Santa Isabel Holiday Rentals

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
25 Dec - 26 Dec
Tomorrow
26 Dec - 27 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Our top choices for Santa Isabel holiday rentals

Fridge, microwave, oven, stovetop
Casa Palma Serena - Garden Retreat • Tropical Stay

Casa Palma Serena - Garden Retreat • Tropical Stay

Casa Palma Serena - Garden Retreat • Tropical Stay
2.0 star property
Santa Isabel
The price is HK$800
HK$2,124 total
includes taxes & fees
9 Jan - 10 Jan 2026
Casa Palma Serena - Garden Retreat • Tropical Stay
Property grounds
Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep

Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep

Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep
Santa Isabel
8.8 out of 10, Excellent, (44)
"It was amazing to be in the center of the culture. Friendly neighbors! Food amazing! Beach’s all around I would definitely stay there again!!!"
United States
Claudine N.
The price is HK$1,555
HK$2,830 total
includes taxes & fees
8 Jan - 9 Jan 2026
Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep
1 bedroom, iron/ironing board, WiFi, bed sheets
Coming and enjoy panoramic views to mountains and sea in Santa Isabel

Coming and enjoy panoramic views to mountains and sea in Santa Isabel

Coming and enjoy panoramic views to mountains and sea in Santa Isabel
Santa Isabel
The price is HK$1,400
HK$2,641 total
includes taxes & fees
30 Dec - 31 Dec
Coming and enjoy panoramic views to mountains and sea in Santa Isabel
Pool
Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL

Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL

Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
Santa Isabel
10.0 out of 10, Exceptional, (1)
"Our stay at Mimi’s VRBO was unforgettable, and we’re already planning our return! After searching for the ideal family rental, we chose Mimi’s listing and it was a game-changer. Her warmth and quick responses made everything seamless. When our flight was delayed, Mimi arranged a car to get us to the property and coordinated a rental car delivery the next morning.The house is a gem in a safe, friendly neighborhood, steps from Walmart and close to dining options. Packed with kid-friendly amenities...
United States
Henry S.
The price is HK$2,274
HK$4,585 total
includes taxes & fees
29 Dec - 30 Dec
Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
Living area
La Gozadera Park

La Gozadera Park

La Gozadera Park
1.0 star property
Salinas
The price is HK$1,166
HK$1,271 total
includes taxes & fees
26 Dec - 27 Dec
La Gozadera Park
Terrace/patio
The Place at the Sea

The Place at the Sea

The Place at the Sea
2.0 star property
Ponce
9.2 out of 10, Wonderful, (217)
"Everything was excellent, rooms super clean, friendly staff. Great location right by the beach. Will definitely stay on our next vacations."
United States
Ednardo
The Place at the Sea
Exterior
Playa Apartments

Playa Apartments

Playa Apartments
2.5 star property
Salinas
7.6 out of 10, Good, (36)
"Definitely clean, safe, user friendly place"
United States
JULIO
The price is HK$981
HK$1,197 total
includes taxes & fees
1 Jan - 2 Jan 2026
Playa Apartments
Interior
Aibonito Hotel 201

Aibonito Hotel 201

Aibonito Hotel 201
2.5 star property
Aibonito
7.4 out of 10, Good, (27)
"Friendly staff and room were clean everything was close by "
United States
Kristi
The price is HK$972
HK$1,040 total
includes taxes & fees
26 Dec - 27 Dec
Aibonito Hotel 201
Exterior detail
Nostra Casa Vagón

Nostra Casa Vagón

Nostra Casa Vagón
2.0 star property
Coamo
10.0 out of 10, Exceptional, (1)
"Everything was very clean and organized I got confused with the address and the owner communicated with me and directed me to the exact address when I go to Puerto Rico again I will contact them again to stay at the same place "
United States
Carlos Reyes
The price is HK$435
HK$1,030 total
includes taxes & fees
9 Jan - 10 Jan 2026
Nostra Casa Vagón
Terrace/patio
Oasis Salinas

Oasis Salinas

Oasis Salinas
Salinas
7.8 out of 10, Good, (13)
"Excellent place to stay near everything in town "
United States
Mayra
The price is HK$739
HK$1,071 total
includes taxes & fees
27 Dec - 28 Dec
Oasis Salinas
Property grounds
Grandpa's lake house lake private access mountain view museum 1950's experience

Grandpa's lake house lake private access mountain view museum 1950's experience

Grandpa's lake house lake private access mountain view museum 1950's experience
Cidra
9.4 out of 10, Exceptional, (6)
"We had a great peaceful visit!"
United States
Kelly N.
The price is HK$505
HK$862 total
includes taxes & fees
28 Dec - 29 Dec
Grandpa's lake house lake private access mountain view museum 1950's experience
Interior
Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR

Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR

Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR
2.0 star property
Coamo
The price is HK$435
HK$1,037 total
includes taxes & fees
31 Dec - 1 Jan 2026
Enjoyable 2nd story, 3-bedroom house with AC in Coamo, PR
Terrace/patio
HW Tiny Home Cidra

HW Tiny Home Cidra

HW Tiny Home Cidra
Cidra
10.0 out of 10, Exceptional, (2)
"Beautiful area, great AC, clean hot tub, lovely acces to lake with paddleboat!"
United States
Elizabeth C.
The price is HK$910
HK$1,462 total
includes taxes & fees
30 Dec - 31 Dec
HW Tiny Home Cidra
Spa
Points Apartments

Points Apartments

Points Apartments
Guayama
9.4 out of 10, Exceptional, (3)
"The host was great. The location was very good too. It fit our needs well. "
United States
Annie B.
The price is HK$973
HK$1,636 total
includes taxes & fees
26 Dec - 27 Dec
Points Apartments
Fridge, microwave, coffee/tea maker, toaster
Trinitarias Guest's House's pool/bar/karaoke/wifi

Trinitarias Guest's House's pool/bar/karaoke/wifi

Trinitarias Guest's House's pool/bar/karaoke/wifi
Salinas
10.0 out of 10, Exceptional, (2)
"Felt like home beautiful super clean quiet I will definitely be back to this home in our vacations Host is amazing Thank You for sharing this beautiful house with my family "
United States
julio
The price is HK$770
HK$1,312 total
includes taxes & fees
7 Jan - 8 Jan 2026
Trinitarias Guest's House's pool/bar/karaoke/wifi
Pool
Cozy studio with private Pool and Bar modern amentities perfect for relaxation.

