Otay Mesa hotels in San Diego from HK$757

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14 Dec - 15 Dec
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19 Dec - 21 Dec
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Our top choices for Otay Mesa hotels

Desk, laptop workspace, blackout curtains, iron/ironing board
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1003)
"Beautiful place "
United States
Joe
The price is HK$821
HK$934 total
includes taxes & fees
21 Dec - 22 Dec
Quality Suites San Diego Otay Mesa
Exterior
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very good, (1560)
"Great place to stay. Really clean and helpful staff "
United States
Zulma
The price is HK$926
HK$1,054 total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 24.2 km from Otay Mesa
9.4 out of 10, Exceptional, (1001)
"Great location "
United States
Mohammad
The price is HK$655
HK$985 total
includes taxes & fees
15 Dec - 16 Dec
Staypineapple, Hotel Z, Gaslamp San Diego
Private kitchenette
Berkshire Motor Hotel

Berkshire Motor Hotel

Berkshire Motor Hotel
2.5 star property
North Park, 26.7 km from Otay Mesa
8.4 out of 10, Very good, (1002)
"Amazing friendly staff"
United States
Jonathan
The price is HK$665
HK$750 total
includes taxes & fees
15 Dec - 16 Dec
Berkshire Motor Hotel
Outdoor pool, pool loungers
Westgate Hotel

Westgate Hotel

Westgate Hotel
4.5 star property
24.9 km from Otay Mesa
9.0 out of 10, Wonderful, (1006)
"Everything about the Hotel including staff was fantastic"
Canada
Donna
Westgate Hotel
Free daily continental breakfast
Old Town Western Inn & Suites

Old Town Western Inn & Suites

Old Town Western Inn & Suites
2.5 star property
Old Town San Diego, 29.6 km from Otay Mesa
7.6 out of 10, Good, (1006)
"Easy check in, clean room, close to the airport ($25 by taxi, $18 by Lyft)"
United States
Jennifer
The price is HK$986
HK$1,112 total
includes taxes & fees
4 Jan - 5 Jan 2026
Old Town Western Inn & Suites
Exterior
Courtyard by Marriott Old Town

Courtyard by Marriott Old Town

Courtyard by Marriott Old Town
3.0 star property
Old Town San Diego, 29.7 km from Otay Mesa
8.6 out of 10, Excellent, (1001)
"All around great stay "
United States
Chasity
The price is HK$928
HK$1,067 total
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott Old Town
In-room safe, desk, laptop workspace, blackout curtains
Ash&9th

Ash&9th

Ash&9th
2.0 star property
24.7 km from Otay Mesa
8.0 out of 10, Very good, (169)
"great place to stay "
United States
Fernando L
The price is HK$589
HK$669 total
includes taxes & fees
16 Dec - 17 Dec
Ash&9th
Seasonal outdoor pool, a heated pool
Ocean Villa Inn

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1134)
"Fantastic location!"
United States
Lydia
Ocean Villa Inn
Exterior
La Pensione Hotel

La Pensione Hotel

La Pensione Hotel
3.0 star property
Little Italy, 25.8 km from Otay Mesa
8.6 out of 10, Excellent, (1911)
"small room, god location, great for the price"
United States
JAIME
La Pensione Hotel
Lobby
Fairfield Inn & Suites San Diego Old Town

Fairfield Inn & Suites San Diego Old Town

Fairfield Inn & Suites San Diego Old Town
2.5 star property
Old Town San Diego, 29.4 km from Otay Mesa
8.8 out of 10, Excellent, (1005)
"Great place to stay with perfect location, healthy breakfast."
United States
Shaoyi
The price is HK$928
HK$1,067 total
includes taxes & fees
21 Dec - 22 Dec
Fairfield Inn & Suites San Diego Old Town
Marina
Sea Harbor Hotel

Sea Harbor Hotel

Sea Harbor Hotel
2.0 star property
30.1 km from Otay Mesa
8.6 out of 10, Excellent, (1003)
"Great stay"
United States
Naomi
Sea Harbor Hotel
Exterior
Homewood Suites by Hilton San Diego Mission Valley/Zoo

Homewood Suites by Hilton San Diego Mission Valley/Zoo

Homewood Suites by Hilton San Diego Mission Valley/Zoo
3.0 star property
28.5 km from Otay Mesa
8.4 out of 10, Very good, (1004)
"Breakfast and manager reception was great."
United States
Chetan
The price is HK$897
HK$1,031 total
includes taxes & fees
4 Jan - 5 Jan 2026
Homewood Suites by Hilton San Diego Mission Valley/Zoo
Front of property
Heritage Inn San Diego

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
31.8 km from Otay Mesa
7.4 out of 10, Good, (1160)
"Clean room, great location "
United States
Benjamin
The price is HK$426
HK$490 total
includes taxes & fees
16 Dec - 17 Dec
Heritage Inn San Diego
Exterior
Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area
3.0 star property
Old Town San Diego, 30.5 km from Otay Mesa
8.6 out of 10, Excellent, (1292)
"Good location, the room was specious and clean. We really enjoyed our stay!"
United States
Yana
The price is HK$928
HK$1,067 total
includes taxes & fees
29 Dec - 30 Dec
Hilton Garden Inn San Diego Old Town/SeaWorld Area
Check-in/check-out kiosk
Urban Boutique Hotel

Urban Boutique Hotel

Urban Boutique Hotel
3.0 star property
Little Italy, 25.7 km from Otay Mesa
8.6 out of 10, Excellent, (1269)
"Locations is excellent and the front desk lady was friendly "
Canada
Ju
Urban Boutique Hotel
Meeting facility
The Beau Downtown San Diego Gaslamp Quar

The Beau Downtown San Diego Gaslamp Quar

The Beau Downtown San Diego Gaslamp Quar
3.0 star property
Gaslamp Quarter, 24.5 km from Otay Mesa
8.8 out of 10, Excellent, (556)
"beautiful hotel, well maintained facilities, convenient location, very kind staff"
United States
Sergio
The price is HK$943
HK$1,073 total
includes taxes & fees
16 Dec - 17 Dec
The Beau Downtown San Diego Gaslamp Quar
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter
4.0 star property
Gaslamp Quarter, 24.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1163)
"Amenities and location were great. "
United States
Julie
The price is HK$1,184
HK$1,689 total
includes taxes & fees
15 Dec - 16 Dec
Margaritaville Hotel San Diego Gaslamp Quarter
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

Gaslamp Plaza Suites
3.5 star property
Gaslamp Quarter, 24.6 km from Otay Mesa
9.0 out of 10, Wonderful, (1014)
"Yes everything was great I will stay there again."
United States
Sergio
The price is HK$926
HK$1,054 total
includes taxes & fees
15 Dec - 16 Dec
Gaslamp Plaza Suites
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
25.2 km from Otay Mesa
8.6 out of 10, Excellent, (1062)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is HK$1,052
HK$1,446 total
includes taxes & fees
21 Dec - 22 Dec
The Westin San Diego Bayview
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter showing signage, street scenes and night scenes

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Pacific Beach Park showing a sandy beach

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Belmont Park showing a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Otay Mesa Hotel Reviews

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

10/10 Excellent
"Above and beyond expectations. "
ROBB 3-night trip
Posted 16 hours ago
Marriott Marquis San Diego Marina

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.