South Main hotels in Houston

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Our top choices for South Main hotels

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (829 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is HK$577
HK$675 total
includes taxes & fees
17 Feb - 18 Feb
Candlewood Suites Houston Medical Center by IHG

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,002 reviews)
"Good"
United States
Yadira
The price is HK$516
HK$604 total
includes taxes & fees
18 Feb - 19 Feb
Quality Inn & Suites NRG Park - Medical Center

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Clean room, helpful staff and good location to hospital."
United States
George
The price is HK$762
HK$892 total
includes taxes & fees
2 Feb - 3 Feb
Comfort Suites Houston near Medical Center- NRG Stadium

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (999 reviews)
"Easy access to stadium "
United States
Richard
The price is HK$850
HK$994 total
includes taxes & fees
21 Jan - 22 Jan
Wingate Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,207 reviews)
"Front desk staff was very professional and kind."
United States
MARINA
The price is HK$1,006
HK$1,177 total
includes taxes & fees
21 Jan - 22 Jan
Wyndham Houston near NRG Park/Medical Center

Fairfield Inn & Suites Houston Intercontinental Airport

Fairfield Inn & Suites Houston Intercontinental Airport
3.0 star property
30.5 km from South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Great place, nice room"
United States
Lester
The price is HK$656
HK$781 total
includes taxes & fees
23 Jan - 24 Jan
Fairfield Inn & Suites Houston Intercontinental Airport

TownePlace Suites by Marriott Houston Intercontinental Arpt

TownePlace Suites by Marriott Houston Intercontinental Arpt
3.0 star property
30.6 km from South Main
9.0 out of 10, Wonderful, (692 reviews)
"Easy check-in, nice hotel, very clean, great location near IAH "
United States
Steven
The price is HK$680
HK$809 total
includes taxes & fees
24 Jan - 25 Jan
TownePlace Suites by Marriott Houston Intercontinental Arpt

Four Points by Sheraton Houston Intercontinental Airport

Four Points by Sheraton Houston Intercontinental Airport
3.0 star property
29.9 km from South Main
8.4 out of 10, Very good, (1,010 reviews)
"This place was amazing! Stayed in 4 places in days, this was the absolute best !"
United States
Debra
The price is HK$655
HK$766 total
includes taxes & fees
30 Jan - 31 Jan
Four Points by Sheraton Houston Intercontinental Airport

Days Inn & Suites by Wyndham Houston Hobby Airport

Days Inn & Suites by Wyndham Houston Hobby Airport
2.5 star property
15.8 km from South Main
8.6 out of 10, Excellent, (1,001 reviews)
"Awesome friendly staff and spotless rooms. Kudos to the manager."
United States
Mauricio
The price is HK$577
HK$675 total
includes taxes & fees
21 Jan - 22 Jan
Days Inn & Suites by Wyndham Houston Hobby Airport

Comfort Suites Houston West at Clay Road

Comfort Suites Houston West at Clay Road
2.5 star property
22.8 km from South Main
8.4 out of 10, Very good, (1,001 reviews)
"Safe hotel"
United States
Nick
The price is HK$570
HK$667 total
includes taxes & fees
29 Jan - 30 Jan
Comfort Suites Houston West at Clay Road

GreenTree Inn Houston IAH Airport

GreenTree Inn Houston IAH Airport
2.0 star property
31.4 km from South Main
6.6 out of 10, (1,005 reviews)
"It was ok, to spend a night waiting for a flight. "
United States
Hamlet
The price is HK$421
HK$493 total
includes taxes & fees
21 Jan - 22 Jan
GreenTree Inn Houston IAH Airport

Hilton Garden Inn Houston/Bush Intercontinental Airport

Hilton Garden Inn Houston/Bush Intercontinental Airport
3.0 star property
31.1 km from South Main
8.4 out of 10, Very good, (1,007 reviews)
"It was a great stay "
United States
Thrideep
The price is HK$680
HK$800 total
includes taxes & fees
7 Feb - 8 Feb
Hilton Garden Inn Houston/Bush Intercontinental Airport

Doubletree by Hilton Houston Hobby Airport

Doubletree by Hilton Houston Hobby Airport
4.0 star property
Southeast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,008 reviews)
"Great room, great service and wonderful people. "
United States
Stanley
The price is HK$761
HK$899 total
includes taxes & fees
7 Feb - 8 Feb
Doubletree by Hilton Houston Hobby Airport

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
3.0 star property
28.8 km from South Main
9.0 out of 10, Wonderful, (981 reviews)
"Area is nice and quiet. Hotel was clean. "
United States
Isabel
The price is HK$611
HK$715 total
includes taxes & fees
8 Feb - 9 Feb
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

Hampton Inn & Suites Houston I-10 West Park Row

Hampton Inn & Suites Houston I-10 West Park Row
2.5 star property
29.3 km from South Main
8.8 out of 10, Excellent, (677 reviews)
"Great staff, Clean room. "
United States
Corliss
The price is HK$618
HK$728 total
includes taxes & fees
26 Jan - 27 Jan
Hampton Inn & Suites Houston I-10 West Park Row

Holiday Inn Express Hotel & Suites Houston NW-Brookhollow by IHG

Holiday Inn Express Hotel & Suites Houston NW-Brookhollow by IHG
2.5 star property
19.4 km from South Main
8.2 out of 10, Very good, (907 reviews)
"Rooms was clean staff was nice just the breakfast was ok not much options"
United States
Araceli
The price is HK$554
HK$648 total
includes taxes & fees
8 Feb - 9 Feb
Holiday Inn Express Hotel & Suites Houston NW-Brookhollow by IHG

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook
3.0 star property
16.8 km from South Main
9.4 out of 10, Exceptional, (153 reviews)
"Such a great place to stay! Absolutely amazing!"
United States
Charlette
The price is HK$683
HK$824 total
includes taxes & fees
8 Feb - 9 Feb
Palace Inn Blue Edgebrook

Four Points by Sheraton Houston Hobby Airport

Four Points by Sheraton Houston Hobby Airport
3.0 star property
Southeast Houston, 15.3 km from South Main
7.8 out of 10, Good, (1,002 reviews)
"Staff"
United States
Omolara
The price is HK$462
HK$540 total
includes taxes & fees
22 Jan - 23 Jan
Four Points by Sheraton Houston Hobby Airport

Hilton Garden Inn Houston Hobby Airport, TX

Hilton Garden Inn Houston Hobby Airport, TX
3.0 star property
15 km from South Main
8.8 out of 10, Excellent, (1,003 reviews)
"Staff was amazing and attentive. Our room was clean, the amenities were enjoyable. We will be back for sure!"
United States
SAMANTHA
The price is HK$714
HK$836 total
includes taxes & fees
7 Feb - 8 Feb
Hilton Garden Inn Houston Hobby Airport, TX

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (84 reviews)
"Good hotel for the price "
United States
Miguel
The price is HK$625
HK$731 total
includes taxes & fees
25 Jan - 26 Jan
Best Western Plus Pearland/Houston Medical Center Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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