Otay Mesa
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.
USS Midway Museum
Experience the thrills and hardships of Navy life at this waterfront museum which has become a San Diego landmark.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour
Mexican Street Food: Tijuana Day Trip from San Diego
Tijuana: Guided City Tour with Local Food and Beer Tasting
From Tijuana: Valle de Guadalupe Shared Winery Tour
Top hotels in Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
"My stay at the Holiday Inn was good, my room unfortunately had a sink that didn’t drain well so it would fill up with water. Thankfully I was just sleeping there cause we had so many activities planned. The elevator is a bit sketchy, it stalls a bit when getting to your floor and takes a while to ..."
Reviewed on 30 May 2026
The Sofia Hotel
"Great staff, wonderful ambiance. Close to dining options. Great value fir your money."
Reviewed on 31 May 2026
Best Western Seven Seas
"Boots was great everyone was professional and friendly"
Reviewed on 31 May 2026
Hard Rock Hotel San Diego
"The valet parking being $70 dollars and our vehicle being returned with what looks like someone punched out drivers side panel."
Reviewed on 30 May 2026
Manchester Grand Hyatt San Diego
"It’s beautiful, clean, close to everything, food is good too’."
Reviewed on 30 May 2026
Wyndham San Diego Bayside
"Room was cleaned, staff was respectful..everything near by."
Reviewed on 30 May 2026
Other neighbourhoods around Otay Mesa
East Village
Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and USS Midway Museum are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Otay Mesa
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