Defiance hotels from HK$488

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Top 10 trending Defiance hotels

The Wildwood Hotel

3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1601)
"The hotel was amazing from the staff to the rooms. Great location as well. Definitely recommend this place if traveling! "
United States
Brandi
The Wildwood Hotel

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
Fenton
8.0 out of 10, Very good, (1031)
"Very friendly staff "
United States
Amber
The price is HK$662
HK$764 total
includes taxes & fees
14 Dec - 15 Dec
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

WoodSpring Suites St Peters-OFallon

2.5 star property
St. Peters
9.8 out of 10, Exceptional, (16)
"The room was super clean and tidy. The staff was very friendly and overall a great experience. "
United States
Fred
The price is HK$576
HK$662 total
includes taxes & fees
9 Dec - 10 Dec
WoodSpring Suites St Peters-OFallon

Best Western Plus St. Louis West-Westport

2.5 star property
Maryland Heights
8.0 out of 10, Very good, (1028)
"The room was great and the bed was very comfortable "
United States
Joyce
The price is HK$771
HK$894 total
includes taxes & fees
9 Dec - 10 Dec
Best Western Plus St. Louis West-Westport

AC Hotel by Marriott St. Louis Chesterfield

3.5 star property
Chesterfield
9.2 out of 10, Wonderful, (236)
"Newer hotel, very clean, up to date and in nice area. "
United States
Johnny
The price is HK$926
HK$1,074 total
includes taxes & fees
21 Dec - 22 Dec
AC Hotel by Marriott St. Louis Chesterfield

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
O'Fallon
8.8 out of 10, Excellent, (1004)
"Nice breakfast, friendly staff"
United States
Damon
The price is HK$680
HK$802 total
includes taxes & fees
11 Dec - 12 Dec
Sleep Inn & Suites O'Fallon MO - Technology Drive

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
O'Fallon
8.6 out of 10, Excellent, (831)
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is HK$646
HK$762 total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express St. Louis West - O'Fallon by IHG

Hampton Inn St. Charles St. Peters

2.5 star property
St. Charles
8.0 out of 10, Very good, (1010)
"Great breakfast, clean room, hot tub!"
United States
Tony
The price is HK$679
HK$780 total
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn St. Charles St. Peters

Baymont by Wyndham Warrenton

2.5 star property
Warrenton
7.4 out of 10, Good, (1000)
"Room very clean, most of staff helpful"
United States
Ranata
The price is HK$589
HK$676 total
includes taxes & fees
12 Dec - 13 Dec
Baymont by Wyndham Warrenton

Sonesta ES Suites St. Louis - Chesterfield

3.0 star property
Chesterfield
8.0 out of 10, Very good, (1031)
"Clean room,Friendly staff, Good location and Good Breakfast options"
United States
Micheal
The price is HK$722
HK$838 total
includes taxes & fees
14 Dec - 15 Dec
Sonesta ES Suites St. Louis - Chesterfield

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1004)
"Hotel was very clean."
United States
christine
The price is HK$895
HK$1,038 total
includes taxes & fees
14 Dec - 15 Dec
Drury Plaza Hotel St. Louis St. Charles

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
Wentzville
9.4 out of 10, Exceptional, (833)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is HK$856
HK$1,028 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Days Inn by Wyndham St Peters/St Charles

2.0 star property
St. Peters
6.4 out of 10, (1000)
"Staff was very friendly. Room was kept clean."
United States
Sandra
The price is HK$490
HK$563 total
includes taxes & fees
4 Jan - 5 Jan 2026
Days Inn by Wyndham St Peters/St Charles

Hollywood Casino & Hotel St. Louis

3.5 star property
Maryland Heights
8.4 out of 10, Very good, (2211)
"Wonderful staff and amazing room. Parking was simple and easy."
United States
London
The price is HK$763
HK$1,003 total
includes taxes & fees
6 Jan - 7 Jan 2026
Hollywood Casino & Hotel St. Louis

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

2.5 star property
St. Charles
5.8 out of 10, (1003)
"Nice staff, respectful."
United States
LaurenRenee
The price is HK$463
HK$537 total
includes taxes & fees
9 Dec - 10 Dec
Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
Fenton
7.8 out of 10, Good, (1104)
"The young lady that checked us in was very friendly and helpful."
United States
Wenona
The price is HK$615
HK$711 total
includes taxes & fees
14 Dec - 15 Dec
Wingate by Wyndham St. Louis/Fenton Route 66

Best Western Plus Washington Hotel

2.5 star property
Washington
9.2 out of 10, Wonderful, (635)
"One of our favorites! This hotel is very clean, breakfast is very good and the kids love the indoor pool."
United States
Debra
The price is HK$1,004
HK$1,143 total
includes taxes & fees
11 Dec - 12 Dec
Best Western Plus Washington Hotel

Super 8 by Wyndham Warrenton

2.0 star property
Warrenton
7.4 out of 10, Good, (619)
"Room was clean. Staff very helpful, accommodating. "
United States
Ranata
The price is HK$476
HK$547 total
includes taxes & fees
15 Dec - 16 Dec
Super 8 by Wyndham Warrenton

Hilton Garden Inn Chesterfield

3.0 star property
Chesterfield
8.2 out of 10, Very good, (783)
"Just a really nice hotel tucked away from everything, but still close to get whereevre you need to go!"
United States
Roy
The price is HK$760
HK$884 total
includes taxes & fees
14 Dec - 15 Dec
Hilton Garden Inn Chesterfield

Super 8 by Wyndham St. Clair MO

2.0 star property
St. Clair
7.2 out of 10, Good, (942)
"Was what I needed after a long drive."
United States
Michael
The price is HK$518
HK$568 total
includes taxes & fees
14 Dec - 15 Dec
Super 8 by Wyndham St. Clair MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

More cheap stays in Defiance

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Hollywood Casino & Hotel St. Louis and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
Stunning 1890's Home - Sleeps 8!: This holiday home rental outside of Defiance is equipped with a BBQ, air conditioning and laundry facilities to help you feel comfortable during your stay. It has 4 bedrooms, as well as a kitchen with a dishwasher, a stovetop and a microwave, so that you can cook with friends or family. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station and Gateway Arch. In Defiance, there are 20 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area and Missouri River. A couple of additional sights to add to your itinerary are Yellow Farmhouse Winery and Chandler Hill Vineyards. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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