Best O Brien Hotels in 2026 from HK$493 - Fully Refundable Options

A calm river with clear water, surrounded by dense trees and rocky banks.

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Our top choices for O Brien hotels

A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.

A hotel room with a large bed, a sofa, a desk, and a wall with a geometric pattern.

A modern kitchen area with a coffee station, including a coffee machine, cups, and a toaster.

A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.

1. La Quinta Inn & Suite by Wyndham Lake City

Lake City

HK$777

HK$874 total

includes taxes & fees

2 Nov - 3 Nov

An outdoor patio area with tables and chairs, surrounded by palm trees and a building with large windows.

A hotel room with a sofa, a desk with a computer, a TV, a mirror, and framed pictures on the wall.

2. Hampton Inn & Suites Lake City

Lake City

James

HK$823

HK$926 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.

A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.

A modern hotel lobby with a fireplace, seating areas, and a bar.

3. Comfort Suites Lake City

Lake City

Carma

HK$757

HK$852 total

includes taxes & fees

28 Oct - 29 Oct

An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.

A modern hotel with a two-story structure, a covered outdoor seating area, and a parking lot with marked spaces.

A modern hotel lobby with a reception desk, seating areas, and a large screen.

A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.

4. Home2 Suites by Hilton Lake City

Lake City

William

HK$859

HK$967 total

includes taxes & fees

18 Oct - 19 Oct

A spacious living area with a grey sofa, a coffee table, and a TV stand.

A modern kitchen with light wood cabinets, granite countertops, and stainless steel appliances. There are signs on the wall advertising different coffee brands.

A hotel room with a sofa, a small table, a lamp, and artwork on the wall.

A hotel entrance with a covered walkway, palm trees, and a clear sky.

5. Best Western Plus Lake City

Lake City

Melissa

HK$629

HK$707 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor patio area with wicker chairs, a round table, and a fire pit.

A hotel room with a bed, a sofa, a small table, a wardrobe, and a kitchenette.

A modern interior with a sofa, round tables, and chairs, a TV mounted on the wall, and a patterned wall.

A modern interior with a dark wood desk, a blue chair, a sofa, and a patterned rug.

6. TownePlace Suites by Marriott Lake City

Lake City

John

HK$1,012

HK$1,139 total

includes taxes & fees

15 Nov - 16 Nov

A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.

An outdoor patio with a stone fire feature, blue cushioned seating, and a grill.

A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

A modern hotel with a flat roof, multiple windows, and a covered entrance.

7. Tru by Hilton Lake City

Lake City

Carlos

HK$769

HK$865 total

includes taxes & fees

25 Oct - 26 Oct

A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.

A reception area with two wooden reception desks, a wall-mounted decorative piece, and a refrigerator stocked with beverages.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A modern restaurant with round tables and yellow chairs, a bar area with a TV, and a menu display.

8. Courtyard By Marriott Lake City

Lake City

Angel

HK$911

HK$1,025 total

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.

A modern living room with two green sofas, a white coffee table, and a flat-screen TV mounted on the wall.

A modern dining area with multiple tables and chairs, a kitchen in the background, and a 'Hello Fall' sign on the wall.

An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.

9. Fairfield Inn & Suites Lake City

Lake City

Pedro

HK$738

HK$830 total

includes taxes & fees

25 Oct - 26 Oct

A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.

A hotel lobby with a reception desk, a clock, a plant, a water dispenser, and a coffee station.

A hotel lobby with a view of the street, a reception desk, and a large map on the wall.

A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.

10. Americas Best Value Inn Lake City

Lake City

Sara

HK$527

HK$593 total

includes taxes & fees

26 Oct - 27 Oct

A hotel room with a teal accent wall, a sofa, a desk with a chair, a small table, and two framed artworks.

A multi-story building with balconies and a sign indicating it is a Holiday Inn.

A gym with treadmills, weight machines, and dumbbells.

A hotel room with a beige sofa, a small table with a book, a TV on a wooden cabinet, and a window with blinds.

