Best East Prairie Hotels in 2026 from HK$502 - Fully Refundable Options

A tree-lined landscape with a river and fields.

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Our top choices for East Prairie hotels

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

1. Hampton Inn Sikeston

Sikeston

Lori

HK$787

HK$895 total

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

2. Drury Inn & Suites Sikeston, MO

Sikeston

Tim

HK$738

HK$848 total

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

3. Best Western Plus Sikeston I-55

Sikeston

Shelley

HK$653

HK$744 total

includes taxes & fees

15 Oct - 16 Oct

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A kitchenette with a coffee machine, a kettle, and storage shelves.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

4. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

HK$730

HK$830 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

5. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

HK$793

HK$901 total

includes taxes & fees

25 Oct - 26 Oct

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

6. TownePlace Suites by Marriott Sikeston

Sikeston

Rubin

HK$855

HK$973 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

A reception area with a counter, a flat-screen TV, and a window with blinds.

7. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

William

HK$467

HK$523 total

includes taxes & fees

15 Oct - 16 Oct

A building with a fountain and flower beds in front.

A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.

A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.

A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

8. The Riverstone Hotel Charleston-Sikeston

Charleston

Kathleen

HK$522

HK$584 total

includes taxes & fees

16 Oct - 17 Oct

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Craig

HK$545

HK$622 total

includes taxes & fees

15 Oct - 16 Oct

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

A spacious lobby with a central atrium, a piano, and a reception desk.

10. Days Inn and Suites by Wyndham Sikeston

Sikeston

David

HK$520

HK$593 total

includes taxes & fees

1 Nov - 2 Nov

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

A living room with two sofas, a coffee table, a TV, and a cabinet.

11. Comfort Inn & Suites Sikeston I-55

Sikeston

Kathryn

HK$623

HK$710 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

A bathroom with a bathtub, toilet, and shower curtain.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

12. Country Yard Inn and Suite

Sikeston

William

HK$459

HK$546 total

includes taxes & fees

15 Oct - 16 Oct

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

A bathroom with a sink, mirror, towel rack, shower, and toilet.

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

13. Eagle Inn Charleston

Charleston

Jackson

HK$518

HK$580 total

includes taxes & fees

15 Oct - 16 Oct

A modern hotel lobby with a reception desk, seating areas, and a large abstract art piece on the wall.

An indoor swimming pool with clear water, safety signs, and chairs around the pool.

A modern office space with a long desk, two chairs, and a computer. There are multiple tables and chairs in the background, and a colorful striped artwork on the wall.

A modern meeting room with red and grey chairs, a large flat-screen TV, and a wooden cabinet with decorative items.

14. Holiday Inn Express & Suites Union City by IHG

Union City

Kevin

HK$926

HK$1,100 total

includes taxes & fees

18 Oct - 19 Oct

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.

A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

A hotel with a central entrance, multiple parking spaces, and a well-lit facade.

15. Super 8 By Wyndham Marston

Marston

Brenda

HK$438

HK$502 total

includes taxes & fees

21 Oct - 22 Oct

An outdoor seating area with a fire pit, cushioned chairs, and a metal fence.

An indoor swimming pool with a no diving sign, lounge chairs, and a no diving sign at the bottom.

A Hampton Inn hotel with a modern design, featuring a well-lit entrance and a clear signage.

A modern hotel lobby with multiple seating areas, a kitchen in the background, and large windows with curtains.

16. Hampton Inn Union City

Union City

Debra

HK$801

HK$951 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A motel with a covered entrance, multiple rooms, and a parking lot.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

17. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Laura

HK$448

HK$511 total

includes taxes & fees

20 Oct - 21 Oct

A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.

A large indoor swimming pool with a tiled floor, surrounded by seating areas and tables.

A modern building with a covered entrance, a nameplate, and a landscaped area with shrubs and a street lamp.

A corridor with a vending machine displaying various beverages and a wall with hanging products.

18. Sleep Inn at Discovery Park of America

Union City

Ben

HK$566

HK$672 total

includes taxes & fees

8 Nov - 9 Nov

A hotel lobby with a reception desk, seating area, and a large window.

A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.

A hotel room with a desk, chair, television, and a lamp.

19. Quality Inn Cairo I-57

Cairo

Santiago

HK$541

HK$601 total

includes taxes & fees

2 Nov - 3 Nov

A hotel dining area with a long counter, multiple tables, and chairs. There are curtains on the windows, a lamp, and a view of the outdoors.

A reception area with a wooden counter, a television, and a sign for 'Quality Inn by Marriott'.

