What is Midtown like?

Travellers are sure to enjoy a stay in St. Louis's Midtown neighbourhood. Make sure that you visit Chaifetz Arena and Washington Avenue Historic District as part of your Midtown travel plans.

Where is the best place to stay in Midtown?

Based on our traveller data, Element by Marriott St. Louis Midtown is one of the top choices for your stay in Midtown. This hotel is a short 6-minute walk from St. Louis University, and it offers free breakfast and an indoor pool.

How many hotels will I be able to find in the Midtown area?

If you're searching for places to stay in St. Louis, Expedia has something to meet your needs with 35 Midtown hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in Midtown, will I receive a refund?

Yes! Most hotel room reservations are refundable if you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of check in. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within 24 hours of booking. Add dates, click "Search", then use the filter option "fully refundable" to get top deals in Midtown.

What are the top things to see and do in Midtown?

Sights like Scott Joplin House State Historic Site, Red Flag and Museum of Contemporary Religious Art can be part of your cultural tour of Midtown. Chaifetz Arena and Washington Avenue Historic District are also a couple of places to visit in the neighbourhood. St. Louis Union Station and Gateway Arch are some popular places to visit in the area around Midtown. While you're out sightseeing, Hermann Stadium and .ZACK Theater are a couple of additional sights to visit in St. Louis.

How can I get around Midtown and the greater St. Louis area?

Ready to get out and explore the city? Grand Station is the closest metro station.

Midtown Hotels: 2026 Top 10 Midtown Hotels with Limited-Time Deals @Expedia

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Our top choices for Midtown hotels

A lobby with a sofa, two armchairs, a coffee table, and a staircase.

1. Hyatt Regency St. Louis at The Arch

Downtown St. Louis, 3.4 km from Midtown

Trevion

HK$1,407 total

includes taxes & fees

1 Oct - 2 Oct

A rooftop terrace with wicker furniture, offering a city view.

2. Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis, 3.4 km from Midtown

Salvatore

HK$1,238 total

includes taxes & fees

4 Oct - 5 Oct

A bar area with a central bar, multiple stools, and a chandelier.

3. Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Downtown St. Louis, 3 km from Midtown

Carol

HK$1,007 total

includes taxes & fees

20 Sept - 21 Sept

A modern outdoor lounge area with seating, a bar, and a view of a cityscape.

4. Live by Loews - St.Louis

Downtown St. Louis, 3 km from Midtown

Judd

HK$1,483 total

includes taxes & fees

27 Sept - 28 Sept

The Clayton Plaza Hotel sign with a stone wall and plants in front.

5. Clayton Plaza Hotel & Extended Stay

9.8 km from Midtown

Sivakumar

HK$862 total

includes taxes & fees

11 Oct - 12 Oct

An indoor swimming pool with a hot tub, lounge chairs, and a brick wall with artwork.

6. Pear Tree Inn St. Louis Near Union Station

Downtown West, 1.2 km from Midtown

Michael

HK$1,073 total

includes taxes & fees

20 Sept - 21 Sept

A rooftop restaurant with round tables, chairs, and a view of the city.

7. Moonrise Hotel

6.8 km from Midtown

Nicole

HK$1,231 total

includes taxes & fees

7 Oct - 8 Oct

A rooftop terrace with outdoor seating, string lights, and a city skyline view.

8. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

0.8 km from Midtown

Arturo

HK$1,168 total

includes taxes & fees

2 Oct - 3 Oct

An indoor pool area with a hot tub, seating, and a stone wall.

9. Drury Plaza Hotel St. Louis Union Station

Downtown West, 1.5 km from Midtown

Katy

HK$1,259 total

includes taxes & fees

20 Sept - 21 Sept

A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.

10. 21C Museum Hotel St Louis

Downtown West, 2.1 km from Midtown

Zane

HK$1,356 total

includes taxes & fees

11 Oct - 12 Oct

A modern lounge with a central fire feature, comfortable seating, and large windows offering a city view.

11. Hilton St. Louis at the Ballpark

Downtown St. Louis, 3.2 km from Midtown

Scott

HK$1,445 total

includes taxes & fees

25 Sept - 26 Sept

A multi-story hotel with a prominent corner location, large windows, and a well-lit facade.

12. Embassy Suites by Hilton St. Louis Downtown

Downtown St. Louis, 3.1 km from Midtown

Andrew

HK$1,063 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with two beds, a chair, a desk, and a large window.