11. Holiday Inn & Suites Lake City by IHG

Lake City

C.jeffery

HK$793

HK$892 total

includes taxes & fees

19 Oct - 20 Oct

A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.

A swimming pool with lounge chairs and umbrellas, surrounded by a brick building with balconies and palm trees.

A restaurant with a yellow accent wall, white tiled floor, and black and blue chairs.

An aerial view of a hotel with a swimming pool, parking lot, and surrounding greenery.

12. Super 8 by Wyndham Lake City

Lake City

Scott

HK$480

HK$540 total

includes taxes & fees

15 Nov - 16 Nov

A covered outdoor area with a paved walkway, benches, and potted plants.

A bedroom with a bed, a desk, a chair, and a ceiling fan.

A grassy area with a picnic table, a car parked in front of a building with a sloped roof, and trees with hanging moss.

A compact kitchen with a blue refrigerator, a black coffee maker, a microwave, and a small black refrigerator.

13. Cindys Motel

Mayo

Diane

HK$689

HK$744 total

includes taxes & fees

5 Nov - 6 Nov

A hotel room with a bed, a desk, a chair, a coffee machine, and a microwave.

A conference room with a stone fireplace, a flat-screen TV, and two office chairs.

A hotel with a covered entrance, a sign indicating it is a Holiday Inn Express, and a well-maintained lawn area.

A reception area with a counter, seating, and a fireplace.

14. Holiday Inn Express & Suites Live Oak by IHG

Live Oak

Tammy

HK$808

HK$889 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.

A hotel dining area with tables and chairs, a reception desk, and a kitchen in the background.

A hotel room with two beds, a desk, a chair, a painting on the wall, and a patterned carpet.

A white building with multiple windows and a sign that reads 'Quality Inn.'

15. Quality Inn Lake City

Lake City

Raphael

HK$594

HK$668 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with two beds, a TV, a desk, and a painting of a sunset.

A hotel room with a large bed, a bedside table, a nightstand, a window, and a bathroom with a toilet and sink.

A kitchen with a black refrigerator and a microwave on a wooden shelf.

A swimming pool with lounge chairs, a small pool house, and a yellow multi-story building with balconies.

16. Days Inn by Wyndham Lake City I-75

Lake City

Jacqueline

HK$565

HK$636 total

includes taxes & fees

18 Oct - 19 Oct

A hotel reception area with a reception desk, seating area, and a view of the parking lot.

A reception area with a wooden floor, a reception desk, a seating area with chairs, and a view through the glass doors to the outside.

A compact room with a flat-screen TV on a wooden cabinet, a microwave on a small black stand, a chair, and a mirror with a light above it.

A hotel room with two beds, a bedside table with a lamp, a phone, and a window with curtains.

17. Econo Lodge Live Oak

Live Oak

Alexia

HK$686

HK$754 total

includes taxes & fees

2 Nov - 3 Nov

An aerial view of a campground with RVs, a swimming pool, and tennis courts.

A covered outdoor dining area with a table and chairs, large windows, and a view of greenery.

A serene lakeside campsite with picnic tables and chairs.

A wooden cabin with a porch, a front door, and a small window.

18. Suwannee River Rendezvous

Mayo

Beth

HK$706

HK$947 total

includes taxes & fees

20 Oct - 21 Oct

A reception area with a stone wall, a blue accent wall, a clock, and a window with a view of the parking lot.

A bathroom with a bathtub, a shower, and a toilet.

A modern bedroom with a wooden headboard, two bedside lamps, a patterned bedspread, and a blue door.

Two doors, one blue and one green, with numbers 105 and 103 respectively, against a brick wall.

19. Regal Inn

Lake City

Samuel

HK$438

HK$493 total

includes taxes & fees

17 Oct - 18 Oct

A modern kitchen with a large window, a flat-screen TV, and a coffee machine.

A hotel lobby with a dining area, a reception desk, and a view of the outside.

A hotel with a swimming pool, white lounge chairs, and a fenced area.