A hotel room with a dining area, a sofa set, a TV mounted on the wall, and a patterned carpet.

A gym with treadmills, elliptical machines, and stationary bikes.

20. Quality Inn Union City US 51

Union City

Terrence Peter

HK$527

HK$626 total

includes taxes & fees

8 Nov - 9 Nov

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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie

Top East Prairie Hotel Reviews

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"good, clean, affordable :)"

Sleep Inn at Discovery Park of America

8/10 Good

"Everything was nice. Bed very comfortable."

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Everything perfect. Drury Inns sweat the details."

Reelfoot Lake Inn

8/10 Good

"Dated but descent."

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"Easy parking, our bathroom sink was leaning forward and we had to place our soap in the sink so it didn't slide on the floor."

Holiday Inn Express & Suites Union City by IHG

10/10 Excellent

"It was the perfect stay."

Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"Clean, comfortable room. Nice staff and good breakfast choices."

Hampton Inn Union City

10/10 Excellent

"The room was pretty spacious and very clean with updated furniture. Breakfast was great!"

The Dragonfly - Sleeps up to 8, Lake views.

10/10 Excellent

"This was the perfect place for us to stay when we were in town for the real foot art and craft show the house was clean. Nice size. We loved the views we had. A a fire that we sat around with and did some mores. It was just wonderful Kristi the host was awesome, very responsive and helpful. Hope to stay there again in the future!"

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO

HK$448

HK$511 total

20 Oct - 21 Oct

includes taxes & fees

7/10 Good! (687 reviews)

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

HK$467

HK$523 total

15 Oct - 16 Oct

includes taxes & fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

HK$520

HK$593 total

1 Nov - 2 Nov

includes taxes & fees

Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN

HK$566

HK$672 total

8 Nov - 9 Nov

includes taxes & fees

9.2/10 Wonderful! (438 reviews)

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

HK$653

HK$744 total

15 Oct - 16 Oct

includes taxes & fees

8.4/10 Very good! (1,000 reviews)

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

HK$787

HK$895 total

18 Oct - 19 Oct

includes taxes & fees

Hotels in East Prairie with star-rating

Frequently asked questions

What's the best place for a stay in East Prairie?

Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Days Inn and Suites by Wyndham Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.

What are some of the best holiday rentals that East Prairie has to offer?

Duck Hunting, Fishing or Relaxing Family Vacation: This holiday home rental outside of East Prairie is located on a lake, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in East Prairie.

If I need to cancel my hotel reservation in East Prairie, will I receive a refund?

Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.

How is it staying in East Prairie?

Visitors will definitely enjoy all that East Prairie has to offer. There are 36 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.

What are the top places to visit in East Prairie?

The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Columbus-Belmont State Park and Fort Defiance State Park in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.

What's the weather like in East Prairie?

The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

East Prairie hotels from HK$502

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in East Prairie

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for East Prairie hotels

1. Hampton Inn Sikeston

2. Drury Inn & Suites Sikeston, MO

3. Best Western Plus Sikeston I-55

4. Holiday Inn Express & Suites Sikeston Southwest by IHG

5. Fairfield Inn & Suites by Marriott Sikeston

6. TownePlace Suites by Marriott Sikeston

7. Super 8 by Wyndham Charleston/Sikeston East MO

8. The Riverstone Hotel Charleston-Sikeston

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10. Days Inn and Suites by Wyndham Sikeston

11. Comfort Inn & Suites Sikeston I-55

12. Country Yard Inn and Suite

13. Eagle Inn Charleston

14. Holiday Inn Express & Suites Union City by IHG

15. Super 8 By Wyndham Marston

16. Hampton Inn Union City

17. Super 8 by Wyndham Sikeston/Miner Area

18. Sleep Inn at Discovery Park of America

19. Quality Inn Cairo I-57

20. Quality Inn Union City US 51

Stay near popular East Prairie attractions

Big Oak Tree State Park

Learn more about East Prairie

Top East Prairie Hotel Reviews

Super 8 by Wyndham Sikeston/Miner Area

Sleep Inn at Discovery Park of America

Drury Inn & Suites Sikeston, MO

Reelfoot Lake Inn

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Hampton Inn Union City

The Dragonfly - Sleeps up to 8, Lake views.

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Charleston/Sikeston East MO

Days Inn and Suites by Wyndham Sikeston

Sleep Inn at Discovery Park of America

Best Western Plus Sikeston I-55

Hampton Inn Sikeston

Hotels in East Prairie with star-rating

Frequently asked questions

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