HK$1,123 total
includes taxes & fees
8 Nov - 9 Nov
TownePlace Suites by Marriott St. Louis Chesterfield
A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

5. Residence Inn by Marriott O'Fallon

Residence Inn by Marriott O'Fallon
3.0 star property
O'Fallon
8.4 out of 10, Very good, (508 reviews)
"Beautiful room, very clean with nice staff"
United States
Rianna
The price is HK$957
HK$1,129 total
includes taxes & fees
20 Nov - 21 Nov
Residence Inn by Marriott O'Fallon
A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

6. The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,680 reviews)
"Clean, quiet, great continental breakfast, and close to several places to eat."
United States
Lori
The price is HK$643
HK$749 total
includes taxes & fees
16 Nov - 17 Nov
The Wildwood Hotel
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

7. Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis
2.5 star property
Chesterfield
7.8 out of 10, Good, (1,000 reviews)
"Mindy was very nice. Bed not so much, please keep a smoke detector in the room instead of taking it apart."
United States
Charissa
The price is HK$640
HK$772 total
includes taxes & fees
29 Nov - 30 Nov
Comfort Inn & Suites Chesterfield - St. Louis
A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

8. Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
3.0 star property
O'Fallon
8.8 out of 10, Excellent, (764 reviews)
"Everything you could need for an overnight or extended stay. Staff was extremely helpful, and the property is well-maintained."
United States
Duane
The price is HK$958
HK$1,137 total
includes taxes & fees
8 Nov - 9 Nov
Hilton Garden Inn St. Louis/O'Fallon MO
A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

9. Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,002 reviews)
"Very clean hotel."
United States
Debbie
The price is HK$1,090
HK$1,265 total
includes taxes & fees
1 Nov - 2 Nov
Hyatt Place St. Louis/Chesterfield
A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

10. Hampton Inn & Suites St. Louis/Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield
3.5 star property
Chesterfield
8.8 out of 10, Excellent, (917 reviews)
"Breakfast selection was good and staff was very helpful"
United States
Vijay
The price is HK$860
HK$1,001 total
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn & Suites St. Louis/Chesterfield
A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
2.5 star property
Chesterfield
9.0 out of 10, Wonderful, (1,001 reviews)
"We drove across America and this property stood out by just having the most comfortable beds and a great breakfast , great staff ."
United States
Terry
The price is HK$839
HK$977 total
includes taxes & fees
29 Nov - 30 Nov
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
An outdoor patio area with wicker furniture and a central fire feature.

12. Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (679 reviews)
"Love the location and most of the staff were very nice! The cafe/Starbucks was a little disappointing."
United States
Kelly
The price is HK$860
HK$1,001 total
includes taxes & fees
19 Nov - 20 Nov
Courtyard by Marriott St. Louis Chesterfield
A spacious lobby with a central round table, two sofas, and a chandelier.

13. Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,312 reviews)
"This was by far one of the nicest places we have stayed in."
United States
Linda
The price is HK$1,020
HK$1,183 total
includes taxes & fees
4 Nov - 5 Nov
Drury Plaza Hotel St. Louis Chesterfield
A spacious lobby with a grand staircase, a fireplace, and comfortable seating areas.

14. Holiday Inn St. Louis West Six Flags by IHG

Holiday Inn St. Louis West Six Flags by IHG
3.0 star property
Eureka
9.0 out of 10, Wonderful, (1,000 reviews)
"Great hotel!"
United States
Rob
The price is HK$988
HK$1,151 total
includes taxes & fees
30 Nov - 1 Dec
Holiday Inn St. Louis West Six Flags by IHG
An outdoor patio with a built-in grill, seating area, and stone walls.

15. Residence Inn by Marriott St. Louis Chesterfield

Residence Inn by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (259 reviews)
"Would stay here again!"
United States
Chelsea
The price is HK$1,483
HK$1,735 total
includes taxes & fees
8 Nov - 9 Nov
Residence Inn by Marriott St. Louis Chesterfield
A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

16. Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (412 reviews)
"Great hotel and Breakfast is nothing special but it makes sense for the price you pay."
United States
Chantelle
The price is HK$663
HK$759 total
includes taxes & fees
15 Nov - 16 Nov
Quality Inn Near Six Flags St. Louis
An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

17. Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (1,000 reviews)
"The breakfast was mediocre and there was road noise but other than that, it was a nice stay."
United States
Scott
The price is HK$684
HK$783 total
includes taxes & fees
1 Dec - 2 Dec
Comfort Inn Near Six Flags St. Louis
A hotel reception area with a counter, coffee machines, a refrigerated display, and artwork on the wall.

18. Fairfield Inn & Suites by Marriott St. Louis Chesterfield

Fairfield Inn & Suites by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (1,000 reviews)
"very nice stay. Great room with easy check in ,nice staff, friendly and helpful. Excellent breakfast, with good setup and fresh food."
United States
Charles
The price is HK$840
HK$975 total
includes taxes & fees
9 Nov - 10 Nov
Fairfield Inn & Suites by Marriott St. Louis Chesterfield
A spacious lobby with a brown leather sofa, multiple chairs, a coffee table with a skull decoration, and a large chandelier.

19. DoubleTree by Hilton Hotel St. Louis - Chesterfield

DoubleTree by Hilton Hotel St. Louis - Chesterfield
4.0 star property
Chesterfield
8.8 out of 10, Excellent, (1,001 reviews)
"Hotel staff were kind and accommodating. Great stay for a great price!"
United States
April
The price is HK$1,087
HK$1,261 total
includes taxes & fees
21 Nov - 22 Nov
DoubleTree by Hilton Hotel St. Louis - Chesterfield
A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.

20. Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (742 reviews)
"Great hotel!"
United States
Jill
The price is HK$1,127
HK$1,279 total
includes taxes & fees
29 Nov - 30 Nov
Hampton Inn St. Louis Wentzville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

7.8/10 (7 reviews)
This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Top Defiance Hotel Reviews

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

10/10 Excellent
"The staff is amazing"
Vincent 1-night trip
Posted 13 hours ago
Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

More cheap stays in Defiance

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO
The price is HK$467 per night from 3 Nov to 4 Nov
HK$467
HK$541 total
3 Nov - 4 Nov
includes taxes & fees

Frequently asked questions

What's the best place to stay in Defiance?
Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Sonesta ES Suites St. Louis - Chesterfield and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
HotTub-2br2b-near Historic Main Street: This holiday home rental outside of Defiance offers a patio, a garden and a BBQ to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. Make the most of Access to hot tub in this rental home to help you unwind. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Sonesta ES Suites St. Louis - Chesterfield: Offers daily, a seasonal outdoor pool and free self parking. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station and St. Louis Zoo. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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