Otay Mesa
San Diego
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Balboa Park
Culture and nature converge in this diverse park located in the heart of the city.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour
Tijuana: Guided City Tour with Local Food and Beer Tasting
From Tijuana: Valle de Guadalupe Shared Winery Tour
Rosarito like a local Day trip from San Diego
Top hotels in Otay Mesa
Paradise Point Resort & Spa
Great place for kids. Lots to do right at the resort, no need to leave, but great attractions nearby. Main pool was great, but get there early and grab some chairs. Signage was not great, took a day or two to get our bearings. Also only one location to get decent coffee and the line was LONG. Restaurant ...
Reviewed on 15 Apr 2026
Best Western Seven Seas
Beautiful pool, hot tubs and grounds
Reviewed on 14 Apr 2026
Hard Rock Hotel San Diego
We were in town for a concert with our teen daughter and her teenage friends. They loved the experience at the Hard Rock Hotel. The decor made them feel like it was a rock & roll weekend. The only small issue was the parking but we got it worked out. We would stay again.
Reviewed on 15 Apr 2026
Handlery Hotel
Very disappointed with our stay at Handlery Hotel (4/9–4/12). It was nothing like advertised and far from the relaxing getaway we booked. Our room was placed directly by a housekeeping closet. Every morning around 6:30–7:00 AM staff gathered there talking loudly, using phones, and slamming doors, ...
Reviewed on 13 Apr 2026
The DEXTRO Little Italy, BW Premier Collection
Confortable, clean hotel. Well located. A bit noisy because it is close to the highway.
Reviewed on 15 Apr 2026
Wyndham San Diego Bayside
Very convenient location for our cruise. Room was kind of old. We had a leak in the air conditioner vent but they came promptly to fix. Then a leak over the sink.
Reviewed on 15 Apr 2026
Other neighbourhoods around Otay Mesa
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Mission Valley
Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.
Otay Mesa
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