Cozy studio with private Pool and Bar modern amentities perfect for relaxation.

Cozy studio with private Pool and Bar modern amentities perfect for relaxation.
Cidra
9.6 out of 10, Exceptional, (4)
"We have a wonderful time! The pool and bar were perfect!"
United States
Anna D.
The price is HK$875
HK$1,962 total
includes taxes & fees
8 Jan - 9 Jan 2026
Cozy studio with private Pool and Bar modern amentities perfect for relaxation.
Property grounds
LA CASITA DEL LAGO

LA CASITA DEL LAGO

LA CASITA DEL LAGO
Cidra
10.0 out of 10, Exceptional, (2)
"The location was amazing "
United States
Maria
The price is HK$762
HK$1,478 total
includes taxes & fees
8 Jan - 9 Jan 2026
LA CASITA DEL LAGO
Outdoor dining
A cozy place to stay walking distance from the beach and Restaurants.

A cozy place to stay walking distance from the beach and Restaurants.

A cozy place to stay walking distance from the beach and Restaurants.
Salinas
9.4 out of 10, Exceptional, (23)
"The description of the house is accurate and the cleanliness of the rental was perfect. The neighborhood was amazing with restaurants and access to the water within walking distance. "
United States
Melanie D.
The price is HK$622
HK$1,237 total
includes taxes & fees
5 Jan - 6 Jan 2026
A cozy place to stay walking distance from the beach and Restaurants.
Property grounds
3-bedroom house in Coamo with AC on bedroom 1

3-bedroom house in Coamo with AC on bedroom 1

3-bedroom house in Coamo with AC on bedroom 1
Coamo
6.4 out of 10, (5)
"The house was nice ,comfortable and community was quiet and safe. we will be back..."
United States
Kenny R.
The price is HK$505
HK$1,071 total
includes taxes & fees
7 Jan - 8 Jan 2026
3-bedroom house in Coamo with AC on bedroom 1
Property grounds
Cozy cabin with hot water jacuzzi and AC in the mountains of Guayama.

Cozy cabin with hot water jacuzzi and AC in the mountains of Guayama.

Cozy cabin with hot water jacuzzi and AC in the mountains of Guayama.
Guayama
10.0 out of 10, Exceptional, (2)
"Property was so beautiful didn’t have any complains. Everything you need in one spot you’d never want to leave."
United States
Jonathan
The price is HK$1,061
HK$1,647 total
includes taxes & fees
1 Jan - 2 Jan 2026
Cozy cabin with hot water jacuzzi and AC in the mountains of Guayama.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Isabel Hotel Reviews

Holiday Inn Ponce & Tropical Casino by IHG

Holiday Inn Ponce & Tropical Casino by IHG

10/10 Excellent
"The room was amzing and the staff extremely friendly and welcoming!!! Best stay so far on the island !!!view spectacular!!! Room spacious and comfortable."
Tamara 1-night trip
Posted 2 days ago
Holiday Inn Ponce & Tropical Casino by IHG

Find out more about Santa Isabel

Search for holiday rentals in Santa Isabel on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Isabel using one of the methods below:

  • View our selection of featured holiday rentals in Santa Isabel
  • Use the map to find apartments and other holiday homes in the Santa Isabel neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Isabel while they last

Look no further and take a look at our great range of rental properties in Santa Isabel!

Frequently asked questions

Are there holiday rentals in Santa Isabel?

Yes, there are holiday rentals close to the most popular sights in Santa Isabel, or you can select a more secluded option if you're looking for a relaxing stay. Santa Isabel is known for its shopping and restaurants. Make sure you have time to check out the beaches while you're in the area.

What are some of the best holiday rentals that Santa Isabel has to offer?

Private Oceanfront Caribbean Escape – Infinity Pool + Tranquil Garden Sanctuary: This highly rated holiday home rental in Santa Isabel is located by the ocean, and has a balcony, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a fridge, a stovetop and a microwave, so that you can cook with friends or family. Make the most of games in this rental home to help you unwind. Other favourite homes for rent in Santa Isabel are Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL and Cultural Oasis: Beachfront Gem, Puerto Rican Heritage at Your Doorstep.

How many holiday rentals will I find in Santa Isabel?

Expedia has 7 holiday rentals for your stay in Santa Isabel.

What can I see and do in Santa Isabel?

Explore the area and family-friendly sights such as Museo de la Musica Puertorriquena, or get out into nature at a spot like Playa La Ochenta. Carribbean Cinemas Santa Isabel and Coamo Springs are a couple of places you'll find in the wider area.

What are holiday rentals like in Santa Isabel?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in Santa Isabel. Holiday rentals provide amenities such as hot tubs, fire pits and patios so you'll feel just like you're staying in your own home. If you're concerned about cleanliness, a holiday rental can provide a sense of privacy away from shared hotel lifts and lobbies bustling with people while still allowing you to travel. You'll also have more space in a holiday rental than in a hotel, which makes a holiday rental an attractive choice for a small group gathering.