Hyannis Main Street Hyannis Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Main Street Hyannis hotels

Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging
3.0 star property
0.6 km from Main Street Hyannis
9.4 out of 10, Exceptional, (1,002 reviews)
"The Anchor In is a lovely hotel with friendly staff and clean, updated rooms. It is very convenient to the ferry and to various dining options in Hyannis. Great place to stay!"
United States
Cynthia
The price is HK$921
HK$1,277 total
includes taxes & fees
21 Jan - 22 Jan
Anchor In Distinctive Waterfront Lodging

Sea Street Inn

Sea Street Inn
4.0 star property
1.5 km from Main Street Hyannis
9.8 out of 10, Exceptional, (45 reviews)
"Adrian was an awesome host. Comfortable bed, safe area to walk, beautiful surroundings."
United States
Jori
The price is HK$1,748
HK$2,001 total
includes taxes & fees
25 Jan - 26 Jan
Sea Street Inn

Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection
3.0 star property
1.9 km from Main Street Hyannis
9.4 out of 10, Exceptional, (101 reviews)
"Clean, nice staff, good amenities, central location"
United States
Malbis
The price is HK$918
HK$1,050 total
includes taxes & fees
18 Jan - 19 Jan
Uncommoner Hotel by Reverie Boutique Collection

Hampton Inn & Suites Cape Cod-West Yarmouth

Hampton Inn & Suites Cape Cod-West Yarmouth
2.5 star property
1.7 km from Main Street Hyannis
8.8 out of 10, Excellent, (1,001 reviews)
"They were excellent. Felt extremely comfortable. Their breakfast was amazing, staff were so friendly!"
United States
Linda
The price is HK$857
HK$981 total
includes taxes & fees
25 Jan - 26 Jan
Hampton Inn & Suites Cape Cod-West Yarmouth

Courtyard Resort

Courtyard Resort
2.0 star property
0.3 km from Main Street Hyannis
8.4 out of 10, Very good, (52 reviews)
"Clean and inexpensive"
United States
Robert
The price is HK$833
HK$954 total
includes taxes & fees
18 Jan - 19 Jan
Courtyard Resort

Courtyard By Marriott Cape Cod Hyannis

Courtyard By Marriott Cape Cod Hyannis
3.0 star property
1.7 km from Main Street Hyannis
8.8 out of 10, Excellent, (490 reviews)
"Parking was free and easy, room was very clean and housekeeping service was top notch. "
United States
Maureen
The price is HK$990
HK$1,133 total
includes taxes & fees
25 Jan - 26 Jan
Courtyard By Marriott Cape Cod Hyannis

Bayside Resort Hotel

Bayside Resort Hotel
3.0 star property
2.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (1,537 reviews)
"The place was clean, staff very nice and a good breakfast! Nice pool and beach area."
United States
LisaAnn
The price is HK$741
HK$937 total
includes taxes & fees
25 Jan - 26 Jan
Bayside Resort Hotel

Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis
4.0 star property
0.9 km from Main Street Hyannis
8.4 out of 10, Very good, (883 reviews)
"It was a decent stay I can’t complain "
United States
Rony
The price is HK$948
HK$1,085 total
includes taxes & fees
7 Feb - 8 Feb
Doubletree by Hilton Cape Cod - Hyannis

Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod
2.5 star property
0.3 km from Main Street Hyannis
8.0 out of 10, Very good, (1,000 reviews)
"Nice hotel had a perfect stay"
United States
David
The price is HK$769
HK$880 total
includes taxes & fees
5 Feb - 6 Feb
Comfort Inn Hyannis - Cape Cod

Cape Sands Inn

Cape Sands Inn
2.5 star property
1.9 km from Main Street Hyannis
8.2 out of 10, Very good, (1,018 reviews)
"Room was nice and spacious, very clean. Upstairs people was a little loud but other than that the stay was good. Would definitely stay again. "
United States
Celestina
The price is HK$581
HK$665 total
includes taxes & fees
19 Jan - 20 Jan
Cape Sands Inn

Hyannis Harbor Hotel

Hyannis Harbor Hotel
3.5 star property
0.6 km from Main Street Hyannis
8.0 out of 10, Very good, (1,000 reviews)
"Lovely stay! One of the best hotels to stay in Hyannis. "
United States
Mary
The price is HK$857
HK$1,296 total
includes taxes & fees
25 Jan - 26 Jan
Hyannis Harbor Hotel

