Best Wykoff Hotels in 2026 from HK$476 - Fully Refundable Options

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Go beyond your typical stay in Wykoff

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Our top choices for Wykoff hotels

A lobby with leather sofas, a reception desk, a clock, and a map of the museum.

A hotel room with a large bed, a separate bathroom with a bathtub, a bedside table with a lamp, and a framed picture on the wall.

A large, single-story motel with a covered parking area and a grassy lawn.

A lobby with a fireplace, leather seating, a television, and a large window.

1. Americas Best Value Inn & Suites Spring Valley

Spring Valley

Donna

HK$698

HK$770 total

includes taxes & fees

29 Sept - 30 Sept

A hotel room with two beds, a desk, a chair, and a lamp.

A living room with a brick fireplace, two armchairs with decorative pillows, and a framed map on the wall.

A lobby with a checkered floor, two blue armchairs, a table with a lamp, and a 'WELCOME' sign.

A hotel lobby with a dining area, a fireplace, and a television displaying a map.

2. Country Trails Inn & Suites

Preston

Jeannie

HK$992

HK$1,095 total

includes taxes & fees

29 Sept - 30 Sept

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A reception desk with a wooden finish, a large illuminated 'C' sign, and a modern light fixture on the ceiling.

A gym with treadmills, elliptical machines, and a stationary bike.

A conference room with round tables and chairs, white walls, and a carpeted floor.

3. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

JOSEPH

HK$607

HK$699 total

includes taxes & fees

25 Oct - 26 Oct

A reception desk with a wooden finish, a glass partition, and a blue wall with climbing plants.

A hotel with a parking lot, a yellow food truck, and several cars parked.

A hotel room with two beds, each with white linens and patterned bedspreads. There are bedside tables with lamps, a desk with a chair, and a wall-mounted TV.

A dining area with wooden tables and chairs, a brick fireplace, and a television mounted above it.

4. America's Stay Inn Stewartville

Stewartville

arnold

HK$494

HK$554 total

includes taxes & fees

15 Oct - 16 Oct

A modern hotel lobby with a reception desk, seating area, and a dining space.

A modern breakfast area with a counter displaying various food items, a water dispenser, and a sign indicating a bakery section.

A modern hotel room with a wooden desk, orange chair, dark sofa, and a small table.

A hotel room with a bed, desk, chair, and a bathroom.

5. Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

Melissa

HK$753

HK$867 total

includes taxes & fees

4 Oct - 5 Oct

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

A hotel room with a large bed, a desk, a chair, and a kitchenette.

A hotel with a covered entrance, multiple floors, and a parking lot.

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

6. Spark by Hilton Rochester South

Rochester

Kimberly

HK$637

HK$733 total

includes taxes & fees

4 Oct - 5 Oct

A multi-story building with a balcony, surrounded by various potted plants and flowers.

A bedroom with a four-poster bed, a sitting area with a sofa, a small table with a vase, and a bathtub.

A bedroom with a four-poster bed, a sofa, a desk, and a fireplace.

An outdoor patio with tables and chairs, green umbrellas, and a wooden deck.

7. Green Gables Inn

Lanesboro

Sandra

HK$661

HK$709 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with wicker chairs and tables, surrounded by vibrant flowers and a red umbrella.

A spacious living area with a high ceiling, wooden beams, a blue armchair, a sofa, and a glass coffee table.

A bedroom with a large bed, a bathtub, a wooden rocking chair, and a desk with a lamp.

A cozy living room with a fireplace, a staircase, and a dining area.

8. Stone Mill Hotel & Suites

Lanesboro

Jenifer

HK$823

HK$884 total

includes taxes & fees

18 Oct - 19 Oct

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

9. Hampton Inn Rochester-South

Rochester

dennis

HK$830

HK$955 total

includes taxes & fees

18 Oct - 19 Oct

A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

A buffet counter with a variety of food items, a coffee station, and a beverage dispenser.

A modern lobby with a teal sofa, yellow chairs, a small round table, and a fireplace with a TV.

An indoor swimming pool with a slide, seating areas, and a lifeguard station.

10. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Rochester

Zoronna

HK$593

HK$683 total

includes taxes & fees

11 Oct - 12 Oct

A bedroom with a sloped ceiling, a brick wall, a bed with floral bedding, two bedside lamps, and a vase with red flowers.

A building with a covered porch, a brick exterior, and a white fence.

A compact living space with a kitchenette, a dining area, and a sofa.

A living room with a brick wall, a television, a refrigerator, and a coffee table.

11. Country Lodge inn

Harmony

Jacob

HK$1,148

HK$1,317 total

includes taxes & fees

1 Oct - 2 Oct

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern lounge area with a sofa, chairs, and tables.

A modern hotel room with a bed, desk, and kitchenette.

12. Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

Vickie

HK$958

HK$1,103 total

includes taxes & fees

3 Oct - 4 Oct

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

A bar with wooden stools and a neon sign.

A hotel room with two beds, a desk, a chair, and a mirror.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

13. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

Jeanne

HK$637

HK$733 total

includes taxes & fees

28 Sept - 29 Sept

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern indoor pool area with lounge chairs and a pool.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

14. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Kathy

HK$925

HK$1,065 total

includes taxes & fees

3 Oct - 4 Oct

An indoor swimming pool with slides, seating areas, and a covered section with umbrellas.

A modern kitchen with a microwave, sink, and granite countertop.

A modern kitchen with black cabinets, white countertops, and a tiled backsplash. There are pendant lights, a refrigerator, and a coffee machine.

A hotel room with a kitchen area, a bed, a TV, and a seating area.

15. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Rochester

Vicky

HK$775

HK$892 total

includes taxes & fees

29 Sept - 30 Sept

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

A hotel dining area with multiple tables and chairs, a coffee station, and a seating area with sofas.

A coffee station with two espresso machines and a variety of coffee pods and cups.

16. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park

Janet

HK$863

HK$993 total

includes taxes & fees

2 Oct - 3 Oct

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

A modern lounge area with seating, a fireplace, and a bar area.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

17. Residence Inn by Marriott Rochester Mayo Clinic Area South

Rochester

Chee

HK$1,035

HK$1,192 total

includes taxes & fees

2 Oct - 3 Oct

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A restaurant interior with wooden tables, chairs, and a stone wall.

A garden with a water feature, rocks, and yellow umbrellas.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

18. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest

Carrie

HK$846

HK$974 total

includes taxes & fees

10 Oct - 11 Oct

A poolside area with wicker chairs and potted plants, a tiled floor, and a clear view of the pool.

A restaurant with a bar area, wooden chairs, and a stone wall.

A reception area with a wooden reception desk, a clock, and a wall-mounted display.

A modern building with large windows and a parking lot.

19. Kahler Inn and Suites - Mayo Clinic Area

Downtown Rochester

Dana

HK$1,122

HK$1,292 total

includes taxes & fees

26 Sept - 27 Sept

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

A hotel lobby with leather sofas, a stone fireplace, and a patterned carpet.

20. Econo Lodge Mayo Clinic Area

Rochester

Ashley

HK$572

HK$658 total

includes taxes & fees

25 Oct - 26 Oct

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Stay near popular Wykoff attractions

Ed's Museum

You can spend time browsing the exhibits at Ed's Museum during your travels in Wykoff. Discover the countryside while you're in the area.

See properties

Top Wykoff Hotel Reviews

Staybridge Suites Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Love this place!"

Kahler Inn and Suites - Mayo Clinic Area

8/10 Good

"Room was clean"

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

8/10 Good

"I will always stay here when I am visiting my childhood home. It is just very comfortable!! Like coming home... thanks to all the staff! Sincerely, Jim Reardon"

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Great breakfast"

Aspen Select

10/10 Excellent

"Very convenient to Saint Mary's hospital"

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"We enjoyed our stay. The breakfast was wonderful. We were disappointed the hot tub only ran for the first evening though and was down for maintenance after. And the exercise room was a bit grimy"

Hampton Inn Rochester-South

10/10 Excellent

"Clean room and hotel. Breakfast was great"

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

10/10 Excellent

"Was there for a surgery at the Mayo and they were so helpful and accommodating. Very grateful for the facility and the staff"

The Berkman

10/10 Excellent

"Great communication with staff and a friendly shuttle over to Mayo Gonda. Apartment was squeaky clean."

