South Main hotels in Houston
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Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,292 reviews)
"Would stay again!"
Austin
The price is HK$776
HK$908 total
includes taxes & fees
25 May - 26 May
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,000 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
Cleota
The price is HK$726
HK$849 total
includes taxes & fees
28 May - 29 May
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,002 reviews)
"Good parking"
joseph
The price is HK$588
HK$688 total
includes taxes & fees
31 May - 1 Jun
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (865 reviews)
"My stay was perfect "
Fredrick
The price is HK$650
HK$761 total
includes taxes & fees
26 May - 27 May
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,005 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is HK$588
HK$688 total
includes taxes & fees
26 May - 27 May
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.6 out of 10, Exceptional, (77 reviews)
"The property was very clean and the staff was great. I would stay here again when back in town."
Cruz
The price is HK$509
HK$596 total
includes taxes & fees
27 May - 28 May
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (251 reviews)
"Simply amazing stay "
Jesus
The price is HK$698
HK$817 total
includes taxes & fees
27 May - 28 May
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,899 reviews)
"Nice overnight stay. Great for close to airport!!!"
Jaime
The price is HK$717
HK$844 total
includes taxes & fees
7 Jun - 8 Jun
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,778 reviews)
"Gorgeous, perfect location, super comfy beds"
Caitlin
The price is HK$859
HK$1,005 total
includes taxes & fees
7 Jun - 8 Jun
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.2 out of 10, Wonderful, (64 reviews)
"We loved it, very nice employees and very clean."
Jorge
The price is HK$768
HK$898 total
includes taxes & fees
25 May - 26 May
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,215 reviews)
"Wonderful place to stay!"
Lisa
The price is HK$926
HK$1,083 total
includes taxes & fees
1 Jun - 2 Jun
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (173 reviews)
"It was very clean"
Jesus
The price is HK$714
HK$860 total
includes taxes & fees
25 May - 26 May
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,002 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
Albert
The price is HK$815
HK$953 total
includes taxes & fees
27 May - 28 May
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,004 reviews)
"Parking was easy."
Chris
The price is HK$761
HK$891 total
includes taxes & fees
1 Jun - 2 Jun
La Quinta Inn & Suites by Wyndham Richmond-Sugarland
La Quinta Inn & Suites by Wyndham Richmond-Sugarland30.3 km from South Main
8.6 out of 10, Excellent, (1,005 reviews)
"Close proximity to plenty of restaurants and to Brazos Bend State Park!"
Katie
The price is HK$659
HK$758 total
includes taxes & fees
27 May - 28 May
Hotel Royale
Hotel Royale20.9 km from South Main
9.2 out of 10, Wonderful, (37 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is HK$635
HK$743 total
includes taxes & fees
25 May - 26 May
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,003 reviews)
"I had an amazing stay! The staff were among the friendliest staff I’ve ever experienced."
Wesley
The price is HK$793
HK$936 total
includes taxes & fees
7 Jun - 8 Jun
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,175 reviews)
"Room very clean and spacious
Good choice for breakfast and staffs very polite"
Kofoworola
The price is HK$659
HK$758 total
includes taxes & fees
25 May - 26 May
Spark by Hilton Houston Bush Intercontinental Airport
Spark by Hilton Houston Bush Intercontinental Airport31.2 km from South Main
8.6 out of 10, Excellent, (1,001 reviews)
"While the breakfast is truly continental, the property and its team are terrific!"
Carleen Lyden
The price is HK$699
HK$818 total
includes taxes & fees
7 Jun - 8 Jun
Hyatt Place Houston/Sugar Land
Hyatt Place Houston/Sugar Land21.4 km from South Main
8.8 out of 10, Excellent, (1,889 reviews)
"Great location and nice walking trail behind the property!"
michael
The price is HK$765
HK$879 total
includes taxes & fees
25 May - 26 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,000 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 865 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,002 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,005 reviews | View | ||||||
 Comfort Suites Houston Near Medical Center- NRG Stadium | 8.8 Excellent 11 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
Club Quarters Hotel Downtown, Houston
10/10 Excellent
