
South Main hotels in Houston
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Our top choices for South Main hotels

Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHG
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical Center
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG Stadium
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical Center
Fairfield Inn & Suites Houston Intercontinental Airport
Fairfield Inn & Suites Houston Intercontinental Airport
TownePlace Suites by Marriott Houston Intercontinental Arpt
TownePlace Suites by Marriott Houston Intercontinental Arpt
Four Points by Sheraton Houston Intercontinental Airport
Four Points by Sheraton Houston Intercontinental Airport
Days Inn & Suites by Wyndham Houston Hobby Airport
Days Inn & Suites by Wyndham Houston Hobby Airport
Comfort Suites Houston West at Clay Road
Comfort Suites Houston West at Clay Road
GreenTree Inn Houston IAH Airport
GreenTree Inn Houston IAH Airport
Hilton Garden Inn Houston/Bush Intercontinental Airport
Hilton Garden Inn Houston/Bush Intercontinental Airport
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby Airport
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
Hampton Inn & Suites Houston I-10 West Park Row
Hampton Inn & Suites Houston I-10 West Park Row
Holiday Inn Express Hotel & Suites Houston NW-Brookhollow by IHG
Holiday Inn Express Hotel & Suites Houston NW-Brookhollow by IHG
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook
Four Points by Sheraton Houston Hobby Airport
Four Points by Sheraton Houston Hobby Airport
Hilton Garden Inn Houston Hobby Airport, TX
Hilton Garden Inn Houston Hobby Airport, TX
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelWhere to stay in South Main

Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.

Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
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