Romantic Holidays in Southwest Houston 2026

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Hotel Granduca Houston

1080 Uptown Park Blvd Houston TX

9 min drive from MD Anderson Cancer Center

Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, 2 bars/lounges and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

The Greenleigh, River Oaks, Autograph Collection

2525 West Loop S Houston TX

6 min drive from MD Anderson Cancer Center

Stay at this hotel in Houston. Enjoy free Wi-Fi, room service and valet parking (surcharge). Our guests praise the clean rooms in their reviews. Popular attractions ...

5.8/10 (1,000 reviews)

"The shower didn’t work, no hot water, I paid a deposit November 8 & here it is December 7th still no refund. The transaction shows pending. They all act like they don’t know what’s what ! They use to be upscale now they are 1/10 highly do NOT recommend"

Reviewed on 7 Dec 2024

Omni Houston Hotel

4 Riverway Houston TX

9 min drive from MD Anderson Cancer Center

Stay at this spa hotel in Houston. Enjoy 2 outdoor pools, a full-service spa and 3 bars/lounges. Our guests praise the helpful staff in their reviews. Popular ...

See all 1,334 properties in Southwest Houston

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.