A reception area with a tiled counter, a computer, a sign reading 'Quality,' and two decorative vases.

20. Quality Inn White Springs Suwanee

White Springs

Pennee

HK$512

HK$563 total

includes taxes & fees

15 Nov - 16 Nov

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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien

A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Hampton Inn & Suites Lake City

10/10 Excellent

"We stopped here last year on our trek to southern Florida too. Such a comfortable beds, friendly staff, and great hotel. Recommend to all our friends da. Breakfast is also very good and included with your stay."

BlueGem Motel

10/10 Excellent

"Very clean rooms and homey atmosphere!"

Baymont by Wyndham Lake City I-75

8/10 Good

"Hotel is in need of major remodeling"

Tru by Hilton Lake City

8/10 Good

"Room was clean- shampoo and conditioner were included. Beds were comfortable. Breakfast was also good. Better than most breakfast buffets I have been too. Friendly and helpful staff."

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

10/10 Excellent

"Great for my sons and grandsons to play for a long weekend. Lots of room and games inside and huge yard to play in. Ideal if you have a boat to enjoy the river."

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

3598 W Us Highway 90 Lake City FL

HK$454

HK$510 total

21 Oct - 22 Oct

includes taxes & fees

5/10 (1,000 reviews)

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL

HK$594

HK$668 total

15 Nov - 16 Nov

includes taxes & fees

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL

HK$629

HK$707 total

15 Nov - 16 Nov

includes taxes & fees

Comfort Suites Lake City

3690 W Us Highway 90 Lake City FL

HK$757

HK$852 total

28 Oct - 29 Oct

includes taxes & fees

Tru by Hilton Lake City

284 NW Centurion Court Lake City FL

HK$769

HK$865 total

25 Oct - 26 Oct

includes taxes & fees

Holiday Inn Express & Suites Live Oak by IHG

6694 Us Highway 129 Live Oak FL

HK$808

HK$889 total

15 Nov - 16 Nov

includes taxes & fees

Frequently asked questions

Where is the best place to stay in O Brien?

La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.

What are some of the best holiday rentals that O Brien has to offer?

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: This highly rated holiday home rental in O Brien is located on the beach, and has a balcony, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. Our travellers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favourite home for rent in O Brien. See all vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

What are some accommodation options with pools in O Brien?

La Quinta Inn & Suite by Wyndham Lake City: Provides buffet, an indoor pool and free self parking. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.

How is it to stay in O Brien?

Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodation options to choose from. Find out more about O Brien.

What are the top places to visit in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Lafayette Blue Springs State Park and Lake City Mall in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.

What's the seasonal weather in O Brien?

The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

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O Brien hotels from HK$493

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in O Brien

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for O Brien hotels

1. La Quinta Inn & Suite by Wyndham Lake City

2. Hampton Inn & Suites Lake City

3. Comfort Suites Lake City

4. Home2 Suites by Hilton Lake City

5. Best Western Plus Lake City

6. TownePlace Suites by Marriott Lake City

7. Tru by Hilton Lake City

8. Courtyard By Marriott Lake City

9. Fairfield Inn & Suites Lake City

10. Americas Best Value Inn Lake City

11. Holiday Inn & Suites Lake City by IHG

12. Super 8 by Wyndham Lake City

13. Cindys Motel

14. Holiday Inn Express & Suites Live Oak by IHG

15. Quality Inn Lake City

16. Days Inn by Wyndham Lake City I-75

17. Econo Lodge Live Oak

18. Suwannee River Rendezvous

19. Regal Inn

20. Quality Inn White Springs Suwanee

Learn more about O Brien

Top O Brien Hotel Reviews

Hampton Inn & Suites Lake City

BlueGem Motel

Baymont by Wyndham Lake City I-75

Tru by Hilton Lake City

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

Quality Inn Lake City

Best Western Plus Lake City

Comfort Suites Lake City

Tru by Hilton Lake City

Holiday Inn Express & Suites Live Oak by IHG

Frequently asked questions

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