Historic Main Street
Visit Historic Main Street
The Knight Center at Washington University
Reviewed on 16 Nov 2025
Popular places to visit
Frontier Park
You can find out about the history of St. Charles with a stop at Frontier Park. Visit the shops and top-notch restaurants in this walkable area.
First Missouri State Capitol Historic Site
You can learn about the history of St. Charles with a stop at First Missouri State Capitol Historic Site. Discover the top-notch restaurants and acclaimed theatre scene in this family-friendly area.
Missouri Artists on Main
You can spend an afternoon browsing the exhibits at Missouri Artists on Main in St. Charles. Visit the shops and top-notch restaurants in this walkable area.
SSM Health St. Joseph Hospital
If SSM Health St. Joseph Hospital is what brings you to town, hopefully you'll have a chance to explore more of St. Charles.
Lewis & Clark Boathouse and Nature Center
You can spend time studying the exhibits at Lewis & Clark Boathouse and Nature Center during your trip to St. Charles. Experience the great live music and acclaimed theatre scene in this family-friendly area.
Frenchtown Heritage Museum
You can spend time browsing the exhibits at Frenchtown Heritage Museum during your trip to St. Charles. Visit the shops and top-notch restaurants in this walkable area.
Top Historic Main Street Hotel Deals
Country Inn & Suites by Radisson, St. Charles Historic District
Ameristar Casino Resort and Spa
The St. Charles Guest House, lovely historic home, fun for families and groups
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
Americas Best Value Inn & Suites St. Louis, St. Charles Inn
1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.
The Hare Suite at Divine Otter
Luxurious, spa-like retreat steps from Main St.
The Otter Suite at Divine Otter
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- Holidays and getaways similar to Historic Main Street
- Hotels Near Historic Main Street
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- The Wild West Getaway- 204-1
- HUGE 2 bedroom unit on Main Street
- The Historic Bricks on Main
- The Owl Suite at Divine Otter
- Scenic South Main Apartment with Breathtaking Views for 3 Guests
- Walking distance to Historic Main Street, St. Charles, MO
- The Buck Suite at Divine Otter
- 3BR Historic St. Charles, MO-Walking distance to Main Street
- The Bear Suite at Divine Otter
- The Fox Suite at Divine Otter
- Western-Themed 2-Bedroom Hideout for Outlaws 204-2
- Relaxing South Main Apartment with Modern Comforts