Byron Byron Town Square Hotels: 2026 Limited-Time Hotel Deals @Expedia

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Our top choices for Byron Town Square hotels

A modern hotel lobby with a reception desk, seating area, and a kitchenette.

1. Spark by Hilton Rochester South

15.8 km from Byron Town Square

Stanton

HK$637 total

includes taxes & fees

22 Nov - 23 Nov

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

2. Econo Lodge Mayo Clinic Area

13.8 km from Byron Town Square

Ashley

HK$608 total

includes taxes & fees

28 Nov - 29 Nov

A modern indoor patio with a fire feature, seating, and large windows.

3. EVEN Hotel Rochester - Mayo Clinic Area by IHG

11.9 km from Byron Town Square

James

HK$1,136 total

includes taxes & fees

6 Nov - 7 Nov

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

4. Residence Inn by Marriott Rochester Mayo Clinic Area South

12.7 km from Byron Town Square

Chee

HK$1,192 total

includes taxes & fees

13 Nov - 14 Nov

A modern dining area with high tables, chairs, and pendant lighting.

5. Hampton Inn & Suites Rochester-North

11.2 km from Byron Town Square

Mark

HK$913 total

includes taxes & fees

7 Nov - 8 Nov

A Comfort Inn & Suites hotel with a modern design, featuring a prominent signage and a parking lot.

6. Comfort Inn & Suites Rochester South Mayo Clinic

17.4 km from Byron Town Square

Terri

HK$645 total

includes taxes & fees

28 Nov - 29 Nov

An outdoor patio area with a concrete floor, wooden fence, and string lights.

7. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

11.2 km from Byron Town Square

Brien

HK$1,049 total

includes taxes & fees

7 Nov - 8 Nov

A modern hotel lobby with a reception desk, seating area, and a dining space.

8. Holiday Inn Express Rochester South - Mayo Area by IHG

15.8 km from Byron Town Square

Rick

HK$831 total

includes taxes & fees

27 Nov - 28 Nov

A coffee shop interior with a wooden counter, menu boards, and seating area.

9. TownePlace Suites by Marriott Rochester Mayo Clinic Area

12.5 km from Byron Town Square

Cory

HK$1,237 total

includes taxes & fees

7 Nov - 8 Nov

A modern living room with a fireplace, comfortable seating, and large windows.

10. Staybridge Suites Rochester - Mayo Clinic Area by IHG

11.9 km from Byron Town Square

Amanda

HK$964 total

includes taxes & fees

25 Nov - 26 Nov

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

11. Quality Inn & Suites Mayo Clinic Area

13.7 km from Byron Town Square

Jessica

HK$613 total

includes taxes & fees

27 Nov - 28 Nov

A spacious lobby with a reception desk, sofas, and a coffee table.

12. Sleep Inn & Suites West-Near Medical Center

8.7 km from Byron Town Square

Jacqueline

HK$705 total

includes taxes & fees

22 Nov - 23 Nov

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

13. Home2 Suites by Hilton Rochester Mayo Clinic Area

12.6 km from Byron Town Square

howard

HK$990 total

includes taxes & fees

7 Nov - 8 Nov

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

14. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

12.8 km from Byron Town Square

Deanna

HK$1,031 total

includes taxes & fees

1 Nov - 2 Nov

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

15. Hampton Inn Rochester-South

13.6 km from Byron Town Square

Susan

HK$883 total

includes taxes & fees

8 Nov - 9 Nov

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

16. AmericInn by Wyndham Rochester Near Mayo Clinic

13.5 km from Byron Town Square

Tammy

HK$681 total

includes taxes & fees

8 Nov - 9 Nov

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

17. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

11.5 km from Byron Town Square

Lin

HK$990 total

includes taxes & fees

22 Nov - 23 Nov

A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

18. Comfort Inn & Suites West - Medical Center

8.8 km from Byron Town Square

Tammy

HK$783 total

includes taxes & fees

28 Nov - 29 Nov

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

19. The Berkman

11.5 km from Byron Town Square

Suzette

HK$1,734 total

includes taxes & fees

21 Nov - 22 Nov

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

20. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

11.5 km from Byron Town Square

MATTHEW

HK$1,021 total

includes taxes & fees

6 Nov - 7 Nov

View all properties

Compare popular hotels close to Byron Town Square

Property	Property class	Guest rating
Spark by Hilton Rochester South	3.0 star property	9.2 Wonderful 601 reviews	View
Econo Lodge Mayo Clinic Area	2.0 star property	9.0 Wonderful 1,013 reviews	View
EVEN Hotel Rochester - Mayo Clinic Area by IHG	4.0 star property	9.4 Exceptional 1,001 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	3.0 star property	9.6 Exceptional 321 reviews	View
Hampton Inn & Suites Rochester-North	2.5 star property	9.2 Wonderful 1,000 reviews	View

