The Quisby is a great place to stay if you're willing and able to do some exploring. I liked the location of the hotel a lot. They provide a guide to nearby attractions and establishments, and all of the spots I visited were great. Definitely recommend checking a few out. It's also very easy to access the FQ via the nearby streetcar route, or on foot if you're willing to walk about 20-30 minutes.
Staff were friendly and I had no issues with check-in or check-out. The room was small by hotel room standards, but it was perfect size for a solo traveler like myself. I could see things being cramped with a second person in the room. Amenities were also fairly basic (you have to go down to the lobby for ice and water, for example) but the AC worked well and that's the most important thing.
A point against the property is that I could see it being difficult to get around if you need to use a mobility aid. While they do have a ramp in the lobby and an elevator, the lack of street parking and somewhat rough terrain outside the door could make things tricky. Also, the shower in my room didn't have a railing or any anti-slip surfaces, which was fine for me but is worth considering.
Overall, I would recommend considering the Quisby, especially if you're traveling alone, are comfortable walking around cities, and willing to make room on the itinerary for new experiences. Would stay again!