13. Forest Park Hotel by MDR

The Hill, 5.4 km from Midtown

wahwah

HK$745 total

includes taxes & fees

14 Oct - 15 Oct

A modern interior with hanging chairs and ottomans, large windows with a view of the street.

14. Home2 Suites by Hilton St. Louis Downtown

Downtown West, 2.5 km from Midtown

kaila

HK$895 total

includes taxes & fees

21 Sept - 22 Sept

A multi-story hotel with a prominent 'Marriott' sign, featuring a classic architectural style with a red brick facade and large windows.

15. Marriott St. Louis Grand

Downtown St. Louis, 3 km from Midtown

Andrew

HK$1,418 total

includes taxes & fees

25 Sept - 26 Sept

A multi-story building with a classic architectural style, featuring numerous windows and a brick facade.

16. Courtyard by Marriott St. Louis Downtown/Convention Center

Downtown St. Louis, 2.9 km from Midtown

Kristy

HK$983 total

includes taxes & fees

4 Oct - 5 Oct

A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.

17. The Royal Sonesta Chase Park Plaza St. Louis

Central West End, 3.6 km from Midtown

Brianna

HK$1,637 total

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with high arched ceilings, ornate columns, and a central fountain.

18. St. Louis Union Station Hotel, Curio Collection by Hilton

Downtown West, 1.7 km from Midtown

Mirjana

HK$1,527 total

includes taxes & fees

20 Sept - 21 Sept

An indoor swimming pool with clear glass ceilings, large windows, and a sunlit area with umbrellas.

19. Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Downtown St. Louis, 3.5 km from Midtown

Alexander

HK$1,120 total

includes taxes & fees

21 Sept - 22 Sept

A modern hotel room with a large bed, a nightstand, a mirror, and a view of the city through arched windows.

20. The Westin St. Louis

Downtown St. Louis, 2.9 km from Midtown

Joanne

HK$1,243 total

includes taxes & fees

27 Sept - 28 Sept

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Where to stay in Midtown

Find the best Midtown areas for the activities you enjoy most.

The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

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A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

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A street corner with a 'Drunken Fish' sushi restaurant and a 'Culpeppers' grill and bar.

Central West End

Enjoy this relaxed area, the ultimate destination for a lazy afternoon. Browse unique stores, admire artworks and sip coffee at sidewalk tables shaded by trees.

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A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

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A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

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Top Midtown Hotel Reviews

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

8/10 Good

"Location was perfect for our family."

Home2 Suites by Hilton St. Louis Downtown

10/10 Excellent

"My friend and I had a great single night experience. We were in St Louis for a concert and this hotel met our needs perfectly. The staff was slammed when we got there just before 4pm check in. They got everything taken care of even though our room wasn't quite ready. There was so much going on but the staff was wonderful and kept us updated. We were able to get sheets and a blanket for the pullout in a nice all-in-one kit. There are several road closures and after reading reviews about the valet parking being impacted, we chose to park in a near by lot. Breakfast the next morning was great and the coffee was strong. We would absolutely stay here again!"

Midtown hotels in St. Louis

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Our top choices for Midtown hotels

1. Hyatt Regency St. Louis at The Arch

2. Drury Plaza Hotel St. Louis at the Arch

3. Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4. Live by Loews - St.Louis

5. Clayton Plaza Hotel & Extended Stay

6. Pear Tree Inn St. Louis Near Union Station

7. Moonrise Hotel

8. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

9. Drury Plaza Hotel St. Louis Union Station

10. 21C Museum Hotel St Louis

11. Hilton St. Louis at the Ballpark

12. Embassy Suites by Hilton St. Louis Downtown

13. Forest Park Hotel by MDR

14. Home2 Suites by Hilton St. Louis Downtown

15. Marriott St. Louis Grand

16. Courtyard by Marriott St. Louis Downtown/Convention Center

17. The Royal Sonesta Chase Park Plaza St. Louis

18. St. Louis Union Station Hotel, Curio Collection by Hilton

19. Hampton Inn St. Louis-Downtown (At the Gateway Arch)

20. The Westin St. Louis

Where to stay in Midtown

Downtown St. Louis

Clayton

Central West End

Creve Coeur

St. Charles Historic District

Top Midtown Hotel Reviews

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

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