Top Byron Town Square Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good

"We’ve been to this property numerous times over the past 2 years for appointments in Rochester and have been pleased. Price has been decent as well."

Comfort Inn & Suites West - Medical Center

10/10 Excellent

"This is the place we stay every year my wife and I make our annual trip to Mayo Clinic for her appointments. The rooms are clean and the staff are super helpful and friendly. It’s a little bit out of the way from Mayo Clinic compared to the other hotels but the price is always so reasonable for what you are getting. It’s also right next to Costco and Aldi so if you need anything from those places you can literally walk there."

TownePlace Suites by Marriott Rochester

10/10 Excellent

"loved the hotel and will return. however the pool/hot tub area was closed two evenings for some repairs to the kiddie pool. there is no need to close the big pool and hot tub just for repairs on the kids pool. i only stay at hotels with hot tubs and am quite frustrated if it is closed, especially 2 nites in a row. do your repairs early in the day. at the end of the day i want to use the hot tub and pool if possible. (thanks for leaving the key pad operational. I did use it both nites, just me, lol. ). love your place."

Other attractions near Byron Town Square

High Point Shopping Center

You can do some window-shopping at High Point Shopping Center during your trip to Byron. Amble around the area's parks or experience its art scene.

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Frequently asked questions

What's the area like around Byron Town Square?

Byron Town Square is located in Byron. You'll find 9 hotels and other accommodations within a few miles for a convenient home base.

Where is the best place to stay close to Byron Town Square?

AmericInn by Wyndham Rochester Near Mayo Clinic is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and free breakfast. You'll find it 8.4 mi (13.5 km) from Byron Town Square. Other good choices around the area include Kahler Grand Hotel and Med City Inn & Suites - Mayo Clinic Area.

How many hotels should I expect to find near Byron Town Square?

Expedia has 9 hotels and other accommodation options a few miles from Byron Town Square.

If I need to cancel the hotel reservation for my stay near Byron Town Square, will I receive a refund?

Yes! Most hotel bookings are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within 24 hours of booking. Add dates, click "Search", then use the "fully refundable" filter to get the best deals available near Byron Town Square.

What can I see and do near Byron Town Square?

Explore nature at Oxbow Park and Douglas Trail. A trip to High Point Shopping Center and Cheery Meadows Center might be just the ticket for souvenir shopping. If you're looking for something to do, plan a visit to Links of Byron Mini Golf, Somerby Golf Club and Putting Green while you're in the area.

Byron Byron Town Square Hotels

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Our top choices for Byron Town Square hotels

1. Spark by Hilton Rochester South

2. Econo Lodge Mayo Clinic Area

3. EVEN Hotel Rochester - Mayo Clinic Area by IHG

4. Residence Inn by Marriott Rochester Mayo Clinic Area South

5. Hampton Inn & Suites Rochester-North

6. Comfort Inn & Suites Rochester South Mayo Clinic

7. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

8. Holiday Inn Express Rochester South - Mayo Area by IHG

9. TownePlace Suites by Marriott Rochester Mayo Clinic Area

10. Staybridge Suites Rochester - Mayo Clinic Area by IHG

11. Quality Inn & Suites Mayo Clinic Area

12. Sleep Inn & Suites West-Near Medical Center

13. Home2 Suites by Hilton Rochester Mayo Clinic Area

14. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

15. Hampton Inn Rochester-South

16. AmericInn by Wyndham Rochester Near Mayo Clinic

17. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

18. Comfort Inn & Suites West - Medical Center

19. The Berkman

20. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Compare popular hotels close to Byron Town Square

Top Byron Town Square Hotel Reviews

AmericInn by Wyndham Rochester Near Mayo Clinic

Other attractions near Byron Town Square

High Point Shopping Center

Frequently asked questions