More cheap stays in Wykoff

Birch Hill Suite Rochester – Med City

3595 Commercial Drive SW Rochester MN

HK$455

HK$524 total

21 Oct - 22 Oct

includes taxes & fees

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

HK$560

HK$645 total

26 Sept - 27 Sept

includes taxes & fees

Comfort Inn & Suites Rochester South Mayo Clinic

7320 Airport View Dr Sw Rochester MN

HK$607

HK$699 total

25 Oct - 26 Oct

includes taxes & fees

Brentwood Inn & Suites

123 Fourth Ave. NW Rochester MN

HK$735

HK$846 total

26 Sept - 27 Sept

includes taxes & fees

Holiday Inn Express Rochester South - Mayo Area by IHG

4141 Maine Avenue SE Rochester MN

HK$753

HK$867 total

4 Oct - 5 Oct

includes taxes & fees

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

1517 16th St Sw Rochester MN

HK$775

HK$892 total

29 Sept - 30 Sept

includes taxes & fees

8.2/10 Very good! (1,000 reviews)

Frequently asked questions

Where is the best place to stay in Wykoff?

Located 22.4 mi (36.1 km) from the heart of Wykoff, AmericInn by Wyndham Rochester Near Mayo Clinic is a top choice for your stay, based on our traveller data. Two other choices for your trip to the area are Kahler Grand Hotel and Kahler Inn and Suites - Mayo Clinic Area. See all available top hotels, or vacation rentals in Wykoff.

What are some of the best holiday rentals that Wykoff has to offer?

Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom: This holiday home rental outside of Wykoff offers a patio, a garden and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. Make the most of games in this rental home to help you unwind. See all vacation rentals in Wykoff.

If I need to cancel my hotel reservation in Wykoff, will I receive a refund?

Yes! You'll find that most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Wykoff.

How is it staying in Wykoff?

Visitors can enjoy all that Wykoff has to offer, including its museums. There are 322 hotels and other accommodation options in the surrounding area. Find out more about Wykoff.

What should I see while I'm in Wykoff?

A favourite place to visit is Ed's Museum. You'll also find Forestville Mystery Cave State Park and Four Daughters Vineyard & Winery in the area. Take a look at what more there is to see and do in Expedia's Wykoff guide.

What's the weather like in Wykoff?

The hottest months are usually July and August, with an average temperature of 20°C, while the coldest months are January and February, with an average of -5°C. The snowiest months in Wykoff are January, March, February and April, with each month seeing an average of 20 cm of snowfall.

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Wykoff hotels from HK$476

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Wykoff

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Wykoff hotels

1. Americas Best Value Inn & Suites Spring Valley

2. Country Trails Inn & Suites

3. Comfort Inn & Suites Rochester South Mayo Clinic

4. America's Stay Inn Stewartville

5. Holiday Inn Express Rochester South - Mayo Area by IHG

6. Spark by Hilton Rochester South

7. Green Gables Inn

8. Stone Mill Hotel & Suites

9. Hampton Inn Rochester-South

10. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

11. Country Lodge inn

12. Home2 Suites by Hilton Rochester Mayo Clinic Area

13. AmericInn by Wyndham Rochester Near Mayo Clinic

14. Hyatt House Rochester/Mayo Clinic Area

15. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

16. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

17. Residence Inn by Marriott Rochester Mayo Clinic Area South

18. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

19. Kahler Inn and Suites - Mayo Clinic Area

20. Econo Lodge Mayo Clinic Area

Stay near popular Wykoff attractions

Ed's Museum

Top Wykoff Hotel Reviews

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kahler Inn and Suites - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Aspen Select

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Hampton Inn Rochester-South

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

The Berkman

More cheap stays in Wykoff

Birch Hill Suite Rochester – Med City

Med City Inn & Suites - Mayo Clinic Area

Comfort Inn & Suites Rochester South Mayo Clinic

Brentwood Inn & Suites

Holiday Inn Express Rochester South - Mayo Area by IHG

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Frequently asked questions

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