The hotel is in a quiet residential neighbourhood, at about a 20min walk from the Colosseum. There are some restaurants very close by if you don't feel like venturing back into central Rome for the odd meal. There's a train station about 10 mins away, and a bus station also. The Baths of Caracalla is a historic site about 9-10 min walk away and well worth a visit.
We (2 adults and a 11year old) walked everywhere, as have always enjoyed exploring a new city that way. If we got late getting back at night, we took a cab - about 11-15 euros depending on where we were.
The hotel room we had was a triple, and spacious for this part of the world and very comfortable. Breakfast provided by the hotel was generous and buffet style, with hot and cold options and good coffee. Staff, whether at reception, or at breakfast were very friendly and helpful.
We thoroughly enjoyed our stay at Hotel San Giovanni - thank you!