East Prairie hotels from HK$382

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
25 Dec - 26 Dec
Tomorrow
26 Dec - 27 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for East Prairie hotels

Individually furnished, desk, laptop workspace, blackout curtains
MainStay Suites Union City, TN

MainStay Suites Union City, TN

MainStay Suites Union City, TN
2.5 star property
Union City
8.6 out of 10, Excellent, (42)
"Perfect, staff was very helpful."
United States
Marcos
The price is HK$692
HK$822 total
includes taxes & fees
29 Dec - 30 Dec
MainStay Suites Union City, TN
Lobby
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (320)
"Wonderful breakfast, awesome room"
United States
Kimberly
The price is HK$623
HK$740 total
includes taxes & fees
2 Jan - 3 Jan 2026
Sleep Inn at Discovery Park of America
Free daily buffet breakfast
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (310)
"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is HK$731
HK$868 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Union City by IHG
Seasonal outdoor pool
Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (370)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is HK$423
HK$502 total
includes taxes & fees
23 Jan - 24 Jan 2026
Hospitality House Union City I 69 / US 51
Reception
Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (549)
"Clean rooms, helpful and polite staff"
United States
Jennifer
The price is HK$560
HK$665 total
includes taxes & fees
26 Dec - 27 Dec
Country Hearth Inn & Suites Union City
Terrace/patio
Hampton Inn Union City

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (165)
"Clean room, nice breakfast"
United States
STUART
The price is HK$797
HK$946 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Union City
Lobby
Quality Inn Union City US 51

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (488)
"The Staff for sure is what keeps me coming back! Plus the rooms are very clean!"
United States
Walter
The price is HK$522
HK$620 total
includes taxes & fees
11 Jan - 12 Jan 2026
Quality Inn Union City US 51
Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (274)
"Break fast was excellent "
United States
Uma
The price is HK$551
HK$612 total
includes taxes & fees
17 Jan - 18 Jan 2026
Quality Inn Cairo I-57
Desk, iron/ironing board, free WiFi, alarm clocks
Eagle Inn Charleston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105)
"Middle of nowhere hotel was ok"
United States
David
The price is HK$470
HK$522 total
includes taxes & fees
26 Dec - 27 Dec
Eagle Inn Charleston
Front of property – evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (613)
"Staff was great! Room was nice. "
United States
Lana
The price is HK$483
HK$536 total
includes taxes & fees
28 Dec - 29 Dec
Super 8 by Wyndham Charleston/Sikeston East MO
Blackout curtains, iron/ironing board, free WiFi, bed sheets
Reelfoot Lake Inn

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (461)
"Bed bugs in two separate rooms, wouldn’t refund my room"
United States
Jacquelynn
The price is HK$542
HK$622 total
includes taxes & fees
26 Dec - 27 Dec
Reelfoot Lake Inn
Iron/ironing board, free WiFi, bed sheets
Country Yard Inn and Suite

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (121)
"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
The price is HK$416
HK$494 total
includes taxes & fees
26 Dec - 27 Dec
Country Yard Inn and Suite
1 bedroom, desk, laptop workspace, blackout curtains
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1002)
"Everything was excellent. Verify happy with everything. Stayed 3 weeks for work and already booked 2 more stays."
United States
James
The price is HK$489
HK$557 total
includes taxes & fees
28 Dec - 29 Dec
Days Inn and Suites by Wyndham Sikeston
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1010)
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is HK$588
HK$670 total
includes taxes & fees
30 Dec - 31 Dec
Best Western Plus Sikeston
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"This our favorite place to stop for a good night sleep. "
United States
Eileen
The price is HK$700
HK$804 total
includes taxes & fees
30 Dec - 31 Dec
Drury Inn & Suites Sikeston, MO
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (723)
"Room was good as usual. This is 4th stay over past 5 years. Only issue I had on this stay was the orange juice from breakfast options. "
United States
Todd
The price is HK$431
HK$492 total
includes taxes & fees
28 Dec - 29 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (282)
"Room was clean, breakfast was very good. "
United States
Connie
The price is HK$687
HK$783 total
includes taxes & fees
30 Dec - 31 Dec
Comfort Inn & Suites Sikeston I-55
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1004)
"Everything was clean, staff was friendly "
United States
Matthew
The price is HK$583
HK$670 total
includes taxes & fees
30 Dec - 31 Dec
Pear Tree Inn Sikeston
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (450)
"clean room, comfy bedding, nice staff, convenient location "
United States
Alexa
The price is HK$759
HK$859 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Sikeston
Desk, laptop workspace, blackout curtains, free WiFi
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (568)
"Awesomeness "
United States
Rick
The price is HK$462
HK$527 total
includes taxes & fees
28 Dec - 29 Dec
Super 8 by Wyndham Sikeston/Miner Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

Best Western Plus Sikeston

Best Western Plus Sikeston

10/10 Excellent
"We had late check in. Check in attendant was very friendly and efficient. Well lot parking lot. Clean comfortable room. I was traveling with my MIL and asked for us to be next to each other and they accommodated me with my needs. "
Sherri 1-night trip
Posted 2 days ago
Best Western Plus Sikeston

More cheap stays in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is HK$431 per night from 28 Dec to 29 Dec
HK$431
HK$492 total
28 Dec - 29 Dec
includes taxes & fees
8.4/10 Very Good! (722 reviews)

Hotels in East Prairie with star-rating

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Hampton Inn Sikeston and Best Western Plus Sikeston. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters: This holiday home rental outside of East Prairie is located on a lake, and has a fireplace, a patio and a BBQ to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 33 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Mississippi River and Big Oak Tree State Park exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

Explore a world of travel with Expedia