Otay Mesa hotels in San Diego
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Our top choices for Otay Mesa hotels
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.0 out of 10, Very good, (1,631 reviews)
"rooms clean and service great"
patricia
The price is HK$1,008
HK$1,147 total
includes taxes & fees
8 Mar - 9 Mar
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay MesaOtay Mesa
7.0 out of 10, Good, (1,003 reviews)
"Great staff.. location close to the airport!"
Vivian
The price is HK$773
HK$880 total
includes taxes & fees
9 Feb - 10 Feb
Crowne Plaza San Diego - Mission Valley by IHG
Crowne Plaza San Diego - Mission Valley by IHG29.8 km from Otay Mesa
8.0 out of 10, Very good, (1,014 reviews)
"Great stay"
Viviann
The price is HK$789
HK$910 total
includes taxes & fees
1 Mar - 2 Mar
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld31.3 km from Otay Mesa
7.4 out of 10, Good, (4,165 reviews)
"Good location friendly staff"
Anya
The price is HK$735
HK$845 total
includes taxes & fees
23 Feb - 24 Feb
The DEXTRO Little Italy, BW Premier Collection
The DEXTRO Little Italy, BW Premier Collection25.4 km from Otay Mesa
9.0 out of 10, Wonderful, (1,019 reviews)
"Clean rooms and friendly staff"
Topeka
The price is HK$906
HK$1,051 total
includes taxes & fees
22 Feb - 23 Feb
Sycuan Casino Resort
Sycuan Casino Resort28.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1,709 reviews)
"Very clean resort. "
Petrina
Comfort Inn San Diego Old Town
Comfort Inn San Diego Old TownOld Town San Diego, 29.6 km from Otay Mesa
8.2 out of 10, Very good, (1,960 reviews)
"Room was nice and clean, staff was very accomidating and friendly."
Steve
The price is HK$688
HK$790 total
includes taxes & fees
22 Feb - 23 Feb
Kings Inn San Diego
Kings Inn San Diego29.1 km from Otay Mesa
8.8 out of 10, Excellent, (3,626 reviews)
"Love the Kings Inn, always on our travel list!!"
Linzee
Hyatt Regency Mission Bay Spa and Marina
Hyatt Regency Mission Bay Spa and MarinaMission Bay, 33.9 km from Otay Mesa
8.4 out of 10, Very good, (1,596 reviews)
"Balcony view is awesome, clean room, staff at counter and restaurant service was stunning."
francisco
The price is HK$1,242
HK$1,841 total
includes taxes & fees
8 Feb - 9 Feb
Bay Club Hotel & Marina
Bay Club Hotel & Marina29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (3,361 reviews)
"We had great time and enjoyed our stay "
sadra
The price is HK$1,005
HK$1,156 total
includes taxes & fees
24 Feb - 25 Feb
Loews Coronado Bay Resort
Loews Coronado Bay Resort17.2 km from Otay Mesa
8.8 out of 10, Excellent, (1,075 reviews)
"Clean room, gorgeous grounds, very friendly staff "
Taryn
The price is HK$1,477
HK$2,020 total
includes taxes & fees
8 Feb - 9 Feb
Courtyard by Marriott San Diego Airport/Liberty Station
Courtyard by Marriott San Diego Airport/Liberty Station29.7 km from Otay Mesa
9.2 out of 10, Wonderful, (1,329 reviews)
"Our room was clean, well stocked staff was great & very comfortable bed."
Benny
The price is HK$1,314
HK$1,511 total
includes taxes & fees
8 Feb - 9 Feb
Motel 6 El Cajon, CA - San Diego
Motel 6 El Cajon, CA - San Diego27 km from Otay Mesa
7.4 out of 10, Good, (1,518 reviews)
"We only stayed one night but it was comfortable and clean "
Brandy
The price is HK$511
HK$563 total
includes taxes & fees
12 Feb - 13 Feb
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Residence Inn by Marriott San Diego Downtown/Gaslamp QuarterGaslamp Quarter, 24.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1,268 reviews)
"Friendly staff, great location, excellent value overall "
Maryann
The price is HK$1,010
HK$1,171 total
includes taxes & fees
8 Feb - 9 Feb
Days Inn by Wyndham San Diego Hotel Circle
Days Inn by Wyndham San Diego Hotel Circle28.8 km from Otay Mesa
8.0 out of 10, Very good, (2,454 reviews)
"Very easy to check in and check out, room was clean and location was fantastic. "
Melissa
The price is HK$624
HK$717 total
includes taxes & fees
23 Feb - 24 Feb
Best Western Plus Island Palms Hotel & Marina
Best Western Plus Island Palms Hotel & Marina29.3 km from Otay Mesa
9.0 out of 10, Wonderful, (1,579 reviews)
"Great place.very clean great for family would definitely stay there again."
Joseph
The price is HK$1,113
HK$1,279 total
includes taxes & fees
8 Mar - 9 Mar
Lafayette Hotel & Club
Lafayette Hotel & Club26.8 km from Otay Mesa
9.4 out of 10, Exceptional, (1,456 reviews)
"Nice staff, very clean, good food"
TIM
The price is HK$1,789
HK$2,053 total
includes taxes & fees
23 Feb - 24 Feb
Staypineapple, Hotel Z, Gaslamp San Diego
Staypineapple, Hotel Z, Gaslamp San DiegoGaslamp Quarter, 24.2 km from Otay Mesa
9.4 out of 10, Exceptional, (1,002 reviews)
"Great location and stay. "
Simran
The price is HK$809
HK$1,163 total
includes taxes & fees
22 Feb - 23 Feb
Wyndham San Diego Bayside
Wyndham San Diego Bayside25.7 km from Otay Mesa
8.4 out of 10, Very good, (6,019 reviews)
"Great place to stay"
David
The price is HK$1,189
HK$1,650 total
includes taxes & fees
8 Feb - 9 Feb
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.
Gaslamp Quarter
San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.
Ocean Beach
Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Ocean Beach Farmers Market.
Top Otay Mesa Hotel Reviews
The DEXTRO Little Italy, BW Premier Collection
10/10 Excellent
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