Get Your Car Car Hire in Southern Illinois
Photo by Southernmost Illinois Tourism Bureau
Change your mindPenalty-free cancellation on many/select car hire
Treat yourselfMembers save 10% or more on over 1 million car hire
Shop smartCompare car suppliers to unlock big savings
Explore a world of travel with Expedia
- Casino Hotel Hotels in Southern Illinois
- Fairfield Hotels
- Hotels near William Jennings Bryan Statue
- 5 Star Hotels in Corinth
- Pet-Friendly Hotel Hotels in Carlyle
- Golf Hotel Hotels in Sparta
- 4 Star Hotels in Carmi
- Cabin Rentals in Waltonville
- Extended Stay America Hotels in Carlyle
- Cabin Rentals in Marion
- Cabin Rentals in Christopher
- Lodges in Enfield
- Hotels near Flora City Hall
- Pet-Friendly Hotel Hotels in Marion
- 3 Star Hotels in Du Quoin
- Albion Hotels
- Independent Hotels in Sparta
- 3 Star Hotels in Carmi
- Hotels near Mount Vernon Outland
- Drury Inn & Suites Hotels in New Baden
- Hotels near Southern Illinois
- Cisne Hotels
- Red Lion Hotels in Southwest Illinois
- 4 Star Hotels in Carbondale
- Family Hotel Hotels in Grayville
- Cheap Hotels in Grayville
- Motels in Herrin
- Ina Hotels
- Marissa Hotels
- Spa Hotel Hotels in Carlyle
- Sparta Hotels
- Pet-Friendly Hotel Hotels in Mount Vernon
- Hotels near Stone Creek Golf Club and Resort
- 5 Star Hotels in Marissa
- Family Hotel Hotels in Harrisburg
- Hotels near Rend Lake College
- Romantic Hotel Hotels in Carterville
- Motel 6 Hotels in Carlyle
- Luxury Hotel Hotels in Southern Illinois
- Cheap Hotels in Du Quoin
- 3 Star Hotels in Keyesport
- Independent Hotels in Centralia
- Noble Hotels
- Cabin Rentals in Carbondale
- Hotels near Kokopelli Golf Club
- Apartments in Pinckneyville
- Hotel with Pool Hotels in Carlyle
- Motels in Albion
- Mulberry Grove Hotels
- Marion Hotels
- Ava Hotels
- Sesser Hotels
- Hotels near West Access Marina
- Carlyle Hotels
- Lodges in Herrin
- Hotels near Salem Fairgrounds
- Hilton Hotels in Ewing
- Mount Vernon Hotels
- 3 Star Hotels in Odin
- Apartments in Carlyle
- Guest Houses in Southwest Illinois
- 4 Star Hotels in Tamaroa
- Hotels near William Jennings Bryan Boyhood Home and Museum
- Dix Hotels
- 3 Star Hotels in Aviston
- Cabin Rentals in Dix
- B&B in Southern Illinois
- Hamilton County Hotels
- Creal Springs Hotels
- Farmstay in Southwest Illinois
- La Quinta Inn & Suites Hotels in Southern Illinois
- Adventure Sport Hotel Hotels in Marion
- 4 Star Hotels in Sims
- Kinmundy Hotels
- Red Roof Inn Hotels in Carbondale
- Cabin Rentals in Southern Illinois
- Cheap Hotels in Carbondale
- Chalets in Southern Illinois
- Lodges in Whittington
- Nashville Hotels
Heading to Southern Illinois? Explore Southern Illinois with Expedia's Travel Guides to find the best hotels, holiday packages, car hire deals and more!