Holiday Inn Hyannis by IHG

Holiday Inn Hyannis by IHG
3.0 star property
2.9 km from Main Street Hyannis
8.2 out of 10, Very good, (982 reviews)
"Nice place"
United States
Linda
The price is HK$889
HK$1,017 total
includes taxes & fees
22 Jan - 23 Jan
Holiday Inn Hyannis by IHG

Sea Breeze Inn

Sea Breeze Inn
2.5 star property
1.8 km from Main Street Hyannis
7.8 out of 10, Good, (193 reviews)
"Nice place to stay "
United States
Kevin
The price is HK$616
HK$705 total
includes taxes & fees
19 Jan - 20 Jan
Sea Breeze Inn

Hyannis Plaza Hotel

Hyannis Plaza Hotel
2.5 star property
0.9 km from Main Street Hyannis
7.0 out of 10, Good, (989 reviews)
"The best staff abd it was clean and beautiful "
United States
Heather
The price is HK$587
HK$750 total
includes taxes & fees
18 Jan - 19 Jan
Hyannis Plaza Hotel

Sal's Place

Sal's Place
2.0 star property
2.5 km from Main Street Hyannis
The price is HK$3,119
HK$4,505 total
includes taxes & fees
19 Jan - 20 Jan
Sal's Place

The Village Inn Cape Cod

The Village Inn Cape Cod
3.5 star property
6.1 km from Main Street Hyannis
10.0 out of 10, Exceptional, (224 reviews)
"It was so charming, would definitely stay there again! "
United States
Kyle
The price is HK$1,209
HK$1,383 total
includes taxes & fees
21 Jan - 22 Jan
The Village Inn Cape Cod

Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod
4.0 star property
3.3 km from Main Street Hyannis
8.8 out of 10, Excellent, (428 reviews)
"We are very happy with all the people at margaritaville, they are awesome 💝"
United States
Ewerton
The price is HK$2,098
HK$2,848 total
includes taxes & fees
13 Feb - 14 Feb
Margaritaville Resort Cape Cod

The Escape Inn

The Escape Inn
2.5 star property
7.6 km from Main Street Hyannis
9.4 out of 10, Exceptional, (662 reviews)
"Great place"
United States
Karim
The price is HK$626
HK$717 total
includes taxes & fees
21 Jan - 22 Jan
The Escape Inn

Aiden by Best Western Cape Cod - West Yarmouth

Aiden by Best Western Cape Cod - West Yarmouth
3.0 star property
3.7 km from Main Street Hyannis
8.0 out of 10, Very good, (1,000 reviews)
"Clean room | Breakfast | Bar | Staff"
United States
Daniel
The price is HK$756
HK$865 total
includes taxes & fees
25 Jan - 26 Jan
Aiden by Best Western Cape Cod - West Yarmouth

The Mariner Resort Cape Cod by The Red Collection

The Mariner Resort Cape Cod by The Red Collection
3.0 star property
4.3 km from Main Street Hyannis
8.0 out of 10, Very good, (445 reviews)
"yes, clean room, staff are great, amenities are fine."
United States
James and Lisa
The price is HK$569
HK$729 total
includes taxes & fees
21 Jan - 22 Jan
The Mariner Resort Cape Cod by The Red Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Main Street Hyannis Hotel Reviews

Hotels near other Main Street Hyannis attractions

Frequently asked questions

What's the area like around Main Street Hyannis?
Main Street Hyannis is located in a walkable area of Hyannis known for its top seafood restaurants and major shopping area. If you're looking for a convenient place to stay, take a look at the 183 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay near Main Street Hyannis?
Adjacent to Main Street Hyannis, Courtyard Resort is one of the top choices for your stay based on our traveller data, and this hotel offers an indoor pool and free parking. Other good options within a short distance include Hyannis Travel Inn and Comfort Inn Hyannis - Cape Cod.
How many hotels can I expect to find near Main Street Hyannis?
Expedia has 183 hotels and other accommodation options within a mile from Main Street Hyannis.
If I need to cancel the hotel reservation for my stay near Main Street Hyannis, will I receive a refund?
Yes! Most hotel reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and get a refund within 24 hours of your booking. Add dates, click "Search", then filter by "fully refundable" to review the top deals on offer near Main Street Hyannis.
What can I see and do near Main Street Hyannis?
John F. Kennedy Hyannis Museum, Whydah Pirate Museum and Cape Cod Maritime Museum feature captivating exhibits. Hyannis Harbor, Edward Gorey House and Sandy Neck Lighthouse are landmarks that you won't want to miss. You can enjoy live performances at Cape Cod Melody Tent and Barnstable Performing Arts Center.