Otay Mesa
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Balboa Park
Culture and nature converge in this diverse park located in the heart of the city.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Things to do
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour
From Tijuana: Valle de Guadalupe Shared Winery Tour
Tijuana: Guided City Tour with Local Food and Beer Tasting
Crossing Borders: Tijuana Day Trip from San Diego
Top hotels in Otay Mesa
Sheraton San Diego Resort
The entire hotel was clean and smelled amazing the staff was friendly the food in the restaurants over priced.
Reviewed on 5 Jan 2026
Bay Club Hotel & Marina
Be AWARE. They charge a San Diego Transient Tax that is NOT mentioned on this website! Also our shower had black mold on the curtains. Aside from that, it was a nice stay. But we will not be returning.
Reviewed on 7 Jan 2026
Courtyard by Marriott San Diego Downtown Little Italy
I enjoyed the stay. Staff was pleasant just upset the ice machine didn’t work and could of used more towels
Reviewed on 5 Jan 2026
The DEXTRO Little Italy, BW Premier Collection
Staff was friendly and we were able to check in early without a problem. Room is clean and shower is great!
Reviewed on 5 Jan 2026
DoubleTree by Hilton Hotel San Diego - Mission Valley
都很好
Reviewed on 8 Jan 2026
Hilton San Diego Mission Valley
Can room
Reviewed on 9 Jan 2026
Other neighbourhoods around Otay Mesa
East Village
Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Marina District
Known for its fantastic nightlife and captivating waterfront views, there's plenty to explore in Marina District. Check out top attractions like Seaport Village and New Children's Museum, and jump on the metro at Seaport Village Station or Convention Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Otay Mesa
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