Rochester Mayo Clinic Hotels: 2026 Limited-Time Hotel Deals @Expedia

A historic building with a prominent tower, two American flags, and a modern glass structure in the foreground.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Mayo Clinic hotels

Premium bedding, pillow-top beds, laptop workspace, blackout curtains

1. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Jorge

HK$960

HK$1,106 total

includes taxes & fees

21 Aug - 22 Aug

Egyptian cotton sheets, premium bedding, pillow-top beds, minibar

2. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.6 km from Mayo Clinic

Timothy

HK$900

HK$1,036 total

includes taxes & fees

27 Aug - 28 Aug

3. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

Richard

HK$994

HK$1,144 total

includes taxes & fees

5 Sept - 6 Sept

Indoor pool, open 5:00 AM to 10:00 PM, pool loungers

4. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

Jennifer

HK$1,345

HK$1,548 total

includes taxes & fees

22 Aug - 23 Aug

5. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 1.8 km from Mayo Clinic

Jon

HK$876

HK$1,008 total

includes taxes & fees

3 Sept - 4 Sept

6. The Berkman

Folwell, 1.4 km from Mayo Clinic

Jana

HK$1,607

HK$1,868 total

includes taxes & fees

1 Sept - 2 Sept

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

paul

HK$785

HK$1,009 total

includes taxes & fees

28 Aug - 29 Aug

Premium bedding, pillow-top beds, in-room safe, desk

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Marissa

HK$902

HK$1,055 total

includes taxes & fees

6 Sept - 7 Sept

Indoor pool, pool umbrellas, pool loungers

Premium bedding, down duvets, desk, laptop workspace

9. The Towers At Kahler Grand Hotel

Downtown Rochester, 0.1 km from Mayo Clinic

Chris

HK$2,792

HK$3,215 total

includes taxes & fees

23 Aug - 24 Aug

Desk, laptop workspace, blackout curtains, iron/ironing board

10. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

MATTHEW

HK$887

HK$1,021 total

includes taxes & fees

21 Aug - 22 Aug

11. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

Lin

HK$862

HK$993 total

includes taxes & fees

28 Aug - 29 Aug

Premium bedding, desk, blackout curtains, iron/ironing board

12. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

Sean

HK$910

HK$1,048 total

includes taxes & fees

21 Aug - 22 Aug

In-room safe, laptop workspace, blackout curtains, iron/ironing board

13. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

Lynne

HK$734

HK$844 total

includes taxes & fees

28 Aug - 29 Aug

In-room safe, desk, laptop workspace, soundproofing

Coffee/tea maker, fridge, microwave, oven

14. Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester, 0.3 km from Mayo Clinic

Camille

HK$1,327

HK$1,528 total

includes taxes & fees

4 Sept - 5 Sept

15. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

Markus

HK$550

HK$633 total

includes taxes & fees

6 Sept - 7 Sept

16. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Melissa

HK$1,248

HK$1,436 total

includes taxes & fees

21 Aug - 22 Aug

Premium bedding, in-room safe, desk, laptop workspace

17. Aspen Suites

1.2 km from Mayo Clinic

CASEY

HK$1,112

HK$1,345 total

includes taxes & fees

5 Sept - 6 Sept

18. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

Misty

HK$808

HK$930 total

includes taxes & fees

21 Aug - 22 Aug

Premium bedding, pillow-top beds, iron/ironing board

19. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 0.3 km from Mayo Clinic

Eileen

HK$894

HK$1,030 total

includes taxes & fees

28 Aug - 29 Aug

20. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Bryan

HK$981

HK$1,129 total

includes taxes & fees

18 Aug - 19 Aug

View all properties

Compare popular hotels close to Mayo Clinic

Property	Property class	Guest rating
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 551 reviews	View
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,001 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 300 reviews	View
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 637 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 733 reviews	View

Top Mayo Clinic Hotel Reviews

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, take a look at the 149 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Med City Inn & Suites - Mayo Clinic Area.

How many hotels should I expect to find near Mayo Clinic?

Expedia has 149 hotels and other accommodation options within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, most hotel bookings are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Mayo Clinic.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Plummer House and Assisi Heights. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mayo Clinic hotels

1. TownePlace Suites by Marriott Rochester Mayo Clinic Area

2. Home2 Suites by Hilton Rochester Mayo Clinic Area

3. Residence Inn by Marriott Rochester Mayo Clinic Area South

4. Hilton Rochester Mayo Clinic Area

5. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

6. The Berkman

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

9. The Towers At Kahler Grand Hotel

10. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

11. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

12. Candlewood Suites Rochester Mayo Clinic Area by IHG

13. Hampton Inn Rochester-South

14. Broadway Plaza, Trademark Collection by Wyndham

15. Econo Lodge Mayo Clinic Area

16. Hyatt House Rochester/Mayo Clinic Area

17. Aspen Suites

18. Hotel Indigo Rochester – Mayo Clinic Area by IHG

19. Hilton Garden Inn Rochester Downtown, MN

20. Brentwood Inn & Suites

Compare popular hotels close to Mayo Clinic

Top Mayo Clinic Hotel Reviews

Frequently asked questions

Explore a world of travel with Expedia